scholarly journals Effect of vitamin C supplementation on gingival bleeding

2018 ◽  
Vol 30 (3) ◽  
pp. 178
Author(s):  
Indra Mustika Setia Pribadi ◽  
Nunung Rusminah ◽  
Yanti Rusyanti ◽  
Anne Agustina Suwargiani
Keyword(s):  
Vitamin C ◽  
Chronic Periodontitis ◽  
Host Defence ◽  
Periodontal Pathogens ◽  
Defence Mechanisms ◽  
Periodontal Health ◽  
High Category ◽  
Gingival Bleeding ◽  
Before And After ◽  
Vitamin C Supplementation

Introduction: Periodontitis is a multifactorial disease caused by a disproportion between environmental factors such as periodontal pathogens and the host defence. Genetic factors, hormones, and nutrition may influence host defence mechanisms. One of the nutrition needed for periodontal health is vitamin C. This study was aimed to evaluate the effect of vitamin C supplementation on gingival bleeding. Methods: As much as ninety-eight patients with chronic periodontitis consisted of 42 males and 56 females, aged 30 – 59-years-old participated in this study. Gingival bleeding was assessed before and after 3 months administered with vitamin C supplementation. Gingival bleeding criteria was based on Van der Velden with tooth selection based on Ramfjörd. Result: Gingival bleeding before the administration of vitamin C supplementation was found in the high category at 4 patients (4.1%), medium at 36 patients (36.7%), and low at 58 patients (59.2%).  After 3 months administration of vitamin C supplementation, high category gingival bleeding was found in 2 patients (2%), medium in 16 patients (16.3%), and low in 80 patients (81.6%). Conclusion: There was an effect of vitamin C supplementation on gingival bleeding.Keywords: Chronic periodontitis, vitamin C supplementation, gingival bleeding.

Effect of High Dose Vitamin C Supplementation on Muscle Soreness, Damage, Function, and Oxidative Stress to Eccentric Exercise

2006 ◽  
Vol 16 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S.C. Bryer ◽  
A.H. Goldfarb
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Eccentric Exercise ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Damage Function ◽  
High Dose ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Glutathione Oxidation

This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P ≥ 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Gluta-thione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.

scholarly journals The effect of vitamin C on the gene expression profile of sperm protamines in the male partners of couples with recurrent pregnancy loss: A randomized clinical trial

2020 ◽  
Vol 47 (1) ◽  
pp. 68-76
Author(s):  
Saeideh Hamidian ◽  
Ali Reza Talebi ◽  
Farzaneh Fesahat ◽  
Mohammad Bayat ◽  
Ali Mohammad Mirjalili ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vitamin C ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Sperm Chromatin ◽  
Dna Integrity ◽  
Male Partners ◽  
Expression Levels ◽  
Before And After ◽  
Vitamin C Supplementation

Objective: Since sperm abnormalities are known to be a major reason for recurrent pregnancy loss (RPL), any defects in DNA structure and chromatin condensation can place embryos at risk in the early stage of development and implantation. As antioxidants such as vitamin C may play a protective role against the destruction of protamine genes in sperm chromatin, this study was conducted to evaluate the effects of vitamin C on chromatin and the expression of protamine genes in the male partners of couples with RPL.Methods: Twenty male partners of couples with RPL were selected as the intervention group and received vitamin C supplementation (250 mg daily for 3 months). Healthy fertile men (n=20) were included as controls. Sperm chromatin, DNA integrity, and the expression levels of protamine genes were evaluated before and after treatment.Results: Significant differences were found in sperm morphology, protamine deficiency, and apoptosis between the two groups and before and after vitamin C administration. A significant change was found in mRNA levels of <i>PRM1, PRM2</i>, and the <i>PRM1/PRM2</i> ratio after treatment.Conclusion: Daily oral administration of vitamin C may improve human sperm parameters and DNA integrity by increasing protamine gene expression levels in the male partners of couples with RPL. The beneficial effects of vitamin C supplementation as an antioxidant for the male partners of couples with RPL could lead to improved pregnancy outcomes in these cases.

