PROBLEMATIC ASPECTS OF IN HERITANCE OF INTELLECTUAL PROPERTY RIGHTS TO VARIOUS WORKS OF SCIENCE, LITERATURE AND ART

Among the key problems of law enforcement practice and legal science in modern conditions is the problem of inheritance of intellectual rights to works of science, literature and art, the peculiarity of which is due to their intangible nature and the legal nature of the actual acceptance of the inheritance. The aim of the study is an objective assessment of the grounds for the inheritance of intellectual property rights, criteria for intellectual property rights to be inherited. The scientific novelty of the research lies in a comprehensive diagnosis of the powers of the heirs of intellectual rights, the content of the process of inheritance of intellectual rights to works of science, literature and art, identifying the differences between the circle of heirs by law and by will.

Management of the Two Dental Developmental Anomalies in Two Maxillary Incisors for Improved Esthetic Appearance: A Case Report

Introduction: The presence of a developmental dental anomaly in maxillary incisors usually affects esthetic appearance. Therefore, gemination and supernumerary teeth are considered anomalies and need a careful and comprehensive diagnosis and treatment. Case Description: This clinical report presents a 10-year-old girl complaining of the esthetic appearance of her anterior maxillary teeth. Clinical and radiographical examinations revealed a maxillary geminated permanent left central incisor and a supplemental supernumerary permanent right lateral incisor. The treatment has been performed in different stages, including preventive, conservative, surgical, and orthodontic treatments. Thus, the large geminated incisor has been restored to its normal shape, and the problem of anterior incisor crowding resolved through alignment. Conclusion: Dental anomalies in the anterior segment are common and need time during treatment. Selective grinding for the large geminated incisor and the extraction of the supplemental tooth followed by orthodontic treatment may be the right decisions that a dental practitioner may consider during the management of such cases.

Application of Mass Spectrometry in Pancreatic Cancer Translational Research

Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.

A Comprehensive Diagnosis Method of Rolling Bearing Fault Based on CEEMDAN-DFA-Improved Wavelet Threshold Function and QPSO-MPE-SVM

A comprehensive fault diagnosis method of rolling bearing about noise interference, fault feature extraction, and identification was proposed. Based on complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), detrended fluctuation analysis (DFA), and improved wavelet thresholding, a denoising method of CEEMDAN-DFA-improved wavelet threshold function was presented to reduce the distortion of the noised signal. Based on quantum-behaved particle swarm optimization (QPSO), multiscale permutation entropy (MPE), and support vector machine (SVM), the QPSO-MPE-SVM method was presented to construct the fault-features sets and realize fault identification. Simulation and experimental platform verification showed that the proposed comprehensive diagnosis method not only can better remove the noise interference and maintain the original characteristics of the signal by CEEMDAN-DFA-improved wavelet threshold function, but also overcome overlapping MPE values by the QPSO-optimizing MPE parameters to separate the features of different fault types. The experimental results showed that the fault identification accuracy of the fault diagnosis can reach 95%, which is a great improvement compared with the existing methods.

Intelligent Algorithm-Based Computed Tomography Image Features in Diagnosis of the Effect of Radiofrequency Ablation in Liver Cancer

To provide a reference for finding a reasonable evaluation method for treatment effect of radiofrequency ablation (RFA), computed tomography (CT) image optimized by the intelligent segmentation algorithm was utilized to evaluate the liver condition of hepatocellular carcinoma (HCC) patients after RFA and to estimate the patient’s prognosis. Eighty-eight patients with HCC who needed RFA surgery after diagnosis in our hospital were selected. The CT images before optimization were set as the control group; the CT images after optimization were set as the observation group. Comprehensive diagnosis was taken as the gold standard to compare the ablation range and residual lesions under CT scans before and after surgery. The results showed that the consistency of the two sets of CT images was compared with comprehensive diagnosis under different diameters of the lesion. The difference between the two groups was not statistically considerable when the diameter of the lesion was less than 50 mm ( P > 0.05 ). For lesions larger than 50 mm in diameter, the consistency of the observation group (83%) was remarkably higher than that of the control group (40%), and the difference was substantial ( P < 0.05 ). The kappa value of the observation group was 0.84 and that of the control group was 0.78. The kappa value of observation group was better than the control group, with considerable difference ( P < 0.05 ). In conclusion, the diagnostic effect of CT image based on intelligent segmentation algorithm was superior to conventional diagnosis when the diameter of the lesion was larger than 50 mm. Moreover, the overall improvement rate of patients after RFA treatment was far greater than the recurrence rate, indicating that the clinical adoption of RFA was very meaningful.

Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury

Acute kidney injury after cardiac surgery is characterized by specific patterns of damage and recovery that are important to consider for management and outcome. The Kidney Disease: Improving Global Outcomes (KDIGO) classification covers only part of the conceptual framework and is thus insufficient for a comprehensive diagnosis. This review highlights the strengths and limitations of the recent criteria and provides an overview of biomarkers of cardiac surgery-associated acute kidney injury (CSA-AKI). The evolving understanding of CSA-AKI as a time-sensitive condition has increased the demand to enhance the diagnostic criteria and translate biomarkers into clinical practice.

Concepts and Clinical Applications of Intraoral 3D Scanning in the Management of Patients with Orofacial Clefts

Digital workflow in the dental is on the brink of completely replacing the traditional workflow. This opened the frontier for the introduction of intraoral scanners (IOS). In the craniofacial field, IOS has proven its applicability in various procedures with highly promising results. This includes comprehensive diagnosis of patients with orofacial clefts and custom-made treatment planning of challenging cases as well as its use in nasoalveolar molding (NAM) therapy. IOS also opened the horizon to the advanced digital workflow required for appliances design, manufacturing, and virtual surgical planning. IOS offer various advantages that decrease the time, effort for both the patients, their families and care providers. IOS adopt different optical technologies what aim for precise recording of a three-dimensional (3D) object. This chapter aims to provide a comprehensive review of the use of intraoral scanners in the craniofacial field.

The lived body (Der Leib) as a diagnostic and therapeutic instrument in general practice

SummaryBased on vignettes from clinical cases, supervision and Balint groups this article presents a neo-phenomenological perspective on the lived experience of healthcare professionals in interactions with patients and relatives. Specifically, the familiar phenomenon of “something in the air” between two persons will be analyzed.Constellations and situations are presented as fundamental and generic (ontological) categories that can be differentiated to understand the details and the whole (die Gestalt) of an interaction.The term atmosphere is introduced to investigate the material carrier of something that “colors the air” between healthcare provider and patient.The neo-phenomenological taxonomy of the lived body (der Leib) is used to describe the recipient structure of atmospheric mood.Finally, the potential of these concepts for a more comprehensive diagnosis and for therapeutic use in general practice will be elucidated.

Frailty Pathogenesis, Assessment, and Management in Older Adults With COVID-19

The 2019 coronavirus disease (COVID-19) is a highly contagious and deadly disease. The elderly people are often accompanied by chronic inflammation and immunodeficiency, showing a frail state. The strength, endurance, and physiological function of the elderly are significantly decreased, and the ability to deal with stress response is weakened. They are the high-risk group that suffering from COVID-19, and rapidly developing to critical illness. Several recent studies suggest that the incidence rate of COVID-19 in elderly patients with frailty is high. Early assessment, detection, and effective intervention of frailty in COVID-19 patients are conducive to significantly improve the quality of life and improve prognosis. However, there are insufficient understanding and standards for the current evaluation methods, pathogenesis and intervention measures for COVID-19 combined with frailty. This study reviews the progress of the research on the potential pathogenesis, evaluation methods and intervention measures of the elderly COVID-19 patients with frailty, which provides a reference for scientific and reasonable comprehensive diagnosis and treatment in clinical.

AGED CHANGES OF DYNAMIC COMPONENT OF THE VERTICAL STABILITY IN WOMEN 60-74 YEARS OLD

В статье представлена характеристика динамического компонента постурального баланса и выявлены его особенности у женщин пожилого возраста с постуральным дефицитом. Оценку динамического компонента постурального баланса проводили на компьютерном стабилометрическом комплексе «Balance Manager» у женщин 60-74 лет с падениями в анамнезе и без них. При постуральном дефиците наиболее значимые изменения проявляются в увеличении времени реализации и снижении эффективности выполнения сложных двигательных актов. В факторной структуре показателей динамического компонента постурального баланса при постуральном дефиците ведущим является фактор, характеризующий скоростные и силовые показатели при реализации сложных двигательных актов. Исследование динамического компонента постурального баланса рекомендуется включать в комплексную диагностику нарушений ходьбы у лиц пожилого возраста и при оценке эффективности лечебных и реабилитационных мер. The article presents characteristics of the dynamic component of postural balance and its features in elderly women with postural deficit. The assessment of the dynamic component of postural balance was performed on a computer stabilometric complex «Balance Manager» in women aged 60-74 with and without a history of falls. The most significant changes are manifested by an increase in the time of implementation and a decrease in the effectiveness of performing complex motor acts. In the factor structure of indicators of the dynamic component of postural balance in postural deficit, the leading factor is the factor that characterizes speed and power indicators in the implementation of complex motor acts. The study of the dynamic component of postural balance is recommended to be included in the comprehensive diagnosis of walking disorders in the elderly and in evaluating the effectiveness of treatment and rehabilitation measures.