scholarly journals Cutaneous Scalp Metastases from a Left Hallux Subungual Melanoma: An Instructive Case of Scalp Nodules scalp metastases from a left hallux subungual melanoma: An instructive case of scalp nodules

2021 ◽  
Vol 5 (1) ◽  
pp. 51-55
Author(s):  
Llewelyn Yi Chang Tan ◽  
Chee Hian Tan ◽  
Joel Hua Liang Lim
Keyword(s):  
Clinical Presentation ◽  
Asian Population ◽  
The Body ◽  
Superficial Spreading ◽  
Acral Lentiginous Melanoma ◽  
Patient Morbidity ◽  
Scalp Metastasis ◽  
Ethnic Variations ◽  
Instructive Case ◽  
Subungual Melanoma

Melanoma is the most aggressive form of skin cancer affecting patients worldwide and has the potential to metastasize to virtually any organ in the body. Early detection is of paramount importance to minimize patient morbidity and mortality. However, there has been increasing evidence highlighting that geographical and ethnic variations in the clinical presentation of melanoma do exist. Unlike the Western population, the major subtype of melanoma affecting the Asian population is in fact, acral lentiginous melanoma (ALM) and not superficial spreading melanoma (SSM).We hereby present a case of left hallux subungual melanoma with scalp metastasis. This case underscores the importance of the examination of acral skin and the nail apparatus for melanoma in Asians.

scholarly journals Recurrent Thrombotic Vasculopathy in a Former Cocaine User

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Preeti Jadhav ◽  
Hassan Tariq ◽  
Masooma Niazi ◽  
Giovanni Franchin
Keyword(s):  
Clinical Presentation ◽  
Rehabilitation Program ◽  
The Body ◽  
Drug Rehabilitation ◽  
Cocaine User ◽  
Cocaine Use ◽  
The Past ◽  
Urine Toxicology ◽  
History Of ◽  
Infectious Etiology

We report a case of a 35-year-old female who presented to the emergency room (ER) complaining of a pruritic rash involving multiple areas of the body. She had a significant history of cocaine use in the past. She had first developed a similar rash in 2013 when she was diagnosed with cocaine-induced vasculitis. Her urine toxicology had been positive for cocaine in the past until July 2013. She was incarcerated and attended a drug rehabilitation program after which she quit cocaine use, which was consistent with negative urine toxicology on subsequent admissions. Further workup did not reveal any other, autoimmune or infectious, etiology of this clinical presentation. The patient underwent biopsy of the skin lesion that was consistent with thrombotic vasculopathy likely secondary to levamisole.

scholarly journals Tuberculosis in Otorhinolaryngology: Clinical Presentation and Diagnostic Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Rajiv C. Michael ◽  
Joy S. Michael
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Clinical Presentation ◽  
Extrapulmonary Tuberculosis ◽  
Common Type ◽  
The Body ◽  
Diagnostic Challenge ◽  
Cervical Adenitis ◽  
Important Form

Tuberculosis affects all tissues of the body, although some more commonly than the others. Pulmonary tuberculosis is the most common type of tuberculosis accounting for approximately 80% of the tuberculosis cases. Tuberculosis of the otorhinolaryngeal region is one of the rarer forms of extrapulmonary tuberculosis but still poses a significant clinical and diagnostic challenge. Over three years, only five out of 121 patients suspected to have tuberculosis of the otorhinolaryngeal region (cervical adenitis excluded) hadMycobacterium tuberculosisculture-proven disease. Additional 7 had histology-proven tuberculosis. Only one patient had concomitant sputum-positive pulmonary tuberculosis. We look at the various clinical and laboratory aspects of tuberculosis of the otorhinolaryngeal region that would help to diagnose this uncommon but important form of extrapulmonary tuberculosis.

scholarly journals Siblings with Bardet Beidl Syndrome

2013 ◽  
Vol 33 (3) ◽  
pp. 236-238
Author(s):  
Ram Peter ◽  
Priya Jose ◽  
MNG Nair
Keyword(s):  
Clinical Features ◽  
Autosomal Recessive ◽  
Clinical Presentation ◽  
The Body ◽  
Bardet Biedl Syndrome ◽  
Recessive Condition ◽  
Autosomal Recessive Condition

Bardet Biedl syndrome is an autosomal recessive condition affecting many parts of the body. Incidence of BBS is 1 in 100000. Its clinical features varies in person to person though from same family too. We are reporting two siblings with Bardet Beidl syndrome with different clinical presentation. DOI: http://dx.doi.org/10.3126/jnps.v33i3.8081   J. Nepal Paediatr. Soc. 2013;33(3):236-238

scholarly journals Sepsis Associated Encephalopathy

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Neera Chaudhry ◽  
Ashish Kumar Duggal
Keyword(s):  
Critically Ill ◽  
Clinical Presentation ◽  
Neurological Complication ◽  
Symptomatic Treatment ◽  
Endothelial Activation ◽  
The Body ◽  
Brain Inflammation ◽  
Deep Coma ◽  
Critically Ill Patient ◽  
Cns Infection

