Evaluation of Antifungal Activity of CalvatiaCraniiformis and IverMectin as Novel Alternative Therapies for Aspergillus Niger Associated Acute Otitis Media with Special Refer to SocioDemographic Factors Among Rural Children of Diyala Province-Iraq

2017 ◽  
Vol 9 (08) ◽  
Author(s):  
Ghassan H. Jameel ◽  
Ali Ibrahim Ali Al-Ezzy
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Otitis Media ◽  
Family Size ◽  
Acute Otitis Media ◽  
Sociodemographic Factors ◽  
P Value ◽  
Rural Children ◽  
Alcohol Extract ◽  
Family Economy

Objectives are to determine antifungal activity of Ivermectin and Calvatiacraniiformis as a novel alternative therapy for aspergillus niger associated acute otitis media (AOM) among rural children of Diyala province; correlation of sociodemographic factors with frequency of infection. Ear swabs taken from 58 infected children and cultured onSabouraud dextrose agar for 7-14 days .Macroscopic and microscopic criteria used for diagnosis of A.niger .High isolation rate for A.niger (27.59%) among children of (4-6) years with significant difference between age groups ( p value 0.039); genders ( p value 0.004);house status(p value=0.018);family size (p value =0.00006334) and month of infection (p value=0.000). A.niger infection negatively correlated with patients age (p value =0.039), family economy and house status (p value =0.000),family size (p value =0.000). Alcohol extract of C.craniiformis (100mg, 200mg, 400mg, 500mg, 600mg, 800mg and 1000 mg) and ivermectin (0.5%,1 % and 2%) restricted the growth of A. niger after 3 days .Significance difference reported between all concentrations except 100 mg and 200 mg ; 600 mg and 800 mg. Significance difference in inhibitory activity between concentration 1% and 2%,0.5% and 2% of Ivermectin respectively. Conclusions: A.niger infections positively correlated with family size and inversely with age and family economy. The growth of A nigersignificantly restricted by alcohol extract of C.craniiformis and Ivermectin in concentration dependent manner. The powerful concentration was 1000mg, for C.craniiformis and 2% for Ivermectin. Thus, C.craniiformis and Ivermectin consider a novel antifungal agents that can be used in clinical practice for treatment of A.niger associated otitis media that represents a clinical problem in children and need serious attention from clinicians.

scholarly journals Effectiveness of Tympanic Thermometry for diagnosing Acute Otitis Media

2019 ◽  
Vol 8 (2) ◽  
pp. 74-78
Author(s):  
Muhammad Zubair ◽  
Ghulam Saqulain ◽  
Arfat Jawaid
Keyword(s):  
Tympanic Membrane ◽  
Otitis Media ◽  
Temperature Difference ◽  
Acute Otitis Media ◽  
P Value ◽  
Upper Respiratory Tract ◽  
Mean Temperature ◽  
Ear Wax ◽  
The Mean ◽  
Group B

Background: Acute Otitis Media (AOM) is a common upper respiratory tract infection (URTI) in children and usually presents with fever and otalgia. AOM is characterized by congested tympanic membrane and possible increase in temperature, which might be picked up by infrared tympanic thermometry. The objective of this study was to compare the temperature difference of tympanic membrane of affected ear with the unaffected ear and axilla in unilateral acute otitis media, and compare it with the control group.Material and Methods: This case control study comprised of 200 cases of both genders, aged up to 5 years. They were divided into two groups; Group A included 100 clinically diagnosed cases of acute otitis media (AOM), who reported in the ENT Outpatient Department (OPD) and Group B included 100 controls who presented in General Filter Clinic with no ear complaints. Cases with chronic ear disease, ear discharge, and use of local drugs including ear drops, impacted ear wax, tragal tenderness and congenital malformations of the ear were excluded by taking a detailed history. Clinical examination including otoscopy by an expert was done before subjecting patients to axillary and tympanic thermometry measurements and data recording. Data was collected and tabulated using Microsoft Excel Worksheet and analyzed by SPSS 16. Qualitative data like gender were presented as percentage and ratio, while means and standard deviation were calculated for the quantitative data. Difference between the means of experimental and control groups were analyzed by independent sample t-test and P value of less than or equal to 0.05 was taken as significant.Results: This study included 100 cases of unilateral AOM and 100 normal controls without AOM. In patients with AOM, the mean temperature difference between the affected ear and axilla was 1.41ºF as compared to 0.075ºF in controls (p=0.026). While the mean temperature difference between the affected ear and other ear was 0.65ºF as compared to 0.19ºF in controls (p=0.069).Conclusion: In acute otitis media, the temperature of affected ear is significantly higher than axilla but was not significantly higher than the other ear. The finding may help establish thermometry as a diagnostic tool in clinics manned by doctors not competent to do otoscopy.

