Effectiveness of Homoeopathy in Tinea corporis and Tinea cruris – A Prospective, Longitudinal Observational Study

2021 ◽  
Vol 10 (1) ◽  
pp. 618-627
Author(s):  
Yogeshwari Gupta ◽  
◽  
Sonia Tuteja ◽  
Ankita Acharya ◽  
Vikrant Tripathi ◽  
...  
Keyword(s):  
Observational Study ◽  
Fungal Infection ◽  
Clinical Symptom ◽  
Fungal Infections ◽  
Tinea Corporis ◽  
P Value ◽  
Tinea Cruris ◽  
Longitudinal Observational Study ◽  
Before And After ◽  
Prospective Longitudinal

Dermatophytoses refers to superficial fungal infection of keratinized tissues caused by keratinophilic dermatophytes. According to observations worldwide, dermatophytoses are the most common of the superficial fungal infections. It is common in tropics and may present in epidemic proportions in areas with high rates of humidity. This prospective, longitudinal, observational study was conducted at SKHMC, Jaipur for a period of 1 year (April 2018 to March 2019), aiming to ascertain the effectiveness of homoeopathic medicines in the treatment of Tinea corporis and Tinea cruris. In this study, 65 cases of Tinea Infection (33 cases of Tinea cruris & 32 cases of Tinea corporis) were treated with homoeopathic medicines prescribed on the basis of totality of the symptoms. Treatment outcomes were assessed using Clinical Symptom Score, designed for this study & approved by Institutional Ethical Committee. Out of 65 patients, 41 patients (63.1%) got improved; 19 patients (29.2%) were at status quo and 05 patients (07.7%) became worse. Maximum patients were found to be in the age group of 11-40 years (n=50; 76.9%). Males were observed to be affected more as compared to females. Paired t-test was conducted on the Clinical Symptom Scores obtained before and after treatment and the result showed that p value is < 0.05 & value of t (11.623) is greater than the tabulated value in t-table at df = 64 (1.997), which was statistically significant and which also concluded that homoeopathic medicines were effective in treating Tinea corporis and Tinea cruris. Keywords Homeopathy; Dermatophytoses; Fungal infection; Observational study

scholarly journals Complications Associated with Osmotic Therapy in Acute Stroke Patients- A Prospective Longitudinal Observational Study

2020 ◽  
Author(s):  
Sudhan Rackimuthu ◽  
Pawan Raj Pulu Ishwara ◽  
Sucharitha Suresh
Keyword(s):  
Renal Function ◽  
Observational Study ◽  
Acute Stroke ◽  
Cumulative Dose ◽  
Low Dose ◽  
P Value ◽  
Serum Urea ◽  
Stroke Patients ◽  
Longitudinal Observational Study ◽  
Prospective Longitudinal

Introduction: Mannitol is one of the most frequently used drugs to treat cerebral oedema resulting from ischemic and haemorrhagic strokes. Mannitol administration is associated with complications such as Acute Kidney Injury (AKI) and electrolyte imbalance. Aim: To study effect of mannitol therapy on electrolyte levels and renal function in acute stroke patients. Materials and Methods: The present prospective longitudinal observational study was carried out from January 2019 till September 2019 in Father Muller Medical College, Mangalore, India. After taking informed consent, patients with acute stroke who received mannitol were recruited into the study. Nature of the stroke, presence of comorbidities and dosage of mannitol given were recorded. Serum electrolytes, Serum urea and creatinine were recorded at admission and on fifth day. Serum urea was measured by enzymatic photometric method using urease and glutamate dehydrogenase and serum creatinine was measured by Jaffe’s kinetic method. Comparison of data among different groups was performed using student t-test, ANOVA test, Mann-whitney test and Pearson test. The p-values <0.05 were taken as statistically significant. Results: Total of 72 patients were included in the study. Mean age was 57.7±14.6 years and male: female ratio was 2.27:1. Of the total study subjects, 16 suffered from diabetes (22.22%), 40 from hypertension (55.55%). Ischemic stroke was seen in 41.66% patients and haemorrhagic stroke was seen in 58.33% of the patients. The dose of mannitol administered to all the patients was less than 1 gram/kg/day (low dose mannitol). Cumulative dose of mannitol was 180±177.3 grams. Serum sodium levels were significantly lower on fifth day compared to admission (p-value 0.030) whereas serum potassium and chloride levels were not significantly changed during therapy. There was statistically significant elevation in serum urea levels from admission to fifth day (p-value <0.001) whereas creatinine levels were not significantly altered. Total cumulative dose was compared to serum electrolyte levels and urea and creatinine at admission and fifth day and no significant changes were found. On analysing comorbidities, electrolyte fluctuations were more common in diabetics and Chronic Kidney Disease (CKD) patients whereas renal function parameters were abnormal in diabetics, CKD and hypertensive patients. None of the patients needed any corrective measures to treat the dyselectrolytemias or altered renal function. Conclusion: Low dose mannitol therapy does not produce any significant electrolyte or renal function abnormality in patients with acute stroke. Careful monitoring may be required while treating patients with additional comorbidities.

