Can the Skin Microbiota of Patients Suffering from Atopic Dermatitis be Modified after Balneotherapy?

2017 ◽  
Vol 1 ◽  
pp. s34
Author(s):  
S Seite ◽  
D Moyal
Keyword(s):  
Atopic Dermatitis ◽  
Skin Microbiota

Abstract Not Available

scholarly journals A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1682
Author(s):  
Ewa Łoś-Rycharska ◽  
Marcin Gołębiewski ◽  
Marcin Sikora ◽  
Tomasz Grzybowski ◽  
Marta Gorzkiewicz ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Food Allergy ◽  
Gut Microbiota ◽  
Bacterial Species ◽  
Rrna Gene ◽  
Healthy Children ◽  
Skin Microbiota ◽  
Fecal Samples ◽  
Healthy Infants ◽  
Α Diversity

The gut microbiota in patients with food allergy, and the skin microbiota in atopic dermatitis patients differ from those of healthy people. We hypothesize that relationships may exist between gut and skin microbiota in patients with allergies. The aim of this study was to determine the possible relationship between gut and skin microbiota in patients with allergies, hence simultaneous analysis of the two compartments of microbiota was performed in infants with and without allergic symptoms. Fifty-nine infants with food allergy and/or atopic dermatitis and 28 healthy children were enrolled in the study. The skin and gut microbiota were evaluated using 16S rRNA gene amplicon sequencing. No significant differences in the α-diversity of dermal or fecal microbiota were observed between allergic and non-allergic infants; however, a significant relationship was found between bacterial community structure and allergy phenotypes, especially in the fecal samples. Certain clinical conditions were associated with characteristic bacterial taxa in the skin and gut microbiota. Positive correlations were found between skin and fecal samples in the abundance of Gemella among allergic infants, and Lactobacillus and Bacteroides among healthy infants. Although infants with allergies and healthy infants demonstrate microbiota with similar α-diversity, some differences in β-diversity and bacterial species abundance can be seen, which may depend on the phenotype of the allergy. For some organisms, their abundance in skin and feces samples may be correlated, and these correlations might serve as indicators of the host’s allergic state.

scholarly journals Staphylococcal Communities on Skin Are Associated with Atopic Dermatitis and Disease Severity

2021 ◽  
Vol 9 (2) ◽  
pp. 432
Author(s):  
Sofie Marie Edslev ◽  
Caroline Meyer Olesen ◽  
Line Brok Nørreslet ◽  
Anna Cäcilia Ingham ◽  
Søren Iversen ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Alpha Diversity ◽  
Skin Microbiota ◽  
Specific Primers ◽  
Staphylococcus Lugdunensis ◽  
Disease Symptoms ◽  
Lesional Skin ◽  
Staphylococcus Capitis ◽  
Staphylococcus Hominis

The skin microbiota of atopic dermatitis (AD) patients is characterized by increased Staphylococcus aureus colonization, which exacerbates disease symptoms and has been linked to reduced bacterial diversity. Skin bacterial communities in AD patients have mostly been described at family and genus levels, while species-level characterization has been limited. In this study, we investigated the role of the bacteria belonging to the Staphylococcus genus using targeted sequencing of the tuf gene with genus-specific primers. We compared staphylococcal communities on lesional and non-lesional skin of AD patients, as well as AD patients with healthy controls, and determined the absolute abundance of bacteria present at each site. We observed that the staphylococcal community, bacterial alpha diversity, and bacterial densities were similar on lesional and non-lesional skin, whereas AD severity was associated with significant changes in staphylococcal composition. Increased S. aureus, Staphylococcus capitis, and Staphylococcus lugdunensis abundances were correlated with increased severity. Conversely, Staphylococcus hominis abundance was negatively correlated with severity. Furthermore, S. hominis relative abundance was reduced on AD skin compared to healthy skin. In conclusion, various staphylococcal species appear to be important for skin health.

scholarly journals The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis

2021 ◽  
Vol 22 (19) ◽  
pp. 10661
Author(s):  
Pamela Gallegos-Alcalá ◽  
Mariela Jiménez ◽  
Daniel Cervantes-García ◽  
Eva Salinas
Keyword(s):  
Atopic Dermatitis ◽  
Complex Disease ◽  
Skin Diseases ◽  
Current Knowledge ◽  
Immune Dysregulation ◽  
Chronic Inflammatory Disease ◽  
Skin Microbiota ◽  
External Agents ◽  
Chronic Skin ◽  
Inflammatory Molecules