scholarly journals Hubungan Rinitis Alergi Dengan Otitis Media Akut Pada Anak Di RSUD Dr. H Abdul Moeloek Bandar Lampung Tahun

2021 ◽  
Vol 1 (3) ◽  
pp. 198-203
Author(s):  
Muslim Kasim ◽  
Arti Febriyani Hutasuhut ◽  
Tan’im Arief ◽  
Farah Ulya Suryadana
Keyword(s):  
Allergic Rhinitis ◽  
Data Analysis ◽  
Otitis Media ◽  
Research Design ◽  
Middle Ear ◽  
Acute Otitis Media ◽  
Sampling Technique ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional

ABSTRACT: RELATIONSHIP BETWEEN ALLERGIC RHINITIS AND ACUTE OTITIS MEDIA IN CHILDREN IN RSUD DR. H ABDUL MOELOEK  BANDAR LAMPUNG  Introduction: Background : Acute Otitis Media (AOM) is an inflammation that happen in the middle ear and is very common, especially in children. Children are susceptible to acute otitis media (AOM) due to the shorter and horizontal anatomy of the eustachian tube. Allergic Rhinitis is one of the risk factos that caused acute otitis media in children.Purpose : The purpose of this study was to determine the correlation between Allergic Rhinitis and Acute Otitis Media in ChildrenMethod: This study used an observational analytic research with cross sectional research design. The sample in this study was 59 patients diagnosed with acute otitis media at RSUD Dr. H. Abdul Moeloek in 2019-2020. The sampling technique used total sampling. Data analysis using Chi-Square testResult: The results of this study indicated that there was a relationship between allergic rhinitis and acute otitis media in children with p value = 0,047(<0,05) with an OR = 0,146 (95%CI 0,17-1,232). Conclusion: There is a relationship between Allergic Rhinitis and Acute Otitis Media in children at Dr. H Abdul Moeloek Bandar Lampung in 2019-2020 Keyword : Allergic Rhinitis, Acute Otitis Media, Children  INTISARI: HUBUNGAN RINITIS ALERGI DENGAN OTITIS MEDIA AKUT PADA ANAK DI RSUD DR. H ABDUL MOELOEK BANDAR LAMPUNG  Latar belakang: Otitis Media Akut (OMA) merupakan peradangan yang terjadi pada telinga bagian tengah dan sangat sering terjadi terutama pada anak-anak. Anak-anak rentan terkena Otitis Media Akut (OMA) dikarenakan bentuk anatomi tuba eustachius yang lebih pendek dan horizontal. Rinitis Alergi merupakan salah satu faktor risiko yang menyebabkan Otitis Media Akut pada anak.Tujuan: Tujuan penelitian ini adalah untuk mengetahui hubungan Rinitis Alergi dengan Otitis Media akut pada Anak.Metode: Penelitian analitik observasional dengan desain penelitian cross sectional. Sampel sebanyak 59 pasien dengan diagnosa otitis media akut anak di RSUD Dr. H. Abdul Moeloek tahun 2018. Teknik pengambilan sample menggunakan total sampling. Analisis data menggunakan uji Chi-SquareHasil : Hasil penelitian ini menunjukkan bahwa terdapat hubungan antara rinitis alergi dengan otitis media akut pada anak dengan p value = 0,047(<0,05) dengan nilai OR = 0,146 (95%CI 0,17-1,232).Kesimpulan : Terdapat hubungan antara Rinitis Alergi dengan Otitis Media Akut pada anak di RSUD Dr. H Abdul Moeloek Bandar Lampung tahun 2019-2020 Kata Kunci : Rinitis Alergi, Otitis Media Akut, Anak  

scholarly journals Has Otitis Media Disappeared during COVID-19 Pandemic? A Fortuitus Effect of Domestic Confinement

