scholarly journals Spinal intramedullary tuberculoma in a 3-year-old girl

2021 ◽  
Vol 12 ◽  
pp. 609
Author(s):  
Raj Swaroop Lavadi ◽  
B. V. Sandeep ◽  
Manpreet Singh Banga ◽  
Sangamesh Halhalli ◽  
Anantha Kishan
Keyword(s):  
Complete Resolution ◽  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Combined Treatment ◽  
Tubercular Meningitis ◽  
Pediatric Age Group ◽  
Intramedullary Lesion ◽  
Antitubercular Treatment ◽  
Rare Manifestation ◽  
Difficulty Walking

Background: Spinal intramedullary tuberculoma (IMT) is a rare manifestation of extrapulmonary tuberculosis (TB). Presentation of TB in the pediatric age group is a significant contributor to mortality. Case Description: A young vaccinated girl presented to the neurosurgery department with difficulty walking and urinary incontinence. A magnetic resonance imaging performed outside the hospital showed a hyperintense intramedullary lesion extending from T6 to T9. The patient underwent T6–T9 laminoplasty with intramedullary lesion decompression under neuromonitoring. The dense adherence of the lesion to the cord and nerve roots permitted only debulking. Histopathological examination confirmed the diagnosis of tuberculoma. The patient was started on antitubercular treatment and was then subsequently discharged. After 8 months, the patient was reviewed and showed improvement in her symptoms and complete resolution of the lesion on imaging. The patient has now developed hydrocephalus on the latest computed tomography imaging, which may be due to tubercular meningitis or arachnoiditis. Conclusion: Complete resolution of spinal IMT is possible with a combined treatment approach.

Thoracic intramedullary arachnoid cyst in an infant

2009 ◽  
Vol 3 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Fabian Medved ◽  
Marcel Seiz ◽  
Marc-Oliver Baur ◽  
Eva Neumaier-Probst ◽  
Jochen Tuettenberg
Keyword(s):  
Arachnoid Cyst ◽  
Complete Resolution ◽  
Cystic Lesion ◽  
Histopathological Examination ◽  
Cord Compression ◽  
Age Group ◽  
Resonance Imaging ◽  
Postoperative Course ◽  
Sudden Loss ◽  
Intramedullary Lesion

Symptomatic intramedullary arachnoid cysts are rare, especially in children; these lesions are rarely described as a cause of spinal cord compression in this age group. The authors report on an 18-month-old boy who experienced a sudden loss of his ability to stand and walk due to a paraparesis. Magnetic resonance imaging of the spine exhibited a cystic intramedullary lesion at the level of T5–6. A hemilaminectomy was performed, and after myelotomy the cystic lesion was decompressed by fenestration to the subarachnoid space. The histopathological examination verified the diagnosis of an arachnoid cyst. In the postoperative course the boy experienced complete resolution of the initial paraparesis.

scholarly journals Diffuse leptomeningeal glioneuronal tumor with high-grade features masquerading as tubercular meningitis—a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Sameer Peer ◽  
Vivek Murumkar ◽  
Karthik Kulanthaivelu ◽  
Chandrajit Prasad ◽  
Shilpa Rao ◽  
...  
Keyword(s):  
Case Report ◽  
Early Diagnosis ◽  
Histopathological Examination ◽  
Glioneuronal Tumor ◽  
Communicating Hydrocephalus ◽  
High Grade ◽  
Endemic Region ◽  
Tubercular Meningitis ◽  
Leptomeningeal Enhancement ◽  
Diffuse Leptomeningeal Glioneuronal Tumor