Sepsis associated encephalopathy (SAE) is a common but poorly understood neurological complication of sepsis. It is characterized by diffuse brain dysfunction secondary to infection elsewhere in the body without overt CNS infection. The pathophysiology of SAE is complex and multifactorial including a number of intertwined mechanisms such as vascular damage, endothelial activation, breakdown of the blood brain barrier, altered brain signaling, brain inflammation, and apoptosis. Clinical presentation of SAE may range from mild symptoms such as malaise and concentration deficits to deep coma. The evaluation of cognitive dysfunction is made difficult by the absence of any specific investigations or biomarkers and the common use of sedation in critically ill patients. SAE thus remains diagnosis of exclusion which can only be made after ruling out other causes of altered mentation in a febrile, critically ill patient by appropriate investigations. In spite of high mortality rate, management of SAE is limited to treatment of the underlying infection and symptomatic treatment for delirium and seizures. It is important to be aware of this condition because SAE may present in early stages of sepsis, even before the diagnostic criteria for sepsis can be met. This review discusses the diagnostic approach to patients with SAE along with its epidemiology, pathophysiology, clinical presentation, and differential diagnosis.

scholarly journals Inguinal ulcerated sebaceous carcinoma: an unusual presentation

2013 ◽  
Vol 88 (6 suppl 1) ◽  
pp. 48-51 ◽  
Author(s):  
David Oschilewski Lucares ◽  
Fred Bernardes Filho ◽  
Hernando Vega ◽  
Bernard Kawa Kac ◽  
Maria Rita Pereira ◽  
...  
Keyword(s):  
Male Patient ◽  
Clinical Manifestation ◽  
Clinical Presentation ◽  
Sebaceous Carcinoma ◽  
The Body ◽  
Skin Tumor ◽  
Diagnostic Challenge ◽  
Elderly Male ◽  
Genital Ulcers ◽  
Clinical Description

Sebaceous carcinoma is a rare and aggressive skin tumor. It can be located in any area of the body, the most commonly involved area being the periorbital region. It does not entail a typical clinical presentation, which explains the often late diagnosis. The aim of this report is to outline the rarity of the disease and its atypical clinical description, since to this day, inguinal ulcers with clinical manifestation have not been reported. We present and discuss a case of sebaceous carcinoma with an unusual clinical presentation, in an elderly male patient. The precise approach to genital ulcers, as shown in this case, is a diagnostic challenge that requires a great deal of effort on the part of the clinician.

scholarly journals Unusual Site for a White Nodule on the Palatine Tonsil: Presentation, Differential Diagnosis, and Discussion

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Ashwag Yagoub Aloyouny
Keyword(s):  
Differential Diagnosis ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Fungal Infections ◽  
The Body ◽  
Palatine Tonsil ◽  
Unusual Site ◽  
Case Presentation ◽  
Lymphoepithelial Cysts ◽  
Malignant Lesions

Introduction. Palatine tonsils are part of the mucosa-associated lymphoid tissue, located in the oropharyngeal region. Although these tissues protect the body from foreign intruders, they are more prone to infections due to their anatomical structure and location. For instance, the differential diagnosis of a white lesion on the palatine tonsil can range from benign to malignant lesions. Oral lymphoepithelial cysts commonly arise as painless, yellowish nodules on the floor of the mouth and the ventral or lateral surface of the tongue. Case Presentation. This paper presents a rare case of an unusual site of a lymphoepithelial cyst (LEC) in the oral cavity. The lesion was located in the tonsil of a 20-year-old woman with a chief complaint of a painless, white lump in the back of the mouth for nine months. Discussion. The differential diagnosis of a white lesion on the palatine tonsil is caused by several factors, such as bacterial, viral, and fungal infections; trauma; stones; cysts; abscess; or cancer. In this case, both the clinical presentation and extra- and intraoral examinations were highly associated with LEC. Oral LEC etiopathogenesis is uncertain, and several theories have been proposed to discuss the causes of LEC. In addition, oral LEC could be monitored without surgical intervention if the nodule is asymptomatic. Conclusion. We emphasize the importance of a thorough clinical examination of oral and oropharyngeal lesions, which are usually neglected.

scholarly journals Assessment of Knowledge about Lefort I Fracture Among Dental Students

2020 ◽  
Vol 11 (SPL3) ◽  
pp. 736-739
Author(s):  
Pravinya ◽  
Dhanraj Ganapathy ◽  
Subhashree Rohinikumar
Keyword(s):  
Traffic Accidents ◽  
Clinical Presentation ◽  
Cerebrospinal Fluid Leak ◽  
Dental Students ◽  
The Body ◽  
Intermaxillary Fixation ◽  
Custom Made ◽  
Maxillofacial Fractures ◽  
The Face ◽  
Facial Area