2021 ◽  
Vol 10 (13) ◽  
pp. 2851
Author(s):  
Sara Torretta ◽  
Barbara Cantoni ◽  
Giuseppe Bertolozzi ◽  
Pasquale Capaccio ◽  
Gregorio Paolo Milani ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Patient Flow ◽  
Acute Otitis Media ◽  
Pediatric Emergency ◽  
P Value ◽  
Period 2 ◽  
Middle Ear Infection ◽  
Significant Difference ◽  
Ear Infections

Background: To measure patient flow at our Pediatric Emergency Department (PED) during the Italian lockdown, with particular care in terms of otolaryngological (ENT)-related diagnoses. Methods: A retrospective evaluation of electronic charts of children admitted to our PED in the City Center of Milan (Italy) for any disease. The outcome was to compare distribution of diagnoses performed at our PED during 21 February–3 May 2019 (period 1) to 21 February–3 May 2020 (period 2). Results: A total of 4538 children were evaluated during period 1 compared to 1310 during period 2. A statistically significant overall effect on diagnosis between the study periods was attested (p-value < 0.001; pseudoR2 = 0.010), ENT-related diagnoses being more frequently documented in period 1 (80.4% vs. 19.5%; p-value < 0.001), as well as those related to middle ear infections (92.8% vs. 7.2%; p-value < 0.001). Non-complicated acute otitis media more frequently occurred in period 1 (92.0% vs. 8.0%; p-value < 0.001); no significant difference in the number of complicated middle ear infections occurred (95.8% vs. 4.2%). Conclusions: The exceptional circumstances of the Italian lockdown resulted in a significant decrease in patients’ attendance to our PED, especially when considering diagnoses related to any ENT disorder, middle ear disease, and non-complicated middle ear infection.

scholarly journals Association of Acute Otitis Media with Breast Feeding Position Among Infants in a Tertiary Care Hospital of Pakistan

2020 ◽  
Vol 2 (6) ◽  
Author(s):  
Samia Tul Rasool ◽  
Sana Mansoor ◽  
Tayyab Mumtaz Khan ◽  
Ashar Alamgir ◽  
Maida Meer ◽  
...  
Keyword(s):  
Otitis Media ◽  
Breast Feeding ◽  
Tertiary Care ◽  
Acute Otitis Media ◽  
P Value ◽  
Care Hospital ◽  
Chi Square ◽  
Educational Levels ◽  
Breastfed Infants ◽  
Chi Square Test

Acute otitis media (AOM) is the commonest disease of childhood. High incidence of AOM might be due to immature Eustachian Tube and immaturity of immune system. Exclusive breast feeding is protective against acute otitis media, however, improper breastfeeding  position can increase AOM occurrence in infants. This study aims to assess the association of improper breastfeeding position with occurrence of Acute otitis media in infants and to assess association of Maternal educational levels with feeding positions. 220 breastfed infants satisfying inclusion criteria with diagnosed AOM were enrolled. Study was conducted over a period of 6 months from August 2019 to January 2020. Demographic details and Detailed history regarding feeding positions and maternal educational levels were obtained through a Self-structured proforma from parents. Data analysis was done through descriptive statistics and chi square test and p value less than 0.5 was set significant. Out of 220 infants, 123(55.90%) were male and 97(44.10%) were females. AOM was more common in male infants than female infants, however it was not statistically significant(p=0.169). The mean age for enrolled infants(1-12months) was 6.90(±3.413). Statistically significant association between increase incidence of AOM and breastfeeding position was found(p=0.032). We also found a statistically significant association between maternal educational levels and breastfeeding position (p= 0.000). In this study, we have noted that Breastfeeding in supine position is associated significantly with increase in incidence of AOM. Feeding positions are statistically associated with Maternal Educational levels.

scholarly journals Pneumococcal Conjugate Vaccine (Non-Typeable Haemophilus influenzae (NTHi) Protein D, Diphtheria or Tetanus Toxoid Conjugates) in Prevention of Acute Otitis Media in Children: A Cohort Study

2016 ◽  
Vol 31 (2) ◽  
pp. 13-15 ◽  
Author(s):  
Trixy G. Chu ◽  
Daniel Rafael R. Cachola ◽  
Mary Agnes S. Regal ◽  
Agnes Cecille G. Llamas ◽  
Norberto V. Martinez ◽  
...  
Keyword(s):  
Cohort Study ◽  
Relative Risk ◽  
Haemophilus Influenzae ◽  
Otitis Media ◽  
Conjugate Vaccine ◽  
Tetanus Toxoid ◽  
Pneumococcal Conjugate Vaccine ◽  
Acute Otitis Media ◽  
P Value ◽  
Monthly Basis