Vitamin C supplementation as an adjunct to nonsurgical therapy in the treatment of chronic periodontitis: A clinical and biochemical study

2018 ◽  
Vol 10 (5) ◽  
pp. 256 ◽  
Author(s):  
Anupama Rao ◽  
U Raghavendra ◽  
ShankarRajesh Kashyap ◽  
Jyothi D'Souza ◽  
Vijaya Kumar ◽  
...  
Keyword(s):  
Vitamin C ◽  
Chronic Periodontitis ◽  
Biochemical Study ◽  
Vitamin C Supplementation ◽  
Nonsurgical Therapy

scholarly journals Evaluation of Enterococcus faecalis, Staphylococcus warneri and Staphylococcus aureus species in adults with generalized chronic periodontitis

2017 ◽  
Vol 65 (2) ◽  
pp. 121-127
Author(s):  
Aretuza FRITOLI ◽  
Eduardo LOBÃO ◽  
Geisla Soares ◽  
Belén RETAMAL-VALDES ◽  
Magda FERES
Keyword(s):  
Staphylococcus Aureus ◽  
Enterococcus Faecalis ◽  
Chronic Periodontitis ◽  
Bacterial Species ◽  
Hybridization Technique ◽  
Periodontal Pathogens ◽  
Periodontal Health ◽  
Staphylococcus Warneri ◽  
Percentage Points

ABSTRACT Objective: To identify and quantify the levels of three bacterial species that have recently been identified as potential “new” periodontal pathogens (Enterococcus faecalis, Staphylococcus aureus and Staphylococcus warneri) in subjects with periodontal health and generalized chronic periodontitis. Methods: Thirty adults with generalized chronic periodontitis and 10 periodontally healthy were included in this study. Nine subgingival biofilm samples were collected per subject and individually analyzed by checkerboard DNA-DNA hybridization technique. Results: The mean levels of E. faecalis and S. warneri were higher in chronic periodontitis than in periodontal health (p<0.05). Furthermore, a higher percentage of subjects with periodontitis were colonized by the three species evaluated in comparison with healthy subjects (p<0.05). This represented a difference of 40 percentage points between the two groups, for E. faecalis (present in 90% of individuals with periodontitis and 50% of the healthy individuals) and S. warneri (100% and 60%, respectively), and 26 percentage points for S. aureus (86% and 60%, respectively). Conclusion: E. faecalis and S. warneri have the potential to be periodontal pathogens. The role of S. aureus was less evident, since this species was more prevalent and at relatively higher levels in health than the other two species. These data might guide future studies on the role of these microorganisms in the etiology of periodontitis and help to establish more effective treatments for these infections.

New Bacterial Species Associated with Chronic Periodontitis

2003 ◽  
Vol 82 (5) ◽  
pp. 338-344 ◽  
Author(s):  
P.S. Kumar ◽  
A.L. Griffen ◽  
J.A. Barton ◽  
B.J. Paster ◽  
M.L. Moeschberger ◽  
...  
Keyword(s):  
New Species ◽  
Chronic Periodontitis ◽  
Bacterial Species ◽  
Pcr Amplification ◽  
Periodontal Pathogens ◽  
Cloning And Sequencing ◽  
Periodontal Health ◽  
Oral Flora ◽  
Bacteroidetes Phylum ◽  
Species Specific

Recent investigations of the human subgingival oral flora based on ribosomal 16S cloning and sequencing have shown many of the bacterial species present to be novel species or phylotypes. The purpose of the present investigation was to identify potential periodontal pathogens among these newly identified species and phylotypes. Species-specific ribosomal 16S primers for PCR amplification were developed for detection of new species. Associations with chronic periodontitis were observed for several new species or phylotypes, including uncultivated clones D084 and BH017 from the Deferribacteres phylum, AU126 from the Bacteroidetes phylum, Megasphaera clone BB166, clone X112 from the OP11 phylum, and clone I025 from the TM7 phylum, and the named species Eubacterium saphenum, Porphyromonas endodontalis, Prevotella denticola, and Cryptobacterium curtum. Species or phylotypes more prevalent in periodontal health included two uncultivated phylotypes, clone W090 from the Deferribacteres phylum and clone BU063 from the Bacteroidetes, and named species Atopobium rimae and Atopobium parvulum.

scholarly journals Effect of vitamin C supplementation on serum Cotinine, MDA and vitamin C levels in smokeless Tobacco chewers

2019 ◽  
Vol 10 (2) ◽  
pp. 803-811
Author(s):  
Jaywant Thorat ◽  
Anand Joshi ◽  
Ajit Sontakke ◽  
Kanchan Wingkar
Keyword(s):  
Vitamin C ◽  
Smokeless Tobacco ◽  
Daily Intake ◽  
Serum Vitamin ◽  
Tobacco Consumption ◽  
Serum Cotinine ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Healthy Participants ◽  
Tobacco Chewing

