scholarly journals The Importance of Vanillylmandelic Acid Determination in Opiate Users

2009 ◽  
Vol 28 (3) ◽  
pp. 197-201
Author(s):  
Danijela Janićević-Ivanovska ◽  
Aneta Spasovska-Trajkovska ◽  
Branko Stefanovski ◽  
Slavica Subeska-Stratrova ◽  
Jasmina Jovcevska
Keyword(s):  
Brain Structures ◽  
Heroin Dependence ◽  
Heroin Addiction ◽  
Average Score ◽  
Control Group ◽  
Vanillylmandelic Acid ◽  
Heroin Users ◽  
Indirect Determination ◽  
Urinary Level ◽  
Acid Determination

The Importance of Vanillylmandelic Acid Determination in Opiate UsersAlthough knowledge about the etiology of heroin dependence is rather poor, it is known that the influence of opiates on the opioid, adrenergic and indirectly of GABA on the dopaminergic receptors leads to changes of catecholamine levels in brain structures, which are supposed to be essential in explaining the etiology of the opioid dependence. It is well-known that by analyzing catecholamine, we get vanillylmandelic acid (VMA), which is found in the urine as a final product. Thus, by an indirect determination of VMA it is also possible to define the catecholamine concentration in the brain, which is the aim of this study. This prospective study included 51 dependent heroin users divided into 3 groups, depending on the length of the medical treatment with a conventional detox method (without treatment, second day of the treatment, and after the 10th day of treatment) as well as a control group consisting of 20 healthy subjects. We used the Pissano method chromatographic-spectrophotometric determination - for estimating the level of vanillylmandelic acid, and a scale for defining the severity of symptoms of the withdrawal syndrome (WS). The results showed that the highest average values of the urinary level of VMA were found in the subjects in withdrawal crisis with a high WS scale score in comparison with the other examined groups (statistically significant) as a result of the high adrenergic level. The average score on the scale of depression was high in the subjects in withdrawal crisis where we also found low values of the VMA urinary level. Being aware of the neurobiology of heroin dependence is of great importance for finding new pharmacological treatments for heroin addiction.

Penerapan Model Pembelajaran Problem Based Learning dalam Pembelajaran Matematika di Kelas VIII SMPN 28 Padang

2017 ◽  
Vol 1 (2) ◽  
pp. 225-236
Author(s):  
Andi Susanto ◽  
Sony Ariadi
Keyword(s):  
High School ◽  
Problem Solving ◽  
Junior High School ◽  
Problem Based Learning ◽  
Average Score ◽  
Control Group ◽  
Learning Problem ◽  
Math Ability ◽  
Class Viii ◽  
Randomized Control

This reseach is aimed at knowing the students ability in both solving the math problem and connection those who are taught by Problem Based Learning at class VIII of the Junior High school 28 Padang 2017/2018. This research is categorized as quasy Experimental Research, by using Randomized Control Group Only Design. After implementing the Problem Based Leaning, the student was directly given the test as the result showed that the score  of the student who belong to the experimental class in  problem solving recorded as 74,00 while those who were in the control class only refers to 72,30. The test average score on the experimental class in term of math connection ability was 68,73; while in the control class recorded as 62,43. The T- Test showed that T-Table equals to 1,64 with the degree of reliability 95% . This fact reveals that the students’ ability in solving the problem after being taught through Problem Based Learning is higher than in control class with T-count equals to 3,71; while their connection math ability through Problem Based Learning Model in the Experimental Class is higher than control with T-count 2.17.Keywords: Problem Based Learning, problem solving, mathematics connection

Possibilities of correction of menopausal disorders in women with the use of medicine Menopace

2016 ◽  
pp. 95-100
Author(s):  
G.I. Reznichenko ◽  
◽  
N.Yu. Reznichenko ◽  
V.Yu. Potebnya ◽  
K.I. Kovalenko ◽  
...  
Keyword(s):  
General Condition ◽  
Clinical Symptoms ◽  
Average Score ◽  
Control Group ◽  
Climacteric Syndrome ◽  
Basic Subgroup ◽  
Menopausal Syndrome ◽  
Natural Menopause ◽  
Surgical Menopause ◽  
Observation Period

