scholarly journals The Antifungal activity of alcohol extract of Peganum harmala seeds

2015 ◽  
Vol 9 (1) ◽  
pp. 9-14
Author(s):  
Alkhazraji A.A.H Alkhazraji ◽  
Khalaf E.A Khalaf ◽  
Salman A.S Salman ◽  
Hamza E.SH Hamza ◽  
Gulboy A. Nasir Gulboy
Keyword(s):  
Growth Rate ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Science And Technology ◽  
Control Group ◽  
Inhibition Activity ◽  
Peganum Harmala ◽  
Alcohol Extract ◽  
Penicillium Spp

The study was conducted to evaluate the inhibition activity of alcohol extract of Peganum harmala seeds in somepathogenic fungi (Aspergillus niger, Aspergillus flavus and Penicillium spp.), which was isolated in food researchcenter/ Ministry of Science and Technology. Results revealed that alcohol extract of Peganum harmala seeds wasinhibited the growth of all kind of fungi under study at the extract concentrations (0.012,0.05, 0.25,0.5,1,5,20,50,100 ,200 and 300 mg/ml), colonies diameters for Aspergillus niger was 27, 25 mm at the concentrations 0.012 and0.05 mg/ml respectively in the comparison with its colonies diameter in the control group which was 38 mm forboth concentrations, and it was 26,21 mm for Aspergillus flavus at the same concentration (0.012 and 0.05 mg/ml)respectively, whereas the colonies diameter was decreased to 9,7 mm for Penicillium spp. at 0.012 and 0.05 mg/mlof alcohol extract respectively. In general, the inhibition activity of Peganum harmala seeds alcohol extract wasincreased with the increasing of extract concentrations. The growth rate of all kinds of fungi under study wascompletely inhibited at 0.25mg/ml concentration and above.

Evaluation of Antifungal Activity of CalvatiaCraniiformis and IverMectin as Novel Alternative Therapies for Aspergillus Niger Associated Acute Otitis Media with Special Refer to SocioDemographic Factors Among Rural Children of Diyala Province-Iraq

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Ghassan H. Jameel ◽  
Ali Ibrahim Ali Al-Ezzy
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Otitis Media ◽  
Family Size ◽  
Acute Otitis Media ◽  
Sociodemographic Factors ◽  
P Value ◽  
Rural Children ◽  
Alcohol Extract ◽  
Family Economy

Objectives are to determine antifungal activity of Ivermectin and Calvatiacraniiformis as a novel alternative therapy for aspergillus niger associated acute otitis media (AOM) among rural children of Diyala province; correlation of sociodemographic factors with frequency of infection. Ear swabs taken from 58 infected children and cultured onSabouraud dextrose agar for 7-14 days .Macroscopic and microscopic criteria used for diagnosis of A.niger .High isolation rate for A.niger (27.59%) among children of (4-6) years with significant difference between age groups ( p value 0.039); genders ( p value 0.004);house status(p value=0.018);family size (p value =0.00006334) and month of infection (p value=0.000). A.niger infection negatively correlated with patients age (p value =0.039), family economy and house status (p value =0.000),family size (p value =0.000). Alcohol extract of C.craniiformis (100mg, 200mg, 400mg, 500mg, 600mg, 800mg and 1000 mg) and ivermectin (0.5%,1 % and 2%) restricted the growth of A. niger after 3 days .Significance difference reported between all concentrations except 100 mg and 200 mg ; 600 mg and 800 mg. Significance difference in inhibitory activity between concentration 1% and 2%,0.5% and 2% of Ivermectin respectively. Conclusions: A.niger infections positively correlated with family size and inversely with age and family economy. The growth of A nigersignificantly restricted by alcohol extract of C.craniiformis and Ivermectin in concentration dependent manner. The powerful concentration was 1000mg, for C.craniiformis and 2% for Ivermectin. Thus, C.craniiformis and Ivermectin consider a novel antifungal agents that can be used in clinical practice for treatment of A.niger associated otitis media that represents a clinical problem in children and need serious attention from clinicians.

scholarly journals Synthesis & Antifungal Screening of Novel Azetidin-2-ones

2015 ◽  
Vol 2 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Apoorva Gupta ◽  
Anand K. Halve
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Elemental Analysis ◽  
Spectroscopic Data ◽  
Activity Relationship ◽  
Synthetic Route ◽  
Chemical Structures ◽  
Structure Activity ◽  
Significant Structure

