Apparent Horizontal and Vertical Extents of Patterns with and without a Surround

1995 ◽  
Vol 81 (3_suppl) ◽  
pp. 1299-1306
Author(s):  
R. H. Day ◽  
B. R. Degoldi
Keyword(s):  
Horizontal Line ◽  
Similar Reduction ◽  
Delboeuf Illusion

Following earlier informal observations, the first of two experiments confirmed that, whereas the vertical and horizontal extents of a printed passage are more or less veridically perceived when the passage is surrounded by margins as is usual on a page, they appear reduced when the margins are removed by cropping them close to the edges of the passage. In Exp. 2 with a horizontal-line grating a similar reduction occurred vertically but not horizontally, suggesting that the effect occurs for patterned regions but less or not at all for unpatterned, i.e., uniform, regions. The possible relationship between this effect and the Delboeuf illusion of size is discussed.

Endothelial expression of selectins during endotoxin preconditioning

2000 ◽  
Vol 279 (6) ◽  
pp. R2015-R2021 ◽  
Author(s):  
Philippe Bauer ◽  
Tomas Welbourne ◽  
Takeharu Shigematsu ◽  
Janice Russell ◽  
D. Neil Granger
Keyword(s):  
Nitric Oxide ◽  
Similar Reduction ◽  
Antibody Technique ◽  
Immunodeficient Mice ◽  
Lps Challenge ◽  
Tissue Resistance ◽  
Bacterial Endotoxins ◽  
Circulating Lymphocytes ◽  
Lps Preconditioning ◽  
Oxide Synthase

Although bacterial endotoxins [lipopolysaccharide (LPS)] can confer tissue resistance to subsequent inflammatory insults, the mechanisms that underlie this LPS-preconditioning (LPS-PC) response remain poorly defined. The dual-radiolabeled monoclonal antibody technique was used to examine whether LPS-PC alters the upregulation (protein) of E- and P-selectins after subsequent LPS challenge. In the gut of wild-type (C57BL/6J) mice, LPS-PC was associated with a reduction in E- (66%) and P-selectin (33%) expression. A similar reduction in E-selectin expression was observed in mutant mice that were genetically deficient in either the endothelial or inducible isoform of nitric oxide synthase or that overexpressed the human gene for Cu/Zn superoxide dismutase. Severe combined immunodeficient mice, genetically devoid of lymphocytes, did exhibit partial inhibition of the LPS-PC response. We conclude that 1) LPS-PC can be demonstrated for E- and P-selectins in some vascular beds (e.g., gut), 2) the mechanism(s) underlying this blunted selectin response does not include a major role for either nitric oxide and superoxide, and 3) circulating lymphocytes may contribute to the LPS-PC response.

scholarly journals Do domestic dogs (Canis lupus familiaris) perceive the Delboeuf illusion?

2016 ◽  
Vol 20 (3) ◽  
pp. 427-434 ◽  
Author(s):  
Maria Elena Miletto Petrazzini ◽  
Angelo Bisazza ◽  
Christian Agrillo
Keyword(s):  
Canis Lupus ◽  
Domestic Dogs ◽  
Canis Lupus Familiaris ◽  
Delboeuf Illusion

scholarly journals A Mutual Capacitance Touch Readout IC with Synchronization in Touch and Mobile Display Driving for High Refresh Rate AMOLED Panels

Micromachines ◽  
2021 ◽  
Vol 12 (8) ◽  
pp. 922
Author(s):  
Seunghoon Ko
Keyword(s):  
System Architecture ◽  
Noise Suppression ◽  
Touch Screen ◽  
Horizontal Line ◽  
Time Sharing ◽  
Refresh Rate ◽  
Front End ◽  
Scan Rate ◽  
Mutual Capacitance ◽  
Analog Voltage

