scholarly journals Association of the brain-derived neurotrophic factor Val66Met polymorphism with body mass index, fasting glucose levels and lipid status in adolescents

2020 ◽  
Vol 23 (1) ◽  
pp. 77-82
Author(s):  
V Vidović ◽  
N Maksimović ◽  
I Novaković ◽  
T Damnjanović ◽  
B Jekić ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Body Mass ◽  
Glucose Level ◽  
Neurotrophic Factor ◽  
Fasting Glucose ◽  
Fasting Glucose Level ◽  
Val66met Polymorphism ◽  
Glucose Levels

AbstractBrain-derived neurotrophic factor (BDNF) has an important role in energy balance. It suppresses food intake, reduces hepatic glucose production and converts white fat into brown fat in adipose tissue, leading to energy dissipation, lowered blood glucose and a lean phenotype. Studies have shown that the single nucleotide polymorphism (SNP) Val66Met within BDNF may be associated with obesity, insulin sensitivity, type 2 diabetes mellitus (T2DM) and dyslipidemia. The objective of the study was to investigate the association of the Val66Met polymorphism with body mass index (BMI), fasting glucose levels and lipid profile in Serbian adolescents. The study included 308 randomly selected healthy adolescents, 153 (49.68%) boys and 155 girls (50.32%), 15 years of age. Data including age, gender, height, weight, lipid profile and fasting glucose were recorded. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. No association of this polymorphism was found with BMI and lipid profile. However, significant association was observed between this polymorphism and fasting blood glucose (FBG). Carriers of a Val/Val genotype had significantly higher mean values of fasting glucose level compared to carriers of Val/ Met and Met/Met genotypes (p = 0.01). To confirm these results multiple linear regression analysis was performed. Body mass index and gender were taken as covariates. Carriers of the Val/Val genotype had significantly higher levels of FBG (β = -0.152, p = 0.02). A statistically significant association between BMI and glucose level was also observed (β = 0.124,p = 0.033). This polymorphism could be associated with fasting glucose level in Serbian adolescents, thus further research would be of great interest to validate these results.

Effect of consumption of a carob pod inositol-enriched beverage on insulin sensitivity and inflammation in middle-aged prediabetic subjects

2016 ◽  
Vol 7 (10) ◽  
pp. 4379-4387 ◽  
Author(s):  
Celia Bañuls ◽  
Susana Rovira-Llopis ◽  
Sandra López-Doménech ◽  
Silvia Veses ◽  
Víctor M. Víctor ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Insulin Sensitivity ◽  
Body Mass ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Middle Aged ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Carob Pod

This study assessed the effects of an inositol-enriched beverage (IEB) on blood glucose levels and inflammation status in subjects with an impaired fasting glucose (IFG) state according to body mass index (BMI).

scholarly journals Fasting blood glucose level and its association with sex, body mass index and blood pressure: a cross sectional study on a Bangladeshi public university students

2017 ◽  
Vol 4 (8) ◽  
pp. 2663
Author(s):  
Md Imam Hossain ◽  
Md. Shariful Islam ◽  
Mirza Rokibul Hasan ◽  
Moriom Akter ◽  
Md. Sadek Hosen Khoka
Keyword(s):  
Blood Pressure ◽  
Body Mass Index ◽  
Blood Glucose ◽  
University Students ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels

Background: In resource-limited countries like Bangladesh, there is a scarcity of epidemiological researches examining the relationship of blood glucose level with hypertension and BMI among the graduate level students. This research was therefore undertaken to evaluate fasting blood glucose levels of Mawlana Bhashani Science and Technology University students and to check its associations with sex, body mass index (BMI) and hypertension. Methods: For the study the 240 students (120 male and 120 female) were randomly selected. The demographic data of the study subjects were collected by interviewing the subjects with standardized questionnaires. Their fasting blood glucose levels were measured using portable blood glucose meter. The BMI and blood pressure of the subjects were also recorded following standard protocol. Finally the data were analyzed with SPSS software. Results: The fasting blood glucose levels of the study subjects indicated that 0.4% of subjects were diabetic and, 5.4% of subjects were pre-diabetic. The blood glucose levels (mean±SE) of female subjects (4.88±0.07) were higher than that of the male (4.61±0.04) subjects. The mean blood glucose levels of hypertensive subjects (4.81±0.07 mmol/L) were higher than that of the normotensive counterpart (4.73±0.05 mmol/L). The fasting blood glucose levels shows significant positive associations with SBP (r=0.155, p<0.05) and DBP (r=0.149, p<0.05).The fasting blood glucose levels also showed a significant positive association with the BMI (r=0.193, p<0.01) of the subjects. Conclusions: This study reveals the diabetic and hypertension status of the Bangladeshi graduate level students. The result of the study is very important in the context of public concern health of Bangladesh.  

