Neuroprotective therapy for glaucoma (literature review)

2021 ◽  
pp. 61-64
Author(s):  
O.I. Orenburkina ◽  
◽  
A.E. Babushkin ◽  
E.N. Matyukhina ◽  
◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Literature Review ◽  
Key Words ◽  
Neuroprotective Effect ◽  
Comprehensive Treatment ◽  
Physical Factors ◽  
Therapeutic Action ◽  
Neuroprotective Therapy ◽  
Key Words Glaucoma

This literature review presents data on neuroprotection in glaucoma. In neuroprotective therapy, it is desirable to use a comprehensive treatment that includes drugs of various pharmacological groups acting on different pathogenetic links of glaucoma optical neuropathy. One of the most promising areas of neuroprotection is the simultaneous combined effect of various physical factors (with mutual potency of their therapeutic action) and drug therapy, which increases the neuroprotective effect. However, treatment should be performed against the background of absolutely normalized intraocular pressure. Key words: glaucoma, glaucoma optical neuropathy, neuroprotection, drug therapy, normalized intraocular pressure.

Bacterial conjunctivitis (literature review)

2021 ◽  
pp. 87-90
Author(s):  
A.E. Babushkin ◽  
◽  
N.E. Shrvchuk ◽  
Keyword(s):  
Literature Review ◽  
Antibiotic Therapy ◽  
Key Words ◽  
Wide Spectrum ◽  
Comprehensive Treatment ◽  
Bacterial Conjunctivitis ◽  
Eye Infections ◽  
Gram Negative ◽  
First Choice ◽  
Causative Agents

The article is devoted to bacterial conjunctivitis. The review of scientific works on this problem presents the clinic, diagnosis and comprehensive treatment of this ophthalmopathology. At the same time, much attention is paid to antibiotic therapy of bacterial conjunctivitis. A special place in it is occupied by antibiotic fluoroquinolones, which have a wide spectrum of action, including gram-positive and gram-negative causative agents of eye infections, and can be considered the drugs of first choice in bacterial conjunctivitis, especially resistant to other antibiotics. Key words: bacterial conjunctivitis, clinic, diagnosis, treatment.

Clinical efficacy of osteopathic correction in the complex treatment of patients with unoperated open-angle glaucoma

2020 ◽  
pp. 97-105
Author(s):  
E. N. Simakova ◽  
O. V. Stenkova
Keyword(s):  
Intraocular Pressure ◽  
Drug Therapy ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Open Angle ◽  
Complex Treatment ◽  
Hypotensive Drug

Introduction. Glaucoma is one of the most significant eye diseases. It is often diagnosed, not always amenable to therapy, and can lead to a complete loss of visual functions. In recent years, the method of osteopathic correction has become widespread as one of the effective methods of treatment and rehabilitation of patients with pathologies of various body systems. In the pathogenesis of glaucoma, it is customary to distinguish a dystrophic concept, which considers primary open-angle glaucoma as a result of dystrophic changes in the connective tissue, as well as in the endothelial lining of the trabeculae and Schlemm′s canal, especially destructive changes in mitochondria and the alteration of their functional activity. A vascular concept is also distinguished. According to this concept, the central link in the pathogenesis of glaucoma is circulatory disorder in the ciliary vessels, ocular artery, and major vessels of the head and neck, it can be assumed that osteopathic correction in the treatment of patients with open-angle glaucoma will be pathogenetically substantiated and will have a positive effect on intraocular pressure and trophicity of the optic nerve. The goal of research — to study the influence of in osteopathic correction on the nature of unoperated glaucoma (stage IIA) and to substantiate the possibility of using osteopathic correction in the complex treatment of patients with this pathology.Materials and methods. A prospective controlled randomized study was conducted at 52 city polyclinics, branch 3, Moscow, from January 2018 to January 2019. 40 patients (70 eyes) aged 50 to 75 years with primary open-angle glaucoma IIA stage were examined. At this stage of the disease, patients most often seek medical care and the issue of conservative management is primarily considered. All patients were divided into two groups of 20 people: the main group and the control group. The treatment in the main group included hypotensive drug therapy and osteopathic correction. Patients of the control group received only drug therapy. All patients underwent ophthalmic (visometry, tonometry, perimetry) and osteopathic examination twice: before the treatment and after 3 months.Results. For patients with primary open-angle IIA non-operated glaucoma, regional (most often regions of the head, neck, dura mater) and local (abdominal diaphragm, iliac bones, hip and knee joints) somatic dysfunctions were the most typical. In the main group a statistically significant decrease in the frequency and severity of dysfunctions at all levels was stated. Also, in patients receiving osteopathic correction, a significant decrease in the level of intraocular pressure and perimetric indices was noted. In patients of the control group, no reliable changes in these indicators were obtained.Conclusion. The results obtained indicate that osteopathic correction is clinically effective in the complex treatment of patients with primary open-angle II A glaucoma.

