scholarly journals ASPECTS OF DIAGNOSTIC ACTIVITIES IN PATIENTS WITH DYSFUNCTION OF TEMPOROMANDIBULAR JOINTS AND SIGNS OF BRUXISM

2018 ◽  
Vol 25 (5) ◽  
pp. 77-82 ◽  
Author(s):  
S. P. Rubnikovich ◽  
D. M. Borodin ◽  
Yu. L. Denisova ◽  
I. N. Baradina
Keyword(s):  
Cerebral Cortex ◽  
Treatment Effectiveness ◽  
Treatment Results ◽  
Disease Treatment ◽  
Temporomandibular Joints ◽  
Joint Gap ◽  
Comprehensive Diagnosis ◽  
Risk Of Disease ◽  
High Level ◽  
Therapeutic Activities

Aim. The research was conducted to develop and implement the complex of diagnostic activities in patients with dysfunction of temporomandibular joints with signs of bruxism.Materials and methods. To achieve this aim we conducted a comprehensive diagnosis of 61 patients aged 20-29 years with bruxism and temporomandibular joints dysfunction (TMJD), the patients were divided into two groups. To diagnose and analyze the results of the disease treatment in patients we used a computer analysis with visualization of changes of the osteoarticular surface and parameters of the joint gap in the TMJ. Depending on the ratio of prognostic risk criteria and the development of bruxism, we distinguished the area of low, medium and high level of risk of disease progression.Results. Comparison of the treatment results of patients with bruxism from two groups in 12-24 months showed that patients from the second group had good treatment results. Patients of the second group underwent a complex of diagnostic activities and its data increased the treatment effectiveness. The results obtained from the treatment of patients from the first group indicate the lack of data from the standard examination of patients with bruxism.Conclusion. The developed complex diagnostic activities in patients with bruxism in combination with dysfunction of the TMJ and occlusive attrition of teeth allow to assess not only the local status but also to determine the functional state of dentoalveolar system and the cerebral cortex which affects the amount of therapeutic activities in the patient. 

scholarly journals Expression of the phosphorylated variant of the AKT1-kinase (p-AKT1) in well-differentiated pancreatic neuroendocrine tumors: immunohistochemical evaluation

2018 ◽  
Vol 46 (4) ◽  
pp. 314-322
Author(s):  
V. V. Delektorskaya ◽  
O. N. Solov'eva ◽  
G. Yu. Chemeris ◽  
Yu. I. Patyutko
Keyword(s):  
Liver Metastases ◽  
Neuroendocrine Tumors ◽  
Treatment Effectiveness ◽  
Disease Free Survival ◽  
Immunohistochemical Analysis ◽  
Pancreatic Neuroendocrine Tumors ◽  
Ki 67 ◽  
New Treatment ◽  
Well Differentiated ◽  
High Level

Background:Well-differentiated pancreatic neuroendocrine tumors (pNETs) represent a group of rare epithelial neoplasms with a highly variable clinical course. AKT1 is one of the most frequently activated protein kinases in pNETs, which promotes the tumor growth and is of interest as a prognostic factor and a target for new treatment approaches.Aim:To study the expression of the phosphorylated variant of AKT1-kinase (p-AKT1) in primary pNETs and their liver metastases and to correlate the results with various clinical and pathological parameters and the disease prognosis.Materials and methods:P-AKT1 expression was studied by the immunohistochemical analysis of the primary lesions and liver metastases in 52 pNETs patients.Results:A high level of cytoplasmic and/or nuclear immunoreactivity was detected in 24/52 of the primary pNETs (46.2%) and in 16/27 of their liver metastases (59.3%). p-AKT1 expression was observed in 3 (21.4%) of NET grade (G) 1, in 14 (46.7%) of NET G2, and in 7 (87.5%) of NET G3. p-AKT1 expression was more frequently identified in pNET G3 category and increased during the tumor progression in metachronous liver metastases, as compared to the corresponding primary tumor. In addition, p-AKT1 positivity was significantly associated with an increase of grade from G1 to G3 (p = 0.004), the Ki-67 index (p = 0.029), the pTNM stage (p = 0.0008), perineural invasion (p = 0.031) and a decrease in disease-free survival (p = 0.05).Conclusion:The results suggest that p-АКТ1 plays an important role in the pathogenesis of pNETs and may be an additional criterion for assessment of the prognosis and treatment effectiveness in this type of tumors.