The objective: to determine the efficacy of medicine «Menopace» in treatment of women with natural and surgical menopause. Patients and methods. 20 women (I group) with a natural menopause were examined (basic subgroup consisted of 10 patients who used Menopace for 3 months; control subgroup consisted of 10 patients). 20 women (II group) with surgical menopause were examined (basic subgroup consisted of 10 patients who received Menopace for 3 months; control subgroup consisted of 10 patients). Results. The average score of neurovegetative and emotional manifestations of climacteric syndrome during the observation period decreased in women with natural and surgical menopause who used Menopace, compared with subgroups of patients who had not used the medicine. Conclusions. 1. The use of the medicine Menopace in women with natural menopause after 3 months showed the disappearance of clinical symptoms of climacteric syndrome in 70% of the cases, and significant improvement in general condition in 30% of cases. 2. During surgical menopause after 1 month of treatment with Menopace manifestations of sweating were observed 4.5 times less often than in control group, tides were observed 7 times less often than in control group. Neurovegetative and psychoemotional symptoms of menopause were absent in 80% of women after 3 months of treatment and in 20% of cases significant improvement was shown. 3. The obtained results give grounds to recommend wide use of Menopace in practical work for the treatment of menopausal syndrome during natural and surgical menopause. Key words: menopause, therapy, Menopace.

PENGARUH MODEL PROBLEM BASED LEARNING (PBL) DIPADU MIND MAP TERHADAP KREATIVITAS DALAM MEMECAHAN MASALAH PADA KONSEP PENCEMARAN LINGKUNGAN

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Novi Tri Susanti ◽  
Anna Fitri Hindriana ◽  
Haruji Satianugraha
Keyword(s):  
Problem Solving ◽  
Environmental Pollution ◽  
Problem Based Learning ◽  
Sampling Technique ◽  
Average Score ◽  
Control Group ◽  
Learning Models ◽  
Control Group Design ◽  
Integration Effect ◽  
Map Integration

This study aim to determine the effect of Problem Based Learning (PBL) models in mind map integration to creativity of problem solving in the environmental pollution concept of graders X. The method used is a Quasi-experimental design form Nonequivalent Control Group Design (pretest- posttest). The study population is all the students of graders X academic year 2017/2018 as many as 9 classes with the number of 360 students. The sample used was 80 students from two classes as an experimental class and a control class. Sampling was done by Cluster Random Sampling technique. Instruments used include test descriptions, questionnaires and teacher observation sheets. The results of the analysis of the test descriptions creativity in problem solving obtained results of hypothesis testing (t test) i.e. 20.5 t count > t table of 2.66 means that Ho refused and Hi accepted, it means PBL learning models in Mind Map integration effect on creativity in problems solving. This is indicated by an increase in the average score on each indicator of creativity in problem solving in which students are able to grow various ideas, enrich ideas, add or detail the details of an idea and determine the truth to solve the problems. From the analysis of questionnaire data showed an interest in learning to use the PBL modela in Mind map integration, students agreed that if the model of PBL in Mind map integration may be easier to learn about the concept of Environmental Pollution. In addition, students also agreed that if the PBL models in Mind map integration effect on creativity in problems solving. The results showed that there was a significant influence between learning using PBL models in Mind map integration those not using the learning models to creativity in problems solving in the concept of environmental pollution of graders X.

scholarly journals Integrating Peer Learning Activities and Problem-Based Learning in Clinical Nursing Education

2021 ◽  
Vol 7 ◽  
pp. 237796082110002
Author(s):  
Suci Tuty Putri ◽  
Sri Sumartini
Keyword(s):  
Nursing Education ◽  
Problem Based Learning ◽  
Sampling Technique ◽  
Peer Learning ◽  
Average Score ◽  
Control Group ◽  
P Value ◽  
Clinical Learning ◽  
Control Group Design ◽  
Learning Achievement

Introduction The implementation of nursing clinical learning in Indonesia has several challenges that require innovation in the learning method strategy. The method that has been used so far focuses on the hierarchical relationship between lecturers/preceptors and students, so that there are many shortcomings in learning outcomes. The application of the method of active learning with Peer Learning (PL) and Problem Based Learning (PBL) techniques has proven effective in classroom learning, but its rarely found in clinical learning. Objective The purpose of this study was to determine the effectiveness of the PL and PBL towards the achievement of clinical learning in nursing students. Methods The research method used a true experiment with a posttest only control group design, the sampling technique was taken by randomize control trial. An instrument for clinical learning achievement using AssCE. Results The analysis was carried out as descriptive and bivariate. The results showed the mean in the experimental group was 7.059 and the control group was 6.325. Further statistical test results were obtained p-value = 0.001 (p < 0.05) which showed that the average score there were differences in clinical learning achievement development scores. Conclusion Clinical learning using peer learning and PBL methods can directly improve various aspects of student competency achievement.

