scholarly journals Diagnostic Potential of Calprotectin for Spontaneous Bacterial Peritonitis in Patients Withliver Cirrhosis and Ascites

PRILOZI ◽  
2021 ◽  
Vol 42 (3) ◽  
pp. 97-106
Author(s):  
Fana Lichoska Josifovikj ◽  
Kalina Grivcheva Stardelova ◽  
Beti Todorovska ◽  
Magdalena Genadieva Dimitrova ◽  
Nenad Joksimovikj ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Antibiotic Treatment ◽  
Spontaneous Bacterial Peritonitis ◽  
Mean Value ◽  
Mean Values ◽  
Average Value ◽  
Bacterial Peritonitis ◽  
Diagnostic Potential ◽  
The Mean ◽  
The Difference

Abstract The development of spontaneous bacterial peritonitis (SBP) is a serious and life-threatening condition in patients with cirrhosis and ascites. The aim of this study was to determine the diagnostic potential of calprotectin in ascites, for SBP in patients with liver cirrhosis and ascites before and after antibiotic treatment and to compare the mean values of calprotectin in ascites in patients with and without SBP. This prospective-observational study was comprised of 70 patients with cirrhosis and ascites, divided into two groups, the SBP and the non-SBP group. Quantitative measurements of calprotectin in ascites was completed with the Quantum Blue Calprotectin Ascites test (LF-ASC25), using the Quantum Blue Reader. The average value of calprotectin in the SBP group was 1.5 ± 0.40 μg / mL, and in the non-SBP group it was lower (0.4 ± 0.30). The difference between the mean values was statistically significant with p <0.05. The mean value of calprotectin in ascites before therapy among the SBP group was 1.5 ± 0.4, and after antibiotic therapy, the value decreased significantly to 1.0 ± 0.6; the difference between the mean values was statistically significant with p <0.05. ROC analysis indicated that calprotectin contributed to the diagnosis of SBP with a 94.3% sensitivity rating (to correctly identify positives), and the specificity was 62.5%, which corresponded to the value of 0.275. Our research confirmed that ascitic calprotectin was a good predictor, and is significantly associated with the occurrence of SBP in patients with liver cirrhosis. By monitoring the value of calprotectin in ascites on the 7th day of antibiotic treatment, the effectiveness of antibiotic treatment in patients with SBP can be determined.

scholarly journals Predictive potential of the MELD and Child-Turcotte-Pugh II scores for SBP in patients with cirrhosis and ascites

2021 ◽  
Vol 13 (2) ◽  
pp. 1-9
Author(s):  
Fana Lichoska-Josifovikj ◽  
Kalina Grivcheva-Stardelova ◽  
Beti Todorovska ◽  
Magdalena Genadieva Dimitrovа ◽  
Lidija Petkovska ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Roc Analysis ◽  
Meld Score ◽  
Mean Values ◽  
Average Value ◽  
Percentage Difference ◽  
Class B ◽  
The Mean ◽  
The Difference ◽  
Difference Test