Smokeless tobacco is a commonly used drug in the world. Tobacco use in any form is a rising crisis for the population in developing countries. Tobacco contributes significantly to oxidative stress induced morbidity and mortality. The study was aimed to evaluate the effect of vitamin C supplementation on serum cotinine, malondialdehyde (MDA) and serum vitamin C level in smokeless tobacco (ST) chewers. In addition, the study was aimed to evaluate the effect of duration of tobacco chewing on above-said parameters. A total number of 338 healthy participants of aged between 31 to 60 years were classified into two groups comprising of tobacco chewers and tobacco non-chewers. Tobacco chewers group further divided into three subgroups with respect to tobacco chewing duration. Participants were asked to take 1000 mg of vitamin C daily for 45 days. Serum cotinine, MDA and serum vitamin C were measured in all the participants before and after supplementation of vitamin C. Serum cotinine (p<0.001) and MDA (p<0.001) were significantly increased whereas serum vitamin C level (p<0.001) was significantly decreased in smokeless tobacco chewers as than to controls. However, serum cotinine (p<0.001) and MDA (p<0.001) were significantly decreased whereas vitamin C (p<0.001) level was significantly increased in both the groups after supplementation of vitamin C as compared to before. It was observed that the changes become more prominent with increased smokeless tobacco consumption duration. Daily intake of vitamin C may be beneficial to restore the oxidant-antioxidant balance in tobacco chewers.

scholarly journals Microbiological Response to Periodontal Therapy: A Retrospective Study

2018 ◽  
Vol 12 (1) ◽  
pp. 837-845 ◽  
Author(s):  
Vittorio Checchi ◽  
Gaia Pascolo
Keyword(s):  
Cell Count ◽  
Chronic Periodontitis ◽  
Bacterial Species ◽  
Bacterial Load ◽  
Periodontal Pocket ◽  
Periodontal Pathogens ◽  
Microbiological Test ◽  
Probing Depth ◽  
Before And After ◽  
The Mean

Background:Periodontitis is a multifactorial infection caused by a complex of pathogenic bacterial species that induce the destruction of periodontal structures.Objective:The aim of this study is to evaluate the presence and bacterial load of six periodontal pathogens bacteria, measured at initial visit and after osseous surgery in patients affected by chronic periodontitis and treated between 2005 and 2007.Methods:This cohort study was carried out on a sample of 38 consecutive patients affected by severe chronic periodontitis, diagnosed at baseline on the basis of probing depths equal to 6.68 ± 1.47 mm. On each subject, a microbiological test was performed before periodontal initial therapy and after osseous surgery (one year later). Five compromised teeth were chosen for each patient (the same teeth, before and after surgery), for a total of 190 teeth. Real-time PCR based analysis computed total bacterial load of the samples and quantified six periodontal pathogens:Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia,Treponema denticola, Fusobacterium nucleatumandPrevotella intermedia. Data collection was made consulting medical charts.Results:Pocket probing depth reduction after surgery was 4.50 ± 1.54 mm (p=0.0001). The mean number of sites with bleeding at baseline was 2.08 ± 1.17 and 0.58 ± 1.00 after surgery (p=0.001). The mean number of sites with suppuration at baseline was 0.26 ± 0.86 and 0 after surgery (p=0.02). Cell count of each pathogen and total cell count were significantly higher at baseline than after surgery. Almost all bacteria presented a mean percentage reduction equal to that of the total count, except forAaandPi,which seemed to show a greater resistance. The difference of bacterial load, both before and after surgery, between smokers and non-smokers was not statistically significant (p<0.05). A statistically significant correlation was detected between pocket probing depth variation and bleeding on probing variation before and after the surgery, controlling for age (r=0.6,p=0.001). No significant correlations were observed between pocket probing depth and bacterial loads, except forPg(r=0.5,p=0.001),Tf(r=0.6,p=0.001) andTd(r=0.4,p=0.02).Conclusions:Reduction of presence and bacterial load of the examined periodontal pathogens bacteria after osseous surgery, along with periodontal pocket reduction, appeared to be essential to achieve and maintain periodontal stability over years.

scholarly journals TO EVALUATE IMMUNOMODULATORY EFFECT (Ig A) OF LICORICE ON PERIODONTAL HEALTH STATUS IN CHRONIC PERIODONTITIS PATIENTS BEFORE AND AFTER PERIODONTAL THERAPY

2020 ◽  
pp. 75-77
Author(s):  
K. Ramya ◽  
Pavuluri Aravind Kumar ◽  
Musalaiah S.V.V.S. ◽  
Mandalapu Narendra Babu
Keyword(s):  
Health Status ◽  
Immune Function ◽  
Chronic Periodontitis ◽  
Serum Levels ◽  
Immunomodulatory Effect ◽  
Periodontal Health ◽  
Before And After ◽  
Licorice Extract ◽  
Group A ◽  
Group B

