scholarly journals The skin microbiota in pregnant women suffering from atopic dermatitis

2016 ◽  
Vol 97 (2) ◽  
pp. 222-229
Author(s):  
A Yu Lonshakova-Medvedeva ◽  
K N Monakhov ◽  
A N Suvorov ◽  
O V Lavrova
Keyword(s):  
Staphylococcus Aureus ◽  
Atopic Dermatitis ◽  
Pregnant Women ◽  
Bacterial Load ◽  
Life Quality ◽  
Reproductive Age ◽  
Control Group ◽  
Skin Microbiota ◽  
Healthy Women ◽  
Basic Care

Aim. To study the skin microbiota of pregnant women suffering from atopic dermatitis.Methods. 53 women of reproductive age suffering from atopic dermatitis (28 pregnant and 25 non-pregnant) were examined. The control group included dermatologically healthy women (25 pregnant and 25 non-pregnant). Prior to treatment initiation and on 15-day of study pathological process spread, the SCORAD index (scoring of atopic dermatitis - atopic dermatitis severity assessment), dermatology life quality index determination were conducted. In addition, microbiological study of material taken from the forehead, elbow bend skin and visually unaltered forearm skin was performed.Results. In women (pregnant and non-pregnant), suffering from atopic dermatitis skin total bacterial load is increased. In all groups, the skin microbiota is presented mainly by staphylococci: in dermatologically healthy people - coagulase-negative, in atopic dermatitis - Staphylococcusя aureus. In atopic dermatitis Staphylococcus aureus is isolated from both lesions and visually unaltered skin. In pregnant women with atopic dermatitis skin bacterial load was higher, Staphylococcus aureus was found more commonly. The skin microbiota in dermatologically healthy women was more diverse in respect of species comparing with patients with atopic dermatitis. Basic care remedies use leads to clinical improvement and a decrease in the skin total bacterial load and Staphylococcus aureus load. Daily use of emollients has no effect on saprophytic microorganisms.Conclusion. In pregnant patients with atopic dermatitis higher skin total bacterial load and higher rate of skin colonization by Staphylococcus aureus are observed.

The Quality of Life in the Women of Reproductive Age as Patients with Active Forms of Tuberculosis

10.12737/3314 ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Камаев ◽  
I. Kamaev ◽  
Русановская ◽  
G. Rusanovskaya ◽  
Шпрыков ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pulmonary Tuberculosis ◽  
Life Quality ◽  
Reproductive Age ◽  
Control Group ◽  
Main Process ◽  
Women Of Reproductive Age ◽  
Healthy Women ◽  
Tuberculosis Disease

The authors assessed the quality of life of 263 women of reproductive age. The main group consisted of 139 women aged o18-44 as the patients with active pulmonary tuberculosis disease treated in 2011-2012, and the other group of comparison consisted of 124 healthy women of the same age. To assess the life quality the authors used Russian version of the SF-36 which included questions of medico- social nature. It was proved that all the life quality parameters of the women suffering from tuberculosis disease were reduced in comparison with the control group of the healthy women. The only exception was the pain syndrome for which the statistical significance wasn’t reached at all and the physical functioning was assessed at the lowest level. The life quality problem was identified almost in half of the women that proved by the obtained data. Analysis of quality of life of the women established that 25-34 years respondents had the highest reducing of the rates. The analyzed group of patients differed from the low level of the socio- economic independence relatively favorable structure of clinical tuberculosis forms but with a high frequency of tubercle bacilli discharging and detection of lung tissue destructing. Generally, women with pulmonary tuberculosis had numerous risk factors for disease and co-morbidities aggravating the main process. The unfavorable health and social hygienic characteristics of the analyzed group of patients contribute to late making a diagnosis and spreading the infection among the population, including the women of reproductive age. Therefore health care professionals need to make efforts to promote healthy lifestyle and prevention of tuberculosis with this contingent that will allow to prevent new cases of disease and to reduce morbidity. The aim of any disease treatment, including tuberculosis should be considered as acts to improve the life quality of patients in case of positive clinical dynamics. Therefore it is important to guide medical practice for the patients’ psychosomatic status correcting in the early stages of disease that will be able to solve health problems more successfully. Thereby, the authors think it is necessary to organize services; to open offices where patients could get psychosocial correction and rehabilitation, to train the specialists.

