scholarly journals PERBEDAAN SKOR KECEMASAN TAYLOR MINNESOTA ANXIETY SCALE (TMAS) MATERNAL PADA KEHAMILAN DENGAN PREEKLAMPSIA DAN HAMIL NORMAL

2019 ◽  
Vol 2 (2) ◽  
pp. 92-100
Author(s):  
Joserizal Serudji ◽  
Rizanda Machmud
Keyword(s):  
Symptom Relief ◽  
Pressure Control ◽  
Normal Pregnancy ◽  
Anxiety Scale ◽  
Anxiety Score ◽  
Maternal Anxiety ◽  
Psychological Consequences ◽  
Cross Sectional ◽  
Score Difference ◽  
The Mean

Management of preeclampsia is limited to blood pressure control and symptom relief in combination with close maternal/ fetal surveillance. Until recently, very little attention has been paid to preeclampsia's psychological consequences, especially maternal anxiety. Anxiety disorders can be identified using questionnaires instrument determining anxiety level, the Taylor Minnesota Anxiety Scale (TMAS) questionnaires is one among them. This study aimed to determine the TMAS maternal anxiety score difference between preeclampsia and normal pregnancy. This was an analytical study with a cross-sectional design conducted from March-August 2014 in 40 subjects, consisting of 20 women with preeclampsia and 20 women with normal pregnancy who met the inclusion and exclusion criteria. Anxiety was measured with the TMAS questionnaire. Statistical analysis to determine the TMAS maternal anxiety score difference between preeclampsia and normal pregnancy was t-test. In preeclampsia group, the mean of TMAS maternal anxiety score was 30,45 ± 9,65. While in the normal pregnancy group, the mean of TMAS maternal anxiety score was 18,50 ± 7,62. There was a significant TMAS maternal anxiety score difference between preeclampsia and normal pregnancy (p = 0,000).Keywords: TMAS maternal anxiety score, preeclampsia

scholarly journals The Role of HLAC and NK Cells in Fetal Growth Restriction

2017 ◽  
pp. 142
Author(s):  
Sri Sulistyawati ◽  
Didon M Trimulya ◽  
Supriyadi H Respati ◽  
Soetrisno Soetrisno
Keyword(s):  
Nk Cells ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Nk Cell ◽  
Normal Pregnancy ◽  
Growth Restriction ◽  
Immunohistochemical Method ◽  
Cross Sectional ◽  
The Mean

Objective: To determine the role of HLA-C and NK cell expressions in fetal growth restriction (FGR). Methods: A cross sectional study design was used. This study was conducted at the Obstetrics and Gynecology Department of Dr. Moewardi General Hospital, Surakarta, its affiliated hospitals, and at the Pathological Anatomy Laboratory of the Faculty of Medicine, University of Sebelas Maret Surakarta. A total of 40 samples were included in this study. The samples consisted of 20 normal pregnancies and 20 pregnancies with FGR. HLA-C expression in the trophoblast and NK cells in decidua of the subjects who met the inclusion and exclusion criteria were examined using immunohistochemical method and statistical analysis with T test. Results: The mean expression of HLA-C in the trophoblast in the pregnant group with FGR was 9.021.30, normal pregnancy was 7.96 ± 0.97, p=0.01 (p<0.05). The mean expression of NK cells in decidua of pregnancy with FGR was 10.59 ± 2.11, normal pregnancy was 0.91 ± 8.18, with p=0.00 (p<0.05). Conclusion: The expressions of HLA-C in trophoblast and NK cells in decidua of pregnancy with FGR were higher compared with those of normal pregnancy. [Indones J Obstet Gynecol 2017; 5-3: 142-148] Keywords: fetal growth restriction, HLA-C, NK cells

scholarly journals Anxiety associated with colposcopy at Chris Hani Baragwanath Hospital, Johannesburg

