scholarly journals Depression in adolescents exposed to war trauma Risk factors for development of depression in adolescents exposed to war trauma: does PTSD matter?

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Dmytro Martsenkovskyi ◽  
Olexandr Napryeyenko ◽  
Igor Martsenkovsky
Keyword(s):  
Rating Scale ◽  
School Attendance ◽  
Clinical Care ◽  
Significant Risk ◽  
Repeated Measurements ◽  
War Trauma ◽  
Cross Sectional ◽  
Traumatic Exposure ◽  
Children’S Depression

AbstractBackgroundDepression is frequently comorbid with posttraumatic stress disorder (PTSD) and substantially influences its severity, course and outcomes. Published studies linking war-related paediatric PTSD and Major depressive disorder (MDD) were mainly based on cross-sectional studies.ObjectiveTo prospectively examine the role of PTSD and other risk/protective factors in the development of depression among adolescents with war-related trauma.MethodsA longitudinal study of 160 adolescents aged 15–17 years with war-related trauma and displacement due to war in Eastern Ukraine was performed. Of the 160 adolescents, N = 86 met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-4) criteria for PTSD. All adolescents underwent comprehensive psychiatric assessments that included Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime version (K-SADS-PL) administered to both parents and children. Traumatic exposure was assessed using the modified Traumatic Events Screening Inventory for children (TESI-C). PTSD and MDD were assessed with the Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA) and Children's Depression Rating Scale-Revised (CDRS-R), and diagnosed using DSM-4 criteria. Follow-up and repeated measurements occurred at 6 and 12 months. During the study, adolescents requiring clinical care were referred for best available care in the community.ResultsAmong 92.6% of study completers, 26/79 youth with PTSD developed MDD (32.9%), compared to 6/70 without PTSD (8.5%): relative risk (RR) = 3.83 (95% CI 1.67–8.78), p = 0.0014; Number needed to harm (NNTH) = 4.108 (8.53–2.7). Using logistic regression, variables of school attendance, ‘secondary’ traumatic exposure, and treatment with Trauma-focused Cognitive Behavioral Therapy (TF-CBT) were significantly correlated with the incidence of new-onset depression among adolescents with PTSD.ConclusionsWar-related trauma with subsequent PTSD appears to be a significant risk factor for the later development of depression in adolescents. The role of PTSD as a moderator of depression merits further investigation in larger scale longitudinal studies in diverse populations.

Validation of the Three-Item Skindex-Mini Among Hidradenitis Suppurativa Patients With Diverse Racial Backgrounds

2020 ◽  
Vol 24 (5) ◽  
pp. 457-460
Author(s):  
Lauren A.V. Orenstein ◽  
Adaugo Amah ◽  
Fiona M. Shaw ◽  
Chao Zhang ◽  
Robert A. Swerlick ◽  
...  
Keyword(s):  
Hidradenitis Suppurativa ◽  
Rating Scale ◽  
Clinical Care ◽  
Pearson Correlation ◽  
Life Quality ◽  
Correlation Coefficients ◽  
Numeric Rating Scale ◽  
Secondary Outcome ◽  
Cross Sectional ◽  
And Function

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients’ quality of life (QoL). Instruments such as the 10-item Dermatology Life Quality Index and 16-item Skindex-16 have been used to assess QoL in HS; however, it is unknown whether the shorter 3-item Skindex-mini can also provide an accurate assessment of skin-related QoL in patients with HS. Objectives The aim was to assess how well the Skindex-16 correlates with its shorter adaptation, the Skindex-mini, in capturing QoL among patients with HS. Methods This retrospective cross-sectional study included all HS patients seen in the HS Clinic at The Emory Clinic between January 1, 2019, and August 16, 2019. We compared the correlation between the symptom, emotion, and function domains of the Skindex-16 and Skindex-mini using Pearson correlation coefficients (CC). Secondary outcome measures included individual survey item analysis, ItchyQuant scores, and numeric rating scale of pain. Results We identified 108 encounters among 75 unique hidradenitis suppurativa patients (43 black/African American, 18 white, 5 Asian/Pacific Islander, 3 Latino, 4 Other, 2 unknown). Pearson CC between the Skindex-16 and Skindex-mini domain scores for all encounters were 0.770 ( P < .001), 0.787 ( P < .001), and 0.801 ( P < .001) for the symptom, emotion, and function domains, respectively. The mean pain and ItchyQuant scores were 4.14 (SD 3.31) and 3.55 (SD 3.34), respectively. Conclusions The Skindex-mini correlated highly with the Skindex-16 in a racially diverse group of patients with HS. The Skindex-mini is a streamlined QoL instrument that could be practically implemented into routine clinical care among diverse patients presenting to dermatology.

