scholarly journals First reported case of peritoneal dialysis infection with lactobacillus gasseri: when the body’s friend turns against its host

2020 ◽  
Vol 3 (4) ◽  
pp. 251-254
Author(s):  
Jamil El Moutaouakil ◽  
Agathe Pardon ◽  
Valérie Caudwell
Keyword(s):  
Peritoneal Dialysis ◽  
Duration Of Treatment ◽  
Lactobacillus Gasseri ◽  
Streptococcus Anginosus ◽  
Mucous Membranes ◽  
Peritoneal Infection ◽  
Vaginal Canal ◽  
Small Intestinal ◽  
Pass Through ◽  
Positive Effect

Summary We report a case of lactobacillus gasseri peritonitis in a patient treated by peritoneal dialysis. Streptococcus anginus and lactobacillus gasseri bacteria are commensal organisms of human oral, small intestinal, colic and vaginal mucous membranes. An infection with streptococcus anginosus during peritoneal dialysis, one responsible for an intra-abdominal abscess, has already been described, this type of streptococcus being widely associated with abscess formation. In contrast, no case of peritoneal infection with lactobacillus gasseri has ever been described. This bacterium is native to the mucous membranes, and colonizes the digestive tract of infants during childbirth, as they pass through the vaginal canal. It has local adaptation capacities, namely tolerance to acid pH, adhesion to the mucous membrane and resistance to bile salts. It is recognized as having an antimicrobial and probiotic function due to its production of bacteriocin, its local immunomodulatory role, its attenuation of the development of helicobacter pylori, its positive effect on the balance of the vaginal flora and its improvement of infectious diarrhea. This usually makes it an ally that contributes to our systemic balance but its irruption in the peritoneum has made it a pathogenic bacterium. The treatment of this peritoneal infection required a classic duration of treatment of organisms of digestive origin, i.e. 3 weeks

scholarly journals Intraperitoneal ampicillin treatment for peritoneal dialysis- related peritonitis with Listeria monocytogenes – a case report

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Kristina Boss ◽  
Ina Wiegard-Szramek ◽  
Jan Dziobaka ◽  
Andreas Kribben ◽  
Sebastian Dolff
Keyword(s):  
Peritoneal Dialysis ◽  
Case Report ◽  
Listeria Monocytogenes ◽  
Case Reports ◽  
Chronic Kidney Disease Stage ◽  
Disease Stage ◽  
Serum Concentrations ◽  
Duration Of Treatment ◽  
First Case ◽  
Listeria Infection

Abstract Background Peritoneal dialysis (PD)-related peritonitis is a rare but serious complication and is associated with increased morbidity and mortality rates. It is most commonly caused by Staphylococcus aureus or Staphylococcus epidermidis, but infection with Listeria monocytogenes may also occur. Recommendations for antibiotic treatment of a Listeria infection are currently based on a small number of case reports and suggest the administration of ampicillin. But unlike vancomycin or gentamicin, for ampicillin the route of application, the dosage, and the duration of treatment have not yet been established. We report a case in which PD-associated peritonitis due to Listeria infection was treated with ampicillin administered intravenously and intraperitoneally, separately and in combination. Case presentation A 72-year-old man with chronic kidney disease stage 5 dialysis (CKDG5D) secondary to hypertension and diabetes was hospitalised in April 2020 because of PD-related peritonitis caused by a Listeria infection. In accordance with the results of resistance tests, the patient was treated with intravenous ampicillin at a dosage of 6 g twice daily. After initial treatment the leukocyte count in the PD effluent had decreased substantially, but it was permanently reduced only with the addition of intraperitoneal ampicillin (4 g daily). Efficient serum concentrations of ampicillin were determined for both routes of administration, intravenous and intraperitoneal. Conclusion This is the first case report demonstrating that PD-related peritonitis due to Listeria monocytogenes infection can be treated with intraperitoneal ampicillin and monitored by the determination of peripheral serum concentrations of ampicillin.