2009 ◽  
Vol 15 (2) ◽  
pp. 5
Author(s):  
MYH Moosa ◽  
L Chait ◽  
A Cohen ◽  
L Diamond ◽  
J Dunlop ◽  
...  
Keyword(s):  
Trait Anxiety ◽  
State Anxiety ◽  
Significant Negative Correlation ◽  
Cross Sectional Study ◽  
Anxiety Score ◽  
Cross Sectional ◽  
High Incidence ◽  
The Mean ◽  
Written Informed Consent ◽  
Colposcopy Clinic

<p>Given the high incidence of cervical cancer in South Africa and the distress it causes, we aimed to determine the extent of anxiety in patients undergoing colposcopy at Chris Hani Baragwanath (CHB) Hospital, Johannesburg. <strong></strong></p><p><strong>Method.</strong> A descriptive and cross-sectional study design was applied on a convenient sample of patients from the waiting area of the colposcopy clinic at CHB Hospital. Females attending a first colposcopy appointment were invited to participate by completing the State-Trait Anxiety Inventory (STAI) after written informed consent had been obtained.</p><p><strong> Results.</strong> Among a total of 31 women, the mean STAI score for state anxiety was 46.77 (SD=12.92) and the mean STAI score for trait anxiety was 46.81 (SD=9.50); 51.6% of the patients had a STAI state anxiety score of &gt;50, while 41.9% of the patients had a STAI trait anxiety score &gt;50. There was no significant association between either elevated STAI state or trait anxiety scores and age group ( χ 2 =1.77; p= 0.18 and χ 2 =0.001; p= 0.98, respectively); marital status ( χ 2 =0.301; p= 0.58 and χ 2 =0.834; p= 0.36); level of education ( χ 2 =0.444; p= 0.51 and χ 2 =2.40; p= 0.12); employment status ( χ 2 =1.78; p= 0.18 and χ 2 =0.001; p= 0.98); monthly income ( χ 2 =1.15; p= 0.28 and χ 2 =0.03; p= 0.86) or using stimulants ( χ 2 =0.416; p= 0.52 and χ 2 =0.394; p= 0.53). There was a significant negative correlation between age and STAI state anxiety scores ( r 2 =0.004; p= 0.017) and a positive correlation between age and STAI trait anxiety scores ( r 2 =0.004; p= 0.019).</p><p><strong>Conclusion.</strong> This study reported significantly elevated trait anxiety scores relating to colposcopy and emphasises the need to identify the anxiety and institute a plan to ameliorate it with information booklets, leaflets, video colposcopy and educational counselling.</p>

Pharmacogenomics: Personalizing palliative pharmacotherapy.

2019 ◽  
Vol 37 (31_suppl) ◽  
pp. 126-126
Author(s):  
Caleb Scheckel ◽  
Adrijana Kekic ◽  
Mark Edwin
Keyword(s):  
Palliative Medicine ◽  
Individualized Medicine ◽  
Symptom Relief ◽  
Drug Efficacy ◽  
Cross Sectional Study ◽  
Poor Metabolizers ◽  
Cross Sectional ◽  
Intermediate Metabolism ◽  
The Mean ◽  
Level 1

