scholarly journals Clinical and echocardiographic predictors of silent cerebral infarctions in patients with persistent atrial fibrillation

2014 ◽  
Vol 20 (2) ◽  
pp. 10-17
Author(s):  
Oleg Sychov ◽  
Artem Borodai ◽  
Svetlana Fedkiv ◽  
Elina Borodai ◽  
Taisia Getman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Multivariate Analysis ◽  
Creatinine Clearance ◽  
Independent Predictor ◽  
Univariate Analysis ◽  
Persistent Atrial Fibrillation ◽  
Cross Sectional Study ◽  
Neurological Dysfunction ◽  
Cross Sectional ◽  
History Of

Summary Aim. The aims of the study were to evaluate prevalence of silent cerebral infarctions (SCI) and determine their clinical and echocardiographic predictors in patients with atrial fibrillation (AF). Patients and methods. In prospective cross sectional study we examined 134 patients with non-valvular AF. Clinical examination, laboratory tests, transoesophageal, transthoracic echocardiography and multislice computed tomography of the brain were performed for all patients. According to current guidelines, SCI was defined as imaging (≥3 mm) or neuropathological evidence of central nervous system infarction, without a history of acute neurological dysfunction attributable to the lesion. Results. Silent cerebral infarctions were detected in 34.3% (n = 46) of patients, and infarctions ≥ 15 mm (mean diameter 31.3 mm) were detected in 11.2% (n = 15) of patients. Superficial SCIwere found in 12.7%and basal SCI in 21.6% of cases. In multivariate analysis low creatinine clearance < 90 ml/min was independently associated with small basal SCI (p = 0.04). In univariate analysis age ≥ 65 years was significantly associated with basal SCI, p = 0.004, but not with SCI ≥ 15 mm or superficial SCI. The results of multivariate analysis showed that CHA2DS2VASc score was an independent predictor of superficial SCI; low left atrial appendage velocity (LAAV) < 30 cm/s was independently associated both with SCI ≥ 15 mm (p = 0.03) and superficial SCI (p = 0.02). Conclusions. Large and superficial SCI were significantly and independently associated with low LAAV < 30 cm/s and other echocardiographic embolic risk factors and in case of absence of significant large arteries atherosclerosis may be considered as those of cardiac origin. Small basal SCI were associated with age and low creatinine clearance < 90 ml/min which was their independent predictor. CHA2DS2VASc score is useful for assessment of risk of cerebral infarctions even those without history of acute symptoms

Comparison of Non-radiographic Axial Spondyloarthritis and Ankylosing Spondyltis from a Single Rheumatology Hospital in Morocco

2020 ◽  
Vol 16 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Nessrine Akasbi ◽  
Siar Nihad ◽  
Zoukal Sofia ◽  
El Kohen Khadija ◽  
Harzy Taoufik
Keyword(s):  
Disease Burden ◽  
Axial Spondyloarthritis ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Low Back ◽  
New Classification ◽  
Cross Sectional ◽  
Asas Criteria ◽  
History Of ◽  
High Level

Background: According to the new classification criteria developed by The Assessment of SpondyloArthritis International Society, patients with axial spondyloarthritis (axSpA) can be classified in 2 subgroups: Patients with radiographic axial spondyloarthritis: ankylosing spondylitis patients (AS) and those with non-radiographic axial spondyloarthritis (nr-axSpA). Objective: The aim of the present study is to describe and discuss the differences and similarities between the two subgroups. Patients and Methods: A cross-sectional study was conducted in a single rheumatology hospital in Morocco. These included patients diagnosed as having axial spondyloarthritis according to ASAS criteria 2010, during a period of 6 years. The AS and the nr-axSpA subgroups were compared for the various axSpA-related variables. Results: Of the 277 patients with a diagnosis of axial SpA who were included in this study, 160 had AS and 117 had nr-axSpA. AS and nr-ax-SpA shared a similar age at diagnosis, similar prevalence of low back pain, lumbar stiffness, extra-articular manifestations, BASDAI and BASFI. In the multivariate analysis, AS patients were mainly male with cervical stiffness, enthesitis, coxitis and high level of ESR (erythrocyte sedimentation rate). The females generally had a family history of SpA and arthritis and were associated to the nr-axSpA form in the univariate analysis. Conclusion: This was the first study to characterise patients with AS and nr-axSpA in Morocco. Consistent with other studies published, this study showed that patients with nr-axSpA and patients with AS shared a comparable degree of disease burden.