Abstract Background Diffuse leptomeningeal glioneuronal tumor (DLGNT) has been recently described in the literature. The complete neuroimaging spectrum and histopathological characteristics of this entity are yet to be elucidated. In an endemic region, diffuse leptomeningeal enhancement on neuroimaging with associated communicating hydrocephalus is usually suggestive of infective meningitis and the patients are started on empirical anti-microbial therapy. However, it is important to consider other differential diagnosis of leptomeningeal enhancement in such cases, particularly if the clinical condition does not improve on anti-microbial therapy. An early diagnosis of a neoplastic etiology may be of particular importance as the treatment regimens vary considerably depending on the underlying disease condition. Case presentation In this case report, we describe a case of DLGNT with high-grade histopathological features which was initially managed as tubercular meningitis based on the initial neuroimaging findings. Due to worsening of the clinical course and subsequent imaging findings at follow-up, a diagnosis of DLGNT was considered and subsequently proven to be DLGNT with features of anaplasia on histopathological examination of leptomeningeal biopsy specimen. Conclusion This case highlights the importance of recognizing certain subtle finding on MRI which may help in an early diagnosis of DLGNT which is crucial for appropriate treatment.

scholarly journals Effects of electrochemotherapy with cisplatin and peritumoral IL-12 gene electrotransfer on canine mast cell tumors: a histopathologic and immunohistochemical study

2017 ◽  
Vol 51 (3) ◽  
pp. 286-294 ◽  
Author(s):  
Claudia Salvadori ◽  
Tanja Svara ◽  
Guido Rocchigiani ◽  
Francesca Millanta ◽  
Darja Pavlin ◽  
...  
Keyword(s):  
Mast Cell ◽  
T Lymphocytes ◽  
Mhc Class Ii ◽  
Cellular Response ◽  
Histopathological Examination ◽  
Combined Treatment ◽  
Gene Electrotransfer ◽  
Neoplastic Cells ◽  
Ki 67 ◽  
Mast Cell Tumors

AbstractBackgroundThe study was aimed to characterize tumor response after combined treatment employing electrochemotherapy with IL-12 gene electrotransfer in dogs with spontaneous mast cell tumors (MCT).Materials and methodsEleven dogs with eleven MCTswere included in the study. Histological changes were investigated in biopsy specimens collected before the treatment (T0), and 4 (T1) and 8 weeks (T2) later. Cellular infiltrates were characterized immunohistochemically by using anti CD3, CD20, Foxp3 (Treg), CD68 and anti MHC-class II antibodies. Proliferation and anti-apoptotic activity of neoplastic cells were assessed using anti Ki-67 and Bcl-2 antibodies. Angiogenetic processes were investigated immunohistochemically by using anti Factor VIII and anti CD31 antibodies and micro vessel density quantification.ResultsHistopathological examination of samples at T0confirmed the diagnosis and the presence of scanty infiltrates consisted mainly of T-lymphocytes and macrophages. At T1and T2neoplastic cells were drastically reduced in 7/11 cases, small clusters of neoplastic cells were detected in 3/11 cases and 1/11 cases neoplastic cells were still evident. Proliferation activity of neoplastic cells was significantly reduced at T1and T2and expression of anti-apoptotic protein at T1. Microvessel density was drastically reduced in all samples after treatment. The number of T-lymphocytes increased at T1, although not significant, while Treg were significant higher at T1and macrophages at T2.ConclusionsThe combined electrochemotherapy and IL-12 gene electrotransfer effectively induced a cellular response against neoplastic cells characterized mainly by the recruitment of T-lymphocytes and macrophages and a fibrotic proliferation with reduction of microvessels.

scholarly journals Solitary Schwannoma on the Hypothenar Region of the Hand: A Literature Review

2020 ◽  
Vol 5 (10) ◽  
pp. 449-452
Author(s):  
Kastanis G ◽  
Kapsetakis P ◽  
Magarakis G ◽  
Bachlitzanaki M ◽  
Christoforidis C ◽  
...  
Keyword(s):  
Literature Review ◽  
Clinical Diagnosis ◽  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Final Diagnosis ◽  
Benign Tumors ◽  
Rare Manifestation ◽  
Histopathological Evidence ◽  
Volar Surface

Schwannomas or neurilemmomas are the most common benign tumors of the neural sheaths of the peripheral nerves. Incidence of these tumors in the hand accounts to 0.8-2%. The majority of them appear as an isolated grown mass along the route of the nerves. Peripheral nerves benign tumors present many difficulties concerning the clinical diagnosis and only histopathological evidence provides the final diagnosis. In this case study, we present a 45 year old man with a grown asymptomatic mass on the volar surface of right hand (hypothenar) remained for two years and impinging the skin of the hand only the last months. Initial MRI results diagnosed the mass as gaglion cyst. Histopathological examination revealed a schwannoma. We present this case as a rare manifestation of a schwannoma in hypothenar area of the hand. A literature review of diagnoses and therapeutic management is also presented.