Features of the ovarian reserve of women of reproductive age suffering from autoimmune diseases

GYNECOLOGY ◽  
2020 ◽  
Vol 22 (5) ◽  
pp. 27-30
Author(s):  
Elena N. Andreeva ◽  
Olga R. Grigoryan ◽  
Yulia S. Absatarova ◽  
Irina S. Yarovaya ◽  
Robert K. Mikheev
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Gland ◽  
Autoimmune Diseases ◽  
Ovarian Reserve ◽  
Reproductive Potential ◽  
Reproductive Age ◽  
Control Group ◽  
Antithyroid Antibodies ◽  
Healthy Women

The reproductive potential of a woman depends on indicators of the ovarian reserve, such as the anti-Muller hormone (AMH) and the number of antral follicles (NAF). Autoimmune diseases have a significant effect on fertility and contribute to the development of premature ovarian failure. Aim.To evaluate the parameters of the ovarian reserve in patients with type 1 diabetes mellitus, carriers of antibodies to the thyroid gland in a state of euthyroidism and compare them with similar parameters in healthy women. Materials and methods.In the first block of the study, the level of AMH, follicle-stimulating hormone, luteinizing hormone, NAF was studied among 224 women with diabetes and 230 healthy women in the control group. In block II, the level of the above hormonal indices was studied in 35 carriers of antithyroid antibodies in the state of euthyroidism and 35 healthy women. Results.In patients with type 1 diabetes, the level of AMH, NAF was statistically significantly lower when compared with the control group. Among carriers of antithyroid antibodies and healthy women, no difference in AMH and NAF was found. Conclusion.The autoimmune processes accompanying diabetes are more influenced by the ovarian reserve indices than autoimmune aggression to the tissues of the thyroid gland.

scholarly journals Quality of Sleep and Quality of Life during Pregnancy

2020 ◽  
Vol 38 (3) ◽  
pp. 188-193
Author(s):  
Keun Tae Kim ◽  
Hyoeun Bae ◽  
Jin Gon Bae ◽  
Yong Won Cho
Keyword(s):  
Sleep Quality ◽  
Pregnant Women ◽  
Short Form ◽  
Life Quality ◽  
Control Group ◽  
Quality Of Sleep ◽  
Third Trimester ◽  
Cross Sectional ◽  
Sf 36

Background: The prevalence of sleep disorders increases as pregnancy progresses, which affects the health of pregnant women, fetal health, and the outcomes of pregnancy. The aim of this study is to evaluate the quality of sleep and life in pregnant women in Korea.Methods: This study is a prospective cross-sectional, case-control study of pregnant women and age-matched controls. From July to September 2019, all participants completed Korean-language versions of the sleep questionnaires including Pittsburgh sleep quality index (K-PSQI), Insomnia severity index, Epworth sleepiness scale, Back’s depression inventory-2(K-BDI), STOP (Snoring, Tiredness, Observed apneas, and high blood Pressure), and short-form 36 (K-SF-36).Results: A total of 422 participants consisted of 385 pregnant women and 137 controls. Second and third trimester were 200 and 185, respectively. K-PSQI scores were higher in pregnant women compared with the controls (7.87±3.49 and 8.50±3.55 vs. 5.79±2.76, <i>p</i><0.001). Total score of K-SF-36 was lowest in third trimester (62.07±17.72) and highest in the control group(79.41±13.36). There was no statistical difference between groups in K-BDI.Conclusions: This study demonstrated worsening of sleep quality as well as life quality during pregnancy. More attention to sleep of pregnant women is needed.

scholarly journals Pengaruh PemberianTablet Besi Pada Ibu Nifas Terhadap Anemia Post Partum Di Wilayah Puskesmas Pegandon

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Sri Rahayu
Keyword(s):  
Pregnant Women ◽  
Post Partum ◽  
Reproductive Age ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Kolmogorov Smirnov ◽  
Postpartum Mothers ◽  
Test Control

