scholarly journals Recurrent Thrombotic Vasculopathy in a Former Cocaine User

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Preeti Jadhav ◽  
Hassan Tariq ◽  
Masooma Niazi ◽  
Giovanni Franchin

We report a case of a 35-year-old female who presented to the emergency room (ER) complaining of a pruritic rash involving multiple areas of the body. She had a significant history of cocaine use in the past. She had first developed a similar rash in 2013 when she was diagnosed with cocaine-induced vasculitis. Her urine toxicology had been positive for cocaine in the past until July 2013. She was incarcerated and attended a drug rehabilitation program after which she quit cocaine use, which was consistent with negative urine toxicology on subsequent admissions. Further workup did not reveal any other, autoimmune or infectious, etiology of this clinical presentation. The patient underwent biopsy of the skin lesion that was consistent with thrombotic vasculopathy likely secondary to levamisole.

Somatechnics ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 288-303
Author(s):  
Michael Connors Jackman

This article investigates the ways in which the work of The Body Politic (TBP), the first major lesbian and gay newspaper in Canada, comes to be commemorated in queer publics and how it figures in the memories of those who were involved in producing the paper. In revisiting a critical point in the history of TBP from 1985 when controversy erupted over race and racism within the editorial collective, this discussion considers the role of memory in the reproduction of whiteness and in the rupture of standard narratives about the past. As the controversy continues to haunt contemporary queer activism in Canada, the productive work of memory must be considered an essential aspect of how, when and for what reasons the work of TBP comes to be commemorated. By revisiting the events of 1985 and by sifting through interviews with individuals who contributed to the work of TBP, this article complicates the narrative of TBP as a bluntly racist endeavour whilst questioning the white privilege and racially-charged demands that undergird its commemoration. The work of producing and preserving queer history is a vital means of challenging the intentional and strategic erasure of queer existence, but those who engage in such efforts must remain attentive to the unequal terrain of social relations within which remembering forms its objects.


1995 ◽  
Vol 76 (3) ◽  
pp. 879-882 ◽  
Author(s):  
Jack A. Palmer ◽  
Linda K. Palmer ◽  
David Williamson ◽  
Krista Michiels ◽  
Brian Thigpen

The following factors were examined as possible influences on clients' attrition from inpatient and outpatient drug-rehabilitation programs: depression (Center of Epidemiological Studies–Depression test), attributional style (Attributional Style Questionnaire), primary drug of choice, family incidence of substance abuse, and history of childhood physical abuse. A step-wise regression analysis indicated that a history of childhood abuse was a statistically reliable predictor of program noncompletion for 92 substance abusers who entered a drug-rehabilitation program.


2003 ◽  
Vol 11 (2) ◽  
pp. 122-126 ◽  
Author(s):  
Peter Nyamu ◽  
Mullasari S Ajit ◽  
Peter K Joseph ◽  
Lakshmi Venkitachalam ◽  
Nancy A Sugirtham

Coronary artery ectasia, a variant of coronary atherosclerosis, is a relatively rare entity. Review of literature did not reveal an exclusive study on isolated ectasia. We decided to analyse the clinical presentation and angiographic prevalence of this subset. A retrospective study of patients who underwent coronary angiogram in our institute over the past six years was carried out and the epidemiological, clinical and angiographic characteristics of patients with isolated ectasia were analysed. Distribution of ectasia was with a modification of the Markis classification. Among 6938 angiograms analysed, 134 (2%) had isolated ectasia. Of the 118 symptomatic patients, 34 (25%) had a history of or presented with infarction, with correlation between the territory of infarction and the ectatic vessel in 32 patients. Of 62 patients with lipid abnormality, Hypertriglyceridemia in 42 (65%) was the most common. The left anterior descending artery was the most common vessel involved. Diffuse ectasia most commonly involved the right coronary artery. One patient had spontaneous coronary dissection. There is a relatively high prevalence of isolated coronary ectasia with predominant involvement of the right coronary vessel when diffuse and the left anterior descending artery when discrete. This entity is not innocuous and warrants a detailed study on the available management options.


