scholarly journals Peptic Ulcer Healing Activity of Fruit Pulp Extract and Seed Oil of Adansonia digitata Linn

2019 ◽  
Vol 11 (05) ◽  
Author(s):  
Kajal Kamalso Malgave ◽  
Nilofar Shahnwaj Naikwade ◽  
Padma Laxmikant Ladda ◽  
Tabbasum S. Shikalgar ◽  
Sudhir S. Patil
Keyword(s):  
Secondary Metabolites ◽  
Seed Oil ◽  
Enzyme Level ◽  
Histopathological Study ◽  
Antiulcer Activity ◽  
Marker Enzyme ◽  
Fruit Pulp ◽  
Adansonia Digitata ◽  
Ulcer Index ◽  
Standard Drug

Adansonia digitata (AD) Linn has been used to cure PU in Ayurveda but its efficacy has not been validated. The current study was so carried out to evaluate the antiulcer activity of ethanolic extract of Adansonia digitata fruit pulp (ADFP), n hexane extract of Adansonia digitata seed oil (ADSO) and their combination (ADFP+ADSO) in rats. The effect of AD on gastric ulcer in pylorus ligation induced and ethanol induced models was studied using doses [ADFO (500 mg/kg), ADSO (300 mg/kg) and combination of ADFP and ADSO] for 10 days. Omeprazole (10 mg/kg) were used as the standard drug. Depending on the model, outcomes measures were gastric volume, pH, free acidity, total acidity, ulcer index, percentage inhibition of ulcer index, protein, pepsin, mucus, antioxidant marker enzyme level (Superoxide dismutase, Catalase, Lipid peroxidation), morphological and Histopathological study. The result obtained with combination was set up near to the standard drug and consequence showed that the combination of ADFP and ADSO was found to be more effective than the individual extract of AD. The outcomes were statistically evaluated with the one-way ANOVA followed by the test of Dennett’s‘t’. The secondary-metabolites such as flavonoids, proteins, saponins, tannins, phenols, terpenoids, alkaloids and Fatty acids (palmitic acid, oleic acid, linoleic acid) are potent as antioxidant, antiulcer and anti-inflammatory. The finding of this reading confirmed that AD has antiulcer activity due to 1 or more of the secondary-metabolites present in it. Therefore, this study validates its antiulcer use in Ayurveda. Future investigation on separation of specific phytochemicals and elucidate MOA are needed.

DEVELOPMENT OF ANTIULCER HERBOMINERAL FORMULATION ALCECARE

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (02) ◽  
pp. 54-59
Author(s):  
M Prasad ◽  
◽  
R Rajput ◽  
A. Kushwaha ◽  
R. Bharti
Keyword(s):  
Gastric Juice ◽  
Aqueous Extract ◽  
Seed Oil ◽  
Negative Control ◽  
Control Group ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Calculated Quantity

A herbomineral formulation was developed in suspension form by using the herb, mineral and different excipient and named “Alcecare”. The formulation was prepared by mixing calculated quantity of shatavari aqueous extract, fennel seed oil and praval bhasma to make smooth cream and then other excipients added to form a suspension for the evaluation of antiulcer activity in rats using aspirin model. The anti-ulcer activity of herbomineral formulation showed that the minimum ulcer index was observed with pantoprazole (1.98±0.29) which was nearly comparable with herbomineral formulation (2.85±0.47) and showed significant antiulcer activity compared to negative control with reducing the volume of gastric juice (5.99±0.25, 3.57±0.92, 4.22±0.67 of ulcerated control, standard and herbomineral formulation groups respectively). It was observed that developed herbomineral formulation possess significant antiulcer activity compared to control group and obtained results were nearly comparable with standard drug (pantoprazole).

