scholarly journals Evaluation of Aphrodisiac Activity of Buchanania axillaris (Linn.) Leaves

2017 ◽  
Vol 9 (2) ◽  
Author(s):  
Neeruganti Dora Babu ◽  
Battu Ganga Rao ◽  
Devarakonda Ramadevi
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Methanolic Extract ◽  
Mating Behaviour ◽  
Male Rats ◽  
Albino Rats ◽  
Normal Male ◽  
Methanolic Extracts ◽  
Intromission Frequency ◽  
Mating Performance

The study was aimed at investigate the effect of methanolic extract of Buchanania axillaris linn. (Anacardiaceae) on general mating behaviour, libido, and adverse effects on sexually normal male albino rats. Methanolic extract was administered orally at the dose of 100, 200, and 400 mg / kg, to different groups of male rats (n = 8) once a day for 14 days. All the doses resulted in significant increase in mount frequency, intromission frequency and anogenital sniffing when compared to normal. The methanolic extract of Buchanania axillaris leaves at higher concentration (400 mg/kg body weight) showed significant aphrodisiac activity on male Wister albino rats as evidenced by an increase in number of mounts and mating performance. Thus, in experimental rats, the results of the present study suggest that the methanolic extracts of Buchanania axillaris exert significant aphrodisiac activity

Evaluation of Aphrodisiac Activity of Phaseolus semierectus (L.)Seeds

2017 ◽  
Vol 9 (01) ◽  
Author(s):  
Neerugatti Dorababu ◽  
Battu Ganga Rao ◽  
Devarakonda Ramadevi
Keyword(s):  
Body Weight ◽  
Adverse Effects ◽  
Methanolic Extract ◽  
Mating Behaviour ◽  
Male Rats ◽  
Albino Rats ◽  
Normal Male ◽  
Methanolic Extracts ◽  
Intromission Frequency ◽  
Mating Performance

The study was aimed at investigate the effect of methanolic extract of Phaseolus semierectus(L.) (Leguminosae) on general mating behaviour, libido, and adverse effects on sexually normal male albino rats. Methanolic extract was administered orally at the dose of 100, 200, and 400 mg / kg, to different groups of male rats (n = 8) once a day for 14 days. All the doses resulted in significant increase in mount frequency, intromission frequency and anogenital sniffing when compared to normal. The methanolic extract of Phaseolus semierectus (L.) seeds at higher concentration (400 mg/kg body weight) showed significant aphrodisiac activity on male Wister albino rats as evidenced by an increase in number of mounts and mating performance. Thus, in experimental rats, the results of the present study suggest that the methanolic extracts of Phaseolus semierectus (L.) exert significant aphrodisiac activity.

Screening of Antidiabetic Activity of Extract and Fraction of Biophytum sensitivum in Rats Using STZ-Nicotinamide Induced Diabetes Model

2017 ◽  
Vol 9 (03) ◽  
Author(s):  
Manisha . ◽  
Kumar Suresh
Keyword(s):  
Methanolic Extract ◽  
Mating Behaviour ◽  
Male Rats ◽  
Antidiabetic Activity ◽  
Albino Rats ◽  
Normal Male ◽  
Methanolic Extracts ◽  
Diabetes Model ◽  
Intromission Frequency ◽  
Mating Performance

The study was aimed at investigate the effect of methanolic extract of Phaseolus semierectus(L.) (Leguminosae) on general mating behaviour, libido, and adverse effects on sexually normal male albino rats. Methanolic extract was administered orally at the dose of 100, 200, and 400 mg / kg, to different groups of male rats (n = 8) once a day for 14 days. All the doses resulted in significant increase in mount frequency, intromission frequency and anogenital sniffing when compared to normal. The methanolic extract of Phaseolus semierectus (L.) seeds at higher concentration (400 mg/kg body weight) showed significant aphrodisiac activity on male Wister albino rats as evidenced by an increase in number of mounts and mating performance. Thus, in experimental rats, the results of the present study suggest that the methanolic extracts of Phaseolus semierectus (L.) exert significant aphrodisiac activity.

