scholarly journals The possibility of using autologous adipose tissue for the stage shin wound closing

2021 ◽  
Vol 8 (3) ◽  
pp. 48-53
Author(s):  
S. N. Markov ◽  
A. A. Spiridonov ◽  
A. V. Slepov
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Clinical Case ◽  
Systemic Diseases ◽  
Soft Tissue Defects ◽  
Current Increase ◽  
Healing Wound ◽  
Arterial Insufficiency ◽  
Tissue Defects

Extensive soft tissue defects can be complicated by systemic diseases (trophic ulcers in diabetes mellitus, chronic arterial insufficiency) or the result of trauma (domestic, military, operating, etc.). The current increase in the incidence of this pathology is due to the spread of cardiovascular diseases and diabetes mellitus. Closing an infected long-term non-healing wound, such as a tendon or bone, is one of the most difficult tasks of reconstructive surgery. For example, the use of classical methods of closing wound conditions is difficult to a degree due to the patient's polymorbid background. The clinical case presented in the article shows the possibility of closing deep shin wound with a complex relief by the transplantation of autologous adipose tissue, a patient with severe concomitant pathology.

Giant condiloma of Bushke-Levenstein of anal canal and perianal skin. Clinical case

2021 ◽  
pp. 25-35
Author(s):  
Anton Ivanovich Grechin ◽  
Grigory Vladimirovich Rodoman ◽  
Evgeny Konstantinovich Naumov ◽  
Leonid Vladimirovich Kornev ◽  
Evgeny Mikhailovich Fominykh
Keyword(s):  
High Temperature ◽  
Literature Review ◽  
Clinical Case ◽  
Practical Interest ◽  
Perianal Skin ◽  
Evidence Based ◽  
Perianal Region ◽  
Healing Wound ◽  
Staged Treatment

The article is devoted to a rare disease of the perianal region — Buschke-Levenshtein tumor. A clinical case and a literature review on the etiology, pathogenesis and experience of treating such tumors are presented. Evidence based sources show that currently there is no generally accepted tactics of managing patients with this pathology. In this regard, each case of treatment of such patients is of not only scientific but also practical interest. In this case, the tactics of staged treatment with the use of high-temperature dissectors and immunocorrection was chosen, which made it possible to achieve a good clinical result without the formation of extensive and long-term non-healing wound defects in the perianal region.

Overview of Biomedical Materials

MRS Bulletin ◽  
1991 ◽  
Vol 16 (9) ◽  
pp. 33-38 ◽  
Author(s):  
Michael N. Helmus
Keyword(s):  
Medical Devices ◽  
Synthetic Polymers ◽  
The Body ◽  
Soft Tissue Defects ◽  
Intravenous Catheter ◽  
Biomedical Materials ◽  
Commercial Grade ◽  
Organ Systems ◽  
Tissue Defects

Biomedical materials are synthetic polymers, metals, ceramics, inorganics, and natural macromolecules (biopolymers), that are manufactured or processed to be suitable for use in or as medical devices or prostheses. These materials typically come in contact with cells, proteins, tissues, organs, and organ systems. They can be implanted for long-term use, e.g., an arrtificial hip, or for temporary use, e.g., an intravenous catheter. Except in isolated cases when a material is used by itself, such as collagen injections for filling soft tissue defects, biomedical materials are used as a component in a medical device. The form of the material (perhaps a textile) how it interfaces (blood contacting, for instance), and its time of use will determine its required properties. A material's use needs to be viewed in the context of the total device and its interface with the body. One material property alone is unlikely to lead to a successful and durable device, but the failure to address a key property can lead to device failure. Until recently, medical-grade polymers, ceramics, inorganics, and metals were purified versions of commercial-grade materials. A variety of polymers, biopolymers, and inorganics is now being specifically developed for medical applications. Table I summarizes the types of biomedical materials.

scholarly journals Clinical case of squamous cell carcinoma arising in non-healing wound of foot in patient with diabetes mellitus

2017 ◽  
Vol 0 (3(59)) ◽  
pp. 84-89
Author(s):  
М. В. Свиридов ◽  
О. М. Сулаєва ◽  
А. Є. Голодніков ◽  
Т. В. Огризько
Keyword(s):  
Diabetes Mellitus ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Case ◽  
Healing Wound

scholarly journals Adipose Tissue Regeneration: A State of the Art

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Alessandro Casadei ◽  
Roberta Epis ◽  
Letizia Ferroni ◽  
Ilaria Tocco ◽  
Chiara Gardin ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Adipose Tissue ◽  
State Of The Art ◽  
Soft Tissue Defects ◽  
Adipose Tissue Engineering ◽  
Current State ◽  
Alloplastic Materials ◽  
Foreign Body Reactions ◽  
Culture Strategies ◽  
Tissue Defects