Evaluation of the Antiulcer Activity of Ethanolic Leave Extracts of Saraca indica against Ethanol, Pylorus Ligature and Indomethacin Induced Ulcer in Albino Rats

2020 ◽  
Vol 16 (8) ◽  
pp. 1191-1196
Author(s):  
Pritt Verma ◽  
Shravan K. Paswan ◽  
Vishal K. Vishwakarma ◽  
Priyanshi Saxena ◽  
Chandana V. Rao ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Cellulose Solution ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
High Doses

Background: To evaluate the antiulcer activity of ethanolic leaves extract of Saraca indica against ethanol, pylorus ligature and indomethacin in albino rats. Materials and Methods: Ulcer was produced by ethanol, pylorus ligature and indomethacin in albino rats. Five groups (n=6) of rats were orally pre-treated with carboxymethyl cellulose solution, and ranitidine (80 mg/kg) respectively. In ethanol induced ulcer, the animals were treated with 200 and 400 mg/kg b.w. ethanolic leave extracts of Saraca indica in 0.3% CMC solution, 60 minutes before oral administration of absolute ethanol to produce gastric mucosal injury. In indomethacin induced ulcer, the drug was administered orally at the dose of 30 mg/kg b.w. After 7-9 hours of administration of indomethacin (30 mg/kg); the animals were sacrificed with high doses of anesthesia. In the pylorus ligature method, volume of free acidity, gastric secretion, pH and total acidity were estimated. In all three models, the ulcer index and % protection were estimated. Results: The anti ulcer activity of ethanolic leave extracts of Saraca indica in ethanol, indomethacin and pylorus ligature models is evident from the significant (P<0.001) reduction in ulcer index. In pylorus ligature model, significant (P<0.001) reduction in total acidity gastric volume and increase in pH were observed when compared with the standard drug. Conclusion: Ethanolic leave extracts of Saraca indica were found to be significantly protective against ethanol, indomethacin and pylorus ligature induced gastric ulcers in the experimental albino rats. The result obtained suggest that ethanolic leave extracts of Saraca indica possesses significant anti-ulcer activity.

scholarly journals NEW FLAVONOID COMPOUND FROM ALLIUM HOOKERI THWAITES AS A GASTROPROTECTIVE AGENT

2018 ◽  
Vol 10 (5) ◽  
pp. 24
Author(s):  
Khumanthem Deepak Singh ◽  
Dipak Chetia ◽  
Biplab D. E.
Keyword(s):  
Antioxidant Activity ◽  
Flavonoid Compound ◽  
Histopathological Study ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Allium Hookeri ◽  
Gastroprotective Agent ◽  
Mucosal Layer ◽  
Isolated Compound

Objective: The main objective of this study was to investigate the antiulcer potential of an isolated flavonoid compound from Allium hookeri (AH).Methods: Oral administration of ethanol-induced ulcer to the mucosal layer of the stomach in the rats. The ulcer score and percentage protection was calculated from the stomach and gastric mucosal scrapping was carried out for the biochemical studies. Antioxidant study was carried out in liver and histopathological study of the ulcer stomach was performed.Results: Phytochemical investigation of methanolic extract of AH (MEAH) leaves afforded a new flavonoid compound characterized as 3, 5, 6-trihydroxy-2-(4-hydroxy-3-(6-hydroxy-4, 5, 6, 7-tetrahydro benzofuran-7-yl) phenyl-7-methoxy-4H-chromen-4-one (Compound 1). The flavonoid compound at the dose of 5 mg/kg showed a significant change in ulcer index by reducing the ulcer index and increased in percentage protection. It also increased the in vivo antioxidant activity by increasing the superoxide dismutase (SOD), glutathione (GLU) and catalase (CAT) levels. The isolated compound reversed the increase of mucin content in the mucosal scrapings. The histopathology study showed the reversed of normal gland texture in the mucous layer of the standard and compound 1 treated stomach when compared to the negative control.Conclusion: Present findings demonstrated the significant antiulcer activity and antioxidant activity of the isolated flavonoid compound as the supporting factor.