2018 ◽  
Vol 53 (4) ◽  
pp. 352 ◽  
Author(s):  
M. PERRAKI (Μ. ΠΕΡΡΑΚΗ) ◽  
M. SARIDOMICHELAKIS (Μ. ΣΑΡΙΔΟΜΙΧΕΛΑΚΗΣ) ◽  
C. KOUTINAS (X. ΚΟΥΤΙΝΑΣ) ◽  
A. KOUTINAS (Α. ΚΟΥΤΙΝΑΣ) ◽  
M. PAPAZACHARIADOU (Μ. ΠΑΠΑΖΑΧΑΡΙΑΔΟΥ)

A male, peruvian, 1.5-years old, guinea pig {Cavia porcellus) was admitted to the Clinic of Companion Animal Medicine with a history of intensively pruritic skin lesions lasting for the past two months. Physical examination disclosed hypotrichosis, erythema, hyperpigmentation, scales, crusts, ulcers and papules in a focal to diffuse pattern on both the dorsal and ventral aspects of the body trunk. Whenever the handling of the animal was attempted, it started vocalizing, cycling and rolling in a frenzy manner. Pruritic papules were also observed on some parts of the glabrous skin of the owner. The diagnosis of Trixacarus caviae mange was based on the observation of the parasite in superficial skin scrapings. The subcutaneous administration of three weekly ivermectin injections, at the dose of 0.4 mg/Kg BW, resulted in the disappearance of the lesions and pruritus within a six-week period.


Author(s):  
Monica Green

Given the comparatively slow pace of human evolution, the body, as a biological entity, may be taken more or less as a historical constant during the past 1500 years. But every interaction with that body was mediated by culture, and thus gender analysis is a driving force in the expanding field of the history of health. This essay looks at how changing expectations of gender and knowledge shaped medical and surgical interventions in three circumstances: pregnancy; childbirth emergencies; and the care of intersexed persons. The field of the history of health is still rapidly expanding, and the perspectives of gender analysis are a major part of what is driving that expansion forward.


2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
G Garzoli ◽  
L Biasco ◽  
D Radovanovic ◽  
G Pedrazzini

Abstract Introduction The aim of this study is to evaluate the cardiovascular impact of cocaine in a population of patients enrolled in the Swiss nationwide AMIS Plus registry with a focus on in-hospital outcomes. Methods We retrospectively analysed data of patients enrolled in the Swiss AMIS Plus registry from 2007 to 2018. Baseline and in-hospital data of patients with ACS and cocaine use were compared with the remaining AMIS population as well as to a sex and aged matched ACS patients (1:5 ratio, 540 patients) without history of cocaine consumption. Primary endpoints were death and major adverse cardiac and cardiovascular events (MACCE). Results A total of 20'981 patients had been included in the AMIS Plus registry for ACS in the study period, of them 110 (0.5%) were cocaine user. As compared to the remaining AMIS population, cocaine abusers were significantly younger (46.4±10.8 vs 66.4±13.2 years; p<0.001), presented more frequently with out of hospital cardiac arrest (11.8% vs 4.7%, p<0.001) and STEMI (68,2% vs 54.7%, p=0.007). Apart from active smoke and family history, had a lower burden of CV risk factors. In hospital mortality (3.6% vs 4.4%; p=1) and MACCE (5.4% vs 5.5%; p=0.83) were comparable. When compared to the age matched ACS population without history of cocaine consumption, cocaine abusers were more frequently smokers (87.6% vs 63.6%, p<0.001) but less frequently obese (10.4% vs 25.6%, p=0,001). Clinical presentation was comparable among the two groups, nonetheless cocaine abuse was associated with a higher incidence of death (3.7% vs 0.7%, p<0.05) and MACCE (5.6% vs 1.3%, p<0.05). Conclusion This analysis presents the largest series of cocaine associated ACS available in literature. Cocaine abuse increases by 5 the risk of mortality and by 4 the risk of MACCE as compared to an age matched ACS population. No differences where observed in outcomes when compared to a 20 years older population.