scholarly journals PREVALENSI GANGGUAN PERILAKU PADA WANITA PEKERJA SEKS USIA REMAJA DI KOTA MANADO

e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Mercy Juliana Jacqualine
Keyword(s):  
Conduct Disorder ◽  
Behavioral Disorders ◽  
Sex Workers ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Behavioral Disturbances ◽  
Cross Sectional ◽  
History Of ◽  
The Subject ◽  
Depth Interviews

Abstract: Introduction: Behavioral disorders are mental disorder which are often overlooked by many people. Whereas as a result of behavioral disorders would very dangerous if left unchecked. Adolescence is an particularly vulnerable age for developing conduct disorder. Adolescents who have behavioral disorders have tendency of engage in activities that deviate including againts parents, lying and stealing. These gestures are the types of behavioral disorders and impaired conduction opposed. Perversity is what that associated with behavioral disorders, especially for teenagers who work as female sex workers. Methods: This research is a descriptive cross-sectional study design. By using research instruments informed consent, mini-kid, and kuesioner. The results will be processed by univariate analysis. Fallowed by qualitative research by depth interviews with the subject. Result: Result found as many as 70% had a history of opposing interference, 36.6% had a history of mild behavioral disorders, and 30% had experienced a history of conduct disorder being. Key Words: Behavioral disturbances, interruption againts, adolescent, Mini-Kid.     Abstrak: Pendahuluan: Gangguan perilaku merupakan salah satu gangguan mental yang seringkali diabaikan oleh banyak orang. Padahal akibat dari gangguan perilaku akan sangat berbahaya jika terus dibiarkan. Usia remaja merupakan usia yang sangat rentan untuk terkena gangguan perilaku. Remaja yang mengalami gangguan perilaku memiliki kecendrungan untuk melakukan kegiatan yang menyimpang termasuk melawan orang tua, berbohong dan mencuri. Sikap-sikap tersebut merupakan jenis gangguan perilaku konduksi dan gangguan menentang. Perbuatan menyimpang inilah yang dikaitkan dengan gangguan perilaku terutama bagi remaja yang berprofesi sebagai wanita pekerja seks. Metode: Penelitian ini bersifat deskriptif dengan desain penelitian cross-sectional. Dengan mengunakan instrumen penelitian mini-kid dan kuesioner. Hasil penelitian akan diolah dengan analisis univariat. Dilanjutkan dengan penelitian kualitaif berupa wawancara mendalam dengan 2 subjek, yang hasil penelitiannya akan disajikan dalam bentuk naratif. Hasil: Didapati sebanyak 70% WPS memiliki riwayat gangguan menentang, 36,6% mengalami riwayat gangguan tingkah laku ringan, dan 30% pernah mengalami riwayat gangguan tingkah laku sedang. Kata Kunci: Gangguan tingkah laku, gangguan menentang, remaja, Mini-KID

scholarly journals Quality of Life in Keratoconus: Evaluation With Keratoconus Outcomes Specific Questionnaire (KORQ)

2021 ◽  
Author(s):  
roberto damian pacheco pinto ◽  
Ricardo Yuji Abe ◽  
Flavia Cid Gomes ◽  
Paulo Rodolfo Tagliari Barbisan ◽  
Alexandre Fattah Martini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Wilcoxon Test ◽  
Cross Sectional ◽  
Specific Questionnaire ◽  
Functional Scores ◽  
History Of ◽  
Assess Quality