scholarly journals Gastroprotective Effect of Freeze Dried Stripped Snakehead Fish (Channa striata Bloch.) Aqueous Extract against Aspirin Induced Ulcerogenesis in Pylorus Ligated Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mohammed Safwan Ali Khan ◽  
Abdul Manan Mat Jais ◽  
Javeed Hussain ◽  
Faiza Siddiqua ◽  
A. Gopala Reddy ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Gastric Juice ◽  
Aqueous Extract ◽  
Antiulcer Activity ◽  
Fresh Water Fish ◽  
Ulcer Index ◽  
Standard Drug ◽  
Freeze Dried ◽  
Wide Range ◽  
Channa Striata

Channa striata (Bloch.) is a fresh water fish belonging to the family Channidae. The stripped snakehead fish possesses wide range of medicinal properties. In view of traditional use of C. striata for wound healing, the present study was undertaken to investigate the beneficial effects of orally administered freeze dried aqueous extract of Channa striata (AECS) in experimentally induced gastric ulcers in Wistar rats. Aspirin induced ulcerogenesis in pyloric ligation model was used for the assessment of antiulcer activity and Ranitidine (50 mg/kg) was employed as the standard drug. The various gastric parameters like volume of gastric juice, pH, free and total acidities, ulcer index, and levels of antioxidant enzymes like catalase, superoxide dismutase, and lipid peroxidation marker malondialdehyde were determined. AECS at concentrations of 40% and 50% w/v significantly decreased the volume of gastric juice and increased the levels of catalase while considerable decrease in free and total acidities and increase in superoxide dismutase were observed with the treatment of standard drug and AECS (50% w/v). All the test doses of AECS markedly decreased ulcer index and malondialdehyde compared to the standard drug whereas AECS 30% w/v did not alter volume of gastric juice, pH, free and total acidities, catalase, and superoxide dismutase. From these findings, it can be concluded that AECS is devoid of acid neutralizing effects at lower doses and possesses antisecretory and antiulcer activities and this could be related to its antioxidant mechanism.

Comparative Evaluation of Antiulcer Activity of Ficus religiosa (Stem Bark) Extracts Prepared by Different Methods of Extraction

2020 ◽  
Vol 6 (4) ◽  
pp. 351-359
Author(s):  
Sunita Panchawat ◽  
Joohee Pradhan
Keyword(s):  
Extraction Method ◽  
Soxhlet Extraction ◽  
Stem Bark ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Ficus Religiosa ◽  
Standard Drug ◽  
Hydroalcoholic Extract ◽  
Acute Toxicity Study ◽  
Assisted Extraction

Background: The stem bark of Ficus religiosa L. (Family-Moraceae) is traditionally used to treat gonorrhea, diarrhea, dysentery, leucorrhea, menorrhagia, vaginal and other urogenical disorders, ulcers and gastrohelcosis. Objective: The study was aimed at comparing antiulcer activity (ethanol induced gastric ulcer) for stem bark extracts of Ficus religiosa Linn. prepared by different extraction methods viz. soxhlet, ultrasonication and microwave assisted extraction. Methods: The powdered drug material was extracted by soxhlet (time 48 hours., temperature 60°C and solvent 60% ethanol), Ultrasonic (90 min., 50°C and acetone as solvent)and Microwave (3 min., 60°C and acetone as solvent) assisted extraction method. The acute toxicity study was carried out in adult female albino rats by “fix dose” method of OECD guideline no. 420 for selection of doses. Antiulcerogenic effect of prepared extracts (200mg/kg) was evaluated by ethanol induced ulcer method using omeprazole (40 mg/kg) as standard drug and absolute alcohol 99.5% as necrotizing agent. Result and Conclusion: Acute toxicity study did not show any significant toxicity signs and extracts were said to be practically non-toxic at tested dose level of 2000 mg/kg, b.w. The best antiulcer activity was shown by the hydroalcoholic extract prepared by soxhlet extraction method. Administration of ethanol produced significant ulcer index (41.00 ± 1.75) in the control group. Standard drug omeprazole (40 mg/kg) produced percentage protection of 70.31%. Among all three extracts, Ulcer index is significantly (p<0.001) protected by hydroalcoholic extract (Soxhlet Extraction Method) with percentage protection 52.02%.

Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats

2017 ◽  
Vol 10 (4) ◽  
pp. 3772-3779
Author(s):  
Kintu Patel ◽  
Bhagyabhumi Patel ◽  
Alkesh Patel ◽  
Samir Shah
Keyword(s):  
Inflammatory Cells ◽  
Control Group ◽  
Antiulcer Activity ◽  
Standard Group ◽  
Free Acidity ◽  
Rat Stomach ◽  
Ulcer Index ◽  
Standard Drug ◽  
Group Iii ◽  
Group I

In present study, we evaluated the antiulcer activity of the herbal preparation of Caesalpinia crista in rat models.  Experimental animals were divided into four groups. Rats of group I (disease control) treated with normal saline only, group II (standard group) treated with Omeprazole (2 mg/ kg; p.o.), group III and IV served as test groups and were treated with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. Peptic ulcer was induced by ligating the pyloric portion of rat stomach and was done 45 min after the respective treatment. After 4 hour of pylorus ligation, rats were sacrificed. Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer activity. Histopathological evaluation was also performed. The aqueous extract of Caesalpinia crista seeds reduced the volume of gastric juice, free acidity, total acidity and ulcer index. It increased the pH of the gastric acid. Histopathology of the rat stomach revealed the presence of lesions and infiltration of inflammatory cells in control group. Moreover, animals treated with test drug and standard drug did not reveal any microscopic lesions. These findings suggest that Caesalpinia crista seeds may have anti-secretory and anti-ulcer activity and may be helpful for ulcer therapy. 

scholarly journals Gastro-protective effects of methanol extract of Tephrosia calophylla

2018 ◽  
Vol 8 (6-s) ◽  
pp. 141-145
Author(s):  
C Ramesh ◽  
A. Prameela Rani
Keyword(s):  
Protected Area ◽  
Methanol Extract ◽  
Research Work ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Protective Effects ◽  
Ulcer Index ◽  
Standard Drug ◽  
Soxhlet Apparatus

Objective: The present research work was designed to investigate gastro protective potentials of methanol extract of Tephrosia calophylla. Methods: The aerial parts of Tephrosia calophylla were dried under shade, powdered and deffated with petroleum ether and then marc left over was subjected to methanol extraction using soxhlet apparatus. Antiulcer activity of methanol extract was determined against stress induced and aspirin induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia calophylla have significantly reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compare to vehicle control and there by significantly increased percentage inhibition of ulcers and protected area which was evident by significant rise in pH of gastric content. The effect of extracts was dose dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia calophylla possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats. Keywords: Tephrosia calophylla, Anti ulcer activity, Ethanol, Aspirin Ulcer index, pH, total acidity, Percentage inhibition and percentage of protected area.

scholarly journals Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract

2009 ◽  
Vol 1 (2) ◽  
pp. 345-352 ◽  
Author(s):  
J. Srikanth ◽  
P. Muralidharan
Keyword(s):  
Oral Administration ◽  
Free Acid ◽  
Test Group ◽  
Treated Group ◽  
Morinda Citrifolia ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Ulcer Index ◽  
Total Acid ◽  
Standard Drug