It is very important for patients with spontaneous bacterial peritonitis (SBP) to assess the length of survival and the risk of death, primarily because of the wide range of potential complications that can lead to multisystem organ failure and fatal outcome. The aim of this study was to determine the predictive potential of MELD and Child-Turcotte-Pugh II score for SBP in patients with cirrhosis and ascites. Material and methods: The study was designed as a prospective-analytical-observational and was conducted at the University Clinic for Gastroenterohepatology in Skopje for a period of one year. The study population included 70 hospitalized patients with established liver cirrhosis, regardless of etiology, divided into two groups, 35 patients with SBP and 35 non-SBP. Prognostic scores in patients with liver cirrhosis and ascites: MELD score, according to the formula: MELD = [(0.957 x Ln Creatinin) + (0.378 x Ln Bilirubin) + (1.12 x Ln INR) + (0.643) x 10]. The Child-Turcotte-Pugh II score includes 6 parameters: serum albumin and bilirubin, amount of ascites, degree of encephalopathy ( HE), prothrombin time (PT) and serum creatinine, and assessment of the degree of hepatic encephalopathy according to the West Haven criteria. Results: The average value of the MELD score in patients with SBP was 22.6 ± 8.27 and in non-SBP the average value was lower - 17.83±5.87. According to the Mann-Whitney U test, the difference between the mean values ​​was statistically significant for p <0.05 (z = 2.41; p = 0.015). A score of 30 to 39 was registered in 25.7% of patients with SBP, and only in 2.9% in non-SBP; the percentage difference was statistically significant for p <0.05 (Difference test, p = 0.0064 ). Patients with SBP had an average Child-Pugh score of 13.09 ± 2.48 or 100.0% C-class points. In patients with non-SBP, an average child-Pugh score of 9.63 ± 1.62 was recorded, or class B in 65.7% and class C in 34.3%. The percentage difference was statistically significant for p <0.05 (Difference test, p = 0.000000). According to the Mann-Whitney U test, the difference between the mean values ​​was statistically significant for p <0.05 (z = -5.44; p = 0.00001). ROC analysis indicated that the Child-Turcotte-Pugh II score contributed to the diagnosis of SBP - 90.7% (p = 0.000) (excellent predictor), closer to the ideal value of 1.0 and above the worst value of 0.5. ROC analysis indicated that the MELD score did not contribute to the diagnosis of SBP - 66.7% (p = 0.017) (weak predictor), closer to the worst value of 0.5. Conclusion:Our research confirmed that SBP occurs in patients with severe hepatic dysfunction calculated according to the CTP II score and MELD score. Mean value of the MELD score in patients with SBP was higher then in patients with non-SBP. On the other hand all patients with SBP had an average CTP II score, C-class points,  while the largest percentage of patients with non-SBP were class B-class points. MELD score is a weak predictor of SBP.  The best predictor for predicting SBP is the CTP II score (rank C).

Seasonal trends in the stable isotopic composition of snow and meltwater runoff in a subarctic catchment at Okstindan, Norway

2004 ◽  
Vol 35 (2) ◽  
pp. 119-137 ◽  
Author(s):  
S.D. Gurney ◽  
D.S.L. Lawrence
Keyword(s):  
Isotopic Composition ◽  
Mean Value ◽  
Mean Values ◽  
Stable Isotopic Composition ◽  
Meltwater Runoff ◽  
Stable Isotopic ◽  
The Mean ◽  
The Difference ◽  
Δ18o And Δd

Seasonal variations in the stable isotopic composition of snow and meltwater were investigated in a sub-arctic, mountainous, but non-glacial, catchment at Okstindan in northern Norway based on analyses of δ18O and δD. Samples were collected during four field periods (August 1998; April 1999; June 1999 and August 1999) at three sites lying on an altitudinal transect (740–970 m a.s.l.). Snowpack data display an increase in the mean values of δ18O (increasing from a mean value of −13.51 to −11.49‰ between April and August), as well as a decrease in variability through the melt period. Comparison with a regional meteoric water line indicates that the slope of the δ18O–δD line for the snowpacks decreases over the same period, dropping from 7.49 to approximately 6.2.This change points to the role of evaporation in snowpack ablation and is confirmed by the vertical profile of deuterium excess. Snowpack seepage data, although limited, also suggest reduced values of δD, as might be associated with local evaporation during meltwater generation. In general, meltwaters were depleted in δ18O relative to the source snowpack at the peak of the melt (June), but later in the year (August) the difference between the two was not statistically significant. The diurnal pattern of isotopic composition indicates that the most depleted meltwaters coincide with the peak in temperature and, hence, meltwater production.

scholarly journals Lateral Antebrachial Cutaneous Nerve as a Donor Source for Digital Nerve Grafting: A Concept Revisited

2017 ◽  
Vol 11 (1) ◽  
pp. 1041-1048 ◽  
Author(s):  
Mehmet Bekir Unal ◽  
Kemal Gokkus ◽  
Evrim Sirin ◽  
Eren Cansü
Keyword(s):  
Pearson Correlation ◽  
Mean Value ◽  
Cutaneous Nerve ◽  
Digital Nerve ◽  
Mean Values ◽  
Nerve Grafts ◽  
The Mean ◽  
The Difference ◽  
Mean Time