scholarly journals Bees' Honey Protects the Liver of Male Rats against Melamine Toxicity

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Haddad A. El Rabey ◽  
Madeha N. Al-Seeni ◽  
Suad M. Al-Solamy
Keyword(s):  
Alkaline Phosphatase ◽  
Body Weight ◽  
Adverse Effects ◽  
Protective Effect ◽  
Positive Impact ◽  
Male Rats ◽  
Albino Rats ◽  
Serum Total Protein ◽  
Histological Changes ◽  
Liver Functions

The protective effect of natural bees' honey to the liver of male albino rats against melamine toxicity was studied. Melamine supplementation at a dose of 20000 ppm in the diet for 28 days induced adverse effects on the liver, decreased serum total protein and increased liver enzyme: alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase. Histological changes of the melamine supplemented group showed necrosis in the hepatic tissues around the central veins of the liver and precipitation of melamine crystals. Treating the male albino rats (that were presupplemented regularly with 20000 ppm melamine) with natural bees' honey at a dose of 2.5 g/kg body weight for 28 days improved both liver functions and increased serum protein. In addition, a positive impact on the shape of the cells after treatment with honey compared to the positive melamine supplemented group was observed. In conclusion, the results of this study revealed that the use of natural bees' honey has the ability to protect the liver of rats against the toxic effects of melamine.

scholarly journals Anti-arthritic Evaluation of Different Extracts of Boerhaavia diffusa Linn. in FCA Induced Arthritis In Rats

2018 ◽  
Vol 8 (5-s) ◽  
pp. 388-393 ◽  
Author(s):  
Deepika Parmar ◽  
Neetesh Kumar Jain ◽  
Vivek Tomar
Keyword(s):  
Body Weight ◽  
Phenolic Compounds ◽  
Methanolic Extract ◽  
Hematological Parameters ◽  
Extraction Methods ◽  
The Body ◽  
Haematological Parameters ◽  
Phytochemical Study ◽  
Methanolic Extracts ◽  
Boerhaavia Diffusa

The main aim of study is to evaluate the anti-arthritic effect of different extracts of Boerhaavia diffusa in arthritic rats. Different extracts were prepared by successive solvent extraction methods by using the various polar and non polar solvents and their % yields were calculated. Arthritis was induced by FCA induced arthritis model in rats and paw volume was measured on different days. Body weights of all animals were also measured simultaneously and at the end of experiment some haematological parameters were measured. On preliminary phytochemical studies extracts showed the presence of alkaloids, fatty acids, terpenoids, flavonoids and phenolic compounds. Among all extracts, methanolic extract significantly decreased the paw volume in all treated groups. Methanolic extracts also restored the body weight significantly. The results of our study revealed that all the extracts treated group’s causes significant alterations in the hematological parameters and maximal effects were observed at 400 mg/kg. Since methanolic extract showed best activity in arthritic model and its phytochemical study showed presence of flavonoids and phenolic compounds, so it may be possible that anti-arthritic activity of root extracts may be due to presence flavonoids.  Keywords: Arthritis, FCA induced arthritis, Boerhaavia diffusa, haematological parameters, and Body weight

scholarly journals Biochemical and histological changes in liver and kidney in male Wistar albino rats following exposure to Solignum®: a permethrincontaining wood preservative

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Kingsley C. Patrick-Iwuanyanwu ◽  
Iniobong A. Charles
Keyword(s):  
Body Weight ◽  
Chronic Exposure ◽  
Histopathological Examination ◽  
Wood Preservative ◽  
Inflammatory Cells ◽  
Male Rats ◽  
Albino Rats ◽  
Dependent Manner ◽  
Histological Changes ◽  
Wistar Albino Rats