2020 ◽  
Vol 16 (1) ◽  
Author(s):  
Dalis Collins ◽  
Brian Simons

Abstract Background Polyglactin 910 is a synthetic braided, absorbable suture commonly used in surgery. Though polyglactin 910 suture-related pseudoinfection is well documented in the human literature, it has not been previously reported in the veterinary literature. Case description A 3-year-old female, ovariectomized but otherwise experimentally naïve Yucatan pig was evaluated for a several week history of bilateral multifocal abscesses in the area of the paralumbar fossa, which continued to worsen despite oral antibiotics and non-steroidal anti-inflammatory medications. The multi-focal abscesses continued to worsen and additional diagnostics were pursued including cytology, culture (aerobic, anaerobic and fungal), and bloodwork. All supported a non-infectious etiology. Biopsy results indicated a suture-related pseudoinfection. Despite treatment including parenteral antibiotics, pain medications and superficial surgical debridement, the dermatologic lesions worsened. Euthanasia was elected. Post-mortem necropsy demonstrated a suture-related pseudoinfection with extrusion of suture material from the ovarian pedicle ligatures through the body wall and skin leading to numerous sterile abscesses in the bilateral paralumbar fossa. Conclusions This is the first published report of a significantly delayed polyglactin 910 suture-related pseudoinfection in a Yucatan pig. While likely an isolated incident, it supports further research into this area. Additionally for critical research studies using Yucatan pigs, pre-surgical assessment with hypersensitivity patch testing may be appropriate.


Author(s):  
Charlotte A. Roberts

Leprosy is an infection and neglected tropical disease that is steeped in myths, and, although it is described in history books, it can remain a challenge to manage today. Written in an accessible manner for professionals and the public alike, this book takes a global view of leprosy past and present. As a backdrop, it starts with exploring what we actually know about leprosy from medicine, how it is spread to humans, and its effects on the body. It then moves to consider its diagnosis and treatment in people, past and present. The focus switches next to the ways in which leprosy is diagnosed in skeletons (paleopathology), from just looking at the bones to analyzing the DNA of the bacteria preserved in the bones. By doing so, information on skeletons with evidence of leprosy across the globe is synthesized with the aim of considering the current state of global knowledge regarding the origin, evolution, and history of leprosy. In particular, the book explores how all the people diagnosed with leprosy in their skeletons in the past were buried, and the myth that everybody was ostracized and segregated into leprosy hospitals, due to stigma, is dismissed. It concludes with thoughts on a future for leprosy, the need to continue to dispel its myths and to seriously reconsider the use of the word “leper” when discussing leprosy today and in the past.


2012 ◽  
Vol 12 (2) ◽  
pp. 72-80 ◽  
Author(s):  
Jack Anderson

AbstractIn 2012 London becomes the first city to host an Olympics for the third time. The contrast between the Games of 2012 and those of 1908 and 1948 could not be starker and form a background to some of the matters discussed in this short piece. Central to the discussion is the contention that the development of the body of law now known as sports law is related to the accelerated commercialisation of sport during the past century. In short, the business of modern sport is exactly that – a business; indeed, sport is now a global industry and the commodification of sport will be seen to an exaggerated effect in London throughout the summer of 2012. Accordingly, this article by Jack Anderson begins by giving an outline of the financial robustness of modern sport, epitomised by the Olympics, before presenting a brief history of the evolution of sports law. Thereafter various issues in contemporary sports law are identified and discussed. The conclusion attempts to bring all of these themes together in order to give an overview of the area as a discrete, vibrant, if still emerging, discipline of law.


2009 ◽  
Vol 17 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Pascale Casanova

One of the most difficult and uncertain areas of research offered the historian of literature today is the attempt to define ‘European literature’ as a corpus and an object of literary and/or historical analysis. The various efforts of the past few years – in the form of anthologies as well as histories of literature – usually remain torn between a unitary presupposition that seems to be the only acceptable political-historical way of justifying the body of European literature and an irreducibly composite – not to say heterogeneous – reality that is not amenable to the representations of Europe as reduced to this superficial unity. If we are to reflect on the modalities and specificities of such a historical undertaking – which has so few equivalents in the world that it is all the harder to model – and shake off political models and representations, it seems to me that we need to work from another hypothesis. One of the few trans-historical features that constitutes Europe, in effect, one of the only forms of both political and cultural unity – one that is paradoxical but genuine – that makes of Europe a coherent whole, is none other than the conflicts3 and competitions that pitted Europe’s national literary spaces against one another in relentless and ongoing rivalry. Starting from this hypothesis, we would then have to postulate that, contrary to commonly accepted political representations, the only possible literary history of Europe would be the story of the rivalries, struggles and power relations between these national literatures. As a consequence, rather than a unity that remains if not problematic at least far from being achieved, it would no doubt be better to speak of an ongoing literary unification of Europe, in other words a process that occurs, occurred and is still occurring – paradoxically – through these struggles. This upside-down history would trace the models and counter-models, the powers and dependences, the impositions and the resistances, the linguistic rivalries, the literary devices and genres regarded as weapons in these specific, perpetual and merciless struggles. It would be the history of literary antagonisms, battles and revolts.


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