Reproductive health issues in patients with psoriasis (literature review)

2019 ◽  
Vol 1 (7) ◽  
pp. 5-8
Author(s):  
L. S. Kruglova ◽  
A. A. Osina ◽  
A. A. Khotko
Keyword(s):  
Drug Therapy ◽  
Reproductive Health ◽  
Literature Review ◽  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcome ◽  
Certolizumab Pegol ◽  
Genetically Engineered ◽  
Health Issues ◽  
Degree Of Confidence ◽  
Adverse Pregnancy

Among patients with psoriasis, approximately 50% are women and almost 75 % of them are under the age of 40 years. Thus, most women with psoriasis have childbearing potential. When pregnancy occurs in 22 % of patients, the activity of psoriasis persists, characteristic of the course before pregnancy, in 23 % of women, the course of the disease worsens. The article provides up-to-date data on the management of pregnant patients with psoriasis. To improve pregnancy outcomes in patients with psoriasis, it is important to prevent exacerbation of the disease. The choice of drug therapy in this case is based on an assessment of the ratio of the risk of undesirable effects of the drugs on the developing fetus and the risk of the development of exacerbation of psoriasis, which can cause an adverse pregnancy outcome. Despite the fact that the available clinical experience of using genetically engineered drugs is still limited, with a certain degree of confidence we can say that there is no increase in the risk of adverse pregnancy outcomes associated with therapy with certolizumab pegol.

The role of physical factors in the complex therapy of patients with rheumatoid arthritis

1985 ◽  
Vol 66 (4) ◽  
pp. 318-318
Author(s):  
L. V. Chernetsova ◽  
A. G. Ibragimova
Keyword(s):  
Rheumatoid Arthritis ◽  
Comparative Analysis ◽  
Drug Therapy ◽  
Electromagnetic Waves ◽  
Physical Factors ◽  
Complex Therapy ◽  
Decimeter Range

The comparative analysis of treatment of 76 patients with rheumatoid arthritis using electromagnetic waves of the decimeter range and lithium electrophoresis, depending on the activity of the process and the type of drug therapy.

Strengthening the pharmacological potential of drug therapy in treatment of patients with chronic pancreatitis by using therapeutic physical factors

2020 ◽  
pp. 8-14
Author(s):  
R. M. Mallaeva ◽  
A. N. Makhinko ◽  
M. B. Uzdenov
Keyword(s):  
Quality Of Life ◽  
Chronic Pancreatitis ◽  
Drug Therapy ◽  
Clinical Manifestations ◽  
Medical Rehabilitation ◽  
Control Group ◽  
Physical Factors ◽  
Standard Drug ◽  
Pharmacological Potential