Abtrak. Anemia merupakan masalah kesehatan masyarakat secara global baik dinegara berkembang maupun negara maju. Anemia terjadi pada semua tahap siklus kehidupan, umumnya terjadi pada masa anak-anak dan wanita hamil (WHO, 2008). Di puskesmas Pegandon Kabupaten Kendal pada bulan Agustus 2017 didapatkan ibu hamil dengan kadar HB 8,2 gr% mengalami perdarahan pada saat melahirkan. Penelitian ini bertujuan mengevaluasi pemberian tablet FEpada ibu nifas.Desain penelitian menggunakanmatching pretest-post test control group design. Penelitian ini menggunakan data kohort dari ibu hamil  di puskesmas Pegandon yang melahirkan pada bulan Desember 2017 – Januari 2018. Sampelnya ibu nifas pada bulan  Januari – Maret 2018yang datang di puskesmas Pegandon untuk melahirkan sebanyak 72 ibu nifas. Hasil penelitian menunjukkan sebagian besar  pada responden perlakuan mempunyai usia reproduksi 30 (83,3%),  sebagian berpendidikan (SD danSMP) 28 (77.8%) dan berpenghasilan sesuai UMK 22 (61.1%) sedangkan pada responden control untuk usia reproduksi25 (69%), berpendidikan (SD dan SMP) 31 (86%) dan berpenghasilan sesuai UMK 15 (41.7%).Pada analisis bivariate dengan uji kolmogorov-smirnov didapatkan p> 0.00 pada perlakuan dan kontrol. Disimpulkan bahwa diberikan dan tidak diberikan tablet FE pada ibu nifas didapatkan hasil sama berpengaruh dalam peningkatan kadar HB.Disarankansetiap ibu nifas meminum tablet FE supaya tidak terjadi anemia dan memberikan ASI pada bayinya dengan maksimal.Kata kunci : anemia, ibu nifas, tablet FE The Influence Of Iron Tablets In Pifandon Mother To Post Partum Anemia In Pegandon Community Health Center Area Abtract.Anemia is a global public health problem both in developing and developed countries. Anemia occurs at all stages of the life cycle, generally occurring during childhood and pregnant women (WHO, 2008). In Pegandon Puskesmas Kendal Regency in August 2017 it was found that pregnant women with HB levels 8.2 gr% had bleeding at the time of delivery. This study aims to evaluate the administration of FE tablets to postpartum mothers. The study design used a matching pretest-post test control group design. This study uses cohort data from pregnant women at the Pegandon puskesmas who gave birth in December 2017 - January 2018. The sample was postpartum mothers in January - March 2018 who came to the Pegandon puskesmas to deliver 72 postpartum mothers. The results showed that most of the treatment respondents had a reproductive age of 30 (83.3%), some were educated (SD and SMP) 28 (77.8%) and earning according to MSE was 22 (61.1%) while the control respondents were for reproductive age 25 (69% ), educated (elementary and junior high) 31 (86%) and earning according to UMK 15 (41.7%). In the bivariate analysis with the Kolmogorov-Smirnov test, p> 0.00 was obtained for treatment and control. It was concluded that given and not given FE tablets to the puerperal mothers found the same effect had an effect on increasing HB levels. It is recommended that every puerperal woman take FE tablets so that anemia does not occur and give milk to her baby to the maximum..Keywords: anemia, puerperal mothers, FE tablets

scholarly journals Vaginal Microbiota Diversity of Patients with Embryonic Miscarriage by Using 16S rDNA High-Throughput Sequencing

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Linfen Xu ◽  
Lingna Huang ◽  
Chengying Lian ◽  
Huili Xue ◽  
Yanfang Lu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
16S Rdna ◽  
High Throughput Sequencing ◽  
Interleukin 2 ◽  
Life Quality ◽  
Control Group ◽  
Operational Taxonomic Units ◽  
Causative Relationship ◽  
Rdna Sequencing ◽  
And Control