Objective: The main objective of this study is to evaluate the availability of lateral antebrachial cutaneous nerve (LACN) autograft for acute or delayed repair of segmented digital nerve injuries. Patients and Methods: 13 digital nerve defects of 11 patients; treated with interposition of LACN graft that harvested from ipsilateral extremity were included in the study. Mean follow up period was 35, 7 months. The mean time from injury to grafting is 53, 3 days. The results of the mean 2PDT and SWMT values of injured /uninjured finger at the end of follow up period were evaluated with Paired T test. The correlation between the defect length and the difference of 2PDT, SWMT values between the uninjured and injured finger at the end of follow up period; were evaluated with Pearson - correlation analysis. Results: The mean value of our 2PDT and SWMT results are ~5,923, ~3, 52, respectively in which can be interpreted between the normal and diminished light touch. The defect length and difference percentage of SWMT values is positively and significantly correlated statistically. Mean length of interposed nerve grafts was 18.5 mm. The age of the patient and the mean values of 2PDT and SWMT with the difference % of 2PDT and % of SWMT are not statistically correlated. Conclusion: Based on results regarding sensory regaining at recipient side and negligible sensory deficit at harvesting side, we suggest that lateral antebrachial cutaneous nerve might be a valuable graft option for digital nerve defects.

scholarly journals Renal impairment after Spontaneous Bacterial Peritonitis (SBP) in cirrhotic population.

2019 ◽  
Vol 26 (12) ◽  
pp. 2235-2240
Author(s):  
Asif Javaid Wakani ◽  
Riaz Hussain Awan ◽  
Seema Nayab ◽  
Khadim Hussain Awan ◽  
Faqir Muhammad Awan
Keyword(s):  
Liver Cirrhosis ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Spontaneous Bacterial Peritonitis ◽  
National Hospital ◽  
Cross Sectional ◽  
Bacterial Peritonitis ◽  
Serum Blood Urea Nitrogen ◽  
Patient’S Information ◽  
The Mean

Objectives: To evaluate the frequency of renal impairment after spontaneous bacterial peritonitis (SBP) in cirrhotic population. Study Design: The study was conducted as Descriptive Cross-Sectional. Setting: Liaquat National Hospital Karachi. Period: For six months (October 01, 2015 to March 31, 2016). Methodology: The subjects with liver cirrhosis spontaneous bacterial peritonitis (SBP) were evaluated for serum creatinine and serum blood urea nitrogen (BUN) for evaluation of renal impairment while the patient’s information was recorded on proforma and analyzed in SPSS-15.0. Results: The mean ±SD of age, BUN and serum creatinine for whole population was 50.69±10.69 years, 22.4197±11.64742 and 1.2207±0.92535. Renal impairment was detected in 40 (27.2%) individuals while it is normal in 107 (72.8%) subjects. Conclusion: The renal impairment after SBP in cirrhotic population is higher in present study.

Effect of Erythropoietin on Platelet Function and Glycoprotein Expression in Patients with MDS.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3993-3993
Author(s):  
Fotis F.I. Girtovitis ◽  
Dimitrios D. Bougiouklis ◽  
Michel M.P. Makris ◽  
Elefteria E. Pithara ◽  
Pantelis P.E. Makris
Keyword(s):  
Flow Cytometry ◽  
Platelet Function ◽  
Normal Subjects ◽  
Mean Value ◽  
Special Treatment ◽  
Recombinant Erythropoietin ◽  
Mean Values ◽  
Human Recombinant Erythropoietin ◽  
The Mean ◽  
The Difference