Adipose tissue pathologies and defects have always represented a reconstructive challenge for plastic surgeons. In more recent years, several allogenic and alloplastic materials have been developed and used as fillers for soft tissue defects. However, their clinical use has been limited by further documented complications, such as foreign-body reactions potentially affecting function, degradation over time, and the risk for immunogenicity. Tissue-engineering strategies are thus being investigated to develop methods for generating adipose tissue. This paper will discuss the current state of the art in adipose tissue engineering techniques, exploring the biomaterials used, stem cells application, culture strategies, and current regulatory framework that are in use are here described and discussed.

scholarly journals Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia

2021 ◽  
Author(s):  
Cara Trivett ◽  
Zoe J. Lees ◽  
Dilys J. Freeman
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Maternal Obesity ◽  
Sudden Onset ◽  
Healthy Pregnancy ◽  
Short And Long Term

AbstractGestational diabetes mellitus (GDM) is a common disorder of pregnancy with short- and long-term consequences for mother and baby. Pre-eclampsia is of major concern to obstetricians due to its sudden onset and increased morbidity and mortality for mother and baby. The incidence of these conditions continues to increase due to widespread maternal obesity. Maternal obesity is a risk factor for GDM and pre-eclampsia, yet our understanding of the role of adipose tissue and adipocyte biology in their aetiology is very limited. In this article, available data on adipose tissue and adipocyte function in healthy and obese pregnancy and how these are altered in GDM and pre-eclampsia are reviewed. Using our understanding of adipose tissue and adipocyte biology in non-pregnant populations, a role for underlying adipocyte dysfunction in the pathological pathways of these conditions is discussed.

scholarly journals Use of negative pressure in the treatment of anaerobic non-clostridial perineal infection

2021 ◽  
Vol 8 (3) ◽  
pp. 44-47
Author(s):  
B. A. Salazar Mun'oz
Keyword(s):  
Diabetes Mellitus ◽  
Negative Pressure ◽  
Clinical Case ◽  
Negative Pressure Wound Therapy ◽  
Local Treatment ◽  
Complex Treatment ◽  
Wound Therapy

The article presents a clinical case of a successful complex treatment anaerobic non-clostridial perineal infection in a 54-year-old patient with long-term diabetes mellitus. Particular attention is paid to the possibilities of local treatment using negative pressure wound therapy in the management of this patients category.

Reconstruction of complex soft tissue defects including tendons with anterolateral thigh flap extended to fascia lata: Long term recovery and functional outcomes

Microsurgery ◽  
2019 ◽  
Vol 39 (5) ◽  
pp. 405-415 ◽  
Author(s):  
Pietro G. Summa ◽  
Gianluca Sapino ◽  
Mario Cherubino ◽  
Giorgio De Santis ◽  
Sebastien Durand ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Functional Outcomes ◽  
Fascia Lata ◽  
Anterolateral Thigh Flap ◽  
Soft Tissue Defects ◽  
Anterolateral Thigh ◽  
Tissue Defects

scholarly journals The question of the influence of the dosed tissue stretching on the concentration of the hypoxia-inducible factor (HIF-1α) in the stretched flap

2017 ◽  
Vol 10 (4) ◽  
pp. 283-287
Author(s):  
Maxim Vladimirovich Bagryantsev ◽  
Ilia Viktorovich Pavlenko ◽  
Natalya Alexandrovna Shelchkova ◽  
Andrey Alexandrovich Mironov ◽  
Maxim Georgievich Ryabkov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Soft Tissues ◽  
Hypoxia Inducible Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Soft Tissue Defects ◽  
Cytokine Concentration ◽  
Doppler Flowmetry ◽  
Experimental Animals ◽  
Tissue Defects ◽  
Skin Samples

Relevance: the method of dosed dermotension as one of the options for plastic reconstruction of the foot with the soft tissue defects of various etiologies (including diabetes mellitus) are widely used in surgery. Local circulatory compensated hypoxia, occurs when dosed dermotension, stimulates proliferation of blood vessels, but to date no proven link between measured growth and the concentration of cytokine HIF-1α. Aim: the aim was to identify patterns between local circulatory compensated hypoxia created by carrying out the dosed dermotension and cytokine concentration of HIF-1α in stretched the flap when closing the wound of the soft tissues. Materials and methods: the experiment was carried out on 18 experimental animals, which was simulated wound scapular area and conducted a hardware apparatus dermotension under the control of laser Doppler flowmetry, formed the skin samples and performed enzyme-linked immunosorbent assay to determine the concentration of cytokine HIF-1α after 30 minutes, 24 hours from the beginning of tissue stretching. Results: the concentration of HIF-1α in the skin before the start of the dermotension was (Me [Q1; Q3]) 110 [98,1; 114,8] ng/ml. A statistically significant increase in the concentration of HIF-1α to 148 [122,2; 221,7] ng/ml (p=0.008) recorded in the group of animals who underwent tissue stretching within 30 minutes, research also showed that the concentration of HIF-1α increased to 330 [246,4; 463,3] ng/ml (p=0.007) after 24 hours from the start of the dosed strains. Conclusion: the concentration of cytokine HIF-1α in stretched the flap increases with dosed dermotension. Thus, the regulation of adaptation of the skin to stretching is performed by increasing the concentration of the cytokine HIF-1α.

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