The keratinocyte (KC) is the main functional and structural component of the epidermis, the most external layer of the skin that is highly specialized in defense against external agents, prevention of leakage of body fluids and retention of internal water within the cells. Altered epidermal barrier and aberrant KC differentiation are involved in the pathophysiology of several skin diseases, such as atopic dermatitis (AD). AD is a chronic inflammatory disease characterized by cutaneous and systemic immune dysregulation and skin microbiota dysbiosis. Nevertheless, the pathological mechanisms of this complex disease remain largely unknown. In this review, we summarize current knowledge about the participation of the KC in different aspects of the AD. We provide an overview of the genetic predisposing and environmental factors, inflammatory molecules and signaling pathways of the KC that participate in the physiopathology of the AD. We also analyze the link among the KC, the microbiota and the inflammatory response underlying acute and chronic skin AD lesions.

scholarly journals 949 Skin microbiota alterations induce dysregulated IL-1α responses that drive atopic dermatitis-like skin inflammation

2018 ◽  
Vol 138 (5) ◽  
pp. S161
Author(s):  
N. Archer ◽  
S. Lee ◽  
J. Jo ◽  
D. Kim ◽  
R. Ortines ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Inflammation ◽  
Skin Microbiota

scholarly journals DISORDERS OF SKIN MICROBIOTA AND FORMATION OF ATOPIC DERMATITIS IN CHILDREN

2019 ◽  
Vol 22 (4) ◽  
pp. 243-250
Author(s):  
Galina I. Smirnova ◽  
A. A. Korsunsky
Keyword(s):  
Atopic Dermatitis ◽  
Skin Barrier ◽  
General Concept ◽  
Skin Care ◽  
Special Significance ◽  
Dry Skin ◽  
Skin Microbiota ◽  
Rate Of Development ◽  
The Relationship

The review presents the special significance of changes in the intestinal and skin microbiota in the formation of atopic dermatitis (AD) in children. AD is considered as a form of allergic pathology directly related to the state and quality of the microbiota of a growing organism. The microbiota of the skin of patients with AD is characterized by a small species diversity of bacteria; a decrease in the number of actinomycetes and proteobacteria; increased colonization of various types of staphylococci (S. aureus, S. epidermidis, S. haemolyticus, etc). The relationship between the rate of development of AD and violations of the microbiota of the skin in children is shown. The necessity of maintaining high biodiversity of the microbiota of a growing organism as a strategy for optimizing the microecology of children through the use of adaptive probiotics in a healthy microenvironment is substantiated. The restoration of the barrier function of the skin and the normalization of the composition and quality of the intestinal microbiota are determined as the most important task of the general concept of the treatment of AD, where new dermatological cosmetics and proper skin care play an important role. The possibilities of normalizing the microbiome of the affected skin areas to restore the skin barrier with the help of dry skin care cosmetics are shown.

scholarly journals The skin microbiota in pregnant women suffering from atopic dermatitis

2016 ◽  
Vol 97 (2) ◽  
pp. 222-229
Author(s):  
A Yu Lonshakova-Medvedeva ◽  
K N Monakhov ◽  
A N Suvorov ◽  
O V Lavrova
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Pregnant Women ◽  
Bacterial Load ◽  
Life Quality ◽  
Reproductive Age ◽  
Control Group ◽  
Skin Microbiota ◽  
Healthy Women ◽  
Basic Care