Abstract Aim: We decide to study the effect of erythropoietin on the platelet function and glycoproteins expression in patients (pts) with myelodysplastic syndrome (MDS). All patients suffered from primary MDS but none of them received any special treatment. From our study pts that suffered from diseases or they were receiving medication that affect the function of platelets were excluded. Furthermore pts with platelet count&lt;50,000/μl were excluded also because we were unable to check the aggregation of platelets. Material: 41 subjects were studied, 15 normal subject (10 men and 5 women mean age 66,6±14 years old)and 26 pts (17 men and 9 women with mean age70,9±7,4 years old) suffered from all types of MDS according to FAB criteria (9 with RA, 3 with RARS, 7 RAEB, 4 with CMML and 3 with RAEB-t). We divided them in 2 groups: 1st - 7 Pts receiving human recombinant erythropoietin (rEPO) with mean dose 30.000 iu subcutaneous weekly and 2nd - 19 without rEPO. Methods. 1- The platelet function was studied in Platelet Ionized Calcium Aggregometer (PICA) using Ristocetin, ADP, Collagen and Adrenalin as stimulators. 2- The expression of platelet glycoproteins (GPIb, IX, IIb, IIIa and P-selectin) was studied using the flow cytometry and special monoclonal antibodies. This way the percentage of glycoprotein expressed in platelet membrane and MFI were estimated. We performed the statistical analysis of our results using the t-test with common standard deviation.. Results: our results concerning the aggregation test and flow cytometry are presented in tables 1,2 and 3. From the study of our results we can see that while the decrease of aggregation between the patients under EPO and normal subjects is statistically non significant (p&lt;0.1)the decrease of the corresponding values between the pts that did not received EPO and normal subjects was statistically very significant for all stimulators (p &lt;0,001). pts under EPO show an important increase of platelet expressing GPIIb percentage grater than the expressed percentage of patients without EPO (60% vs. 46,1% correspondingly, p&lt;0.001). The difference of expressed MFI was not statistically significant. Conclusion: The findings of our study show us that erythropoietin improves the function of platelets in patients with MDS, probably through the increase of platelet percentage which express glycoproteins. Table 1 Comparison of the mean value of aggregation between the groups Table 2 Comparison of the mean values of the platelets expressing corresponding glycoproteins percentage between the groups Table 3 Comparison of the mean value of MFI between the groups

The analysis of temperature fluctuations by pulse-counting techniques

1959 ◽  
Vol 6 (2) ◽  
pp. 261-271 ◽  
Author(s):  
A. A. Townsend
Keyword(s):  
Time Derivative ◽  
Temperature Fluctuations ◽  
Mean Value ◽  
Time Intervals ◽  
Mean Values ◽  
Average Value ◽  
Electrical Pulses ◽  
The Mean ◽  
The Stability ◽  
Better Than

To determine experimentally the mean value of a randomly fluctuating quantity, it may be necessary to measure the average value over a considerable interval of time. This problem arose in a recent study of the temperature fluctuations over a heated horizontal plate, and a system was used that depended on the counting of electrical pulses generated at a rate proportional to the quantity being measured. The advantage of this technique is that mean values may be measured over time intervals of almost unlimited length with little added difficulty for the experimenter. Circuits are described which measure: (a) the mean square of a fluctuating quantity and of its time-derivative, (b) the statistical distribution of the fluctuations, (c) the mean frequency of the fluctuation assuming a particular value, and (d) the mean product of two fluctuating quantities. Over the range of use, the stability and linearity of the calibrations is better than 1%, more than sufficient for work on natural convection. In its present form, the equipment responds uniformly to all frequencies below 100 c/s, but it would not be difficult to extend this range of response to higher frequencies.

SERUM MAGNESIUM LEVELS IN THE NEWBORN

PEDIATRICS ◽  
1964 ◽  
Vol 33 (6) ◽  
pp. 969-974
Author(s):  
Constantine S. Anast
Keyword(s):  
Human Milk ◽  
Serum Magnesium ◽  
Mean Value ◽  
Cow’S Milk ◽  
Older Children ◽  
Mean Values ◽  
Cow's Milk ◽  
The Mean ◽  
The Difference ◽  
Breast Fed

Two hundred and thirty-eight determinations of serum magnesium levels during the first 4 days of life were carried out on 78 infants. No statistically significant differences were found when these values were compared to those determined in 111 older children and adults. Differences in mean values between any of the first 5 days were not statistically significant nor were any significant differences found when the values of each day were compared with the mean value of older children and adults or the mean value of the cord bloods. The mean values on days 3, 4, and 5 were higher in breast-fed infants than in infants fed evaporated milk. Higher values in breast-fed infants and lower values in evaporated-milk-fed infants on days 3 and 4 when compared to day 1 in the same infant were found in a significant number of cases. The possibility that the observed differences in these two groups of infants may be related to the difference in phosphate to magnesium ratio in cow's milk as compared to human milk is discussed. Further investigation of this problem is needed before definite conclusions can be drawn.