A new series of 4-[3-chloro-2-(4-hydroxy-3-methoxybenzyllidene)-4-oxoazetidin-1-yl]amino-N-(substituted)benzenesulfonamide, 4-{3-chloro-2-[5-methoxy-2-nitro-4-(prop-2-en-1-yloxy)benz yllidene]-4-oxoazetidin-1-yl}]amino}-N-(substituted)benzenesulfonamide and 4-{3-chloro-2-[4-hydroxy-3-methoxy-5-(prop-2-en-1-yl)benzylidene]-4-oxoazetidin-1-yl}amino}-N-(substituted) benzenesulfonamide were synthesized using appropriate synthetic route. The chemical structures of all the synthesized compounds were deduced on the basis of elemental analysis and spectroscopic data. The antifungal activity of the synthesized compounds was screened against several fungus. The synthesized compounds show potent antifungal activity against Aspergillus niger & Aspergillus flavus and significant structure-activity relationship (SAR) trends.

scholarly journals Antifungal Activity in Urginea indica Kunth. (Asparagaceae)

2020 ◽  
pp. 18-23
Author(s):  
B. Mohana ◽  
Shiva Kameshwari ◽  
M. K. Prasana Kumar
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Fusarium Oxysporum ◽  
Aspergillus Flavus ◽  
Antifungal Agent ◽  
Mycelial Growth ◽  
Sclerotium Rolfsii ◽  
Significant Inhibition ◽  
Poisoned Food Technique ◽  
Urginea Indica

Aqueous extract of Urginea indica kunth. (Udupi acccession) was screened for antifungal activity against Fusarium oxysporum, Sclerotium rolfsii, Magnaporthe orzae, Aspergillus flavus, Alternaria alternata, Aspergillus niger and Fusarium moniliformae by poisoned food technique. The results confirmed Urginea indica extracts showed very significant antifungal activity against Fusarium oxysporum and showed significant inhibition for Sclerotium rolfsii and Magnapothea orzaea it showed no activity against Aspergillus niger and Aspergillus flavus. All the activity was evaluated to determine the lowest concentration required to inhibit visible mycelial growth of the pathogen at minmum concentration. Fusarium oxysporum showed very significant inhibition in 10% concentration (Reconfirmed) while Sclerotium showed significant inhibition in 25% concentration followed by Magnoporthe oryzae. The number of sclerotia spores formed was also reduced drastically. These results show that a potential and safe antifungal agent can be obtained from Urginea.

scholarly journals Inhibition activity of Zingiber offcinale. and Cinnamomum zeylanicum extract against Aspergillus niger and Penicillium notatum

2018 ◽  
Vol 11 (1) ◽  
pp. 15-20
Author(s):  
E Muslim ◽  
A Saeed ◽  
SH Sabeeh
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Fungal Pathogens ◽  
Zingiber Officinale ◽  
Inhibition Activity ◽  
Cinnamomum Zeylanicum ◽  
Penicillium Notatum ◽  
Study Results ◽  
Significant Difference ◽  
Ethanolic Extracts

Aqueous and ethanolic extracts of ginger )Zingier officinale) and (Cinnamomum zeylanicum) were used to investigate an antifungal activity against food spoilage fungal pathogens. Study of the inhibitory effect of these extract was done separately against Aspergillus niger and Penicillium notatum isolated from (tomato pasts, cheese) the samples were cultured on Sabouraud's dextrose agar (SDA) at pH 5.6 and 28°C. In this study, results had shown that the extracts of Both plant demonstrated antifungal activity. When compare extracts of the two plants, C. zeylanicum extracts showed higher inhibition activity than (Zingiber officinale) extracts significantly. Ethanolic extracts of these tow plants gives significantly inhabitation in the mycelia growth of fungi more than their aqueous extracts (16-22), (19-25)mm, P. noitatum and A. niger respectively while the inhibitory observed by the aqueous extract (5-6) mm against A. niger for (6-8) mm. Against P. notatum was the most affected by all extracts while A. niger was the least susceptible. There was a significant difference (P=0.05) between groups in the antifungal activities of tested fungi, and the effectiveness of ethanolic extracts was increased with increase in their concentrations. The ability of these extracts to inhibit the growth of the two fungi must take into consideration an indication of the antifungal potency of cinnamon and Zingiber officinale, that makes them the candidate for the production of antifungal agents.