scholarly journals The Effect of Music Therapy on Problem-Solving Skills

2016 ◽  
Vol 6 (2) ◽  
pp. 169
Author(s):  
Zeinab Sirous Jahedi ◽  
Nasser Amini Khoi
Keyword(s):  
Problem Solving ◽  
Music Therapy ◽  
Sampling Method ◽  
Average Score ◽  
Control Group ◽  
Problem Solving Skills ◽  
Statistical Population ◽  
Quasi Experimental ◽  
And Control ◽  
The Impact

<p>The aim of the present research was study of the impact of music therapy on problem-solving skills of 4 to 6 years old children in Tehran. This research was a quasi-experimental study with pretest-posttest control group. The statistical population was all 4 to 6 years old children in region 2 of Tehran. Using the random sampling method, the study sample was chosen in two experiment (15 individuals) and control (15 individuals) groups.   The experiment group received 12 sessions of music therapy and the control group was waiting for treatment meanwhile. To evaluate the problem-solving skill in children, the three subscales of Wechsler’s Preschool and Primary Scale of Intelligence (WPPSI) were used, including: mazes, cubes and arithmetic.  Analysis of data obtained from the questionnaires was conducted in two parts of descriptive and inferential. The data analysis indicated the significant increase of problem-solving average score of the experiment group compared to the control group.</p>

scholarly journals Self-Regulated Learning Strategy Based on Problem Solving to Improve The Learners’ Learning Outcomes

2019 ◽  
Vol 9 (1) ◽  
pp. 59-72
Author(s):  
Santi Eka Ambaryani ◽  
◽  
Winarti Winarti ◽  
Keyword(s):  
Problem Solving ◽  
Learning Outcomes ◽  
Learning Strategy ◽  
Hypothesis Test ◽  
Average Score ◽  
Control Group ◽  
Science Program ◽  
Self Regulated Learning ◽  
Regulated Learning ◽  
Mathematics And Science

Self-regulated learning is an effort to manage an individual’s learning. This research aims to 1) determine the strategy of self-regulated learning (SRL) based on problem-solving toward the learners’ learning outcomes and 2) determine the learning outcome improvement of the learners in learning by using the SRL based-problem solving. This research is quantitative research with quasi-experimental type and pretest-posttest control group design. The sampling technique was purposive sampling. The research population covered all in Senior High School (SMA 5) Yogyakarta. The samples were from the tenth graders of Mathematics and Science Program 3 as the control group and Mathematics and Science Program 1 as the experimental group. The data collection methods consisted of test and non-test. The analysis result were, the hypothesis test showed that the applied strategy influenced the learners’ learning outcomes and the learners’ learning outcomes had improvements with the N-gain average score of 0.590, categorized moderate. Keywords: Problem-Solving, Self-Regulated Learning Strategy, Simple Harmonic Motion

scholarly journals THE MOZAIC EFFECT ON THE IMPROVEMENT OF FINE MOTOR SKILLS OF 3-4 YEARS OLD CHILDREN IN INTEGRATED HEALTH CARE CENTER, THE WORKING AREA OF PUBLIC HEALTH CENTER WAENA JAYAPURA CITY.

2021 ◽  
Vol 5 (2) ◽  
pp. 139-148
Author(s):  
Suryati Romauli
Keyword(s):  
Health Care ◽  
Health Center ◽  
Motor Skills ◽  
Intervention Group ◽  
Integrated Health Care ◽  
Fine Motor ◽  
Average Score ◽  
Control Group ◽  
Fine Motor Skills ◽  
Integrated Health