Embryonic miscarriage severely affects the life quality and physical and mental state of pregnant women. However, the detailed mechanism underlying embryonic miscarriage is not fully understood. This study is aimed at analyzing embryonic miscarriage. We collected samples from 25 normal pregnant women and 25 embryonic miscarriage patients of similar age to analyze microbiota isolated from the vagina. Crude examination of the vagina isolates showed that compared with the control group, 80% of the embryonic miscarriage group contained a significantly lower number of Lactobacillus, the major healthy microbe in the vagina. Furthermore, the levels of Th1 and Th2 secreted cytokine interleukin 2 (IL-2) and interleukin10 (IL-10), respectively, were examined. Results showed that the IL2 level was higher, and IL10 level was lower in the embryonic miscarriage group than in the control group, whereas the IL2/IL10 level was higher in the embryonic miscarriage group than in the control group. This finding suggested that the immune response was suppressed in the embryonic miscarriage group. To further dissect the microbiota of the vagina in the two groups, 16S rDNA sequencing was performed. Bioinformatics analysis showed that 1096 and 998 overlapped operational taxonomic units were identified from the embryonic miscarriage and control groups, respectively. At the genus level, the relative abundance of Fam_Finegoldia, Lac_Coprococcus_3, and Lac_Roseburia significantly differed in the embryonic miscarriage group. Overall, our analyses provided potential biomarkers for embryonic miscarriage and elucidated the causative relationship between microbiota and immune responses and may enable the possible diagnosis and therapeutics of early pregnancy loss.

scholarly journals Studies on Serum Total Cholesterol, in Second and Third Trimester of Pregnancy

1970 ◽  
Vol 1 ◽  
pp. 1-4 ◽  
Author(s):  
F Husain ◽  
SA Latif ◽  
MM Uddin
Keyword(s):  
Pregnant Women ◽  
Total Cholesterol ◽  
Serum Total Cholesterol ◽  
Reproductive Age ◽  
Control Group ◽  
Serum Concentrations ◽  
Third Trimester ◽  
Medical College ◽  
Unpaired Student

Study was carried out in the department of physiology, Mymensingh Medical College, Mymensingh, Bangladesh during the period of July 2006 to June 2007 to investigate the effect of pregnancy on serum total cholesterol. The serum concentrations of total cholesterol was measured in 100 cases of 2nd and 3rd trimester of pregnancy and in a control group of 100 cases of non pregnant women which was matched on reproductive age. Data were analyzed by computer with SPSS program using unpaired student‘t’ test. The results showed that the pregnant women had significantly higher concentrations of serum total cholesterol. Higher concentration of total cholesterol was more common in pregnant than control and reaching maximum at 3rd trimester of pregnancy. This may be a purely physiological response to pregnancy or it may be indicative of pathology in some women. These results deserve a follow up study to investigative whether the hypercholesterolemia persists after parturition. Key Words: Total cholesterol, pregnancy, parturition, hypercholesterolemia J Bangladesh Soc Physiol. 2006 Dec;(1):1-4.

USE OF FEMOFLOR-16 TEST TO ASSESS GENITAL BIOCENOSIS IN WOMEN WITH INFLAMMATORY AND PROLIFERATIVE DISEASES OF CERVIX

2016 ◽  
Vol 1 (61) ◽  
pp. 90-95
Author(s):  
Иевлева ◽  
Nadezhda Ievleva ◽  
Пермина ◽  
Natalya Permina ◽  
Ивахнишина ◽  
...  
Keyword(s):  
Genital Tract ◽  
Inflammatory Diseases ◽  
Female Genital Tract ◽  
Reproductive Age ◽  
Gardnerella Vaginalis ◽  
Control Group ◽  
Healthy Women ◽  
Opportunistic Bacteria ◽  
Obligate Anaerobic ◽  
Atopobium Vaginae

Qualitative and quantitative assessment of microbes making the microbiocenosis of genital tract in women with inflammatory and proliferative diseases of cervix using Femoflor-16 test was the aim of the research. Scrapings of cervix and vaginal fornix in 100 women of reproductive age with cervicitis, vaginitis and in 31 women with cervical pseudoerosion (ectropion) were studied. The control group consisted of 35 relatively healthy women preparing for pregnancy. Cervical and vaginal dysbiosis was found in women with inflammatory diseases of cervix in 37.0% of cases, in women with pseudoerosion in 32.2% of cases. These are 3.3 (р&#60;0.005) and 2.8 (р&#60;0.02) times as much as in the group of healthy women preparing for pregnancy (11.1%). Dysbiosis structure was represented primarily by obligate anaerobic agents such as Gardnerella vaginalis, Atopobium vaginae, Eubacterium spp. in association with other opportunistic bacteria that are clinically most significant microorganisms colonizing female genital tract. Mycoplasma and yeast-like fungi of Candida species were found primarily with anaerobes. Aerobic and mixed dysbiosis were only found in 7% of cases in women with inflammatory diseases. Femoflor-16 test is a readily available, fast, efficient, up-to-date method enabling one to begin with early adequate antibacterial therapy and monitor it.

