scholarly journals A fitoterapia como uma alternativa terapêutica complementar para pacientes com Diabetes Mellitus no Brasil

2020 ◽  
Vol 9 ◽  
pp. 189-204
Author(s):  
Veronica Perius de Brito ◽  
Mariana Côrtes de Freitas ◽  
Denner Custódio Gomes ◽  
Stefan Vilges de Oliveira
Keyword(s):  
Diabetes Mellitus ◽  
Syzygium Cumini ◽  
Bauhinia Forficata

Introdução: Diabetes mellitus (DM) é um grupo de distúrbios metabólicos de destaque por sua alta prevalência e incidência no Brasil. Assim, a fitoterapia surgiu como uma alternativa terapêutica complementar de baixo custo para pacientes acometidos por essa patologia. Objetivo: Realizar uma revisão sistemática sobre o uso de plantas medicinais em pacientes diabéticos, definir seus mecanismos de atuação e identificar lacunas do conhecimento e desafios a serem enfrentados para sua ampla utilização. Metodologia: Realizou-se uma busca sistematizada nas bases de dados Scielo, Lilacs e PubMed. Em seguida, foram aplicados critérios de inclusão e exclusão, restando 10 artigos ao presente trabalho. Seus dados foram tabulados em 3 tabelas e, posteriormente, analisados. Resultados: Os estudos foram publicados entre os anos de 2007 e 2018, sendo cinco deles observacionais, quatro experimentais pré-clínicos e apenas um clínico. A maioria (60%) foi publicada na língua portuguesa. Dentre os estudos clínicos e pré-clínicos (50%), todos comprovaram a redução da glicemia após o tratamento com fitoterápicos específicos. Discussão: Foram identificados diversos benefícios da fitoterapia, tais como baixo custo e facilidade de obtenção. Destaque foi dado para a Bauhinia forficata e Syzygium cumini, plantas de amplo uso empírico. Os principais efeitos metabólicos proporcionados pelos fitoterápicos são a redução da glicemia e do estresse oxidativo. Identificou-se a necessidade de seguimento dos estudos na área, bem como capacitação dos profissionais e da comunidade. Conclusão: A fitoterapia apresenta-se como uma importante alternativa terapêutica para diabéticos no Brasil, contudo, lacunas do conhecimento ainda devem ser preenchidas. Palavras-chave: Diabetes Mellitus. Fitoterapia. Hipoglicemiantes. Plantas Medicinais.

Comparative Phytochemical Screening of Karela (Momordica charantia) and Jambul (Syzygium cumini) Claimed for Treatment of Diabetes Mellitus

2021 ◽  
Vol 10 (1) ◽  
pp. 22-25
Author(s):  
Reni Nigam ◽  
◽  
Prafull Sen ◽  
Rashmi Singh ◽  
Praveen Garg ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Amino Acids ◽  
Herbal Medicine ◽  
Methanol Extract ◽  
Momordica Charantia ◽  
Syzygium Cumini ◽  
Phytochemical Screening ◽  
Standard Methods ◽  
Successive Extraction ◽  
Treatment Of Diabetes

Phytochemicals from herbal medicine are helpful for human health as well as crucial for the existence. The aim of present study was to investigate phytochemicals present in two medicinal plants Momordica charantia and Syzygium cumini to prove their traditional uses for the treatment of diabetes mellitus. Successive extraction was done with selected solvents viz., ethanol, methanol and water using maceration. Standard methods were used for the identification of phytochemicals like alkaloids test, phenols test, saponins test, carbohydrates test, proteins test, amino acids test, flavonoids test, diterpenes test. In conclusion, our findings showed that the methanol extract of both the plant contain most of the phytoconstituents when compare with other solvent extracts such as ethanol and water. Methanol extract of Syzygium cumini showed positive test with numerous phytoconstituents compare to Momordica charantia.

scholarly journals Determinação dos compostos fenólicos e da capacidade antioxidante de extratos aquosos e etanólicos de Jambolão (Syzygium cuminiL.)

2015 ◽  
Vol 17 (2) ◽  
pp. 267-273 ◽  
Author(s):  
J. VEBER ◽  
L.A. PETRINI ◽  
L.B. ANDRADE ◽  
J. SIVIERO
Keyword(s):  
Diabetes Mellitus ◽  
Syzygium Cumini