Aim. To study the skin microbiota of pregnant women suffering from atopic dermatitis.Methods. 53 women of reproductive age suffering from atopic dermatitis (28 pregnant and 25 non-pregnant) were examined. The control group included dermatologically healthy women (25 pregnant and 25 non-pregnant). Prior to treatment initiation and on 15-day of study pathological process spread, the SCORAD index (scoring of atopic dermatitis - atopic dermatitis severity assessment), dermatology life quality index determination were conducted. In addition, microbiological study of material taken from the forehead, elbow bend skin and visually unaltered forearm skin was performed.Results. In women (pregnant and non-pregnant), suffering from atopic dermatitis skin total bacterial load is increased. In all groups, the skin microbiota is presented mainly by staphylococci: in dermatologically healthy people - coagulase-negative, in atopic dermatitis - Staphylococcusя aureus. In atopic dermatitis Staphylococcus aureus is isolated from both lesions and visually unaltered skin. In pregnant women with atopic dermatitis skin bacterial load was higher, Staphylococcus aureus was found more commonly. The skin microbiota in dermatologically healthy women was more diverse in respect of species comparing with patients with atopic dermatitis. Basic care remedies use leads to clinical improvement and a decrease in the skin total bacterial load and Staphylococcus aureus load. Daily use of emollients has no effect on saprophytic microorganisms.Conclusion. In pregnant patients with atopic dermatitis higher skin total bacterial load and higher rate of skin colonization by Staphylococcus aureus are observed.

scholarly journals Effect of treatments on skin microbiota in patients with atopic dermatitis: a protocol for systematic review

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e053488
Author(s):  
Yang Guo ◽  
Xia Dou ◽  
Xing-ling Jian ◽  
Kao-yuan Zhang ◽  
Ying-jie Zheng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Data Extraction ◽  
Risk Of Bias ◽  
Microbial Interactions ◽  
Skin Microbiota ◽  
Clinical Trial Registry ◽  
Bias Assessment ◽  
Study Selection ◽  
Registration Number

IntroductionAtopic dermatitis (AD) is a chronic inflammatory skin disease and skin microbiota dysbiosis shows an important role in the pathogenesis of AD. Effects of treatment on skin microbiota for patients with AD have been evaluated in recent years; however, the results remained controversial across studies. This systematic review will summarise studies evaluating the effect of treatments on skin microbiota among patients with AD.Methods and analysisWe will search PubMed, EMBASE, Web of Science, ClinicalTrials.gov and Chinese Clinical Trial Registry in November 2021; other data sources will also be considered, including searching specific authors and screening references cited in the enrolled articles. Interventional studies, which enrolled patients with AD receiving treatments and reported treatment-related skin microbiota changes, will be included. Our primary outcomes include skin microbiota diversity and treatment-related differential microbes; the secondary outcomes include microbiota functions and microbial interactions. Risk of bias assessment will be performed using Cochrane risk-of-bias tool for randomised trials, risk of bias in non-randomised studies of interventions and methodological index for non-randomised studies. Two researchers will independently perform study selection, data extraction and risk of bias assessment, with disagreements resolved by group discussions. Subgroup analyses will be performed according to different types of treatment for AD.Ethics and disseminationEthics approval is not required for this systematic review. Findings will be disseminated via peer-reviewed publication or conference proceedings.PROSPERO registration numberCRD42021246566.

scholarly journals Inter- and Intra-patient Variability Over Time of Lesional Skin Microbiota in Adult Patients with Atopic Dermatitis

2020 ◽  
Vol 100 (1) ◽  
pp. 1-2
Author(s):  
E Munckhof ◽  
T Kolk ◽  
H Wall ◽  
D Alewijk ◽  
M Doorn ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Adult Patients ◽  
Skin Microbiota ◽  
Lesional Skin ◽  
Over Time

scholarly journals Relationship between Skin Microbiota and Skin Biophysical Parameters in Inflammatory Skin Disease: A Systematic Review

2021 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Paola Perugini ◽  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Bacterial Flora ◽  
Skin Microbiota ◽  
Biophysical Parameters ◽  
Microbial Composition ◽  
Inflammatory Skin Diseases ◽  
Starting Point ◽  
Inflammatory Skin

Many recent studies highlight the importance of skin microbiota for skin health. Alterations in the balance of bacterial flora cause the development of inflammatory skin diseases such as acne, atopic dermatitis, or psoriasis. This systematic review aims to investigate the relationship, in these skin diseases, between skin microbiota and skin biophysical parameters, such as pH, Transepidermal Water Loss (TEWL), Hydration (HI) and sebum levels. Google Scholar, Medline via Pubmed, and Web of Science were considered as scientific database to search studies about this topic. Research about acne and psoriasis did not produce any results. For this reason, in this review, only articles concerning atopic dermatitis were discussed. Therefore, a possible correlation between skin barrier functionality and microbial composition was also investigated. So, this could be a starting point for the diagnosis of atopic dermatitis or, more generally, for all inflammatory skin diseases.

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