scholarly journals Waist-Hip Circumference Ratio as Strongest Factor Correlation with Blood Glucose Level

2018 ◽  
Vol 6 (3) ◽  
pp. 219
Author(s):  
Mitha - Karimah
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Pearson Correlation ◽  
Hip Circumference ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Pearson Correlation Test

Background: Prevalence of obesity in Indonesia, was increase especially for pre- elderly to elderly which age group 55-64 years of the highest obesity. Insulin resistance that occurs in the obese group can lead to a decrease in insulin work that causes increased glucose levels.Purpose: Aim of the research was to know the correlation between waist-hip circumference ratio and body mass index with blood glucose level. Methods: The study design was cross sectional.  Respondents of this study were 36 elderly with aged beetwen 46-70 years who were registered in elderly posyandu. Sampling used simple random sampling techniques. The variabels of this study were the body mass index, waist-hip circumference ratio and fasting blood glucose level. Data were analyzed using pearson correlation test with a signifi cance level (α) = 0,05. Results: This research showed that, based on body mass index, most of respondents fall into overweight 2 category by 36,10%, abdominal obesity based on waist hip circumference ratio by 63,90% and blood glucose level more than 125 mg/dl by 25%. The result of pearson correlation test showed that there was relationship between waist-hip circumference ratio with blood glucose levels which statistically proved p < 0.05 (p = 0.01; r = 0.486). There was no  relationship between mass index with blood glucose levels which statistically proved p > 0.05  (p = 0.316; r = 0.172).  Conclusion: Waist-hip circumference ratio as strongest factor correlation with blood glucose level when compared with body mass index.

Nilotinib-mediated increase in fasting glucose level is reversible, does not convert to type 2 diabetes and is likely correlated with increased body mass index

2012 ◽  
Vol 36 (4) ◽  
pp. e66-e67 ◽  
Author(s):  
Massimo Breccia ◽  
Giuseppina Loglisci ◽  
Adriano Salaroli ◽  
Alessandra Serrao ◽  
Giuliana Alimena
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Glucose ◽  
Fasting Glucose Level

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

scholarly journals POLYCYSTIC OVARIAN SYNDROME;

2012 ◽  
Vol 19 (06) ◽  
pp. 786-788
Author(s):  
KIRAN BUTT ◽  
FARAH DEEBA ◽  
HAVAIDA ATTIQUE
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Increased Risk ◽  
Commercial Kits ◽  
The University ◽  
Ovarian Syndrome

Objective: The objective of the present study was to determine the changes in the glucose level and lipid profile in patients withpolycystic ovarian syndrome (PCOS). Study Design: Descriptive study. Place and Duration of the study: This study was conducted atInstitute of Molecular Biology and Biotechnology, The University of Lahore from June 2009 to June 2010. Patients and Methods: Total 50patients with PCOS were included and 50 age-matched control subjects were also selected for comparison. Their glucose levels and lipidprofile were assessed using commercial kits. The data thus obtained was subjected to statistical analysis. Results: Significant differences(P<0.05) in fasting blood glucose level and individual parameters of lipid profile were observed in women with PCOS. A higher prevalence ofhypertriglyceridemia, hypercholesterolemia, higher LDL, lower HDL and higher fasting blood glucose levels was explored in PCOS womenthan controls. Conclusions: Abnormal glucose level and lipid profile in PCOS women showed that these women are at an increased risk ofdeveloping diabetes and subsequently cardiovascular diseases.