Experience in using Topicream soothing cream CICA for rehabilitation of skin and mucous membranes after destructive dermatocosmetological procedures in combination therapy of dermatoses

2021 ◽  
pp. 33-38
Author(s):  
L.V. Hrechanska ◽  
O.V. Podluzhna ◽  
S.Р. Ostapenko ◽  
А.Е. Alatorskyh
Keyword(s):  
Clinical Practice ◽  
High Efficiency ◽  
Skin Diseases ◽  
Secondary Infection ◽  
Skin Neoplasms ◽  
Skin Surface ◽  
Punch Biopsy ◽  
Duration Of Treatment ◽  
Inflammatory Reactions ◽  
Mucous Membranes

The widespread introduction of the destructive methods of treatment into the clinical practice of dermatovenerologists is caused by the significant spread of benign skin and mucous neoplasms. At the same time, any effect on the skin — chemical, physical or mechanical — causes damage. Thus, patients using these procedures need proper care for damaged skin and mucous membranes to prevent secondary infection and scaring. Disruption of the epidermal barrier after removal of benign skin neoplasms, carrying out biopsy and chemical peels always requires application of topical agents promoting full recovery of the epidermis. In addition, many skin diseases are accompanied by inflammatory reactions, which are complicated by secondary infection. The use of drugs with anti­inflammatory and reparative properties reduces the duration of treatment and promotes skin recovery.Objective — to evaluate the clinical efficacy and tolerability of using Topicream soothing cream CICA after derma­tocosmetological procedures on the skin and mucous membranes and to investigate the efficacy of its use at various skin and mucous membranes diseases including children.Materials and methods. The study included 57 patients aged 1 to 75 years with various skin diseases, benign skin and mucosal neoplasms, after punch biopsy and cosmetology procedures. Topical application of the Topicream soothing cream CICA on the damaged skin and mucosal areas was recommended to all participants of the study twice a day. Results and discussion. The use of the regenerating cream after dermatological treatment of benign skin neoplasms with apparatus methods, chemical peelings and punch biopsy, as well as the auxiliary treatment of skin diseases such as cheilitis, herpes, perianal fissure, allergic contact dermatitis (including in children) localized in folds and on the face, contributes to a significant reduction in signs of inflammation and subjective sensations, as well as rapid healing of the affected skin surface. At the same time, there is a good tolerance and the absence of side effects of Topicream soothing cream CICA, which allows it to be widely used in clinical dermatovenerology, gynecology and pediatrics.Conclusions. High efficiency and safety of Topicream soothing cream CICA allow its widespread use in clinical practice of dermatovenerologists, gynecologists and pediatricians.

Symptomatic Peritoneal Calcification in a Child: Treatment with Tidal Peritoneal Dialysis

1994 ◽  
Vol 14 (1) ◽  
pp. 26-29 ◽  
Author(s):  
Bradley A. Warady ◽  
Vicki Bahl ◽  
Uri Alan ◽  
Stanley Hellerstein
Keyword(s):  
Abdominal Pain ◽  
Peritoneal Dialysis ◽  
Symptomatic Relief ◽  
Duration Of Treatment ◽  
Child Treatment ◽  
Dialysis Unit ◽  
Case Evaluation ◽  
Fill Volume ◽  
Unique Approach ◽  
Tidal Peritoneal Dialysis

Objective To evaluate the ability of tidal peritoneal dialysis to decrease the pain and frequency of hemoperitoneum associated with peritoneal calcification. Design Prospective case evaluation. Setting The Home Peritoneal Dialysis Unit, Children's Mercy Hospital. Patient Seven-year-old male with diffuse peritoneal calcifications, daily abdominal pain, and recurrent hemoperitoneum. Intervention Tidal peritoneal dialysis was conducted with an initial fill volume of 45 mL/kg and a tidal inflow volume of 23 mL/kg. The patient also maintained a daytime pass volume of 45 mL/kg. Duration of treatment was 7 months. Results The patient's abdominal pain resolved 2 days after initiating tidal peritoneal dialysis. No episodes of hemoperitoneum or abdominal pain have occurred for 7 months. Conclusion Tidal peritoneal dialysis is a unique approach to the achievement of symptomatic relief in the patient with peritoneal calcification.

Uremia and Host Resistance to Peritonitis in C.A.P.D-an Experimental Evaluation

1984 ◽  
Vol 4 (4) ◽  
pp. 202-205 ◽  
Author(s):  
Isabel A. Clarke ◽  
Douglas J. Ormrod ◽  
Thomas E. Miller
Keyword(s):  
Peritoneal Dialysis ◽  
Host Resistance ◽  
The Other ◽  
Risk Of Infection ◽  
Dialysis Fluid ◽  
Important Complication ◽  
Major Disadvantage ◽  
Direct Inoculation ◽  
Peritoneal Infection ◽  
Per Se