Objective: To compare the incidence of acute otitis media among children aged 2 to 6 months old in Sampaloc, Manila who were previously given 3 doses of pneumococcal conjugate vaccine (Non-Typeable Haemophilus influenzae (NTHi) protein D, diphtheria or tetanus toxoid conjugates) and those who did not receive the vaccine, over a period of one year. Methods: Study Design:             Cohort Study Setting:                       Primary Health Center in Sampaloc, Manila, Philippines Participants:              Medical records of well children aged 2 to 6 months were reviewed for inclusion. Participants were categorized into vaccinated and unvaccinated groups. Both groups underwent baseline history and physical examination including otoscopy and any signs and symptoms of active ear infection were noted.  Subjects were followed up for a period of 1 year on a monthly basis for signs or symptoms of acute otitis media. Results: A total of 176 subjects participated in the study. The overall incidence of AOM among participants was 5.11% (9 out of 176). An AOM incidence of 3.75% (3 out of 80) and 6.25% (6 out of 96) was found among the exposed and unexposed groups, respectively. Fisher’s exact test (one-tailed) p value =.34, relative risk (RR) .6 (95 percent CI 0.155, 2.323). Conclusion: The results of this study showed no difference in the development of AOM in the two groups. However, based on the relative risk, Pneumococcal conjugate vaccine is still beneficial in preventing AOM in children. Keywords: Pneumococcal Conjugate Vaccine; Acute Otitis Media

scholarly journals Comprehensive Community Screening of Otological Patients by Trained Technicians Using a Telemedicine Device: An Efficient and Cost-Effective Way to Triage Patients With Ear Diseases

2020 ◽  
pp. 014556132095099
Author(s):  
Nishi Gupta ◽  
K. S. Baghotia ◽  
Manipadama Rabha ◽  
Sanchi Sachdeva ◽  
Garima Sahai ◽  
...  
Keyword(s):  
Otitis Media ◽  
Acute Otitis Media ◽  
Intervention Group ◽  
Cost Effective ◽  
P Value ◽  
Suppurative Otitis Media ◽  
Community Screening ◽  
Ear Diseases ◽  
Rural And Urban ◽  
Underserved Community

Objective: To emphasize the benefits of tele-otology in community screening of patients with ear diseases. Methods: A retrospective study of all patients screened and treated under the Shruti tele-otology program between 2013 and 2019 was conducted. It involved screening, diagnosis, medical management, surgical intervention, and rehabilitation using hearing aid. The study focused on underprivileged and underserved community of rural and urban slums across 12 states of India. The study was conducted using a telemedicine device called ENTraview, that is, a camera-enabled android phone integrated with an otoscope and audiometry screening. Result: A total of 810 746 people were screened, and incidence of various ear diseases was recorded. Ear problems were found in 265 615 (33%) patients, of which 151 067 (57%) had impacted wax, 46 792(18%) had chronic suppurative otitis media, 27 875 (10%) had diminished hearing, 12 729 (5%) had acute otitis media and acute suppurative otitis media (ASOM), and 27 152 (10%) had problems of foreign body, otomycosis, and so on. Of the total 265 615 referred patients, 20 986 (8%) reported for treatment and received treatment at a significantly reduced cost through Shruti program partners. The conversion rate of nonsurgical and surgical procedure was also compared, and it was found that, while 9% of the patients opted for nonsurgical treatment, only 3% opted for surgery in the intervention group giving a significant P value of .00001. Conclusion: The potential for telemedicine to reduce inequalities in health care is immense but remains underutilized. Shruti has largely been able to bridge this gap as it is an innovative, fast, and effective programs that address the ear ailment in the community.

scholarly journals The Antifungal activity of alcohol extract of Peganum harmala seeds