scholarly journals The Incremental Risk of Pancreatic Cancer According to Fasting Glucose Levels: Nationwide Population-Based Cohort Study

2019 ◽  
Vol 104 (10) ◽  
pp. 4594-4599 ◽  
Author(s):  
Dong-Hoe Koo ◽  
Kyung-Do Han ◽  
Cheol-Young Park
Keyword(s):  
Pancreatic Cancer ◽  
Glucose Level ◽  
Cumulative Incidence ◽  
Fasting Glucose ◽  
Population Based ◽  
Incidence Rates ◽  
Fasting Glucose Level ◽  
Glucose Levels ◽  
Level 1 ◽  
Level 2

Abstract Context It has been unclear whether the risk of pancreatic cancer is different according to glucose levels. Objective To determine the association between fasting glucose levels and pancreatic cancer risk using prospectively collected nationwide population-based cohort data in Korea. Design The National Health Insurance Service database of claims and preventive health check-up data recorded was used between 2009 and 2015. Setting and Participants A total of 25.4 million patients who had participated in a preventive health check-up between 2009 and 2013 were evaluated for pancreatic cancer incidence rates according to fasting glucose level. Main Outcomes Measures The cumulative incidence rate for pancreatic cancer was calculated after grouping according to fasting glucose levels as follows: (i) low normal (<90 mg/dL), (ii) high normal (90 to 99 mg/dL), (iii) prediabetes level 1 (100 to 109 mg/dL), (iv) prediabetes level 2 (110 to 125 mg/dL), (v) diabetes (≥126 mg/dL), and (vi) diabetes on anti-diabetic medications. Results The 5-year cumulative incidence rates (per 100,000) were as follows: (i) low normal = 32; (ii) high normal = 41; (iii) prediabetes level 1 = 50; (iv) prediabetes level 2 = 64; (v) diabetes = 75; and (vi) on anti-diabetic medications = 121. The risk of pancreatic cancer increased continuously with elevating fasting glucose levels (P < 0.0001). The incidence of pancreatic cancer increased significantly with increasing fasting blood glucose levels even after adjusting for age, sex, smoking, drinking, exercise, body mass index, and diabetes duration (P < 0.0001). Conclusions The cumulative incidence rate of pancreatic cancer significantly increased as the fasting glucose level elevated, even in populations with a normal glucose level range.

scholarly journals Relation of BMI with Blood Glucose Level amongst Healthy Students of Ayub Medical College, Abbottabad

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Nadia Haleem ◽  
Sarwat Abbasi ◽  
Mohammad Idress ◽  
Zahid Irfan Marwat ◽  
Saadia Sadiq ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Strong Association ◽  
Cross Sectional ◽  
Random Blood Glucose ◽  
Medical College ◽  
Two Parameters

Background: Obesity is a global challenge all over the world. Body mass index is a good marker to measure the adiposity. Obesityis one of the important risk factors for type 2 diabetes mellitus. Normal random blood glucose levels are closely regulated in healthwith a normal range of 4.4-7.8mmol/l (79-140mg/dl), despite the varying demands of food, exercise and fasting. Many diabeticpatients are obese and studies suggest a strong association between the two.Objective: To find an association of BMI with blood glucose level in undergraduate healthy students of Ayub Medical CollegeMaterial and Methods: This cross-sectional study was carried out in 2018, capillary blood samples were collected from 152students of Ayub Medical College Abbottabad to evaluate blood glucose level by Accu chek softclix® lancing device and Accu chekglucometer®, BMI was calculated by the formula (weight in kg/ height in meters squared). Data was collected and analyzed bySPSS version 23.Results: Total 152 (100%) healthy participants with 84 (55.3%) males and 68 (44.7%) females included in this study. Their ageswere ranged from 18-25 with a mean age of 21.02 years (min 17 max 26) having a standard deviation of 1.75. By taking thecorrelation between two parameters i.e. body mass index and serum random blood glucose level by Pearson product of moment(p=.214, r=101) a non-significant result was found.Conclusion: It is concluded that there is no significant association found between two parameters (BMI and serum BGL) in healthyyoung adults.

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