Effectiveness of Characteristic Keynote Prescription of Homeopathic Medicines in Acute Nasopharyngitis in Paediatric Age Group - A Prospective, Longitudinal Observational Study

2021 ◽  
Vol 10 (1) ◽  
pp. 609-617
Author(s):  
Saket Kumar Singh ◽  
◽  
Vikrant Tripathi ◽  
Keyword(s):  
Observational Study ◽  
Common Cold ◽  
School Age Children ◽  
P Value ◽  
School Age ◽  
Age Group ◽  
Upper Respiratory Tract ◽  
Longitudinal Observational Study ◽  
Paediatric Age ◽  
Prospective Longitudinal

Acute Nasopharyngitis is a common upper respiratory tract infection caused by adenoviruses, influenza, rhinovirus, parainfluenza or respiratory syncytial viruses. This prospective, longitudinal, observational study was conducted at SKHMC, Jaipur for a period of 1 year (April 2018 to March 2019), aiming to ascertain the effectiveness of characteristic keynote prescription of homoeopathic medicines in the cases of Acute Nasopharyngitis in paediatric age group. In this study, 59 cases of Acute Nasopharyngitis were treated with homoeopathic medicines prescribed on the basis of totality of the symptoms along with characteristic keynote symptoms. Treatment outcomes were assessed using Common Cold Questionnaire. Out of 59 patients, 36 patients (61.0%) were improved; 15 patients (25.5%) were at status quo, and 08 patients (13.5%) became worse. Maximum patients were found to be in the age group of School Age children (n=27; 45.8%) and Pre-School children (n=21; 35.6%). Males were observed to be affected more as compared to females. Paired ttest was conducted on the CCQ scores obtained before and after treatment and the result showed that p value was < 0.05 & t = 8.404, which was statistically significant which concluded that characteristic keynote prescription of homoeopathic medicines was effective in cases of Acute Nasopharyngitis. Keywords Homeopathy; Common Cold; School age children; Observational study

scholarly journals Efficacy and safety of neem seed extract compared with clotrimazole in tinea corporis/ cruris: A randomized controlled trial

2018 ◽  
Vol 16 (1) ◽  
pp. 24-29
Author(s):  
Isha Poudel ◽  
Elizabeth Amelia V. Tianco ◽  
Lillian L. Villafuerte
Keyword(s):  
Adverse Effects ◽  
Fungal Infections ◽  
Seed Extract ◽  
Post Treatment ◽  
Tinea Corporis ◽  
P Value ◽  
Neem Seed ◽  
Efficacy And Safety ◽  
Tinea Cruris ◽  
Neem Seed Extract

Introduction: Tinea corporis and tinea cruris are common superficial fungal infections. Neem (Azadirachta indica) seed extract has shown antifungal properties in vitro, but no clinical studies have been done for superficial dermatophytoses. This study compared the efficacy and safety of 5% neem seed extract in cream base with 1% clotrimazole cream when used twice daily for four weeks, in the treatment of localized tinea corporis and/or tinea cruris.Materials and Methods: This is a randomized, double blind, clinical trial. Patients with localized tinea corporis and/or tinea cruris were evaluated at baseline, week 1, week 2 and week 4. Clinical, mycological and effective cure rates of both treatment groups were determined. The patients’ post treatment overall satisfaction scores and the incidence of adverse effects were also documented.Results: Sixty patients were recruited, and 30 patients were randomized to each treatment arm. There were no significant differences in post treatment scores (p value=0.221). Effective cure, defined as the combination of marked clinical improvement and mycological cure, was seen in 20/30 (66.67%) in the neem seed extract group and 24/30 (80%) in the clotrimazole group (relative risk = 1.67, 95% confidence interval = 0.69 – 4.0). Post treatment overall satisfaction scores were comparable (p value = 0.333). Two patients experienced adverse effects in the neem seed extract group, while there were no adverse effects in the clotrimazole group.Conclusion: Efficacy and safety of 5% neem seed extract in cream base is comparable to 1% clotrimazole cream for the treatment of localized tinea corporis and/or tinea cruris.

scholarly journals Symptoms of Posttraumatic Stress Disorder and Associated Risk Factors in Patients With Lung Cancer: A Longitudinal Observational Study

2018 ◽  
Vol 17 (4) ◽  
pp. 1195-1203 ◽  
Author(s):  
Jun Ni ◽  
Jian Feng ◽  
Linda Denehy ◽  
Yi Wu ◽  
Liqin Xu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Posttraumatic Stress Disorder ◽  
Observational Study ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Ptsd Symptoms ◽  
Newly Diagnosed ◽  
Cancer Symptoms ◽  
Longitudinal Observational Study ◽  
Prospective Longitudinal