This paper presents a mutual capacitance touch readout IC architecture for 120 Hz high-refresh-rate AMOLED displays. In high-refresh-rate AMOLED panels, whole pixels in a horizontal line should be updated without any time-sharing with each other, leading to an amplified display noise on touch screen panel (TSP) electrodes. The proposed system architecture mitigates severe display noise by synchronizing the driving for the TSP and AMOLED pixel circuits. The proposed differential sensing technique, which is based on noise suppression in reference to mutual capacitance channels, minimizes common-mode display noise. In the front-end circuit, intrinsic circuit offset is cancelled by a chopping scheme, which correlates to the phase of the driving signals in the TSP driver and operating clocks of the front-end. Operating at a 120 Hz scan-rate, it reduces display noise by more than 11.6 dB when compared with the conventional single-ended TSP sensing method. With a built-in 130-nm CMOS, a prototype IC occupies an area of 8.02 mm2 while consuming 6.4-mW power from a 3.3 V analog voltage supply.

scholarly journals Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection

2021 ◽  
Vol 12 (7) ◽  
Author(s):  
Marcela Hernández-Torres ◽  
Rogério Silva do Nascimento ◽  
Monica Cardozo Rebouças ◽  
Alexandra Cassado ◽  
Kely Catarine Matteucci ◽  
...  
Keyword(s):  
T Cells ◽  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Parasite Load ◽  
Peritoneal Macrophages ◽  
T Cell Response ◽  
No Production ◽  
Similar Reduction ◽  
Ifn Γ

AbstractChagas disease is a life-threatening disorder caused by the protozoan parasite Trypanosoma cruzi. Parasite-specific antibodies, CD8+ T cells, as well as IFN-γ and nitric oxide (NO) are key elements of the adaptive and innate immunity against the extracellular and intracellular forms of the parasite. Bim is a potent pro-apoptotic member of the Bcl-2 family implicated in different aspects of the immune regulation, such as negative selection of self-reactive thymocytes and elimination of antigen-specific T cells at the end of an immune response. Interestingly, the role of Bim during infections remains largely unidentified. To explore the role of Bim in Chagas disease, we infected WT, Bim+/−, Bim−/− mice with trypomastigotes forms of the Y strain of T. cruzi. Strikingly, our data revealed that Bim−/− mice exhibit a delay in the development of parasitemia followed by a deficiency in the control of parasite load in the bloodstream and a decreased survival compared to WT and Bim+/− mice. At the peak of parasitemia, peritoneal macrophages of Bim−/− mice exhibit decreased NO production, which correlated with a decrease in the pro-inflammatory Small Peritoneal Macrophage (SPM) subset. A similar reduction in NO secretion, as well as in the pro-inflammatory cytokines IFN-γ and IL-6, was also observed in Bim−/− splenocytes. Moreover, an impaired anti-T. cruzi CD8+ T-cell response was found in Bim−/− mice at this time point. Taken together, our results suggest that these alterations may contribute to the establishment of a delayed yet enlarged parasitic load observed at day 9 after infection of Bim−/− mice and place Bim as an important protein in the control of T. cruzi infections.

Reduced triglyceride secretion: a metabolic consequence of chronic exercise.

1978 ◽  
Vol 234 (3) ◽  
pp. E221 ◽  
Author(s):  
C Simonelli ◽  
R P Eaton
Keyword(s):  
Exercise Training ◽  
Genetic Model ◽  
Secretion Rate ◽  
Lipid Lowering ◽  
Zucker Rat ◽  
Chronic Exercise ◽  
Similar Reduction ◽  
Triglyceride Secretion ◽  
Obese Zucker Rat

Chronic exercise training is recognized to reduce plasma lipid levels in man and animals, but the mechanism(s) mediating this phenomenon have not been defined. In the present study, we examined triglyceride (TG) production and disposal in vivo in a genetic model of human type IV hyperlipemia, the obese Zucker rat. Utilizing the normolipemic thin littermate as the control, we investigated endogenous production of TG utilizing the Triton methodology and peripheral disposal of an exogenous lipid emulsion utilizing Intralipid injection. In the sedentary state, the hyperlipemic obese Zucker rat demonstrated a threefold elevation in triglyceride secretion rate relative to the normolipemic thin littermate. After a 3-wk period of exercise training, a reduction of basal plasma TG concentration of 42% was associated with a 51% reduction in TG secretion rate, a change adequate to account for the hypolipemic response. Moreover, chronic exercise training also improved the ability to dispose of an Intralipid load. A similar reduction in TG production with reduced TG removal was observed in the thin normolipemic rats, a result that suggests that the lipid lowering response to exercise training may be predominantly mediated by reduced secretion of TG. The possible relationship between reduced TG secretion and alterations in the bihormonal axis of insulin and glucagon are discussed.