scholarly journals THE ROLE OF ENDORPHIN HORMONES AS PREDICTORS OF PREGNANCY ANXIETY

2019 ◽  
Vol 2 (3) ◽  
pp. 16-21
Author(s):  
Putriatri Krimasusini Senudin ◽  
Saidah Syamsuddin ◽  
Andi Armyn Nurdin
Keyword(s):  
Rating Scale ◽  
Hormone Production ◽  
Cross Sectional ◽  
Hormone Levels ◽  
Pregnancy Anxiety ◽  
Hamilton Anxiety Rating Scale ◽  
Keywords Anxiety ◽  
Relationship Of ◽  
The Relationship

Pregnancy anxiety is a common problem with a prevalence of 14-54% and is the highest in the third trimester. Pregnancy anxiety is associated with neurotransmitter dysregulation and endocrine changes in the Hypothalamus Pituitary Adrenal (HPA) axis pathway through the increase of synthesis and the release of corticotropin-releasing hormone (CRH), Adrenocorticotropic Hormone (ACTH) and cortisol to suppress endorphin hormone production. This study aims to determine the relationship of endorphin hormone levels to pregnancy anxiety. This study was an observational study using a cross-sectional approach to 57 pregnant women. The anxiety level was measured by using the Hamilton Anxiety Rating Scale (HARS) and the ELISA kit with plasma specimens was employed to examine the endorphin hormone levels. The results showed that endorphin hormone levels acted as predictors of pregnancy anxiety (p = 0,000). Keywords: Anxiety, Pregnancy, Endorphin  

scholarly journals A CROSS SECTIONAL DESCRIPTIVE STUDY OF OCD IN CHILDREN AND ADOLESCENTS

2020 ◽  
pp. 1-4
Author(s):  
Chhitij Srivastava ◽  
Abhishek Pratap Singh ◽  
Zeeshan Anwar ◽  
Santosh Kumar Kesharwani
Keyword(s):  
Children And Adolescents ◽  
Rating Scale ◽  
Demographic Data ◽  
Positive Family History ◽  
Clinical Information ◽  
Obsessive Compulsive ◽  
Degree Relative ◽  
Cross Sectional ◽  
Multicentric Study ◽  
Children’S Depression

This study was a part of a bigger multicentric study to examine the socio-demographic and clinical characteristics of children and adolescents (age ≤18 years) with OCD. Our sample comprised 30 subjects with OCD. Socio-demographic data was collected on a proforma specifically designed for this study. Clinical information was obtained on Structured clinical interview for Diagnostic and Statistical Manual, 5th edition Research Version (SCID), Children’s Yale Brown Obsessive Compulsive Scale (CYBOCS), the Children’s Depression Rating Scale–Revised (CDRS) and the Family Interview for Genetic Studies (FIGS). In our sample 70% of participants were male and 67.7% had onset of symptoms before 14 years of age. Most common obsessions in our participants were of doubts about contamination and magical thinking/superstitious while the most common compulsions were those involving checking, washing and rituals involving other persons. Comorbid psychiatric disorders were seen in 63.3% patients with most common being depression, Obsessive Compulsive Related Disorders (OCRDs), intermittent explosive disorder and anxiety disorder. The associated OCD symptoms on CYBOCS including lack of insight, avoidance and indecisiveness were on a spectrum. 46.6% had positive family history of OCD in first degree relative.