Abstract Purpose: To assess quality of life in keratoconus patients using the Keratoconus Outcomes Research Questionnaire (KORQ) translated and validated to Portuguese language. KORQ is the only validated keratoconus specific questionnaire and has high rating for psychometric properties.Methods: In this cross-sectional study enrolled 100 patients with keratoconus from a tertiary referral eye hospital, from April 2018 to June 2019. Associations between age, gender, allergic conjunctivitis, keratoconus stage, best-corrected visual acuity (BCVA), maximum simulated keratometry (Kmax), steep keratometry (K2), pachymetry, treatments performed, hydrops and KORQ scores were evaluated with univariate (Wilcoxon test and the Kruskal Wallis test) and multivariate linear regression with stepwise backward modeling. Lower scores of KORQ are associated with better quality of life, as well as higher scores are associated with greater impairment of functional activities and symptoms.Results: Out of the 100 patients, mild, moderate and severe keratoconus, was observed in 15%, 46% and 39% of participants, respectively. Univariate analysis showed lower values for function scores with male gender (p<0.05) and both functional and symptoms scores statistically associated with BCVA<0.3 (LogMAR) (p<0.05). Multivariate analysis indicated significantly lower functional scores in individuals with BCVA<0.3 (p<0.001) and those with history of crosslinking treatment (p=0.022), while symptom scores were only statistically associated with BCVA<0.3 (p<0.001).Conclusions: In patients with keratoconus, BCVA in the better eye and history of crosslinkig are factors were associated with better quality of life scores using KORQ.

scholarly journals Weight Status and Depressive Smptoms in 18 Year-Old Greek Adolescents

2010 ◽  
Vol 2 (2) ◽  
pp. 51-54
Author(s):  
Vasiliki Matziou ◽  
Kalliopi Hatira ◽  
Pantelis Perdikaris ◽  
Ioannis Zachos ◽  
Kassiani Mellou ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Weight Status ◽  
Univariate Analysis ◽  
Depression Scale ◽  
Cross Sectional Study ◽  
Epidemiologic Studies ◽  
Cross Sectional ◽  
History Of ◽  
Mental Institution ◽  
Old Greek

Depressive symptoms in adolescence have been a subject of considerable controversy in terms of their nature, severity and identification. The aim of the study was to investigate the possible association between weight status and depressive symptoms among 18 year-old Greek adolescents. A cross-sectional study design was used. The study population consisted of 200 students of the University of Athens who fulfilled the following criteria: age 18 years, absence of clinical depression, no history of hospitalization in a mental institution, no history of alcohol abuse. Weight status was assessed by Body Mass Index (BMI) (kg/m2) and calculated from weight and height measurements. Severity of depressive symptoms was assessed by Centre for Epidemiologic Studies-Depression Scale (CES-D). In univariate analysis, CES-D score was significantly associated with adolescents’ gender and BMI. The multivariate analysis showed that CES-D score was negatively related to BMI even after controlling the confounding effect of gender (P=0.018, B=-0.378). Depressive symptoms are related to weight status of adolescents.

Abstract 13512: Sex-related Differences on Valvular Calcifications in Patients With Aortic Stenosis

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Marianne Deslandes ◽  
Marine Clisson ◽  
Ezequiel Guzzetti ◽  
Alexandra Barriault ◽  
Erwan Salaun ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Aortic Valve ◽  
Independent Predictor ◽  
Cross Sectional Study ◽  
Aortic Valve Area ◽  
Mitral Annular Calcification ◽  
Cross Sectional ◽  
Multidetector Compute Tomography ◽  
Annular Calcification ◽  
Valve Area

Introduction: It has been shown that women present lower coronary artery (CAC) and aortic valve calcification (AVC) loads while heavier mitral annular calcification (MAC) than men. However, the sex-specific predictors to these cardiac calcifications remain poorly characterized. Methods: We conducted a cross-sectional study in patients with at least mild AS (indexed aortic valve area: AVAi < 1.5 cm 2 /m 2 , Peak aortic jet velocity: Vpeak > 2.0 m/s, or Mean gradient: MG >15 mmHg). Doppler-echocardiography and non-contrast multidetector compute tomography were performed within 3 months. Ascending aorta calcification (AAC), AVC, CAC and MAC scores were measured using the Agatston method. Descriptive statistical analyses (t-test, Wilcoxon, univariate and multivariate analysis) were performed. Results: We studied 406 patients (71±11 years, 33% women) with AVAi= 0.59±0.21 cm 2 /cm 2 , Vpeak= 3.1±9.8 m/s, MG= 24.7±17.8 mmHg (equivalent between men and women, all p>0.34). Women present less AVC (480[222-1191] vs 1005[485-2364]AU; p<0.0001), and CAC (366[50-914] vs 626[167-1354]AU; p=0.006), but more MAC (60[1-887] vs 48[0-363]AU; p=0.05) and AAC (227[43-863] vs 142[7-493]AU; p=0.03) than men. Even after comprehensive adjustment, sex remained an independent predictor of each cardiac calcification (all p<0.01). In multivariate analysis, correlates with higher AVC or higher MAC were sex dependent (cf. table). Collinearity was avoided with all variance inflating factor <2.5. Conclusion: In AS patients, sex is a powerful and independent predictor of cardiac calcifications. Moreover, predictors of valvular calcification appear to be sex specific.