Anti-Fungal Activity of Cressa cretica, Leptadenia pyrotechnica and Pulicaria crispa, indigenous plants of Cholistan desert, Pakistan

2020 ◽  
Vol 18 ◽  
Author(s):  
Faheem Hadi ◽  
Tahir Maqbool ◽  
Sameera Khurshid ◽  
Aisha Nawaz ◽  
Saira Aftab ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Fungal Infections ◽  
Fungal Species ◽  
Fungal Activity ◽  
Aspergillus Ustus ◽  
Mother Tincture ◽  
Anti Fungal

Background: Fungal infections have always remain a problem and they are getting worse with passage of each year due to their resistance against available antibiotics. Natural ways of treatment with homoeopathic medicines made of mother tinctures of plants have no reported side effects and have been proved effective against many bacterial and fungal infections. Materials & Methods: Preparation of mother tinctures of plants Cressa cretica, Leptadenia pyrotechnica and Pulicaria crispa was done and used to evaluate the anti-fungal potential of these plants against potentially pathogenic fungal species like Aspergillus niger, Aspergillus flavus, Aspergillus ustus and Candida albicans by agar disc diffusion method. Each tincture was evaluated at 0.25 ml, 0.5 ml and 1 ml volume per disc and zone of inhibition was measured in millimetres and compared with commercial drug Fluconazole (2 mg/ml) which was used as standard. Results: The results showed that satisfactory anti-fungal activity of these plants in comparison to standard drug Fluconazole. The ratio of antifungal activity of Cressa cretica measured as the zone of growth inhibition of these cultures against Aspergillus niger, Aspergillus flavus, Aspergillus ustus and Candida albicans was 24 mm / 27 mm, 30mm / 28 mm, 23 mm/ 30 mm and 32 mm/ 30 mm respectively. In the case of Leptadenia pyrotechnica, the mother tincture’s antifungal activity was 32 mm / 27 mm, 30 mm / 28 mm, 17 mm/ 30 mm and 24 mm/ 30 mm. In case of our third plant Pulicaria crispa, antifungal activity came out to be 23 mm/ 27 mm, 26 mm/ 28 mm, 26 mm / 30 mm and 24 mm/ 30 mm. Conclusion: Our study proved that mother tincture of these plants can be a potential new therapy to treat fungal infections and has the potential to rule out fungal problems. Further research using mother tincture of these plants against other fungal species has the potential to prove them a safer and widespread anti-fungal homoeopathic medicine.

scholarly journals An investigation into the microbial infestation of poultry feeds

2016 ◽  
Vol 13 (1) ◽  
pp. 79-86
Author(s):  
MM Rahman ◽  
MS Islam ◽  
MZ Alam ◽  
M Ashrafuzzaman
Keyword(s):  
Aspergillus Niger ◽  
Moisture Content ◽  
Aspergillus Flavus ◽  
Fungal Species ◽  
Fusarium Spp ◽  
Fungal Population ◽  
Fungal Flora ◽  
Poultry Feeds ◽  
Penicillium Spp ◽  
Feed Samples

The Experiments were carried out during the period of July 2001 to December 2002. Infestation of poultry feeds by fungi and aflatoxins content in feeds were determined. Ten feed samples were collected from ten different farms located in three different areas of Bangladesh. Five different fungal species belonging four genera were detected which were Aspergillus flavus, Aspergillus niger, Fusarium spp, Rhizopus stolonifer and Penicillium spp. Among them Aspergillus flavus and Aspergillus niger were found in all the feed samples and the rest were occasionally found. Effect of storage and moisture content of feeds were studied for determining the influence on occurrence of fungal flora in feeds. Higher the storing period of feed along with higher moisture content resulted superior incidences of fungal population in stored feeds. Studied on storage practice with 4 duration of F1 sample revealed that the presence of aflatoxins were 30.52ppb, 33.36ppb, 37.32ppb and 48.35ppb of 5, 10, 15 and 20 days after production of feeds, respectively.J. Bangladesh Agril. Univ. 13(1): 79-86, June 2015

scholarly journals Antifungal Activity of Pomegranate and Oak Galls Extracts Against Penicillium spp. and Aspergillus niger

2011 ◽  
Vol 22 (3) ◽  
pp. 1-10
Author(s):  
Abdulilah S. Ismaeil ◽  
Musa I. Taha ◽  
Abdul-ghany O. Sarmamy
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Penicillium Spp

scholarly journals Fungi causing rots in onions at storage and market

1970 ◽  
Vol 6 (2) ◽  
pp. 245-251 ◽  
Author(s):  
MAM Ara ◽  
ML Khatun ◽  
M Ashrafuzzaman
Keyword(s):  
Aspergillus Niger ◽  
Fusarium Oxysporum ◽  
Aspergillus Flavus ◽  
Fusarium Moniliforme ◽  
Room Temperature ◽  
Storage Period ◽  
Fungal Species ◽  
Disease Development ◽  
Duration Of Storage ◽  
Penicillium Spp