INTRODUCTION: Several dietary additives are reported to be effective to enhance the immune function. Licorice has been frequently used as herbal medicine to supress inflammation. It has anti stress effects, enhance detoxification in liver and supress inflammatory reaction and enhance the immune function. OBJECTIVES: To evaluate effect of licorice on immunomodulatory (Ig A) before and after SRP METHODOLOGY: Twenty subjects were randomly assigned into two groups. Group A (Supplemented with licorice along with SRP ). Group B (SRP Only). All the clinical parameters like gingival index, probing depth, clinical attachment level along with serum levels of Ig A were evaluated before and after SRP. RESULTS: There was a statistically significant increase of Ig A levels in group A compared to group B. CONCLUSION: The present study showed that licorice extract significantly effect on enhancing the immunomodulatory effect not only the periodontal health status of chronic periodontitis and also significant effect on overall health status.

scholarly journals Evaluation of NLRP3 and IL-18 Levels after Periodontal Therapy

2021 ◽  
Author(s):  
Shahrzad Shahbeik ◽  
Ferial Taleghani ◽  
Mandana Sattari ◽  
Mahyar Mahvash Mohammadi ◽  
Mohammadreza Moravej
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Pearson Correlation ◽  
Treatment Phase ◽  
Periodontal Treatment ◽  
Enzyme Linked Immunosorbent Assay ◽  
Clinical Parameters ◽  
Periodontal Pathogens ◽  
Mean Values ◽  
Before And After

The progression of periodontitis depends on interactions between the periodontal pathogens and the host immune cytokines, including interleukin (IL)-1β and IL-18. Production of IL-1β is regulated by NOD-like receptors family pyrin domain containing 3 (NLRP3). This study aimed to evaluate the effect of periodontal treatment on the concentrations of IL-18 and NLRP3 in patients with chronic periodontitis. In this experimental study, 18 patients with chronic periodontitis and a mean age of 46.2±8.95 years, were included. The gingival crevicular fluid (GCF) was collected at the beginning of the study, 4 weeks after non-surgical (phase I), and 4 weeks after surgical periodontal treatment. The levels of NLRP3 and IL-18 were measured; using an enzyme-linked immunosorbent assay. Pearson correlation test was used to analyze the concentration of NLRP3 and IL-18 before and after the treatments with CAL and PD. There was a significant association between the level of NLRP3 and the mean values of PD and CAL before treatment. After each treatment phase, a significant decrease was observed in the NLRP3 level. There was no significant relationship between IL-18 and clinical parameters before and after periodontal treatments. Given the possible association between the level of NLRP3 and clinical parameters, we suggest it as a possible indicator of inflammation in chronic periodontitis and an index for evaluating the treatment outcome.

scholarly journals The impact of hospitalization on periodontal health status: an observational study

2017 ◽  
Vol 65 (3) ◽  
pp. 216-222
Author(s):  
Vinícius Aguiar LAGES ◽  
Thaís Torres Barros DUTRA ◽  
Alessandra Noleto de Almeida Nunes LIMA ◽  
Regina Ferraz MENDES ◽  
Raimundo Rosendo PRADO JÚNIOR
Keyword(s):  
Oral Hygiene ◽  
Private Hospital ◽  
Hospital Staff ◽  
Periodontal Health ◽  
Need For Treatment ◽  
Periodontal Condition ◽  
Gingival Bleeding ◽  
Before And After ◽  
The Impact ◽  
Oral Hygiene Habits

ABSTRACT Objective To evaluate the impact of hospitalization on the periodontal status of patients admitted to a private hospital. Methods A sample of 41 patients answered a questionnaire on oral hygiene habits before and after hospitalization. An examiner measured the Periodontal Screening and Recording ratio (PSR) within 24 hours after hospitalization (T0), after five (T1) and after ten days of hospital admission (T2). Results 47 patients were examined at T0, 37 at T1 and 21 at T2. Between T0 and T1, the periodontal condition of 32.4% of patients worsened (p = 0.001). The score of ten patients changed from PSR = 0 to PSR = 1 and the score of two changed from PSR = 1 to PSR = 2, after 5 days of hospitalization. At T2, 38% of patients had deteriorated (p = 0.005) with 4 developing gingival bleeding and 4 presenting calculus. 19% of patients (p=0.046) declined between T1 and T2, and 4 patients presented calculus. None of the patients received any guidance on oral hygiene by hospital staff. Conclusion The periodontal condition of hospitalized patients deteriorated over the course of the stay in hospital and, consequently, there was an increased need for treatment. This draws attention to the importance of oral hygiene care in hospital.

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