The present investigation was aimed to determine the effect of sub-chronic exposure to Solignum<sup>®</sup>, a permethrin-containing wood preservative on biochemical and histological changes in liver and kidneys of male Wistar albino rats. Thirty-two male rats were randomly divided into four groups: control and three treatment concentrations containing 8 rats each. The treatment groups were exposed to Solignum<sup>®</sup> at dose rates of 100, 200 and 400 mg/kg body weight (BW) respectively per day orally for four weeks. Data obtained from the study showed a progressive increase in the body weight of rats in control whereas, rats treated with different concentrations (100, 200 and 400 mg/kg BW) of Solignum<sup>®</sup> decreased significantly (≤0.05) especially at the end of the second and fourth week when compared with control. On the other hand, there was a significant decrease in the relative liver weights of rats treated with 100 and 200 mg/kg BW Solignum<sup>®</sup> while rats treated with 400 mg/kg BW showed a significant increase when compared with control. The relative weight of kidneys in experimental groups increased significantly when compared with control. Biochemical analysis results illustrated that there was a significant increase in marker enzymes namely alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity at the end of the fourth week. Similarly, total bilirubin, serum urea, creatinine and electrolytes (Na<sup>+</sup>, K<sup>+</sup> and Cl<sup>-</sup>) levels increased in a dose dependent manner in treated rats when compared with untreated control group. Serum total protein decreased significantly in experimental rats when compared with control. However, cholesterol and triglycerides showed no significant difference when compared with control. Histopathological examination of hepatocytes in treated rats was characterized by mild periportal inflammatory cells and cytoplasmic degeneration. Furthermore, histopathological examination of rat kidneys revealed inflammatory cells, congested vessel and interstitial hemorrhage in rats treated with Solignum<sup>®</sup>. Therefore, this present study is aimed to evaluate the hepatotoxic and nephrotoxic potentials associated with sub-chronic exposure to the commercial pesticide Solignum<sup>®</sup>.

scholarly journals Aphrodisiac property of aqueous and methanolic extracts of Raphia vinifera (Arecaceae) in sexually experienced male rats

2019 ◽  
Author(s):  
Pierre Watcho ◽  
Fred Lih ◽  
Patrick Brice Defo Deeh ◽  
Modeste Wankeu-Nya ◽  
Esther Ngadjui ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
Sildenafil Citrate ◽  
Male Rats ◽  
Total Proteins ◽  
Methanolic Extracts ◽  
Experienced Male ◽  
Intromission Latency ◽  
Copulatory Activity ◽  
Male Wistar Rats ◽  
Biochemical Analyses

Background: Raphia vinifera (Arecaceae) is a medicinal plant commonly used as a sexual enhancer. Objective: To investigate the aphrodisiac potential of aqueous extract (AE) and methanolic extract (ME) of R. vinifera in sexually experienced male rats. Materials and Methods: Thirty male Wistar rats were randomly distributed into six groups (5 rats per group) and administered for 14 days with distilled water (10 ml/kg), sildenafil citrate (1.44 mg/kg), and AE or ME of R. vinifera (100 or 500 mg/kg). The copulatory activity was tested on days 0, 7, and 14 using receptive females. Further, on day 14, rats were sacrificed and biochemical analyses (testosterone, total protein, and acid phosphatase) were performed. Results: Sildenafil citrate significantly decreased the intromission latency (day 14, p = 0.04) and frequency (days 7 and 14, p = 0.03) but increased the mount frequency (day 14, p = 0.04), compared with control. Remarkably, R. vinifera enhanced the sexual activity by significantly decreasing the intromission latency (AE and ME, 500 mg/kg, day 14, p = 0.04) and increasing the mount frequency (AE and ME, 100 mg/kg, day 7, p = 0.02) compared with control. Moreover, R. vinifera improved plasmatic (AE, 100 mg/kg, p = 0.03; AE, 500 mg/kg, p = 0.001; ME, 100 mg/kg, p = 0.01) and testicular (AE, 100 mg/kg, p = 0.001; AE, 500 mg/kg, p = 0.01; ME, 100 mg/kg, p = 0.001; ME, 500 mg/kg, p = 0.01) testosterone levels as well as plasmatic total proteins concentration (ME, 500 mg/kg, p = 0.04). Conclusion: These findings showed that R. vinifera possesses an aphrodisiac property which could further justify its folkloric use in traditional medicine as a sexual enhancer.