RESUMO:A espécie Syzygium cumini conhecida como Jambolão é uma das plantas mais utilizadas na medicina popular principalmente no tratamento de febre, estomalgia, gastropatia e diabetes mellitus tipo 2. O rendimento extrativo de compostos bioativos, e mesmo sua propriedade farmacológica, no caso, a capacidade de desativação de radicais livres, são influenciados pelo método e solvente utilizados. No presente estudo foi avaliado o efeito de extração aquosa a quente e a frio, e as extrações hidroalcoólicas em quatro diferentes concentrações de etanol, de folhas e frutos de Jambolão em diferentes estágios de maturação. A quantificação de compostos fenólicos dos extratos foi realizada pelo método de Folin-Ciocalteau, enquanto o método para avaliar a atividade antirradical livre foi realizado através da capacidade de desativação do radical DPPH•. As folhas apresentaram maior quantidade de compostos fenólicos totais (237,52 mg. EAG100 g-1) em relação a qualquer dos cinco extratos dos frutos, independente do estágio de maturação destes. Entre os extratos dos frutos, aquele proveniente de frutos verdes apresentou maior quantidade de compostos fenólicos (109,17 mg.EAG100 g-1). A extração hidro-etanólica a 50% de etanol promoveu os maiores conteúdos de fenóis totais, independente do material vegetal. A maior atividade antirradical livre encontrada dentre os extratos mais ricos em fenóis foi obtida com frutos verdes, IC50 = 2,27 mg.mL-1, a partir da infusão a quente por 30 minutos. Nos extratos de folhas, a maior atividade antirradical livre encontrada foi IC50= 23,07 mg.mL-1 proveniente do extrato hidro-etanólico a 50 % (v/v).

scholarly journals Establishment of long-term high-fat diet and low dose streptozotocin-induced experimental type-2 diabetes mellitus model of insulin resistance and evaluation of seed extracts of Syzygium cumini

2021 ◽  
Vol 10 (3) ◽  
pp. 331-338
Author(s):  
Pratibha Nadig ◽  
Meharban Asanaliyar ◽  
Kevin Manohar Salis
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
High Fat Diet ◽  
Low Dose ◽  
Syzygium Cumini ◽  
High Fat ◽  
Glut 4 ◽  
Seed Extracts

Introduction: The principal mechanism responsible for reducing blood glucose is through insulin-stimulated glucose transport into skeletal muscle. The transporter protein that mediates this uptake is GLUT-4. A defect in this step is associated with reduced glucose utilization in muscle and adipose tissue, as observed in insulin-resistant type-2 diabetes mellitus (T2DM) patients. This study aimed to develop an experimental T2DM model and evaluate altered glucose transporter type 4 (GLUT-4) levels as a biomarker of insulin resistance. Antidiabetic activities of Syzygium cumini hydro-ethanolic seed extracts (SCE) were also evaluated. Methods: Adult male Wistar albino rats were fed a high-fat diet for 12 weeks and dosed intraperitoneally with streptozotocin (35 mg/kg). After treatment for 21 days, all investigations were done. The homeostasis model of assessment (HOMA) was used for the calculation of insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) index. Diaphragm muscle and retroperitoneal fat were collected for real-time polymerase chain reaction (RT-PCR) studies. Results: A significant increase in fasting blood glucose, HOMA-IR, and serum lipids, and a decrease in serum insulin and HOMA-B were observed in the diabetic group, effects that reversed following pioglitazone and SCE treatment. The diabetic group showed a downregulation of GLUT-4 expression in skeletal muscle while an increase was observed in adipose tissue. Conclusion: A high-fat diet and low dose streptozotocin-induced experimental T2DM model of insulin resistance was developed to screen novel insulin sensitizers. Data generated demonstrated that altered GLUT-4 levels could be used as a biomarker of insulin resistance. Antidiabetic activity of S. cumini hydro-ethanolic seed extract was also confirmed in this study.

scholarly journals Analysis of the volatile oils from three species of the gender Syzygium

2021 ◽  
Vol 10 (7) ◽  
pp. e13510716375
Author(s):  
Amanda Silva Reis ◽  
Liliane de Sousa Silva ◽  
Christiane França Martins ◽  
José Realino de Paula
Keyword(s):  
Diabetes Mellitus ◽  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Traditional Medicine ◽  
Volatile Compounds ◽  
Respiratory Infections ◽  
Syzygium Cumini ◽  
Volatile Oils ◽  
Syzygium Jambos ◽  
The Family

The species Syzygium cumini, Syzygium malaccense and Syzygium jambos, belong to the family Myrtaceae and are popularly known, respectively, by jambolan, red jambo and yellow jambo. These species are used in traditional medicine to treat diabetes mellitus, asthma, bronchitis, diuresis, gastrointestinal and respiratory infections, properties antipyretic, anti-inflammatory, antirheumatic and several other uses. The objective of this work is to identify and quantify the volatile compounds in the leaves of S. cumini, S. malaccense and S. jambos. The volatile oils were obtained by hydrodistillation using Clevenger apparatus and analyzed by Gas Chromatography Coupled to Mass Spectrometry (GC-MS). It was possible to identify 44 compounds present in the volatile oils of the leaves, being 20 compounds of S. cumini, 9 compounds of S. malaccense and 15 compounds of S. jambos. The major compounds present in the species S. cumini were α-terpineol, β-caryophyllene and α-humulene; for the species S. malaccense were aristolochene, γ-himachalene and δ-amorphene; and for S. jambos species were β-cariophyllene, (E,E)-α-farnesene and cariophyllene alcohol. The species S. cumini, S. malaccense and S. jambos showed considerable differences in terms of volatile compounds, it is important to know their constituents in order to promote further studies focused on their medicinal potential.

scholarly journals Utilização de hipoglicemiantes no controle de diabetes mellitus