scholarly journals POLYPHARMACY IN DIABETIC PEOPLE: EVIDENCE FROM THE ENGLISH LONGITUDINAL STUDY OF AGEING (ELSA)

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S482-S483
Author(s):  
Yun-Ting Huang ◽  
Paola Zaninotto ◽  
Andrew Steptoe ◽  
Li Wei
Keyword(s):  
Risk Factors ◽  
Older People ◽  
Significant Risk ◽  
Cross Sectional Study ◽  
Health Condition ◽  
Cross Sectional ◽  
Nationally Representative ◽  
English Longitudinal Study

Abstract Diabetes among older people is becoming more common worldwide, and usually accompanied by polypharmacy. However, the role of polypharmacy in older people with diabetes remains uncertain. A nationally representative cross-sectional study, ELSA 2012/2013, was used and 7729 participants aged 50-109 were investigated. Polypharmacy was defined as taking five to nine long-term used medications daily for chronic diseases or chronic symptoms, while using ten or more medications was excessive polypharmacy. The presence of illness was defined as either self-reported diagnosis or being prescribed specific medications for the condition. Data showed the prevalence of polypharmacy was 21.4%, and only 3% was excessive polypharmacy. 51.6% of diabetic people reported polypharmacy and 10.2% excessive polypharmacy. These rates were significantly higher than the 16.4% polypharmacy and 1.8% excessive polypharmacy among people without diabetes (p &lt; 0.001). Among people with three or more comorbidities, polypharmacy was present in 61.5% of people with diabetes, compared with 36.0% in people without diabetes. Significant risk factors for polypharmacy were diabetes (Relative-risk ratios/RRR=4.06, 95% CI 3.38, 4.86), older age (RRR=1.02, 95% CI 1.01, 1.03), male (RRR=0.64, 95% CI 0.55, 0.75), more comorbidity (RRR=2.46, 95% CI 2.30, 2.62), living with a partner (RRR=1.20, 95% CI 1.01, 1.42), and less wealth (RRR=0.93, 95% CI 0.87, 0.98). However, age, cohabitation, and wealth were not significantly related to excessive polypharmacy. Diabetes and the number of comorbidities were predominant risk factors for excessive polypharmacy. Current evidences confirmed both health condition and socioeconomic status were associated with medication use in older adults.

ROLE OF ANAESTHETIST IN POST ANAESTHESIA VISIT - QUESTIONNAIRE STUDY AMONG ANAESTHESIOLOGISTS

2021 ◽  
pp. 26-28
Author(s):  
Manjula Devi S ◽  
Ravi Madhusudhana
Keyword(s):  
Online Survey ◽  
Care Pathway ◽  
Clinical Care ◽  
Quality Care ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Operative Care ◽  
Anaesthesia Service ◽  
Clinical Care Pathway

Background The role of anaesthetist has increased tremendously from just being in the operative team to the recovery of the patient in the post-operative period. The recovery without any complication requires multidisciplinary team which should be embedded in a clinical care pathway with focus on enhancing patient recovery. Objectives: To evaluate the need for post anaesthesia visit, among Anaesthesiologists to improve the post-operative and post anaesthesia quality care. Methodology: This was a cross sectional study conducted among 275 anaesthesiologists by an online survey using a validated pretested questionnaire Results: Majority of the study participants were males. 92.4 % had regular post-anaesthesia service available in their hospitals. More than 70% of the patients had post-operative visits. Majority of the post-operative visit was on the day of surgery and on the rst post-operative day. Conclusion: It is the responsibility of the anaesthesiologist to guarantee that patients have completely recovered from the given anaesthesia and to detect and treat any probable anaesthetic-related complications. Hence, a post-operative care team involving the surgeons and anaesthetist can alleviate the complications, shorten the duration of hospital stay and improved recovery.