scholarly journals Cerebral cortex classification by conditional random fields applied to intraoperative thermal imaging

2016 ◽  
Vol 2 (1) ◽  
pp. 475-478
Author(s):  
Nico Hoffmann ◽  
Edmund Koch ◽  
Uwe Petersohn ◽  
Matthias Kirsch ◽  
Gerald Steiner
Keyword(s):  
Cerebral Cortex ◽  
Random Fields ◽  
Conditional Random Fields ◽  
Intraoperative Imaging ◽  
A Priori ◽  
Approaches To Learning ◽  
Time Frequency ◽  
Classification Framework ◽  
Preprocessing Technique ◽  
High Level

AbstractIntraoperative thermal neuroimaging is a novel intraoperative imaging technique for the characterization of perfusion disorders, neural activity and other pathological changes of the brain. It bases on the correlation of (sub-)cortical metabolism and perfusion with the emitted heat of the cortical surface. In order to minimize required computational resources and prevent unwanted artefacts in subsequent data analysis workflows foreground detection is a important preprocessing technique to differentiate pixels representing the cerebral cortex from background objects. We propose an efficient classification framework that integrates characteristic dynamic thermal behaviour into this classification task to include additional discriminative features. The first stage of our framework consists of learning this representation of characteristic thermal time-frequency behaviour. This representation models latent interconnections in the time-frequency domain that cover specific, yet a priori unknown, thermal properties of the cortex. In a second stage these features are then used to classify each pixel’s state with conditional random fields. We quantitatively evaluate several approaches to learning high-level features and their impact to the overall prediction accuracy. The introduction of high-level features leads to a significant accuracy improvement compared to a baseline classifier.

How to Assess Risk of Disease Transmission to Patients When There Is a Failure to Follow Recommended Disinfection and Sterilization Guidelines

2007 ◽  
Vol 28 (2) ◽  
pp. 146-155 ◽  
Author(s):  
William A. Rutala ◽  
David J. Weber
Keyword(s):  
Infection Control ◽  
Disease Transmission ◽  
Scientific Literature ◽  
Assessment Model ◽  
Risk Assessment Model ◽  
The Public ◽  
Potential Adverse Event ◽  
Risk Of Disease ◽  
Critical Components ◽  
High Level

Background.Disinfection and sterilization are critical components of infection control. Unfortunately, breaches of disinfection and sterilization guidelines are not uncommon.Objective.To describe a method for evaluating a potential breach of guidelines for high-level disinfection and sterilization of medical devices.Methods.The appropriate scientific literature was reviewed to determine the frequency of failures of compliance. A risk assessment model was constructed.Results.A 14-step protocol was constructed to aid infection control professionals in the evaluation of potential disinfection and sterilization failures. In addition, a model is presented for aiding in determining how patients should be notified of the potential adverse event. Sample statements and letters are provided for communicating with the public and individual patients.Conclusion.Use of a protocol can guide an institution in managing potential disinfection and sterilization failures.

Thalamocortical Networks

2017 ◽  
pp. 99-108
Author(s):  
David A. McCormick
Keyword(s):  
Cerebral Cortex ◽  
Normal Function ◽  
Normal Brain ◽  
Basic Circuit ◽  
Waking State ◽  
Thalamocortical Oscillations ◽  
Thalamocortical Network ◽  
High Level ◽  
The Brain

The thalamus and cerebral cortex are intimately linked through strong topographical connections, not only from the thalamus to the cortex, but also from the cortex back to the thalamus. As in many parts of the brain, the basic circuit of thalamocortical connectivity is relatively simple, although intracortical and corticocortical connectivity provides a high level of complexity. One of the basic operations of the thalamocortical network is the generation of rhythmic oscillations, which are now relatively well understood. In the normal brain, these thalamocortical oscillations typically occur during sleep, although their pathological counterparts may appear as seizures during sleep or waking. Unfortunately, the normal function of reciprocal thalamocortical connectivity during the waking state is still unknown. Even so, focused research is yielding insights into the properties of each of the cellular and synaptic components of these networks and how they interact to perform circuitwide operations.