scholarly journals ПОРУШЕННЯ ВАРІАБЕЛЬНОСТІ СЕРЦЕВОГО РИТМУ ЯК МЕТОД ОЦІНЮВАННЯ АДАПТАЦІЙНИХ РЕАКЦІЙ ОРГАНІЗМУ ВАГІТНИХ ПРИ НАЯВНОСТІ ШКІДЛИВИХ ЗВИЧОК

2018 ◽  
Author(s):  
V. H. Korniienko ◽  
A. S. Fitkalo
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Nervous System ◽  
Pregnant Women ◽  
Cardiac Rhythm ◽  
Main Group ◽  
Reproductive Age ◽  
Control Group ◽  
Cardiac Rhythm Variability ◽  
Adaptive Reactions

According to modern data, the cardiovascular system is a kind of indicator of the organism's adaptive activity, and the structure of the heart rhythm carries information about the development of adaptive reactions in response to irritating factors of the external and internal environment.The aim of the study – to investigate the functional state of the autonomic nervous system in pregnant women who have harmful habits by evaluating and analyzing the parameters of heart rate variability in order to prevent complications of non-delivery of gestational process.Materials and Methods. The study involved 73 pregnant women, 53 of them were pregnant (the main group) who had malignant habits in history. Before studying adaptive reactions in pregnant women, a study of cardiac rhythm variability was performed in practically healthy non-pregnant women of reproductive age (25.3±2.2) years). The control group consisted of 20 pregnant women without any harmful habits. Determination of heart rate variability was performed on the basis of peripheral heart rate recording, which included measuring the sequence of RR intervals for 5 minutes, followed by mathematical analysis using the PlsMntr software product.Results and Discussion. It was established that in the main group, in the complicated failure to pass the gestational process, violations of cardiac rhythm variability were detected in 59.7 % of cases. There is an increase in the frequency of very low frequency (VL F) waves (43.5 % relative to control, p<0.05), indicating a predominance of humoral and metabolic rate of regulation of the cardiac rhythm. At the threat of premature births, a decrease in the particle (LF) is observed at 36.6 %, a decrease in the share of high-frequency waves (НF) by 30.8 %. Taking into account the results of the study, one can speak of a decrease in the tone of the sympathetic and parasympathetic nervous system, reducing the influence of the reflexive vegetative level of regulation, which, in turn, indicates the depletion of regulatory mechanisms and the lack of an adaptive protective effect of n.vagus on the heart.Conclusions. Our innovative low-invasive method of evaluating the adaptive reactions of the organism through the determination and analysis of indicators of cardiac rhythm variability in pregnant women with the existing harmful habits offers us the opportunity to observe manifestations of functional stress of regulatory systems of pregnant women, preceding the development of complication of non-delivery of gestational process.

scholarly journals Influence of osteopathic correction on the psychoemotional state and quality of life of pregnant women with concomitant pathology of the urinary system

2020 ◽  
pp. 66-74
Author(s):  
E. N. Nenashkina
Keyword(s):  
Drug Therapy ◽  
Pregnant Women ◽  
Emotional State ◽  
Life Quality ◽  
Pain Syndrome ◽  
Main Group ◽  
Chronic Pyelonephritis ◽  
Control Group ◽  
Psychoemotional State ◽  
Traditional Drug