scholarly journals How Occupational Mercury Neurotoxicity Is Affected by Genetic Factors. A Systematic Review

2020 ◽  
Vol 10 (21) ◽  
pp. 7706 ◽  
Author(s):  
Francesco Chirico ◽  
Egeria Scoditti ◽  
Carlo Viora ◽  
Nicola Magnavita
Keyword(s):  
Genetic Factors ◽  
Significant Risk ◽  
Elemental Mercury ◽  
Cross Sectional ◽  
Pubmed Central ◽  
Exposed Workers ◽  
Neurotoxic Effects ◽  
Occupationally Exposed ◽  
Meta Analyses

Occupational exposure to elemental mercury still represents a significant risk in the workplace. The sensitivity of the exposed subjects varies considerably. This study aims to summarize the literature on the role of genetic factors in occupationally exposed cohorts. A systematic search of the literature was carried out on PubMed Central (PMC), MEDLINE, and Google Scholar databases in accordance with the “Preferred Reporting Items for Systematic reviews and Meta-Analyses” (PRISMA) guidelines, from 1946 to July 2020. Ten cross-sectional studies were included in the review. All studies referred to the polymorphisms that can favour some neurotoxic effects of the metal in occupational cohorts. Some genetic variants may be associated with an increase in the occupational effects of mercury. Given the limited evidence, genetic screening of all mercury-exposed workers is not recommended. However, a personalized search for polymorphisms could be taken into consideration if exposed workers report early neurotoxic symptoms.

scholarly journals M28. BIDIRECTIONAL INFLUENCES BETWEEN PSYCHOTIC EXPERIENCES AND SUICIDAL IDEATION IN CHILEAN ADOLESCENTS: THE ROLE OF DEPRESSIVE SYMPTOMS AS MEDIATORS

2020 ◽  
Vol 46 (Supplement_1) ◽  
pp. S144-S145
Author(s):  
Daniel Nunez ◽  
Susana Campos ◽  
Rosario Spencer ◽  
María Faúndez ◽  
Andrés Fresno ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Suicidal Ideation ◽  
Rating Scale ◽  
Community Sample ◽  
Clinical Samples ◽  
Psychotic Experiences ◽  
Cross Sectional ◽  
Mediation Analyses ◽  
Increased Risk

Abstract Background Along with other domains of psychopathology, adolescents are at increased risk for psychotic experiences (PE) as well as for suicidal ideation (SI) and suicidal attempts. Literature has found robust associations between PE and SI, with suicidal risk appearing higher in subjects with persistent PE, in general and clinical samples. However, the associations between psychotic experiences and suicidal ideation are not clearly understood, and the role of common risk factors in this link, such as depression (DS), is controversial. Moreover, causality has yet to be properly stablished between PE and SI. A study recently found psychosis may be consequential to suicidal behavior. Under the novel “suicidal drive hypothesis for psychosis” framework, we examined whether depressive symptoms mediate the association between psychotic experiences and suicidal ideation on cross-sectional data from a community sample of adolescents. Additionally, we tested this mediating role when both PE and SI were the outcome variables. Methods 1708 Chilean school adolescents aged 13–19 years (M=15.68 + 1, 67, women= 39%) answered an online mental health screening between May and October 2019. The screening encompassed several questionnaires adapted for Chilean subjects, including the Columbia-suicide Severity Rating scale, the Community assessment for Psychic experiences (CAPE-P15) and the Patient Health Questionnaire (PHQ-9). Informed consent was granted by the parents and caregivers of adolescents. Mediation analyses were executed with the PROCESS statistical package. PROCESS runs regression-based mediations based on the Baron & Kenny procedure. A 5000 bootstrap resampling was used to estimate 95% confidence intervals; these are used to identify an indirect effect that suggests mediation. Results Pearson’s correlations showed significant associations between all the variables in (SI-DS: r= .624, p&lt;.001; PE-SI: r= .539, p&lt;.001; PE-DS: r= .708, p&lt;.001). No demographic variables (i.e age, gender, education) were correlated significantly to the dependent variable (DV), therefore no covariates were controlled for in the mediation analyses. In the mediation analyses, model 1 showed SI as the DV. The link between psychotic experiences and suicide was mediated by depression (b= .3433, 95% BCa CI [.2981, .3885]). When the mediators were not included in the model, PE significantly predicted SI (b = .113, t = 26.45, p &lt; 0.001). Additionally, in model 2, where PE was the DV, the link between suicidal ideation and psychotic experiences was mediated by depression as well (b= .3794, 95% BCa CI [.3431, .4150]). When the mediators were not included in the model, SI significantly predicted PE (b = 2.57, t = 26.45, p &lt; 0.001). Both models exhibit robust and significant partial mediations. Discussion Our results indicate that depressive symptoms partially mediate the association between SI and PE. Moreover, either PE or SI could be outcome variables when depressive symptoms are mediators. This adds new evidence supporting that PE could consequential to SI as stated by the “suicidal drive hypothesis for psychosis”. Our exploratory findings must be carefully interpreted, mainly because of our cross-sectional design, and the fact that there could be unmeasured or non-controlled psychopathological confounder variables in our models.