126 Background: Pharmacogenomics (PGx) is a developing field in individualized medicine concerned with understanding genetic polymorphisms that may explain inter-individual variation in drug efficacy and toxicity. Understanding these polymorphisms is a key tool in guiding clinician’s selection and dosing of specific medications to optimally manage patient symptoms. Common pharmacogenes that impact analgesic prescribing include: CYP2D6, OPRM1, and COMT; for mood disorders: CYP2C19. This cross-sectional study explored the activity of pharmacogenes of clinical significance in palliative medicine with either Level 1 or 2 evidence. Methods: We performed PGx testing on 50 new referrals to the palliative medicine clinic with an active malignancy. Each patient underwent PGx testing with clinical pharmacist review and interpretation prior to their initial office appointment. Results: In our cohort 54% were men and the mean age was 64.7 (24-87). The average number of medications, medication allergies, and creatinine clearance were 10.5 (1-22), 1.3 (0-13), and 78.4 (31-120), respectively. Among the pharmacogenes impacting opiate and antiemetic prescribing, 14% (7/50) of patients were poor metabolizers of CYP2D6 and 8% (4/50) were rapid or ultra-rapid metabolizers. Another 60% (30/50) showed intermediate metabolism which would impact initial dosing. Poor metabolism of COMT or OPRM1 was seen in 8% (4/50) with another 36% (18/50) demonstrating rapid metabolism. Activity for the pharmacogene CYP2C19, which impacts many psychotropics, revealed 32% (16/50) rapid or ultra-rapid metabolizers and no poor metabolizers. Overall, 66% (33/50) of patients had pharmacogene activity suggestive of significant clinical impact necessitating either drug avoidance due to toxicity risks or substantial dose adjustment to be efficacious. Conclusions: Polymorphisms impacting pharmacotherapy were common in our cohort. Patients with difficult-to-control symptoms or multiple medication toxicities can utilize PGx testing as a guide to symptom relief. As PGx technology becomes readily accessible and economical, opportunities for patients to have precision genomic information guide healthcare decisions is expected to increase.

scholarly journals Help Seeking Preferences to Informal and Formal Source of Care for Depression: a Community Based Study in Northwest Ethiopia

2020 ◽  
Author(s):  
shegaye shumet ◽  
Tilahun Kassew ◽  
Telake Azale ◽  
Getinet Ayano ◽  
Dessie Abebaw ◽  
...  
Keyword(s):  
Mental Health ◽  
Social Support ◽  
Help Seeking ◽  
Mental Health Problems ◽  
Northwest Ethiopia ◽  
Community Based ◽  
Cross Sectional ◽  
Score Difference ◽  
High Propensity ◽  
The Mean

Abstract Background: Depression is the leading cause of disability at a population level and globally 350 million people are suffering from depression. Many people suffer from depression use different sources of help for their mental health problems. People with different mental health problems seek help from formal and/or informal sources. This gives crucial information on community,s beliefs and perception regarding their preference for help if they faced depression. This study helps to guide effective planning and provision of mental health services and health policy of the country to explore the community,s preferences of help-seeking. Objective: The aim of this community based cross-sectional study was to contrast patterns of formal and informal help-seeking preferences for depression among residents of Aykel town, Northwest Ethiopia. Methods: This cross-sectional population based study included 832 participants. We used a major depressive disorder case vignette and general help-seeking questionnaire (GHSQ) to assess the preferences to seek help. Study participants were selected by multistage cluster sampling technique. Data were collected by face-to-face interviews. An independent- sample t- test and analysis of variance test (ANOVA) was performed to determine mean score difference in socio-demographic characteristics of the participants for informal sources of help.Results: A total of 656 subjects (78.8%) showed high propensity to intimate partner, and 655 (78.7%) of the study subjects had high propensity to mental health professional. The mean score of the residents’ preference to seek help from informal sources was 3.41±0.60.The mean score of preference to seek help from formal sources was 3.18±0.75. A total of 276 (33.2%) subjects showed high propensity to both informal and formal sources of help. The result also showed that there was mean score difference in preferences to informal help between subjects with strong social support and low and/ moderate social support (P<0.001).Conclusion: The result suggests that the majority of the residents had a higher preference to seek help from informal sources compared to formal sources of care. Mean score difference was observed in degree of social support and occupational status(student,housewife and jobless) for informal sources of help. Providing and strengthening both formal and informal sources of help in conjunction is crucial to get a more qualified and effective care of depressed patients.

scholarly journals The Correlation between Calcium Serum and Calcium Urine Level with the Blood Pressure in Preeclampsia