scholarly journals The Role of Reduced Methionine in Mediating the Metabolic Responses to Protein Restriction Using Different Sources of Protein

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2609
Author(s):  
Han Fang ◽  
Kirsten P. Stone ◽  
Sujoy Ghosh ◽  
Laura A. Forney ◽  
Thomas W. Gettys
Keyword(s):  
Amino Acids ◽  
Dietary Protein ◽  
Target Genes ◽  
Protein Restriction ◽  
Metabolic Phenotype ◽  
Sulfur Amino Acids ◽  
Transcriptional Responses ◽  
Similar Reduction ◽  
Dietary Protein Restriction ◽  
Methionine Restriction

Dietary protein restriction and dietary methionine restriction (MR) produce a comparable series of behavioral, physiological, biochemical, and transcriptional responses. Both dietary regimens produce a similar reduction in intake of sulfur amino acids (e.g., methionine and cystine), and both diets increase expression and release of hepatic FGF21. Given that FGF21 is an essential mediator of the metabolic phenotype produced by both diets, an important unresolved question is whether dietary protein restriction represents de facto methionine restriction. Using diets formulated from either casein or soy protein with matched reductions in sulfur amino acids, we compared the ability of the respective diets to recapitulate the metabolic phenotype produced by methionine restriction using elemental diets. Although the soy-based control diets supported faster growth compared to casein-based control diets, casein-based protein restriction and soy-based protein restriction produced comparable reductions in body weight and fat deposition, and similar increases in energy intake, energy expenditure, and water intake. In addition, the prototypical effects of dietary MR on hepatic and adipose tissue target genes were similarly regulated by casein- and soy-based protein restriction. The present findings support the feasibility of using restricted intake of diets from various protein sources to produce therapeutically effective implementation of dietary methionine restriction.

scholarly journals Unsplit superconducting and time reversal symmetry breaking transitions in Sr2RuO4 under hydrostatic pressure and disorder

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Vadim Grinenko ◽  
Debarchan Das ◽  
Ritu Gupta ◽  
Bastian Zinkl ◽  
Naoki Kikugawa ◽  
...  
Keyword(s):  
Hydrostatic Pressure ◽  
Symmetry Breaking ◽  
Time Reversal ◽  
Order Parameter ◽  
Muon Spin Rotation ◽  
Horizontal Line ◽  
Time Reversal Symmetry ◽  
Zero Field ◽  
Symmetry Protected ◽  
Line Node

AbstractThere is considerable evidence that the superconducting state of Sr2RuO4 breaks time reversal symmetry. In the experiments showing time reversal symmetry breaking, its onset temperature, TTRSB, is generally found to match the critical temperature, Tc, within resolution. In combination with evidence for even parity, this result has led to consideration of a dxz ± idyz order parameter. The degeneracy of the two components of this order parameter is protected by symmetry, yielding TTRSB = Tc, but it has a hard-to-explain horizontal line node at kz = 0. Therefore, s ± id and d ± ig order parameters are also under consideration. These avoid the horizontal line node, but require tuning to obtain TTRSB ≈ Tc. To obtain evidence distinguishing these two possible scenarios (of symmetry-protected versus accidental degeneracy), we employ zero-field muon spin rotation/relaxation to study pure Sr2RuO4 under hydrostatic pressure, and Sr1.98La0.02RuO4 at zero pressure. Both hydrostatic pressure and La substitution alter Tc without lifting the tetragonal lattice symmetry, so if the degeneracy is symmetry-protected, TTRSB should track changes in Tc, while if it is accidental, these transition temperatures should generally separate. We observe TTRSB to track Tc, supporting the hypothesis of dxz ± idyz order.

scholarly journals Nidotherapy in the treatment of substance misuse, psychosis and personality disorder: secondary analysis of a controlled trial

2011 ◽  
Vol 35 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Peter Tyrer ◽  
Katarina Milošeska ◽  
Craig Whittington ◽  
Maja Ranger ◽  
Ibrahim Khaleel ◽  
...  
Keyword(s):  
Substance Misuse ◽  
Clinical Symptoms ◽  
Controlled Trial ◽  
Secondary Analysis ◽  
Cost Savings ◽  
Social Function ◽  
Similar Reduction ◽  
Assertive Outreach ◽  
Hospital Bed ◽  
Mean Cost