The Body Feature Study of Young Women from Northeastern China

2014 ◽  
Vol 1048 ◽  
pp. 567-570
Author(s):  
Jun Wang ◽  
Xiao Jiu Li ◽  
Xiao Mei Chen ◽  
Tong Yao ◽  
Li Pan
Keyword(s):  
Young Women ◽  
Mean Value ◽  
Northeastern China ◽  
The Body ◽  
3D Scanner ◽  
Mean Values ◽  
Adult Females ◽  
Width Direction ◽  
The Mean ◽  
The Difference

This study aims to investigate the anthropometric feature of young women aged between 18 and 25 from Northeastern China, and compare the difference between the young Northeastern China women and the national adult females. More than 400 young Northeastern China women were measured, and the body data were collected by mix-measurement of 3D scanner and manual method, and the main sizes were extracted to descript the total anthropometric characterizes. The high mean value of the Northeastern young women is 162.3 CM, which is 5.75 CM higher than the national adult females. In the high direction, the other mean values of the samples are variously higher than the national adult females. Overall, the young Northeastern China women are taller than the national adult females and well proportioned. In the width direction, the mean values of bust, waist and neck of the 18-25 years old young women are larger than the national adult females, except the hip.

scholarly journals Analysis of Thermodynamic Parameter Variability in a Chamber of a Furnace for Thermo-Chemical Treatment

Energies ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2903
Author(s):  
Magda Joachimiak
Keyword(s):  
Boundary Conditions ◽  
Chemical Treatment ◽  
Mean Value ◽  
Mean Values ◽  
Cylinder Length ◽  
Unsteady Heat Conduction ◽  
The Mean ◽  
The Absolute ◽  
The Difference ◽  
Relative Differences

This paper presents results of research on unevenness of cylinder heating in a furnace for thermo-chemical treatment. Experimental research was conducted with respect to nitriding. Various heating speeds and settings of the fan operation in the furnace were considered. Boundary conditions were calculated in the form of temperature and the heat transfer coefficient (HTC) on the cylinder boundary in four planes along the cylinder length. Calculations were performed with the use of the inverse problem for non-linear and unsteady heat conduction equations. Boundary conditions from individual planes were compared with the mean value of them all. The variability of the calculated boundary conditions (temperature and HTC) along the cylinder length was investigated based on values of the absolute and relative differences for temperature and HTC. Estimates: mean value, mean value from the absolute value and the maximum values for the absolute and the relative differences of temperature and HTC were also calculated. Estimates were the measurements of the unevenness of cylinder heating in a furnace for thermo-chemical treatment. Based on the results of our research, it was found that an increase of the fan rotational speed from 50% to 100%, with the same heating speed, resulted in a significant leveling of temperature in the analyzed planes. The difference in temperature along the cylinder length was reduced from 6.8 °C to 3.3 °C. The increase of the heating speed from 5 °C/min to 10 °C/min resulted in an increase of the unevenness of the cylinder heating. Values of the absolute differences of temperature in the analyzed planes with reference to the mean temperature changed from an interval from −2.7 °C to 2.3 °C to a range from −4 °C to 5 °C. In processes with a heating speed greater than 5 °C/min, more intensive heating in the end part of the cylinder (close to the cylinder) was achieved than it was in other planes. It was proven by temperature values, which were higher, even, by 5.4 °C, and by HTC values, higher by 11.4 W/m2K, when compared with mean values. Obtained results can form the basis for nitriding process optimization.

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