scholarly journals The prevalence of Toxoplasma gondii in mice living in Danish indoor sow herds

2019 ◽  
Vol 61 (1) ◽  
Author(s):  
Stine Thorsø Nielsen ◽  
Isabella Linde Westergaard ◽  
Grith Kirkhoff Guldbech ◽  
Henrik Vedel Nielsen ◽  
Maria Vang Johansen
Keyword(s):  
Toxoplasma Gondii ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Polymerase Chain Reaction Analysis ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Present Cross Sectional Study ◽  
Faecal Samples ◽  
Human Infections

Abstract Background Toxoplasma gondii is found worldwide, and consumption of undercooked meat is considered a significant risk factor for human infections. In Denmark, little is known about the distribution of T. gondii, but a recent study revealed a seroprevalence of 34% in Danish indoor sows. The present cross-sectional study aimed to investigate the role of mice for the transmission of T. gondii in Danish indoor sow herds. Results In total, 56 sow herds were visited, 137 mice were caught by snap traps from 32 farms, and 52 cat faecal samples were collected from 22 farms. Eight percent of the mice were positive for T. gondii DNA, representing 11% of the farms. Significant associations were found between the presence of T. gondii-positive mice and both open feed systems (P= 0.041) and extra rodent control on the farm (P= 0.024). All cat faecal samples were deemed negative for T. gondii by light microscopy examination and real-time polymerase chain reaction analysis. Conclusion Mice captured inside Danish sow herds were found to be infected with T. gondii and may thus contribute to the transmission of T. gondii to sows, which may explain the high seroprevalence found in Danish pigs.

scholarly journals Assessing longitudinal and cross-sectional effects of age on adult obesity in an Iranian population: results from a large population-based cohort study

2020 ◽  
Author(s):  
Mahsa Rafiee Alhossaini ◽  
Anoshirvan Kazemnejad ◽  
Farid Zayeri ◽  
Masoumeh Sadeghi
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Large Population ◽  
Significant Risk ◽  
Repeated Measurements ◽  
Noncommunicable Diseases ◽  
Public Health Issue ◽  
Related Factors ◽  
Cross Sectional ◽  
Longitudinal Effects