2015 ◽  
Vol 9 (1) ◽  
pp. 9-14
Author(s):  
Alkhazraji A.A.H Alkhazraji ◽  
Khalaf E.A Khalaf ◽  
Salman A.S Salman ◽  
Hamza E.SH Hamza ◽  
Gulboy A. Nasir Gulboy
Keyword(s):  
Growth Rate ◽  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Flavus ◽  
Science And Technology ◽  
Control Group ◽  
Inhibition Activity ◽  
Peganum Harmala ◽  
Alcohol Extract ◽  
Penicillium Spp

The study was conducted to evaluate the inhibition activity of alcohol extract of Peganum harmala seeds in somepathogenic fungi (Aspergillus niger, Aspergillus flavus and Penicillium spp.), which was isolated in food researchcenter/ Ministry of Science and Technology. Results revealed that alcohol extract of Peganum harmala seeds wasinhibited the growth of all kind of fungi under study at the extract concentrations (0.012,0.05, 0.25,0.5,1,5,20,50,100 ,200 and 300 mg/ml), colonies diameters for Aspergillus niger was 27, 25 mm at the concentrations 0.012 and0.05 mg/ml respectively in the comparison with its colonies diameter in the control group which was 38 mm forboth concentrations, and it was 26,21 mm for Aspergillus flavus at the same concentration (0.012 and 0.05 mg/ml)respectively, whereas the colonies diameter was decreased to 9,7 mm for Penicillium spp. at 0.012 and 0.05 mg/mlof alcohol extract respectively. In general, the inhibition activity of Peganum harmala seeds alcohol extract wasincreased with the increasing of extract concentrations. The growth rate of all kinds of fungi under study wascompletely inhibited at 0.25mg/ml concentration and above.

scholarly journals Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media

2020 ◽  
Vol 21 (23) ◽  
pp. 9291
Author(s):  
Blendi Ura ◽  
Fulvio Celsi ◽  
Luisa Zupin ◽  
Giorgio Arrigoni ◽  
Ilaria Battisti ◽  
...  
Keyword(s):  
Otitis Media ◽  
Pathological Condition ◽  
Sleep Apnea Syndrome ◽  
Acute Otitis Media ◽  
P Value ◽  
Two Dimensional Gel Electrophoresis ◽  
Adenotonsillar Hypertrophy ◽  
Obstructive Sleep ◽  
Neutrophil Degranulation ◽  
Proteomic Study

Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (p-value < 0.05) changes in protein amount, recognizing proteins involved in neutrophil degranulation and glycolysis pathways.

scholarly journals Tragal perichondrium as graft material in tympanoplasty: our experience

2021 ◽  
Vol 7 (3) ◽  
pp. 430
Author(s):  
Vivek K. Pathak ◽  
Pradeepti Nayak ◽  
Sonali Tyagi ◽  
Rohit Chaudhary
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Age Groups ◽  
Acute Otitis Media ◽  
Chronic Otitis Media ◽  
Uttar Pradesh ◽  
Cell System ◽  
P Value ◽  
Graft Material

<p class="abstract"><strong>Background:</strong> It has been defined as a permanent abnormality of pars tensa or flaccida, as a result of acute otitis media, negative middle ear pressure or otitis media with effusion. It manifests clinically as ear discharge and decreased hearing and may lead to numerous changes in the tympanic membrane, middle ear cleft, and mastoid air cell system. It has been classified into two types: mucosal and squamosal types. Chronic otitis media (COM) is a very common condition in developing countries in both adult and paediatric age groups. This study has been conducted to determine the outcome and graft uptake of tragal perichondrium in type 1 tympanoplasty.</p><p class="abstract"><strong>Methods:</strong> The prospective analytical study was conducted department of otorhinolaryngology, School of Medical Sciences and Research, Greater Noida, Uttar Pradesh, India over a period of 12months from 01 January 2019 to 31 December 2019. 30 patients according to inclusion criterion underwent tympanolpasty using tragal perichondrium were included in study. The data obtained was analyzed using statistical package for the social sciences (SPSS), version 21.0. P value less than 0.05 was taken as statically significant.  </p><p class="abstract"><strong>Results:</strong> Preoperative mean hearing loss was 38.45±7.01 dB, mean air bone gap was 20.20±3.75 dB, and postoperative air bone gap was reduced to an average of 10.86±3.82 dB. 8.51 dB of hearing gain was achieved and an air bone gap réduction of 8.51 dB was observed.</p><p class="abstract"><strong>Conclusions:</strong> Our study concluded tragal perichondrium is a suitable graft material is n mucosal type of COM.</p>

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