2016 ◽  
Author(s):  
Deni W. Suryono
Keyword(s):  
Blood Pressure ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Spearman Correlation ◽  
Sectional Study ◽  
Inclusion Criteria ◽  
Urine Level ◽  
Cross Sectional ◽  
Spearman Correlation Test ◽  
The Mean

Objective: To analyze the differences of calcium serum and calcium urine level in preeclampsia and normal pregnancy, and to analyze the correlation between calcium serum and calcium urine level with blood pressure. Method: This study is a cross sectional study with 44 women with preeclampsia and 45 women with normal pregnancies, that meet our inclusion criteria. The samples were obtained from Dr. Hasan Sadikin Hospital and six satellite hospitals from June to September 2011. The comparison of mean calcium serum and calcium urine level of the preeclampsia group was calculated using Mann-Whitney test, and the correlation between calcium serum and calcium urine level and preeclampsia were calculated using Rank Spearman correlation test. Result: The result of the characteristic test in two groups of study shows that both groups are homogenic and comparable. The mean of calcium serum level in women with preeclampsia (7.97 mg/dl) is lower than in normal pregnancy (8.82 mg/dl) with p

scholarly journals PERBEDAAN KADAR ASAM FOLAT SERUM PENDERITA ABORTUS SPONTAN DENGAN KEHAMILAN NORMAL

2019 ◽  
Vol 2 (1) ◽  
pp. 53-61
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Folic Acid ◽  
Spontaneous Abortion ◽  
Cell Function ◽  
Serum Levels ◽  
Normal Pregnancy ◽  
Acid Group ◽  
P Value ◽  
Cross Sectional ◽  
Anal Ysis ◽  
The Mean

Abortion is the termination of pregnancy before fetus can survive in the outside world, regardless of the cause. One cause of spontaneous abortion due to maternal nutritional factors, such as folic acid defi-ciency, lead to disruption of cell function and ends with apoptosis as well as continuing with fetal death. The study was conducted to determine differences in the levels of folic acid serum between patients with normal pregnancy and spontaneous abortion in some hospitals in West Sumatra. The study was con-ducted by the method of analytic observational comparative cross-sectional design. This research was carried out on pregnant women who come to the clinic and emergency obstetric Dr.M.Djamil hospital Padang, Batusangkar Hospital, Reksodiwiryo Hospital Padang and examinations conducted in biomed-ical laboratory medical faculty Andalas University the period August-December 2014. The total number of women included in the statistical calculation after the inclusion and exclusion criteria are met is 54 people, statistical analysis was done afterwards. The mean levels of serum folic acid is lower in sponta-neous abortion patients compared with average levels of folic acid in normal. Results of statistical anal-ysis using t-test found significant differences in the mean serum levels of folic acid group of spontaneous abortion patients with normal pregnancy group, it can be seen from p-value 0.001 (p <0.05).Keywords: Spontaneous abortion, folic acid, fetus death

The correlation between death anxiety and anxiety in elderly with chronic obstructive pulmonary disease

2016 ◽  
Vol 6 (1) ◽  
pp. 63-69 ◽  
Author(s):  
B. Nal ◽  
I. Aydın Avcı ◽  
M. Ayyildiz
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Trait Anxiety ◽  
State Anxiety ◽  
Death Anxiety ◽  
Anxiety Scale ◽  
Anxiety Score ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Mean

Purpose: This study aims to determine the correlation between death anxiety and anxiety in elderly patients with chronic obstructive pulmonary disease. Materials and methods: This study has been conducted on the individuals with chronic obstructive pulmonary disease (COPD) who were over 65 years. They received outpatient and inpatient treatment at a hospital. 171 elderly persons that were determined via power analysis were included in the research. Data was collected using a survey form, Death Anxiety Scale, State Anxiety Scale, and Trait anxiety scale. We used the following test statistics: t-test, ANOVA and Kruskal-Wallis Variance Analysis, and Pearson Correlation Test analysis. Results: 66.1 percent (113) of the participants are male and 33.9%(58) female; mean age is 726.83. The mean death anxiety score of the participants is 9.044.02. The mean State Anxiety score of elderly individuals with chronic obstructive pulmonary disease is 44.81.29; the trait anxiety mean score is 48.851.13. In those chronic obstructive pulmonary disease patients, we found a significant (p<0.001) correlation between state and trait anxiety, and that the latter two are high in cases where death anxiety is high. Conclusion: We found that death anxiety and anxiety are high in patients with COPD.