Adaptation of CCIM Technology for HLW Treatment: Results of Research and Development

2010 ◽  
Author(s):  
Vladimir Lebedev ◽  
Sergey Stefanovsky ◽  
Alexander Kobelev ◽  
Fyodor Lifanov ◽  
Sergey Dmitriev
Keyword(s):  
High Level Waste ◽  
Cold Crucible ◽  
Savannah River ◽  
Treatment Results ◽  
Auxiliary Equipment ◽  
Automated Control ◽  
Automated Control System ◽  
New Perspective ◽  
High Level ◽  
River Site

Results of feasibility tests of application of Cold Crucible Inductive Melting (CCIM) technology to high level waste (HLW) treatment on examples of Savannah River Site, USA, and PA “Mayak”, Russia, HLW, carried out at SIA Radon, and results of design of new perspective bench-scale HLW vitrification facility are presented in this report. Full-scale low level waste (LLW) vitrification plant is under operation at Radon since 2003. Successful Radon experience aroused an interest to this technology from US DOE. Since 2001 Radon performed tests on vitrification of surrogates of various types of HLW stored at US DOE Sites. Process variables were determined and vitrified wastes were characterized in details. Since 2007 Radon was a subcontractor in the project on design and construction of a new CCIM based vitrification facility at PA “Mayak”. From preliminary tests on Mayak HLW surrogates the main technological features of CCIM process were determined and principles of the process control were formulated. Radon performed the design of the cold crucible and automated control system. On the base of analysis of previously and newly obtained data the main requirements to designing of cold crucible melters and auxiliary equipment, intended for actual HLW treatment, were worked out.

Genetic analyses of the parasitic nematode, Parelaphostrongylus tenuis, in Missouri and Kentucky reveal unexpected levels of diversity and population differentiation

Parasitology ◽  
2020 ◽  
pp. 1-11
Author(s):  
L. S. Eggert ◽  
L. K. Berkman ◽  
K. Budd ◽  
B. J. Keller ◽  
A. M. Hildreth ◽  
...  
Keyword(s):  
Nuclear Dna ◽  
Disease Risk ◽  
Sequence Data ◽  
Release Site ◽  
Primary Host ◽  
Dna Sequence Data ◽  
Increased Risk ◽  
Parelaphostrongylus Tenuis ◽  
Risk Of Disease ◽  
High Level

Abstract Wildlife translocations, which involve the introduction of naive hosts into new environments with novel pathogens, invariably pose an increased risk of disease. The meningeal worm Parelaphostrongylus tenuis is a nematode parasite of the white-tailed deer (Odocoileus virginianus), which serves as its primary host and rarely suffers adverse effects from infection. Attempts to restore elk (Cervus canadensis) to the eastern US have been hampered by disease caused by this parasite. Using DNA sequence data from mitochondrial and nuclear genes, we examined the hypothesis that elk translocated within the eastern US could be exposed to novel genetic variants of P. tenuis by detailing the genetic structure among P. tenuis taken from white-tailed deer and elk at a source (Kentucky) and a release site (Missouri). We found high levels of diversity at both mitochondrial and nuclear DNA in Missouri and Kentucky and a high level of differentiation between states. Our results highlight the importance of considering the potential for increased disease risk from exposure to novel strains of parasites in the decision-making process of a reintroduction or restoration.

scholarly journals Subclinical Characteristics and Treatment Results of Shigella in Gastroeterology Department, Vietnam National Children’s Hospital 2019

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Hong Tu Nguyen ◽  
Thi Thuy Ha Dang ◽  
Bich Ngoc Hoang ◽  
Thi Luong Nguyen
Keyword(s):  
Treatment Failure ◽  
Treatment Effectiveness ◽  
Descriptive Study ◽  
Stool Culture ◽  
Cure Rate ◽  
Treatment Results ◽  
Cross Sectional ◽  
Children's Hospital ◽  
Results Of Treatment ◽  
Children’S Hospital

Purpose: To describe some subclinical characteristics of Shigella dysentery in children of the Gastroenterology Department at the Vietnam National Children’s Hospital in 2019 and review the results of treatment in these patients. Methods: A cross-sectional descriptive study was conducted on patients under 15 years of age admitted to the Gastroenterology Department at Vietnam National Children's Hospital. Results: The CRP index increased to 81.8%, of which the increase was mainly in the S.sonnei group. The rate of the most common bacteria strain is S.sonnei accounting for 87.1%, followed by S.fexneri 11.8%, S.dysenteriae encountered a case of 1.1%. No cases of stool culture resulted in S.boydii. The cure rate with Ciprofloxacin is 89.5%. The recovery rate is quite high, 93.3%, the percentage of patients who are also significantly better at 6.7% and there is no case of treatment failure. Conclusions: The number of leukocytes and CRP in the peripheral blood is increased in most cases. The main antibiotic used is Ciprofloxacin, the treatment effectiveness with Ciprofloxacin antibiotic is 89.5%, the cure rate is high and there is no case of treatment failure.