scholarly journals Access to childbirth care by adolescents and young people in the Northeastern region of Brazil

2016 ◽  
Vol 50 (0) ◽  
Author(s):  
Érida Zoé Lustosa Furtado ◽  
Keila Rejane Oliveira Gomes ◽  
Silvana Granado Nogueira da Gama
Keyword(s):  
Multivariate Analysis ◽  
Health Insurance ◽  
Young People ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Northeast Region ◽  
Childbirth Care

ABSTRACT OBJECTIVE To identify the factors that interfere with the access of adolescents and young people to childbirth care for in the Northeast region of Brazil. METHODS Cross-sectional study with 3,014 adolescents and young people admitted to the selected maternity wards to give birth in the Northeast region of Brazil. The sample design was probabilistic, in two stages: the first corresponded to the health establishments and the second to women who had recently given birth and their babies. The data was collected by means of interviews and consulting the hospital records, from pre-tested electronic form. Descriptive statistics were used for the univariate analysis, Pearson’s Chi-square test for the bivariate analysis and multiple logistic regressions for the multivariate analysis. Sociodemographic variables, obstetrical history, and birth care were analyzed. RESULTS Half of the adolescents and young people interviewed had not been given guidance on the location that they should go to when in labor, and among those who had, 23.5% did not give birth in the indicated health service. Furthermore, one third (33.3%) had to travel in search of assisted birth, and the majority (66.7%) of the postpartum women came to maternity by their own means. In the bivariate analysis, the variables marital status, paid work, health insurance, number of previous pregnancies, parity, city location, and type of health establishment showed a significant association (p < 0.20) with inadequate access to childbirth care. The multivariate analysis showed that married adolescents and young people (p < 0.015), with no health insurance (p < 0.002) and from the countryside (p < 0.001) were more likely to have inadequate access to childbirth care. CONCLUSIONS Adolescents and young women, married, without health insurance, and from the countryside are more likely to have inadequate access to birth care. The articulation between outpatient care and birth care can improve this access and, consequently, minimize the maternal and fetal risks that arise from a lack of systematic hospitalization planning.

scholarly journals High-density lipoprotein lipid peroxidation in association with presence of coronary artery disease and atrial fibrillation in a large cross-sectional study

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
N Pagonas ◽  
B Sasko ◽  
R Mueller ◽  
M Jaensch ◽  
W Dammermann ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Independent Predictor ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Hdl Function ◽  
Antioxidant Function ◽  
Artery Disease