Abstract BackgroundObesity is a significant risk factor for noncommunicable diseases, and it is related to many adverse health consequences. The risk of obesity commonly changes with age, which is called a longitudinal (aging) effect. Also, individuals enter the study of the same age have similar living conditions that may influence their obesity risk in a particular way; this is a cross-sectional effect.ObjectiveTo assess the cross-sectional and longitudinal effects of age, using a Marginal Logistic Regression (MLR) model.MethodsIn the current study, we used the information of individuals who had participated in the Isfahan Cohort Study (ICS). Participants were a large group of Iranian adults over 35 years of age in 2001, who lived in the central region of Iran. They were followed up for 12 years. Repeated measurements of obesity were obtained in 2001, 2007, and 2013. The Marginal Logistic Regression model including the effects of the age at baseline and its difference with current age, is used.ResultsFrom 2001 to 2013, the percentage of obesity in men and women has raised from 13% to 18% and from 31% to 44%, respectively. Both cross-sectional and longitudinal effects of age were significantly associated with the odds ratio of obesity. There was a rise in the probability of obesity for individuals with baseline age 35 to 60 and a decline for the older ones. Furthermore, the odds of obesity had about 2% increase (on average) by each year of aging, regardless of the baseline age.ConclusionThe high frequency of obese individuals and its fast growth has been a serious public health issue among Iranians adults aged 35-60 years, especially in women. To better understand the effect of age on obesity and identify the related factors, both cross-sectional and longitudinal effects of age should be considered.

scholarly journals The Role of Oxidative Stress in Suicidal Behaviour Among Bipolar Patients: A Cross-Sectional Study in a Malaysian Sample

2021 ◽  
Vol 12 ◽  
Author(s):  
Jiann Lin Loo ◽  
Nurul Ain Mohamad Kamal ◽  
Jo Aan Goon ◽  
Hanafi Ahmad Damanhuri ◽  
Jaclyn Ai Chin Tan ◽  
...  
Keyword(s):  
Dna Damage ◽  
Suicidal Ideation ◽  
Suicidal Behaviour ◽  
Rating Scale ◽  
Suicide Attempts ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Bipolar Patients

Background: Oxidative stress markers are found to be linked with depression and suicide attempts in bipolar disorder (BD), although the role of DNA damage as a marker of suicidal ideation and attempt has yet to be determined. We aim to investigate the association between DNA damage and suicidal behaviour, i.e., suicidal ideation and suicide attempt, among suicidal ideators in BD patients while accounting for clinical and psychosocial risk factors.Methods: A cross-sectional study was conducted in the Universiti Kebangsaan Malaysia Medical Centre on 62 consecutive BD patients diagnosed using the M.I.N.I. Neuropsychiatric Interview and 26 healthy control participants. Socio-demographic and clinical assessments were performed using the Columbia Suicide Severity Rating Scale (C-SSRS) for lifetime suicidal ideation and attempt, Quick Inventory of Depressive Symptomatology (QIDS) for depression severity, Clinical Global Impression for Bipolar Disorder (CGI-BD) for illness severity [both mania (CGI-Mania) and major depressive episode (CGI-MDE)], Social Readjustment Rating Scale (SRRS) for change in life events, and Barratt Impulsiveness Scale (BIS) for behavioural impulsivity. The degree of DNA damage in peripheral blood samples was determined using a standard protocol of comet assay.Results: Multivariable logistic regression revealed higher scores of CGI-MDE as the sole significant factor for lifetime suicidal ideation (OR = 1.937, 95% CI = 1.799–2.076). Although initial bivariate analysis showed a significant association between DNA damage, malondialdehyde (MDA), catalase (CAT), and suicidal behaviour, the findings were not seen in multivariable logistic regression. Bivariate subgroup analysis showed that moderate and severe DNA damage (p = 0.032 and p = 0.047, respectively) was significantly associated with lifetime suicide attempts among lifetime suicidal ideators. The study is the first to look at the connexion between DNA damage and suicidal risk in bipolar patients. It is limited by the small sample size and lack of information on illicit substance use.Conclusions: More severe DNA damage was significantly associated with lifetime suicide attempts among lifetime suicidal ideators in BD. However, the severity of depression was found to be independently associated with lifetime suicidal ideation per se rather than DNA damage in BD. Larger prospective studies are required to ascertain the potential of DNA damage as a biomarker for the transition from suicidal ideation to a suicide attempt.

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