The study was designed to investigate the antiulcer activity of ethyl acetate extract of the fruits of Morinda citrifolia Linn (Rubiaceae) using different models of gastric and duodenal ulceration in rats. Gastric ulcers were induced by oral administration of ethanol, aspirin and by pyloric ligation and duodenal ulcers were induced by oral administration of cysteamine HCl. The extract was administered at a dose of 200 and 400 mg/kg orally 30 min prior to ulcer induction. Ranitidine (50 mg/kg) was used as a reference standard.  The antiulcer activity was accessed by determining and comparing the ulcer index in the test group with that of the standard drug treated group. Gastric volume, total acid and free acid were estimated in the pylorus-ligated rats. M.citrifolia (400mg/kg) showed maximum inhibition of gastric acid, free acid and total acid to 53.54%, 52.55% and 30.30%, respectively. The ulcer index in the M.citrifolia treated animals was found to be significantly less in all the models compared to standard drug treated cases. The antiulcer activity of M.citrifolia was, however, less than that of ranitidine. The results suggest that M.citrifolia possesses significant antiulcer property which could be due to cytoprotective action of the drug or strengthening of gastric and duodenal mucosa with the enhancement of mucosal defence. Keywords: Morinda citrifolia; Antiulcer.© 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.DOI: 10.3329/jsr.v1i2.1625

scholarly journals EVALUATION OF GASTROPROTECTIVE EFFECTS OF METHANOL EXTRACT OF TEPHROSIA VILLOSA AGAINST EXPERIMENTALLY INDUCED ULCERS IN WISTAR RATS

2021 ◽  
pp. 20-23
Author(s):  
PINKEY RAWAL ◽  
RAMESH C. ◽  
SOMA PRAMANIK
Keyword(s):  
Protected Area ◽  
Methanol Extract ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Soxhlet Apparatus ◽  
Study Results ◽  
Experimentally Induced

Objective: The present research work was designed to investigate the gastroprotective potentials of methanol extract of Tephrosia villosa. Methods: The aerial parts of Tephrosia villosa were dried under shade, powdered and deffated with petroleum ether and then marc leftover was subjected to methanol extraction using soxhlet apparatus using soxh-let apparatus. Antiulcer activity of methanol extract was determined against stress-induced and aspirin-induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. Results: Methanol extract of Tephrosia villosa at medium (200 mg/kg) and high (200 mg/kg) could significantly (P<0.01) reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compared to vehicle control and thereby significantly (P<0.01) increased percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. The effect of extracts was dose-dependent and results were comparable to that of standard drug omeprazole. Conclusion: The results obtained from the present work suggest that the methanol extract of Tephrosia villosa possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.

scholarly journals Inhibitory Potentials of Ethanol Extract of Nymphaea nauchali against Experimentally Induced Ulcers in Wistar Rats

2021 ◽  
Vol 70 (2) ◽  
Author(s):  
Poornachandra C ◽  
Ramesh C ◽  
Shabana S ◽  
Pinkey Rawal ◽  
Soma Pramanik
Keyword(s):  
Protected Area ◽  
Wistar Rats ◽  
Ethanol Extract ◽  
Albino Rats ◽  
Antiulcer Activity ◽  
Total Acidity ◽  
Ulcer Index ◽  
Standard Drug ◽  
Soxhlet Apparatus ◽  
Experimentally Induced

The current investigational work was designed to evaluate inhibitory effect of ethanol extract of Nymphaea nauchali against experimentally induced ulcers in albino wistar rats. The aerial parts of Nymphaea nauchali were dried under shade, powdered and deffated with petroleum ether and then marc left over was subjected to ethanol extraction using soxhlet apparatus. Antiulcer activity of ethanol extract was determined against ethanol induced and aspirin induced ulcers in experimental animal models. The total number of ulcers formed, ulcer index, percentage inhibition, ulcerated area, protected area, pH and Total acidity were parameters in the study. The ethanol extract of Nymphaea nauchali have significantly reduced the total number of ulcers formed, ulcer index, ulcerated area and total acidity in therapeutic groups compare to vehicle control and there by significantly increased percentage inhibition of ulcers and protected area which was evident by significant rise in pH of gastric content. The effect of extracts was dose dependent and results were comparable to that of standard drug omeprazole. The results obtained from the present work suggest that the ethanol extract of Nymphaea nauchali possess significant anti-ulcer potentials against experimentally induced ulcers in albino rats.

Sign in / Sign up

Export Citation Format

Share Document