The Child development speed is unique; it varies due to the child’s nature and its stimulants. Lack of stimulants will affect late fine motoric development of children. Data from the Waena Health Center inform, 190 toddlers have impaired fine motor development. This research objective was to determine the effect of mosaic techniques on the enhancement of fine motor skills in children aged 3-4 years in Integrated Health Care Waena area, Jayapura City. A quantitative descriptive research was done with Two Group Pretest-Postest Group Design. The results before the mosaic technique showed in intervention group, had dubious fine motor skills (55.6%) and 16.6% deviant. Whereas in the control group had dubious fine motor skills (83.3%) and 5.6% deviant. After using mosaic technique the intervention group had fine motor skills (77.8%) and small part doubted (22.2%). The average score after improving fine motor skills in the intervention group was 8, while the control group was 7.1 with independent t-test statistical test at a significance value of 95% ( = 0.05) obtained p-value 0.042 or p <α (0.05), thus there is an effect of mosaic techniques on improving fine motor skills of children at the Integrated Health Care Waena area, Jayapura City. Keyword: Mozaik Technique, Fine motor skill, children age 3-4 tahun

scholarly journals PENGEMBANGAN PERANGKAT PEMBELAJARAN BIOLOGI BERBASIS INKUIRI TERBIMBING (PPBIT) DALAM MENINGKATKAN KEMAMPUAN BERARGUMEN SISWA

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Dewi Seprianingsih ◽  
A. Wahab Jufri ◽  
Jamaluddin
Keyword(s):  
Sampling Technique ◽  
Thinking Skills ◽  
Critical Thinking Skills ◽  
Average Score ◽  
Control Group ◽  
Learning Tools ◽  
Control Group Design ◽  
The Subject ◽  
Mathematics And Science

Arguing ability was a part of critical thinking skills which important to be mastered by the students. In fact, students’ ability to argue was still relatively low. This referred to the TIMSS report (The Trends in International Mathematics and Science Study) in 2011, and showed that Indonesian children’s level in science was positioned in 42 from 45 countries. One kind of efforts to improve the quality of the ability to argue was applying the model of guided inquiry. This study was aimed to develop inquiry-based learning tools (PPBIT) and analyzed its effectiveness in developing the ability to argue of students at SMAN 2 Taliwang-West Sumbawa. PPBIT was carried out by applying 4D procedure. Then, pretest posttest control group design also completely concerned in determining the effectiveness of PPBIT. There were 66 students as the sample which was scattered from two classes and was selected by using purposive sampling technique. The results showed that PPBIT was appropriately to be used for students argumentation  skills’ activities by an average of feasibility syllabus 78.71%, RPP 83.5, LKITS 75%, and Instruments KB 80.25%, and effective in improving the ability to argue the class X SMAN 2 Taliwang, particularly on the subject of environmental pollution and recycling of waste by the average score of the students' ability from 48.22 up to 85.08Keyword: PPBIT, Argument

scholarly journals PENERAPAN PEMBELAJARAN INVESTIGASI KELOMPOK UNTUK MENINGKATKAN KETERAMPILAN PROSES SAINS DITINJAU DARI INTELLIGENCE QUOTIENT SISWA

2017 ◽  
Vol 2 (2) ◽  
Author(s):  
Raudatus Solihah ◽  
Agus Abhi Purwoko ◽  
Erin Ryantin Gunawan
Keyword(s):  
Intelligence Quotient ◽  
Average Score ◽  
Control Group ◽  
Control Group Design ◽  
Process Skill ◽  
Group Design ◽  
Science Process Skill ◽  
Quasi Experimental ◽  
And Control ◽  
Experimental Group

This research aims to know the effect of group investigation learning on student’s science process skill based on their IQ in SMAN 1 Mataram for eleventh grade students. This is a quasi experimental study using pretest postest control group design design. Pretest was taken to get data of student’s IQ. Posttest was also conducted to measure student’s science process skill. Sample was taken using nonprobability sampling from the population of eleventh grade student in SMAN 1 Mataram.The sample was two group of student each from two class, class XI sains 6 and as experimental group and class XI sains 5 as control group. The average os Student’s IQ on experimental group and control group were equal, both at 112. Learning processes were 12 x 45 minutes long in total. The experimental group showed better average score on posttest where they scored 82.40 on average, while control group only scored 74.83 on average. This value is statistically significant, at p = 0.007, less that 0.005. This result shows that implementation of group investigation can increase student’s science process skill.Keywords: Group investigation, science process skill, intelligence Quotient (IQ)ABSTRACT

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