Conjecturas ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 736-750
Author(s):  
Vitória Caroline Gonçalves Anacleto ◽  
Isadora Oliveira Gondim
Keyword(s):  
Diabetes Mellitus ◽  
Salvia Officinalis ◽  
Bauhinia Forficata

As plantas medicinais vêm sendo utilizadas através dos milênios como tratamento de feridas e doenças. O uso de Salvia officinalis e Bauhinia forficata  no controle da glicose em indivíduos que possuam Diabetes Mellitus tipo II tem sido bastante discutido e pesquisado, já que ambas espécies apresentam resultados positivo ao tratamento desses indivíduos, conseguindo reduzir de forma significativa os níveis de glicose no sangue. Considerando essas especificidades, o Sistema Único de Saúde (SUS) inclui essas plantas, a lista de fitoterápicos ofertados. Esta pesquisa visa analisar a incorporação da Política Nacional de Plantas Medicinais e Fitoterapia e a inclusão da  Salvia officinalis e Bauhinia forficata no SUS, considerando os benefícios e regulamentação. Os resultados mostram um avanço, com o benéficos e a incorporação da Salvia officinalis e Bauhinia forficata sendo comprovados e a regulamentação apresentando grande grau de detalhamento, vedando o uso indiscriminado. Por tudo isso, conclui-se que esses fitoterápicos têm sido utilizados, retomando saberes tradicionais e trazendo benefícios para além da medicina convencional. 

scholarly journals Antidiabetic Compounds in Syzygium cumini Decoction and Ready to Serve Herbal Drink

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
P. R. D. Perera ◽  
S. Ekanayake ◽  
K. K. D. S. Ranaweera
Keyword(s):  
Diabetes Mellitus ◽  
Thin Layer ◽  
Sequential Extraction ◽  
Gallic Acid ◽  
Thin Layer Chromatography ◽  
Ellagic Acid ◽  
Syzygium Cumini ◽  
Health Promoting ◽  
Layer Chromatography ◽  
Specific Health

Herbal beverages with desirable sensory attributes are an ideal way to offer consumers with phytochemicals having specific health promoting functionalities. Syzygium cumini bark decoction is used in treating diabetes mellitus in Ayurveda medicine. This work attempted to prove the presence of antidiabetic compounds in the S. cumini decoction and the ready to serve (RTS) herbal drink developed using the decoction. Activity guided fractionation of the decoction of the S. cumini was carried out by sequential extraction with organic solvents of different polarities. Thin Layer Chromatography (TLC) with authentic compounds and HPLC were performed for identification and confirmation of the compounds in the decoction and the RTS herbal drink. Presence of gallic and ellagic acids in the decoction and RTS herbal drink was proven and confirmed with HPLC. The LC UV-VIS spectra of the two compounds were identical with the corresponding spectra of the library. Further, gallic acid and umbelliferone were determined as the active compounds in the decoction by TLC and were confirmed by cochromatography with authentic compounds. The present investigation confirmed the presence of gallic acid, ellagic acid, and umbelliferone which are proven to have antidiabetic activities in the decoction and the RTS herbal drink prepared with the decoction.

The effect of Syzygium cumini (L.) skeels on post-prandial blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes mellitus

1997 ◽  
Vol 56 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Claudio Coimbra Teixeira ◽  
Luciano Pilla Pinto ◽  
Felix Henrique Paim Kessler ◽  
Lia Knijnik ◽  
Cristiano Pilla Pinto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Diabetic Rats ◽  
Syzygium Cumini ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Streptozotocin Induced Diabetes

scholarly journals AN IN VITRO STUDY OF SYZYGIUM CUMINI SEED EXTRACT ON GLUCOSE UPTAKE ACTIVITY IN L-6 CELL LINES

2019 ◽  
Vol 9 (4-A) ◽  
pp. 256-259
Author(s):  
Maneemegalai Sivaprakasam ◽  
Narmatha M
Keyword(s):  
Diabetes Mellitus ◽  
Skeletal Muscle ◽  
Glucose Uptake ◽  
Ethanol Extract ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Syzygium Cumini ◽  
Rat Skeletal Muscle ◽  
Uptake Activity

Diabetes mellitus is the most common endocrine disorder. The plant Syzygium cumini has been used in traditional medicine for the treatment of diabetes. The present study investigated the effect of ethanol extract of S. cumini seeds on uptake of glucose by L-6 rat skeletal muscle cells. S. cumini seeds were extracted with varying solvents and quantitative phytochemical analysis was carried out, ethanol extract of seeds exhibited higher content of tested phytochemicals. The effect of different concentrations (300µg/ml – 1000µg/ml) of ethanol extract of seeds were studied on glucose uptake activity of L-6 rat skeletal muscle cells. It was observed that with the increase in concentration, the glucose uptake activity was also increased. The results of the study supports and demonstrates the antidiabetic potential of ethanol seed extracts of Syzygium cumini utilizing in vitro model. KEY WORDS: Diabetes mellitus, Syzygium cumini, phytochemicals, glucose uptake, L-6 cells

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