scholarly journals Infectious diseases as complications following spinal cord injury

2021 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
John Nolan ◽  
Tjokorda Gde Bagus Mahadewa
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Infectious Diseases ◽  
Daily Activity ◽  
Infectious Complication ◽  
Infectious Complications ◽  
Treatment Results ◽  
Mortality And Morbidity ◽  
Cord Injury ◽  
High Level

Background: Infectious complications in spinal cord injury (SCI) patients can increase the mortality and morbidity of the patients. The inability to do daily activity is the main cause of the occurrence of infectious complications. Good understanding and high awareness are needed to notice some infectious complications which are difficult to be diagnosed. Method: This paper is a literature review which was done by reviewing and searching journals with “infectious complication”, “spinal cord injury”, “infection” on the search engines. The authors found 52 articles are suitable to be composed as references for this paper. Outcome: Several infectious complications may occur following the incidence of SCI and have a lot of disadvantages. The causes of these infections are multifactorial. Urinary tract infection, infected pressure ulcer, pneumonia, and some other infectious diseases may appear as complications. Extra care in hygiene and sanitation is needed, besides, high awareness is needed to discover these complications. Conclusion: Monitoring post-SCI complications are complex and difficult. A high level of suspicion should be raised with frequent aseptic actions and procedures. Appropriate management including non-surgical or surgical procedures can be chosen to achieve the best outcomes. Early diagnosis and management are critical for the best treatment results.

scholarly journals Miteinander sprechen – verantwortlich, kompetent, reflektiert

2021 ◽  
Keyword(s):  
Interdisciplinary Research ◽  
The Self ◽  
Research And Teaching ◽  
Self Image ◽  
History Of ◽  
The Subject ◽  
Speech Science ◽  
Professional Fields ◽  
High Level ◽  
Therapeutic Activities

Speech science has a history of over 120 years. In addition to the self-image of the discipline, this book focuses on everything that makes the subject so attractive: With its vital research and teaching subject, speaking and people talking to each other, it is both application-oriented and up-to-date. This explains the continuing high level of interest among students, research partners, and practical professional fields in education, art, media, counseling, therapy, and prevention. With study locations in Halle, Jena and Marburg, Speech Science is represented throughout Germany. As an interdisciplinary research and working subject with links to linguistics, medicine, pedagogy, psychology, politics and sociology, among others, there are also diverse collaborations in research, teaching and practice. This volume offers surprising insights into the diversity of speech science – from its history to the present to an outlook on what will be possible in the future. Susanne Voigt-Zimmermann holds a degree in speech science. After scientific, speech-educational, and clinical-therapeutic activities at the universities of Jena, Heidelberg, and Magdeburg, she has been a professor of speech science at the Department of Speech Science and Phonetics at Martin Luther University Halle-Wittenberg since 2017.

scholarly journals Clinical and radiological variants of lung damage in infection caused by Staphylococcus aureus

2021 ◽  
Author(s):  
Anton S. Vinokurov ◽  
Aleksandra D. Smirnova ◽  
Olga I. Belenkaya ◽  
Andrey L. Yudin ◽  
Elena A. Yumatova
Keyword(s):  
Lung Diseases ◽  
Pleural Empyema ◽  
The Body ◽  
Lung Damage ◽  
Treatment Results ◽  
Laboratory Methods ◽  
Septic Pulmonary Embolism ◽  
High Level ◽  
Inflammatory Changes ◽  
Modern Technologies

Despite the high level of modern technologies in the field of laboratory methods and imaging of the respiratory system, the problem of early and accurate differential diagnosis of inflammatory lung diseases remains important in practical medicine. It leads to improved treatment results and a reduction in the number of complications (pleural empyema, fistulas, mediastinitis, sepsis, etc.), and in some cases allows to suspect the presence of a primary purulent source in the body, as in the case of septic pulmonary embolism. The review examines the features of S. aureus as a pathogen of lung diseases, relevant epidemiology, pathogenesis, clinical features and imaging diagnostics of various types of inflammatory changes in the lungs with a focus on destruction.

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