Fractures of the middle third of the face have increased in number over the past two decades. Trauma to the facial area results in injuries not only to dental structures but also maxillomandibular fractures. In addition, these injuries frequently occur in combination with injuries of other parts of the body. The etiology of these fractures have various causes, such as traffic accidents, falls, assaults, sports, and others. The aim of the study was to assess the knowledge and awareness about LeFort I fracture among undergraduate dental students. A custom made questionnaire comprising of 10 questions to assess the knowledge about LeFort I fracture was formulated and circulated among 100 undergraduate dental students. The responses were then subjected to statistical analysis. Among 100 undergraduate dental students, 52% of them were aware of the types of maxillofacial fractures, and LeFort I fracture is a maxillary fracture, 34% of them have reported that Le Fort I fracture causes disruption of the cribriform plate of the ethmoid bone,35% of them reported that LeFort I fracture might be associated with cerebrospinal fluid leak and 25% of them were still unaware that floating palate is the typical clinical presentation of LeFort I fracture. Also, only 30% were aware that intermaxillary fixation is the management of LeFort I fracture. The present study suggests that among undergraduate dental students, the knowledge about the clinical presentation and the management of LeFort I fracture is inadequate.

Amelanotic subungual melanoma after trauma: An unusual clinical presentation

2011 ◽  
Vol 17 (6) ◽  
Author(s):  
Sophia Rangwala ◽  
Christine Hunt ◽  
Gunjan Modi ◽  
Bhuvaneswari Krishnan ◽  
Ida Orengo
Keyword(s):  
Clinical Presentation ◽  
Subungual Melanoma

scholarly journals Evaluation of brain lesion distribution criteria at disease onset in differentiating MS from NMOSD and MOG-IgG-associated encephalomyelitis

2018 ◽  
Vol 25 (4) ◽  
pp. 585-590 ◽  
Author(s):  
Jae-Won Hyun ◽  
So-Young Huh ◽  
Hyun-June Shin ◽  
Mark Woodhall ◽  
Su-Hyun Kim ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Brain Lesion ◽  
Disease Onset ◽  
Brain Magnetic Resonance Imaging ◽  
Asian Population ◽  
The Body ◽  
Predictive Values ◽  
Mri Scans ◽  
Sensitivity Specificity ◽  
The Brain

Objectives: We aimed to evaluate the utility of the recently described brain lesion distribution criteria to differentiate multiple sclerosis (MS) from aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein immunoglobulin G-associated encephalomyelitis (MOG-EM) at disease onset in an Asian cohort. Methods: A total of 214 patients who fulfilled the published criteria for MS, NMOSD, or MOG-EM and underwent brain magnetic resonance imaging (MRI) within 3 months of disease onset were enrolled. The brain lesion distribution criteria were defined as the presence of a lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe, or an S-shaped U-fiber lesion, or a Dawson’s finger-type lesion. Results: Brain lesions were identified in the initial MRI scans of 166/214 patients. The distribution criteria were applied to these scans (MS ( n = 94), NMOSD ( n = 64), and MOG-EM ( n = 8)). The sensitivity, specificity, and positive and negative predictive values of the criteria for MS versus NMOSD were 79.8%, 87.5%, 90.4%, and 74.7%, and for MS versus MOG-EM these were 79.8%, 100%, 100%, and 29.6%, respectively. Conclusion: These findings suggest that the brain lesion distribution criteria are helpful in distinguishing MS from NMOSD and MOG-EM in an Asian population, even at disease onset.

scholarly journals Primary Amyloidosis of the Genitourinary Tract

2020 ◽  
Author(s):  
Khaleel I. Al-Obaidy ◽  
David J. Grignon
Keyword(s):  
Personal Experience ◽  
Clinical Presentation ◽  
Senior Author ◽  
The Body ◽  
Genitourinary Tract ◽  
Primary Amyloidosis ◽  
Urogenital System ◽  
Organ Function ◽  
Pathologic Findings ◽  
Neoplastic Process

Context.— Amyloidosis is caused by the deposition of misfolded proteins as insoluble eosinophilic material in the extracellular tissues of the body, leading to impairment of organ function. It can be systemic or localized. Localized genitourinary tract amyloidosis is rare and can be incidentally seen; however, in some cases, it can be the only presenting disease. Objective.— To review the clinical presentation and pathologic findings related to primary amyloidosis of the urogenital system and highlight some of the associated pathologic findings based on our personal experience. Data Sources.— Published peer-reviewed literature and personal experience of the senior author. Conclusions.— Primary localized amyloidosis within the urogenital tract can present as a neoplastic process and may be clinically and radiologically considered as a mass. Awareness of primary amyloidosis by pathologists and clinicians is required for accurate diagnosis and proper patient management.

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