Abstract Background The function of high-density lipoprotein (HDL) cholesterol may play a more important role in the prevention of cardiovascular disease compared to the concentration of the HDL. Cardiovascular diseases such as coronary artery disease (CAD) and atrial fibrillation (AF) have been linked to impaired HDL function. Purpose The aim of the present study is to assess a biochemical measure of the antioxidant function of HDL and its association with presence of CAD and AF. Methods Patients admitted for elective cardiac catheterization were recruited in this cross-sectional study. Out of 1231 participants that were included in the analyses, 727 patients had confirmed CAD (CAD group), 369 patients had no CAD (no CAD group) and 129 persons were included as a control group. HDL function was measured in sera by determination of HDL-lipid peroxidation content (HDLox) assessed by a validated fluorometric cell-free biochemical assay and was normalized for the levels of HDL cholesterol (normalized HDLox/HDL-C ratio or nHDLox; no units). Results are expressed as median with interquartile range. Associations of nHDLox with presence of CAD and AF were assessed by univariate and multivariate analyses. Results Participants in the CAD group had higher levels of nHDLox (0.80, 0.61–1.03) compared to the no CAD (0.70, 0.55–0.93) and control (0.66, 0.55–1.03, no units, p&lt;0.001) group. Out of 1206 participants, 233 (19%) had AF and 973 (81%) had no AF. Patients with AF have also higher nHDLox (0.82, 0.60–10.03) compared to persons without AF (0.73, 0.58–0.98, p=0.03). In univariate analysis nHDLox was associated with CAD (p&lt;0.001). In multivariate analysis adjusted for age, gender, CAD, BMI and hypertension, nHDLox was a strong independent predictor of atrial fibrillation (p=0.015) but was not an independent predictor of CAD (p&gt;0.05) Conclusions Reduced antioxidant function of HDL (increased HDLox measured by a biochemical assay), a metric of HDL function, is increased in patients with atherosclerosis and manifested CAD and is also associated with the presence of atrial fibrillation independent of the presence of CAD. FUNDunding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): Medical School of Brandenburg-MHB Fontane

scholarly journals Assessment of Alcohol use Disorder and its Associated Factors among Alcohol users of Medical and Surgical Outpatients Attending a Specialized Hospital in Gondar, Ethiopia: A cross-sectional study

2020 ◽  
Author(s):  
Demeke Demilew ◽  
Berhanu Boru ◽  
Getachew Tesfaw ◽  
Habtamu Kerebih ◽  
Endalamaw Salelew
Keyword(s):  
Multivariate Analysis ◽  
Alcohol Use ◽  
Associated Factors ◽  
Alcohol Use Disorder ◽  
Alcohol Use Disorders ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
History Of ◽  
Male Sex

Abstract Background: Alcohol use disorders increase the risk of physical harm, mental or social consequences for patients and others in the community. Studies on alcohol use disorder and associated factors among medical and surgical outpatients in Ethiopia are limited. Therefore, this study is meant to provide essential data on alcohol use disorders and associated factors among alcohol user medical and surgical outpatients for future interventions. Methods: An institution-based cross-sectional study was conducted using the systematic random sampling technique. Alcohol use disorders were assessed using the World Health Organization’s 10-item Alcohol Use Disorder Identification Test (AUDIT) questionnaire. Data were analyzed using the Statistical Package for Social Sciences (SPSS) version 20. Bivariate and multivariate logistic regression analyses were performed, a P-value less than 0.05 were considered statistically significant in the multivariate analysis and the strength of association was measured using AOR at a 95% confidence interval.Results: The prevalence of alcohol use and use disorder were 322 (68.50%) and 111 (34.5%), respectively. In the multivariate analysis, male sex (AOR=3.33, 95%CI: 1.40, 7.93), history of mental illness (AOR=2.68, 95%CI: 1.12, 6.38), drinking for relaxation (AOR=1.88, 95%CI: 1.02, 3.48) and history of lifetime tobacco use (AOR=5.64, 95%CI: 1.95, 16.29) were significantly associated with the disorders. Conclusion: The prevalence of alcohol use disorders among medical and surgical outpatients was found to be high. Male sex, history of mental illness, alcohol for relaxation and tobacco smoking need more attention in the assessment of the outpatient departments.

Abstract P712: Metabolic Syndrome is Associated With Risk of Ischemic Stroke in Patients With Non-Valvular Atrial Fibrillation- A National Estimate

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Urvish K Patel ◽  
Priyadarshee Patel ◽  
Vikram Preet Kaur ◽  
Mohammed Ali Abdulqader ◽  
Srishti Laller ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Metabolic Syndrome ◽  
Ischemic Stroke ◽  
Nationwide Inpatient Sample ◽  
Cross Sectional Study ◽  
Primary Objective ◽  
Secondary Diagnosis ◽  
Cross Sectional ◽  
Low Hdl ◽  
History Of