Purpose. This study aimed to measure symptoms of posttraumatic stress disorder (PTSD) in Chinese patients following a new diagnosis of lung cancer. Secondary aims were to explore factors at diagnosis that may predict PTSD symptoms at 6 months. Methods. This was a prospective longitudinal observational study that included 93 patients with newly diagnosed lung cancer. PTSD symptomology was assessed using the PTSD Checklist Civilian Version (PCL-C) and health-related quality of life (HRQoL) was assessed with the European Organisation for the Research and Treatment of Cancer questionnaire. Measures were completed at diagnosis and 6 months. Results. No patient had PTSD at baseline or 6 months as measured by a score of ⩾50 in the PCL-C. However, at diagnosis, 44% of patients had “mild” symptoms of PTSD. At 6 months, 64% of patients had “mild” and 8% had “moderate” PTSD symptoms. PTSD symptom scores significantly worsened over 6 months (mean difference [95% CI] = 7.2 [5.4 to 9.0]). Six months after diagnosis, higher PTSD scores were seen in people who at diagnosis were younger ( P = .003), had a lower smoking pack history ( P = .012), displayed less sedentary behavior ( P < .005), or initially had worse cancer symptoms, including fatigue ( P = .001) and poorer HRQoL ( P = .004). Conclusions. Mild PTSD symptoms are common in patients with lung cancer 6 months after treatment; however, a full diagnosis of PTSD is uncommon. Screening for PTSD symptoms may be considered for at-risk patients with newly diagnosed lung cancer.

scholarly journals Prothrombotic disturbances of hemostasis of patients with severe COVID-19: A prospective longitudinal observational study

2021 ◽  
Vol 197 ◽  
pp. 20-23 ◽  
Author(s):  
Michaël Hardy ◽  
Isabelle Michaux ◽  
Sarah Lessire ◽  
Jonathan Douxfils ◽  
Jean-Michel Dogné ◽  
...  
Keyword(s):  
Observational Study ◽  
Longitudinal Observational Study ◽  
Prospective Longitudinal

scholarly journals Prediction of nutritive sucking in preterm babies (<34 weeks) and preterm sucking readiness scale

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Nisha Kumari ◽  
Ashish Jain ◽  
Siddarth Ramji
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Observational Study ◽  
Gestational Age ◽  
Negative Association ◽  
Medical College ◽  
Longitudinal Observational Study ◽  
Nutritive Sucking ◽  
Preterm Babies ◽  
Prospective Longitudinal

Abstract Objective To determine predictors of nutritive-sucking in babies < 34 weeks and estimate the appropriate preterm sucking readiness (PTSR) score as an indicator of readiness of nutritive-sucking. Methods Prospective longitudinal observational study conducted in Neonatal unit of a referral hospital attached to Medical College. Forty-nine inborn babies of 28-34 weeks’ gestation and on full gavage feeds were enrolled. Results (a) Nutritive-sucking was achieved at a median age of 14 days (Range 7–50). (b) Low birth weight (LBW) (< 1531.1 ± 142.8) and lesser gestational age (GA) (< 32.8 ± 1) were poor predictors (p < 0.05) and have a significant independent negative association (Correlation birth weight (BW) - 0.0222, GA − 2.2177) with age at which established nutritive-sucking was achieved. (c) PTSR score of ≥9 had the best prediction for achievement of nutritive-sucking at 14-days of life, with a sensitivity of 92.3% and specificity of 100%. Conclusion PTSR score is a sensitive and specific tool to predict the readiness for nutritive-sucking in preterm babies < 34 weeks.

scholarly journals Clinicomycological evaluation of dermatophytosis at tertiary care hospital in central India

2018 ◽  
Vol 4 (3) ◽  
pp. 409
Author(s):  
Shyam Govind Rathoriya ◽  
Ankit Kumar Jain ◽  
Kavita A. Shinde
Keyword(s):  
Fungal Infections ◽  
Tertiary Care ◽  
Age Groups ◽  
Central India ◽  
Common Species ◽  
Tinea Corporis ◽  
Valuable Insight ◽  
Care Hospital ◽  
Cross Sectional ◽  
Tinea Cruris

<p class="abstract"><strong>Background:</strong> Dermatophytoses are the infection of keratinized tissues such as the epidermis, hair, and nails caused by a group of closely related filamentous fungi known as dermatophytes.</p><p class="abstract"><strong>Methods:</strong> It was a hospital based cross-sectional study. A total number of 150 clinically diagnosed cases of skin, hair and nail infections were randomly selected from all the age groups and of both the sexes, attending Dermatology Outpatient department of CMCH, Bhopal from January 2016-December 2017.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of total 150 subjects, most common clinical type of dermatophytosis, identified in our study, was tinea corporis in 53 (35.3%) subjects followed by tinea cruris in 34 (22.6%) subjects. 134 (89.3%) subjects were tested positive by direct microscopy (KOH mount) and 69 (46.0%) by culture. Highest KOH mount positivity was seen in patient suffering from tinea corporis (94.3%) followed by tinea cruris (94.1%). Culture positivity was highest with tinea corporis (54.7%) followed by tinea lesions on more than one site (47.3%) and tinea cruris (47.0%). In our study, total 69 culture positive samples were isolated and the most common species isolated was T. rubrum in 41 (59.42%) cases.</p><p><strong>Conclusions:</strong> The present study gives valuable insight regarding clinical and mycological pattern of superficial fungal infections in this region as well as shows the importance of mycological examination of dermatophytosis samples for planning effective management. </p>

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