Diuretic activity of ethanol extract of Mirabilis jalapa (Linn.) leaf in normal male Wistar rats

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Musa T. Yakubu ◽  
Adenike M Oyagoke ◽  
Luqman A. Quadri ◽  
Anthonia O. Agboola ◽  
Hussein O.B. Oloyede
Keyword(s):  
Body Weight ◽  
Carbonic Anhydrase ◽  
Urine Volume ◽  
Ethanol Extract ◽  
The Body ◽  
Male Rats ◽  
Normal Male ◽  
Diuretic Activity ◽  
Urine Ph ◽  
Mirabilis Jalapa

Background: Ethanol extract of Mirabilis jalapa leaf (EEMJL) has been used in the folk medicine of Nigeria as diuretics without any scientific evidence.Aim: Ethanol extract of Mirabilis jalapa leaf at 200, 400 and 600 mg/kg body weight was investigated for diuretic activity in male Wistar rats.Setting: Fresh leaf of M. jalapa was collected from a farmland at the Alanamu area in Ilorin, Kwara State, Nigeria, authenticated and processed for the study.Methods: Thirty male rats (231.50 g ± 13.51 g) were assigned into five groups (A–E) of six rats each. Rats in group A (control) received 1.0 mL of physiological saline (the vehicle). Animals in groups B (positive control), C, D and E received 1.0 mL equivalent to 100 mg/kg body weight of furosemide, 200, 400 and 600 mg/kg body weight of EEMJL, respectively. All administrations were done by oral gavage. The animals were monitored for indicators of diuresis for 5 h using standard methods.Results: Ethanol extract of Mirabilis jalapa leaf dose-dependently increased (p < 0.05) urine volume, urine concentrations of Na+, K+ and Cl− and decreased (p < 0.05) the body weight of the animals. Ethanol extract of Mirabilis jalapa leaf increased the urine pH, saliuretic activity, saliuretic index, Na+ index, K+ index, Cl− index, diuretic action (diuretic index), kaliuretic index, Lipschitz value and percentage saline load excreted, whereas the latency of urination, natriuretic index, carbonic anhydrase inhibitory activity and carbonic anhydrase inhibition index were decreased. The EEMJL treatment-related changes in these parameters were essentially similar to those of the furosemide-treated animals.Conclusion: This study has thus validated diuretic activity of M. jalapa leaf with the 600 mg/kg body weight of EEMJL being the most effective.

The anti-diabetic effect of some plant extracts against Streptozotocin - induced diabetes type 2 in male albino rats.

2020 ◽  
Vol 20 ◽  
Author(s):  
Heba F. Gomaa ◽  
Imen Ben Abdelmalek ◽  
Khaled G. Abdel-Wahhab
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Total Cholesterol ◽  
Plant Extracts ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Male Rats ◽  
Postprandial Blood Glucose ◽  
Albino Rats