Objective: Primary objective of this study is to find prevalence of metabolic syndrome (MetS) in patients with acute ischemic stroke (AIS) amongst non-valvular atrial fibrillation (NVAF). Secondary aim of this study is to identify the independent components of MetS (obesity, diabetes, hypertension, high TG, low HDL), those predict AIS and compare with CHA 2 DS 2 VASc score (CHF, HTN, age>75, DM, history of stroke/TIA/thromboembolism, history of vascular disease, sex: female) amongst NVAF. Methods: A cross-sectional study was performed to identify cohort of adult hospitalization with secondary diagnosis of NVAF from Nationwide Inpatient Sample of 2008-2017. From patients with NVAF, primary hospitalization for AIS and secondary diagnosis of MetS, its components, and components of CHA 2 DS 2 VASc score were identified using ICD 9 & 10 codes. Weighed analysis using multivariable survey logistic regression was performed to evaluate the predictive potential of MetS and its components as well as to compare them with CHA2DS2VASc for AIS. Results: Amongst 33,462,134 hospitalizations with NVAF, 2.9% were due to AIS. Amongst AIS hospitalizations prevalence of MetS was 0.16% (vs 0.20%) [obesity (8.4 vs 13.7%), DM (31.6 vs 34.1%), HTN (84.3 vs 75.9%), high TG (0.4 vs 0.2%), low HDL (0.02 vs 0.02%)] in comparison to non-AIS. (p<0.001) In regression analysis, patients with MetS [aOR 1.16 (95%CI 1.04-1.30)] and its component DM [1.3 (1.3-1.4)], HTN [2.2 (2.1-2.3)], high TG [1.8 (1.7-2.0)], low HDL [1.02 (0.7-1.4) weak significant] had higher risk of AIS. Amongst CHA 2 DS 2 VASc components besides HTN and DM, history of stroke/TIA, history of vasc. disease, female and age 65-74 and >75 had higher odds of AIS (Table 1) . Conclusion: MetS and its components high TG and low HDL independently predict a high risk of AIS. Future study would evaluate whether adding of high TG and low HDL in CHA 2 DS 2 VASc score and starting anticoagulants amongst patients MetS may mitigate the risk of AIS.

Plasma Irisin Levels in Subjects with Type 1 Diabetes: Comparison with Healthy Controls

2018 ◽  
Vol 50 (11) ◽  
pp. 803-810 ◽  
Author(s):  
Anastasios Tentolouris ◽  
Ioanna Eleftheriadou ◽  
Dimitrios Tsilingiris ◽  
Ioanna Anastasiou ◽  
Ourania Kosta ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 1 Diabetes ◽  
Multivariate Analysis ◽  
Waist Circumference ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Serum Triglycerides ◽  
Cross Sectional

AbstractIrisin is a myokine that increases energy expenditure. In this cross-sectional study, we examined for differences in plasma irisin concentrations between subjects with type 1 diabetes mellitus and healthy individuals and searched for associations between plasma irisin levels and clinical and biochemical characteristics as well as self-reported physical activity. A total of 79 subjects with type 1 diabetes [age 38.2±12.5 years, men/women (n): 27/52], were consecutively recruited. Moreover, 53 healthy controls, matched for age and body mass index with those with diabetes were recruited. Plasma irisin was measured with ELISA. Participants were asked about their physical activity during the last week. We also measured trunk and visceral fat. Circulating irisin levels were lower in subjects with diabetes than in controls [median value (interquartile range): 53.0 (35.2, 106.3) vs. 178.1 (42.6, 641.6) ng/ml, respectively, p<0.001]. In the group of diabetes, univariate analysis showed that irisin levels were associated with waist circumference (beta=–0.283, p=0.023), serum triglycerides (beta=–0.282, p=0.031), and trunk fat (beta=–0.324, p=0.012). In multivariate analysis after adjustment for potential confounders, irisin levels were associated independently only with waist circumference (beta=–0.403, p=0.005). Among controls, multivariate analysis demonstrated that irisin levels were associated with pack-years of smoking (beta=–0.563, p=0.012) and fasting triglycerides (beta=–0.338, p=0.041). Circulating irisin levels were lower in subjects with diabetes in comparison with healthy-matched controls. In conclusion, plasma irisin concentrations in subjects with diabetes were associated with waist circumference, while in controls with serum triglycerides and pack-years of smoking.

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