Aims and methodTo examine the clinical outcome and bed usage in patients with comorbid substance misuse and psychosis. The patients were randomised to ordinary assertive outreach team care or to enhanced assertive outreach with nidotherapy. Ratings of clinical symptoms, social function, engagement with services, bed usage (primary outcome after 1 year) and economic costs were assessed at baseline and at 6 and 12 months after randomisation.ResultsPatients referred to nidotherapy had similar reduction in symptoms and engagement, with marginal superiority in social function (P= 0.045). There was a 110% reduction in hospital bed use after 1 year compared with control assertive care (P= 0.03). The mean cost savings for each patient allocated to nidotherapy was £14705 per year, mainly as a consequence of reduced psychiatric bed use.Clinical implicationsNidotherapy shows promise in the treatment of substance misuse and psychosis and may reduce hospital bed usage.

Feature Analysers, Optical Illusions, and Figural Aftereffects

Perception ◽  
1977 ◽  
Vol 6 (4) ◽  
pp. 401-406 ◽  
Author(s):  
Tadasu Oyama
Keyword(s):  
Interaction Model ◽  
Size Ratio ◽  
Absolute Distance ◽  
Test Circle ◽  
Optical Illusions ◽  
Tuning Width ◽  
The Absolute ◽  
Delboeuf Illusion

Simple displacement models cannot explain some aspects of optical illusions and figural aftereffects. The orientation-detector interaction model proposed by Blakemore and others is more suitable to explain many aspects of the Zöllner illusion, positive and negative illusions, the effect of gap between the inducing and test lines, and the anisotropy of illusions. If we hypothesize size detectors whose tuning width and distribution steps are proportional to logarithmic size, interactions between them explain well the fact that the Delboeuf illusion and figural aftereffects of circles are determined by the size ratio of the inducing to test circle, not by the absolute distance between the contours of these circles.

Soybean Sensitivity to Florpyrauxifen-benzyl during Reproductive Growth and the Impact on Subsequent Progeny

2017 ◽  
Vol 32 (2) ◽  
pp. 135-140 ◽  
Author(s):  
M. Ryan Miller ◽  
Jason K. Norsworthy
Keyword(s):  
Plant Height ◽  
Field Studies ◽  
Yield Reduction ◽  
Growth Stages ◽  
Soybean Plant ◽  
Reproductive Growth ◽  
Similar Reduction ◽  
Structural Class ◽  
Soybean Plants ◽  
The Impact

AbstractTo address recent concerns related to auxin herbicide drift onto soybean, a study was developed to understand the susceptibility of the reproductive stage of soybean to a new auxin herbicide compared with dicamba. Florpyrauxifen-benzyl is under development as the second herbicide in a new structural class of synthetic auxins, the arylpicolinates. Field studies were conducted to (1) evaluate and compare reproductive soybean injury and yield following applications of florpyrauxifen-benzyl or dicamba across various concentrations and reproductive growth stages and (2) determine whether low-rate applications of florpyrauxifen-benzyl or dicamba to soybean in reproductive stages would have similar effect on the progeny of the affected plants. Soybean were treated with 0, 1/20, or 1/160, of the 1X rate of florpyrauxifen-benzyl (30 g ai ha−1) or dicamba (560 g ae ha−1) at R1, R2, R3, R4, or R5 growth stage. Soybean plant height and yield was reduced from 1/20X dicamba across all reproductive stages. High drift rates (1/20X) of florpyrauxifen-benzyl also reduced soybean plant height >25% and yield across R1 to R4 stages. Germination, stand, plant height, and yield of the offspring of soybean plants treated with dicamba and florpyrauxifen-benzyl were significantly affected. Dicamba applied at a rate of 1/20X at R4 and R5 resulted in 20% and 35% yield reduction for the offspring, respectively. A similar reduction occurred from florpyrauxifen-benzyl applied at R4 and R5 at the 1/20X rate, resulting in 15% to 24% yield reduction for the offspring, respectively. Based on these findings, it is suggested that growers use caution when applying these herbicides in the vicinity of reproductive soybean.

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