Introduction. The presence of somatic diseases during pregnancy leaves a serious imprint on the emotional state of a woman, significantly worsens the quality life indicators and affects the clinical characteristics of pregnancy. One of these diseases is chronic pyelonephritis. There are a fairly large number of recommendations for the treatment of this pathology. However the focus is mainly on drug therapy. At the same time the existing restrictions on the number of drugs using during pregnancy, the problem of polypragmasia, and the increase in the number of allergic complications of drugs using dictate the need to search alternative methods of treatment, primarily non-drug ones. Moreover, the problems of pregnant women life quality with chronic pyelonephritis during complex drug therapy are often not given due attention.The goal of research — to assess the impact of osteopathic correction on the psycho-emotional state and life quality of pregnant women with concomitant pathology of the urinary system.Materials and methods. A prospective controlled randomized study was conducted in the period 03.2016– 01.2018 on the basis of medical clinics of LLC «Mokhov Institute of osteopathy» and LLC «Vasileostrovskaya clinic of reproduction and genetics». There were observed work 48 pregnant women with chronic pyelonephritis aged 25–45 years, with a gestation period 13–27 weeks. During the processing of the clinical material, 8 patients were eliminated. As a result of the selection process, a group of 40 people was formed. All pregnant women with chronic kidney disease, depending on the used treatment method, were divided into two groups using a simple randomization method with a random number generator. There was formed the main group (20 people), and the control group (20 people). Patients of the main group received medication and osteopathic correction (3 procedures with an interval of 7–10 days). Patients in the control group received only traditional drug therapy. All pregnant women with chronic pyelonephritis had an osteopathic examination before and after treatment with forming an osteopathic conclusion, and the assessment of the pain syndrome severity by a visual analog scale (VAS), the general psycho-emotional state (the method of rapid assessment of health, activity and mood — HAM), and the level of life quality (Questionnaire Medical Outcomes Study — Short Form).Results. Pregnant women with chronic pyelonephritis were characterized by a weak pain syndrome, a psychoemotional state violations in the categories «well-being» and «activity», and a decrease in both the physical and mental components of life quality. After the complex treatment including the additional to traditional drug therapy osteopathic correction methods, the statistically significant decrease of the pain severity degree (p=0,001), increase of psychoemotional state rates in the category of «activity» (p=0,05) and the increase of physical and mental components of life quality (p=0,02) were observed in the main group compared with the control.Conclusion. Chronic pathology of the kidneys during pregnancy affects the emotional state of a woman, significantly worsens life quality indicators. The use of osteopathic correction as a part of the complex therapy of pregnant women with chronic pyelonephritis can improve the emotional state and life quality; reduce the pain severity, and so can be used to improve medical care for this population category. 

CLINICAL AND LABORATORY JUSTIFICATION FOR USE OF POLYVALENT BACTERIOPHAGE IN TECHNIQUE OF DELAYED PRESCRIBING OF ANTIBIOTICS IN PATIENTS WITH ARS

2021 ◽  
Vol 74 (6) ◽  
pp. 1445-1450
Author(s):  
Vasyl I. Popovych ◽  
Ivanna V. Koshel ◽  
Mahmoud J. Al Hariri
Keyword(s):  
Staphylococcus Aureus ◽  
Sea Water ◽  
Nasal Congestion ◽  
Bacterial Load ◽  
Intervention Group ◽  
Control Group ◽  
Isotonic Solution ◽  
Haemophilus Influenza ◽  
Acute Rhinosinusitis ◽  
The Third

The aim: Of research was to evaluate the effectiveness of bacteriophage in patients with acute rhinosinusitis in respect of technique of delayed prescribing of antibiotics. Materials and methods: There were examined 155 patients who were given irrigation therapy with isotonic solution of sea water 4 times a day and mometasone furoate of 100 mg twice a day for 10 days. The patients of intervention group (n - 80) were additionally prescribed the polyvalent bacteriophage endonasally, in drops of 2-10 ml 3 times a day. Results: The patients in the control group were observed the decrease in intensity of rhinorrhea, nasal congestion and post-nasal drip on the third day of supervision (p < 0.05), the reduction in bacterial load with Staphylococcus aureus, S. pneumoniae, Haemophilus influenza and M. Catarrhalis (р <0,005), the increase of IgА and sIgA levels (p<0,005) and the reduction in prescription of antibacterial medications by 20%. Conclusions: Adding of polyvalent bacteriophage contributes to reducing the use of antibiotics and is recommended in the framework of the strategy of delayed prescribing of antibiotics.

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