scholarly journals Higher Cortisol Level Would Increase the Risk of Spontaneous Abortion

2016 ◽  
Author(s):  
Christian Sastra
Keyword(s):  
Spontaneous Abortion ◽  
Cortisol Level ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Equation Model ◽  
Cross Sectional ◽  
Significant Difference ◽  
Version 2.0 ◽  
The Mean ◽  
Logistic Regression Equation

Objective: To understand the correlation between cortisol level and spontaneous abortion in normal pregnancy with gestational age less than 20 weeks. Method: The study design was a correlative analytic prospective study with cross sectional observational approach. This study started from June 2012 until the number of participant sufficiently from Prof. Dr. R.D. Kandou General Hospital. The data then processed SPSS version 2.0, ROC and logistic regression equation model (chance model). Result: The study included 50 cases consisted of 25 spontaneous abortion cases and 25 normal pregnancies with gestational age less than 20 weeks, and got result if cortisol level for 18.52 μg/dl so spontaneously abortion chance for 35.7% and if cortisol level for 24.0 μg/dl would chance for spontaneous abortion for 99.3%. Conclusion: In this study, there was a significant difference in cortisol level in women with spontaneous abortion and < 20 weeks normal pregnancy. Higher cortisol level would increase spontaneous abortion risk. The mean cortisol level in spontaneous abortion was 27.28892 μg/dl. While the mean cortisol level in women with normal pregnancy was 11.7660 μg/dl. Analysis of the correlation between cortisol level and spontaneous abortion gave a cut off point for cortisol level of 19.1 μg/dl with sensitivity of 92% and specificity of 92%. [Indones J Obstet Gynecol 2013; 37-1: 17-20] Keywords: cortisol level, normal pregnancy, spontaneous abortion

scholarly journals Lower Glutathione Peroxidase Serum Level Compared to Normal Pregnancy

2016 ◽  
Author(s):  
Kadek Pramarta
Keyword(s):  
Glutathione Peroxidase ◽  
Gestational Age ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Hospital Data ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Group 2 ◽  
Group 1

Objective: To determine the difference of glutathione peroxidase (GPx) in threatened miscarriages and normal pregnancy. Method: This is an analytic cross sectional study with 42 samples divided into two groups. Group 1 consists of 21 cases of threatened miscarriages with < 20 gestational age and group 2 is divided into 21 normal pregnancies of < 20 weeks gestational age. We took 3 cc of blood samples from the cubiti veins and mixed it with EDTA. Its GPx quantities were than examined at the Pathology Lab at Sanglah General Hospital. Data was then analyzed using the Shapiro Wilk Test and the independent t-test with p < 0.05. Result: From this research, we obtained the mean GPx levels on the threatened miscarriages was 49.92 ± 14.17 U/g Hb lower than the mean of normal pregnancy levels, which was 88.94 ± 30.11 U/g Hb. Conclusion: The quantities of GPx between threatened miscarriages and normal pregnancies are statistically different, in which the quantity of GPx in threatened miscarriages is lower compared to normal pregnancy. [Indones J Obstet Gynecol 2012; 36-3: 112-5] Keywords: GPx, normal pregnancy, threatened miscarriages

scholarly journals PERBANDINGAN KADAR ZINC PADA PERSALINAN PRETERM DAN KEHAMILAN NORMAL