scholarly journals Retrospective Evaluation of Pediatric Patients With Abdominal Tuberculosis: A Single Center Experience

2020 ◽  
Vol 54 (4) ◽  
pp. 204-211
Author(s):  
Sevgi Yaşar Durmuş ◽  
Gönül Tanır ◽  
Ayşe Seçil Ekşioğlu ◽  
Türkan Aydın Teke ◽  
Yasemin Taşçı Yıldız ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Extrapulmonary Tuberculosis ◽  
Abdominal Tuberculosis ◽  
Diagnostic Methods ◽  
Mycobacterium Tuberculosis Infection ◽  
Reactive Protein ◽  
Single Center Experience ◽  
Antituberculosis Treatment ◽  
History Of ◽  
The Mean

Objective: Abdominal tuberculosis is a kind of extrapulmonary tuberculosis that can usually occur during the lymphohematogenous spread of first Mycobacterium tuberculosis infection, develop by neighborhood from an abdominal focus or a mesenteric lymph node. The aim of this study is to evaluate pediatric cases diagnosed with abdominal tuberculosis. Material and Methods: Between 2012-2018, seven patients diagnosed with abdominal tuberculosis through patients who diagnosed with extrapulmonary tuberculosis in our hospital, were included in study. Demographic and clinical characteristics, diagnostic methods, commenced treatments and clinical follow up of patients were listed from medical records. Results: Of patients, four were female. The mean age was 144.2 ± 42.7 months. None of the patients had a history of tuberculosis contact. The median complaint time was 20 days (5-180). The most frequent complaint was abdominal pain and the most frequent physical examination finding was abdominal tenderness. Mean white blood cell count was 9.26 x 103 ± 4.77 x 103 μ/L, C reactive protein level: 79.9 ± 54.9 mg/dL, erytrocyte sedimentation rate: 45 ± 30 mm/h. Tuberculin skin test was positive in two patients, interferon gamma releasing assay was positive in three patients, and in two patients, both tests were positive. There were findings suggesting tuberculosis on pulmonary imaging in five patients and abdominal imaging in all patients. Histopathological examination of the specimens of six patients revealed findings consistent with tuberculosis. The presence of M. tuberculosis was confirmed microbiologically in clinical specimens taken from three patients. The most common abdominal tuberculosis type was mesenteric lymphadenitis. The mean time from admission to diagnosis was 15 ± 12.8 days. All patients recieved antituberculosis treatment. Conclusion: Abdominal tuberculosis should be kept in mind, in patients presenting with abdominal complaints lasting more than five days. Ultrasonography and computed tomography are useful to determine abdominal tuberculosis type. The disease can be sucsessfully treated with standart antituberculosis treatment.

Lucio Phenomenon: A Rare Manifestation of Leprosy in Selangor, Malaysia

2021 ◽  
Vol 5 (0-2) ◽  
pp. 20
Author(s):  
Shahrizan Majid Binti Allapitchai
Keyword(s):  
Peripheral Nerves ◽  
Histopathological Examination ◽  
Skin Condition ◽  
Lepromatous Leprosy ◽  
Lower Limbs ◽  
Who Guidelines ◽  
Rare Manifestation ◽  
Hands And Feet ◽  
Multiple Ulcers ◽  
Made In

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, predominantly affecting the skin and peripheral nerves. Lucio phenomenon is a rare reactional state presenting in patient with lepromatous leprosy and described as acute cutaneous necrotising vasculitis. We discussed the case of a 38-year-old male patient presenting with oedematous and dusky discolouration of bilateral hands and feet associated with diffuse facial involvement. His skin condition gradually worsened to form multiple ulcers with bizarre shaped purpuric lesion over bilateral upper and lower limbs, trunk, and face. Histopathological examination of the skin biopsy showed multiple acid-fast bacilli and diagnosis of Lucio’s phenomenon was made in the background of lepromatous leprosy. He was treated with multi drug therapy (MDT) as recommended by the WHO guidelines. A better understanding of rarer manifestation of this illness is important for early diagnosis and to prevent significant morbidity associated with it.International Journal of Human and Health Sciences Supplementary Issue-2: 2021 Page: S20

scholarly journals Two cases of tuberculous spondylodiscitis: a rare manifestation of extrapulmonary tuberculosis