Five varieties of diseased onion samples, four local (Taherpuri, Faridpuri, Kalashnagari, and Zitka) and one Indian (Pusa Red) were collected from different markets of Mymensingh, to isolate and identify the associated fungi. Five different fungal species belonging to three genera were repeatedly isolated. Healthy looking and diseased onions were kept at room temperature. The population of associated fungi increased proportionately with the duration of storage period. The isolated fungi were Aspergillus niger, Aspergillus flavus, Penicillium spp., Fusarium oxysporum and Fusarium moniliforme. Healthy onion bulbs were inoculated (with injury and without injury) with these fungi. Individual fungi produced distinguishable symptom of disease in incubation chamber at 22-23°C temperature. After 30 days of inoculation, bulbs showed comparatively low amount of disease development than those at 60 and 90 days. Maximum disease development was found in the variety Pusa Red (with injury) and it was minimum in Zitka variety (without injury). Keywords: Fungi; Onion; Disease development DOI: 10.3329/jbau.v6i2.4818 J. Bangladesh Agril. Univ. 6(2): 245-251, 2008

scholarly journals Evaluation of Antifungal Activity of Various Plant Latex against Selected Fungal Strains

2021 ◽  
Vol 9 (10) ◽  
pp. 875-883
Author(s):  
Mubashira Begum
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Trichoderma Viride ◽  
Aloe Vera ◽  
Diffusion Method ◽  
Calotropis Procera ◽  
Calotropis Gigantea ◽  
Fungal Strains ◽  
Plumeria Rubra

Abstract: Latex is a natural plant polymer and milky white fluid distributed throughout the plant body like leaves, stems, roots and fruits of all flowering plants and consists of proteins, alkaloids, starches, sugars, oils, tannins, resins and gums that coagulate on-air exposure. It is secreted by specialized plant cells called Laticifers. Plants exude latex in response to physical damage. The present study was carried out to assess the potential antifungal activity of latex of five different plants namely Plumeria rubra, Plumeria alba, Aloe vera, Calotropis procera and Calotropis gigantea against three different pathogenic strains of fungi. All five latexes were found to show good to moderated activity against all the three fungal strains, namely Trichoderma viride, Aspergillus flavus and Aspergillus niger. The latex of each plant was tested in two volumes (i.e. 10µl & 20µl), and it was found that the antifungal activity was volume-dependent, and a significant difference was also observed in the case of different fungal strains. The antifungal activity of plant latexes was evaluated by Agar well diffusion method; results revealed that among all the five latexes, the fresh latex of Plumeria rubra (Vol: 10µl &20µl) showed excellent antifungal activity against Aspergillus niger and Aspergillus flavus, whereas fresh latex of Aloe vera (Vol: 10µl & 20µl) showed excellent antifungal activity against Trichoderma viride. The results of the current research imply that the antifungal activity of latex varies with the species of plants and the fungal strains used. The results therefore demonstrated that, the used five latexes effectively inhibited the growth of three tested fungi. Hence, these plant latexes are natural, ecofriendly and can be used as good candidates for the treatment of various fungal diseases. In further words, they can be used for therapy of antifungal-resistant fungi. Keywords: Antifungal activity, Proteins, Alkaloids, Tannins, Resins, Laticifers, Plumeria rubra, Plumeria alba, Aloe vera, Calotropis procera, Calotropis gigantea, Aspergillus flavus, Aspergillus niger, Trichoderma viride, Latex, Agar well diffusion.

scholarly journals Antifungal activity of water-stable copper-containing metal-organic frameworks

2017 ◽  
Vol 4 (10) ◽  
pp. 170654 ◽  
Author(s):  
Supaporn Bouson ◽  
Atiweena Krittayavathananon ◽  
Nutthaphon Phattharasupakun ◽  
Patcharaporn Siwayaprahm ◽  
Montree Sawangphruk
Keyword(s):  
Growth Rate ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Coordination Polymers ◽  
Metal Organic Frameworks ◽  
Antimicrobial Activities ◽  
Porous Coordination Polymers ◽  
Metal Organic ◽  
Agricultural Industries

Although metal-organic frameworks (MOFs) or porous coordination polymers have been widely studied, their antimicrobial activities have not yet been fully investigated. In this work, antifungal activity of copper-based benzene-tricarboxylate MOF (Cu-BTC MOF), which is water stable and industrially interesting, is investigated against Candida albicans , Aspergillus niger , Aspergillus oryzae and Fusarium oxysporum . The Cu-BTC MOF can effectively inhibit the growth rate of C. albicans and remarkably inhibit the spore growth of A. niger , A. oryzae and F. oxysporum . This finding shows the potential of using Cu-BTC MOF as a strong biocidal material against representative yeasts and moulds that are commonly found in the food and agricultural industries.

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