Background: One of the widely spread disorders is Diabetes mellitus, especially type 2 (T2DM). T2DM is attributed to the change in life style and stress. A possible strategy to block dietary carbohydrate absorption, is regulation of postprandial blood glucose level as well, the use of some natural plant extracts with inhibitory effect against carbohydrate digestive enzymes such as alpha-amylase and fewer side effects than synthetic drugs. This study was conducted to investigate the anti-diabetic effect of Cinnamon and Saussurea extract, individually, on blood glucose, lipid profile, insulin, interleukin1-beta and weight loss in diabetic rats treated with Streptozotocin (STZ). Methods: The experiment was performed on 60 Wistar male rats, the experimental study include 6 groups (10 rats each): (I) normal rats, (II) Streptozotocin- induced diabetic rats, (III) normal rats orally received (200 mg/kg/day) Saussurea ethanolic extract (SEE) for consecutive 4 weeks, (IV) normal rats orally received (100mg/kg/day) Cinnamon aqueous extract (CAE) for consecutive 4 weeks, (V) Streptozotocin –treated rats received SEE orally (200mg /kg/ day) for consecutive 4 weeks, and (VI) Streptozotocin –treated rats received CAE orally (100mg /kg/ day) for consecutive 4 weeks. Results: The results of the following study revealed that SEE has more anti-diabetic effect against Streptozotocin treatment than CAE due to the high α-amylase inhibition potential and higher phenolic content, Also, GC-MS analysis of SEE exhibited higher concentrations of phenolic compounds such as : dehydrocostus lactone, azuleno, eicosa-pentaenoic acid and linoelaidic acid that revealed anti-diabetic, anti-lipidemic and anti-inflammatory activities, while CAE showed presence of cinnamic and quinic acids. Injection of STZ resulted in a decline in the insulin, high density lipoprotein and body weight values matched with increase of glucose, total cholesterol, LDL-Cholesterol, triglycerides and interleukin1- β (IL-1β). The administration of extracts of SEE and CAE into STZ-treated rats separately resulted in a decline in the elevated levels of blood glucose, total cholesterol, triglycerides and improving serum HDL-Cholesterol and body weight. Conclusion: Both tested herbal extracts performed anti-diabetic effect that mainly could be mechanized via the α-amylaseinhibitory potentials due to the high phenolic and flavonoids content.

Analgesic Activity of Tragia involucrata

1970 ◽  
Vol 4 (1) ◽  
Author(s):  
M Alimuzzaman ◽  
Muniruddin Ahmed
Keyword(s):  
Body Weight ◽  
Acetic Acid ◽  
Oral Dose ◽  
Ethyl Acetate ◽  
Analgesic Activity ◽  
Methanolic Extract ◽  
Radiant Heat ◽  
Tail Flick ◽  
Methanolic Extracts ◽  
Whole Plant

The work was carried out to investigate the analgesic activity of the whole plant of Tragia involucrata Linn. The dried whole plant was successively extracted with petroleum ether, ethyl acetate and methanol. Experiments were carried out with these extracts for their peripheral and central antinociceptive potentials on acetic acid induced writhing and radiant heat tail-flick models in mice, respectively. Both the ethyl acetate and methanolic extracts showed significant writhing inhibition while the elongation of tail-flick time was most prominent with methanolic extract at an oral dose of 500 mg/kg body weight. Key words: Tragia involucrata, Analgesic activity, Acetic acid induced writhing, Radiant heat tail-flick. Dhaka Univ. J. Pharm. Sci. Vol.4(1) 2005 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Actions of Diethylstilbestrol in the Albino Rat

1957 ◽  
Vol 190 (2) ◽  
pp. 255-258 ◽  
Author(s):  
E. W. Hartsook ◽  
N. D. Magruder
Keyword(s):  
Body Weight ◽  
Feed Efficiency ◽  
Body Weight Gain ◽  
Albino Rats ◽  
Normal Male ◽  
Albino Rat ◽  
Feeding Technique ◽  
Testes Size ◽  
Ad Libitum ◽  
Ad Libitum Feeding

Four experiments were conducted utilizing either weanling or young adult normal male albino rats. These animals were fed either stock diets or semi-synthetic diets, containing either 0, 0.15, 0.3, 0.6 or 2.4 µg of diethylstilbestrol/gm, either by the trio or ad libitum feeding technique for periods of 6–15 weeks. It is concluded that diethylstilbestrol feeding in the albino rat induces statistically significant decreases in body weight gain, feed efficiency, body length, and testes size; it induces statistically significant increases in basal metabolic rate and in pituitary, thyroid and adrenal sizes.

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