2017 ◽  
Vol 7 (1) ◽  
pp. 132-137
Author(s):  
José Antonio de Jesús Batún-Garrido ◽  
Marisol Salas-Magaña ◽  
Oscar Alejandro García-Padrón ◽  
Nicolás Valencia-Serrano
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Rare Manifestation ◽  
Tuberculous Spondylodiscitis

Eosinophilic enteritis – case report of a rare manifestation and review of updates

2020 ◽  
Vol 74 (6) ◽  
pp. 492-496
Author(s):  
Eliška Hloušková ◽  
Kateřina Bajerová ◽  
Jakub Pecl ◽  
Petr Jabandžiev ◽  
Marta Ježová ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Histopathological Examination ◽  
Corticosteroid Treatment ◽  
Elimination Diet ◽  
Eosinophilic Infiltration ◽  
Duodenal Wall ◽  
Dietary Restrictions ◽  
Rare Manifestation ◽  
Eosinophilic Gastrointestinal Disorders

Eosinophilic enteritis is one of the eosinophilic gastrointestinal disorders characterised by various clinical symptoms. Histopathologic proof of dense eosinophilic infiltration is the cornerstone for the diagnosis. There is no consensus on how dense the infiltration should be, and cut-off values of the eosinophilic count in HPF have not been defined yet. Therapy for eosinophilic enteritis is based on an elimination diet and corticosteroid treatment. Herein the authors report a case of 14-year-old boy who suffered from acute abdominal pain. Computer tomography of the abdomen revealed a thickening of the duodenal wall mimicking a tumour, which seemed to infiltrate the gallbladder and omentum. Histopathological examination of samples taken during laparoscopy showed eosinophilic infiltration and sclerotic changes of the gallbladder and duodenum. Follow-up endoscopy proved extensive eosinophilic infiltration of the gastrointestinal tract: eosinophilic esophagitis, duodenal ulcer with dense eosinophilic presence and eosinophilic proctitis. The patient recovered after dietary restrictions and prednisone.

A Clinicopathological Study of Various Conjunctival Lesions in Children

2016 ◽  
Vol 1 (4) ◽  
pp. 143-147
Author(s):  
Juhi Goel ◽  
Swapnila Prasad ◽  
Ashutosh Dokania
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Uttar Pradesh ◽  
Capillary Hemangioma ◽  
Treatment Modalities ◽  
Age Group ◽  
Pediatric Age ◽  
Medical College ◽  
Pediatric Age Group ◽  
Clinicopathological Study

ABSTRACT Conjunctival cysts are of a common occurrence in clinical parlance. These tend to be mostly asymptomatic. However, the underlying cause may be vision threatening. Thus, we conducted a clinicohistopathological study of conjunctival cysts in pediatric age group who presented to our outpatient department in Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India. The aim was to analyze the risk factors, clinical presentation, treatment modalities, and a certain type of cysts in order of their frequency. Significant history, detailed ocular examination, and relevant investigations that were carried out in 10 cases of conjunctival lesions were noted. The management was done and the histopathological examination (HPE) reports were charted. Despite a similar clinical presentation, HPE revealed varied diagnosis. These comprised choristomatous cysts (4), subconjunctival cysticercosis (2), inclusion cysts (2), inflammatory cyst (1), and capillary hemangioma (1). Conjunctival cysts are not just a cosmetic blemish. A detailed ocular examination, early diagnosis, and treatment can help prevent various vision-threatening complications. How to cite this article Goel J, Prasad S, Dokania A. A Clinicopathological Study of Various Conjunctival Lesions in Children. Int J Adv Integ Med Sci 2016;1(4):143-147.

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