The purpose of the study is to improve rehabilitation treatment of patients with chronic pancreatitis (CP) at inpatient stage by strengthening pharmacological potential of drug therapy due to inclusion of therapeutic physical factors (TPF) in therapeutic programs. Materials and methods. 159 patients with acute CP were observed. By simple randomization, 4 groups were formed: the control group (MG, 39 people) received standard drug therapy; 1st comparison group (GC1; 38 people) additionally received TPF; GC2 (40 people) in addition to treatment in GC1 had drinking mineral water «Slavyanovskaya»; in main group (42 people) in addition to the treatment in GC2 got preformed peloidotherapy on the cervical-collar zone. All the patients underwent the evaluation of clinical score and quality of life before and after medical rehabilitation. Results. In MG, clinical symptomatology leveling was by 78,2% (p<0,01), in GC1 — by 71,5% (p<0,01), GC2 — by 62,3% (p<0,01), CG — by 57,2% (p<0,01) on average immediately after the treatment, which was in a clear correlation with indicators of quality of life. In the long term (in 6 and 12 months), the advantage of combination therapy was noted with the same validity, the preservation of the achieved positive result was mostly noted in the MG: after 6 months the improvement in physical health compared to the initial values was noted by 34,4% (p<0,01), after 12 months — by 24,0% (p<0,05); mental — by 32,3% (p<0,01) and 22,5% (p<0,05), respectively. In both comparison groups, positive dynamics was 10–12% lower, and in the control group, after 6 months, there was only a tendency to improve quality of life indicators. Conclusion. The inclusion of TPF in the programs of the inpatient stage of medical rehabilitation of patients with chronic pancreatitis by strengthening the pharmacological potential of drug therapy contributes to the leveling of clinical manifestations (abdominal pain, dyspepsia and diarrhea), the result of which is an improvement in the quality of life of this category of patients.

scholarly journals Oesophageal impaction in an indigenous goose

1970 ◽  
Vol 6 (2) ◽  
pp. 231-232
Author(s):  
BC Das ◽  
A Azizunnesa ◽  
BC Sutradhar ◽  
MO Faruk
Keyword(s):  
Drug Therapy ◽  
Key Words ◽  
Plant Material ◽  
Neck Muscles ◽  
Cervical Region ◽  
Post Operation ◽  
Animal Sciences ◽  
Veterinary Hospital

An esophageal impaction consisting of plant material was diagnosed and treated in an indigenous goose. An adult freeflying indigenous goose with flaccid neck muscles, lethargic, emaciated and mildly dehydrated was brought to TVH (Teaching Veterinary Hospital), Chittagong Veterinary and Animal Sciences University, Khulshi, Chittagong, Bangladesh. Palpation of neck revealed solid tubular mass ventrally in the mid cervical region. Treatment included oesophagotomy and drug therapy. The bird was fully recovered within 10 days of post operation. Key words: Impaction, cervical region, oesophagotomy   doi: 10.3329/bjvm.v6i2.2344 Bangl. J. Vet. Med. (2008). 6 (2): 231-232

scholarly journals Do impresso ao digital: a história do Jornal do Brasil

2016 ◽  
Vol 2 (2) ◽  
pp. 230
Author(s):  
Ana Cristina Menegotto Spannenberg ◽  
Cindhi Vieira Belafonte Barros
Keyword(s):  
Comparative Analysis ◽  
Literature Review ◽  
Key Words ◽  
Descriptive Analysis ◽  
Digital Platform ◽  
Palabras Clave ◽  
Digital Journalism ◽  
History Of ◽  
Press History ◽  
History Of Journalism

O trabalho propõe uma análise comparativa dos formatos impresso e online do Jornal do Brasil (JB), a fim de investigar as transformações no perfil editorial do periódico a partir de sua transição definitiva para a plataforma digital, que ocorreu em 2010. Ao todo, foram analisadas 14 publicações do JB, entre impressas e digitais, buscando uma análise comparativa das edições nas duas mídias. O presente artigo apresenta um resgate da história do JB. Além disso, expõe a análise descritiva, com base nos indicadores de identidade levantados em revisão bibliográfica específica e, posteriormente, apresenta os resultados obtidos, tecendo comparações entre os formatos. Palavras-chave: Jornal do Brasil; Jornalismo Digital; Jornalismo Impresso; Imprensa; História do Jornalismo.  Abstract: The paper proposes a comparative analysis of printed and online formats of Jornal do Brazil (JB) in order to investigate the changes in the journal's editorial profile from its final transition to the digital platform, which took place in 2010. Altogether, 14 JB issues were analyzed, both printed and digital ones. This article presents a bailout in the history of JB. In addition, it presents the descriptive analysis, based on the identity indicators raised in specific literature review and subsequently presents the results obtained, weaving comparisons between formats. Key-words: Jornal do Brasil; Digital Journalism, Journalism Printed; Press; History of Journalism.  Resumen:El documento propone un análisis comparativo de los formatos impresa y electrónica de Jornal do Brasil (JB) con el fin de investigar los cambios en el perfil editorial del diario de su transición final a la plataforma digital, que tuvo lugar en 2010. En total, el estudio analizó 14 publicaciones de JB entre impresos y digitales, para esbozar un análisis comparativo de los temas en los dos medios. En este artículo se presenta un plan de rescate en la historia de JB. Además, se presenta el análisis descriptivo, basado en la identidad de los indicadores planteados en revisión de la literatura específica y, posteriormente, presenta los resultados obtenidos, tejiendo las comparaciones entre los formatos. Palabras clave: Jornal do Brasil; Periodismo digital; Periodismo de impresión; Prensa; Historia del periodismo.