2018 ◽  
Vol 12 (3) ◽  
pp. 212
Author(s):  
Visti Delvina ◽  
Arni Amir ◽  
Ermawati Ermawati
Keyword(s):  
Preterm Labor ◽  
Normal Pregnancy ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
T Test ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Significant Difference ◽  
The Mean ◽  
Zinc Levels

<p><strong><em>The Comparative   Zinc Levels in Preterm Labor and Normal Pregnancy</em></strong></p><h1 align="center"><em>ABSTRACT</em><em></em></h1><p><em> </em></p><p><em>               </em><em>Preterm labor occurs between 20 weeks and before 37 weeks of pregnancy. It is indicated by regular contractions of the uterus and it may cause the thinning and flattening of the cervix. Preterm labor also causes the high rates of perinatal morbidity and mortality. Deficiency zinc during pregnancy can stimulate the preterm labor. The design of this reseacrh was a comparative cross sectional study. It was conducted in Rasidin District Hospital, Siti Rahmah Hospital and Biomedical Laboratory, Faculty of Medicine, Andalas University, Padang on Februari 2017 to June 2018. There were 50 samples in this reseach. It was selected by consecutive sampling. The samples were divided into two groups: preterm labor and normal pregnancy. Zinc levels are examined by the ELISA method. Then, the data were analyzed by using the t test. The results of this reseach showed that the mean zinc level in the preterm labor group was 12.22 ± 0.41 μmol / L and 13.96 ± 0.64 μmol / L of the mean zinc level in the normal pregnancy group with P= 0.000. Moreover, statistical test inffered that there was significant difference between zinc levels in preterm labor and normal pregnancy. In short, it can be concluded that zinc levels group in the preterm labor were lower than the normal pregnancy group.</em><em></em></p><p><em> </em></p><p><em> </em></p><p><strong><em>Keywords</em></strong><em>: Zinc, Preterm Labor</em><em></em></p><p align="center"><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><em> </em></p><p><strong><em>Perbandingan Kadar Zinc Pada Persalinan Preterm dan Kehamilan Normal</em></strong></p><h1 align="center"><em>ABSTRAK</em><em></em></h1><p><em> </em></p><p><em>Persalinan</em><em> </em><em>preterm adalah persalinan yang terjadi antara 20 minggu dan sebelum 37 minggu kehamilan yang ditandai</em><em> </em><em>adanya kontraksi teratur dari </em><em>uterus</em><em> </em><em>yang dapat</em><em> </em><em>menyebabkan</em><em> </em><em>penipisan dan pendataran</em><em> </em><em>serviks. Persalinan preterm menyebabkan tingginya angka morbiditas dan mortalitas perinatal. Defiseiensi zinc selama kehamilan dapat menstimulasi terjadinya persalinan preterm. Desain penelitian ini adalah cross sectional komparatif, penelitian dilakukan di RSUD Rasidin, RSI Siti Rahmah dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang pada bulan Februari 2017 – Juni 2018. Jumlah sampel sebanyak 50 yang dipilih secara consecutive sampling, yang dibagi menjadi dua kelompok yaitu persalinan preterm dan kehamilan normal. Kadar zinc diperiksa dengan metode ELISA. Data dianalisa menggunakan uji t test. </em><em>Hasil penelitian rerata kadar zinc pada kelompok persalinan preterm 12,22 ± 0,41 µmol/L dan rerata kadar zinc pada kelompok kehamilan normal adalah 13,96 ± 0,64 µmol/L dengan nilai p 0,000. Secara statistik terdapat perbedaan yang bermakna antara kadar zinc  pada persalinan preterm dan kehamilan normal. Kesimpulan, kadar zinc pada kelompok persalinan preterm lebih rendah daripada kelompok kehamilan normal.</em><em></em></p><p><em> </em><em></em></p><p><em> </em></p><p><strong><em>Kata Kunci</em></strong><em> : Zinc, Persalinan Preterm</em></p>

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