scholarly journals HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7849 ◽  
Author(s):  
Hiromitsu Kunimi ◽  
Yukihiro Miwa ◽  
Yusaku Katada ◽  
Kazuo Tsubota ◽  
Toshihide Kurihara
Keyword(s):  
Intraocular Pressure ◽  
Visual Evoked Potentials ◽  
Retinal Thickness ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion ◽  
Hypoxia Inducible Factor ◽  
Retinal Ischemia ◽  
Retinal Ganglion ◽  
Neuroprotective Effects ◽  
Retinal Neurodegeneration

Purpose The therapeutic approach for retinal ganglion cell (RGC) degeneration has not been fully established. Recently, it has been reported that hypoxia-inducible factor (HIF) may be involved with retinal neurodegeneration. In this study, we investigated neuroprotective effects of a HIF inhibitor against RGC degeneration induced in a murine model of retinal ischemia-reperfusion (I/R). Methods Eight-weeks-old male C57/BL6J mice were treated with intraperitoneal injection of a HIF inhibitor topotecan (1.25 mg/kg) for 14 days followed by a retinal I/R procedure. Seven days after the I/R injury, the therapeutic effect was evaluated histologically and electrophysiologically. Results The increase of HIF-1α expression and the decrease of retinal thickness and RGC number in I/R were significantly suppressed by administration of topotecan. Impaired visual function in I/R was improved by topotecan evaluated with electroretinogram and visual evoked potentials. Conclusions Topotecan administration suppressed HIF-1a expression and improved RGC survival resulting in a functional protection against retinal I/R. These data indicated that the HIF inhibitor topotecan may have therapeutic potentials for RGC degeneration induced with retinal ischemia or high intraocular pressure.

Chlamydial conjunctivitis: clinic, diagnosis, treatment (literature review)

2021 ◽  
pp. 102-106
Author(s):  
A.E. Babushkin ◽  
Keyword(s):  
Literature Review ◽  
Key Words ◽  
Systemic Treatment ◽  
Review Article ◽  
Diagnostic Methods ◽  
Clinical Forms ◽  
Chlamydial Infections

The review article addresses the practical aspects of chlamydial conjunctivitis. In particular, it summarizes the clinical forms, diagnostic methods, local and systemic treatment of chlamydial infections of the eyes, as well as the prevention of this disease. Key words: chlamydial conjunctivitis, clinic, diagnosis, treatment.

Modern strategy of drug treatment of patients with myocardial infarction without ST segment elevation

2021 ◽  
Vol 22 (3) ◽  
pp. 90-93
Author(s):  
L. V. Kremneva ◽  
◽  
O. V. Abaturova ◽  
N. Yu. Stogniy ◽  
S. N. Suplotov ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Coronary Syndrome ◽  
Drug Therapy ◽  
Literature Review ◽  
Drug Treatment ◽  
Modern Approach ◽  
St Segment Elevation ◽  
Coronary Syndrome ◽  
St Segment

The modern approach to the treatment of patients with acute coronary syndrome without ST segment elevation on electrocardiogram (NSTEMI) involves the implementation of invasive interventions and the appointment of drug therapy. This literature review presents data on the features of drug treatment of patients with NSTEMI.

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