Peritonitis is an important complication of CAPD. Because uremia is believed to impair immunity, we sought to determine whether uremia per se predisposes patients on CAPD to peritoneal infection. Using an animal model of CAPD, we have evaluated the effect of severe uremia on host resistance to peritonitis. Intraperitoneal catheters were implanted in severely uremic and sham-operated non-uremic rats, which were then dialysed four times a day for two days. Alternatively, they were infused with dialysis fluid twice daily for eight days without drainage of the dialysate. Peritonitis was induced by direct inoculation of Escherichia coli; the bacteria in the peritoneal cavity and spleen were counted 24 hours after this challenge. Uremia did not impair resistance to experimentally induced peritonitis in either the dialysed or infused host. Continuous ambulatory peritoneal dialysis (CAPD) is becoming increasingly popular as a method for longteffil treatment of chronic renal failure. The major disadvantage is the risk of infection and peritonitis remains the single most important complication and reason for transfer of patients to another mode of therapy. Uremia is believed to impair immunity and predispose patients to infection (1, 2). Hence the question arises: Are patients on CAPD predisposed to peritoneal infection by the uremia itself? We developed a model of chronic uremia in rats, which made possible studies uncomplicated by many variabies associated with the clinical management of uremic patients. This paper examines the contribution of uremia to the susceptibility of the dialysed host to peritonitis. In the rats, we found it difficult to maintain dialysis for longer than two days because of rapid blockage of catheters by fibrin and connective tissue. As a consequence, we employed two models: one carried out peritoneal dialysis for two days, and the other involved infusions of dialysate without drainage for a longer period. Uremic and sham-operated animals, either dialysed or infused without drainage, were compared with noffilal controls with respect to their ability to withstand an intraperitoneal challenge with viable Escherichia cali.

Tenckhoff Catheter Penetrated by Aspergillus Fumigatus: A Case Report

1988 ◽  
Vol 8 (4) ◽  
pp. 281-283 ◽  
Author(s):  
Frants Wegmann ◽  
Aina M. Heilesen ◽  
Thomas Horn
Keyword(s):  
Peritoneal Dialysis ◽  
Case Report ◽  
Aspergillus Fumigatus ◽  
Peritoneal Fluid ◽  
Clinical Signs ◽  
Tenckhoff Catheter ◽  
Microbiological Examination ◽  
Peritoneal Infection

A case of fungal penetration (AspergIllus fumigatus) of a Tenckhoff catheter in a 68-year-old female treated for five years with peritoneal dialysis is reported. Though histopathological and microbiological examination of the removed catheter revealed disseminated colonization, the patient presented no clinical signs of peritoneal infection, cultures of peritoneal fluid were negative, and dialysis procedures were without problems.

Streptococcus Peritonitis with Urticaria

1992 ◽  
Vol 12 (2) ◽  
pp. 214-215 ◽  
Author(s):  
Angela Edward ◽  
Karl Nolph
Keyword(s):  
Abdominal Pain ◽  
Peritoneal Dialysis ◽  
Nausea And Vomiting ◽  
White Female ◽  
First Episode ◽  
First Report ◽  
Peritoneal Infection ◽  
Peritoneal Dialysis Effluent

Peritonitis following urticaria on two occasions in a 46-year-old white female treated with CAPD for nine years is reported. On both occasions an episode of urticaria and pruritis occurred 24 hr before the dialysate became cloudy, and the patient experienced abdominal pain, nausea, and vomiting. The culture of the peritoneal dialysis effluent grew gamma Streptococcus with the first episode. To our knowledge this is the first report of CAPD peritonitis preceded by urticaria where the skin findings were most likely related to the peritoneal infection.

3,4-DGE in Peritoneal Dialysis Fluids Cannot be Found in Plasma after Infusion into the Peritoneal Cavity

2008 ◽  
Vol 28 (3) ◽  
pp. 277-282 ◽  
Author(s):  
Martin Erixon ◽  
Anders Wieslander ◽  
Torbjörn Lindén ◽  
Ola Carlsson ◽  
Jan Åke Jönsson ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Human Plasma ◽  
Peritoneal Cavity ◽  
Degradation Products ◽  
High Reactivity ◽  
The Other ◽  
Glucose Degradation Products ◽  
Pass Through ◽  
Dialysis Fluids

Objective Glucose degradation products (GDPs) are important in the outcome of peritoneal dialysis (PD) treatment. 3,4-dideoxyglucosone-3-ene (3,4-DGE) is the most cytotoxic GDP found in conventionally manufactured fluids and may, in addition, be recruited from 3-deoxyglucosone (3-DG). It is not known what happens with those GDPs in patients during PD. The aim of this study was to investigate if the 3,4-DGE and 3-DG in PD fluids can be found in plasma during treatment. Design PD patients were dialyzed with a conventional PD fluid containing 43 μmol/L 3,4-DGE and 281 μmol/L 3-DG. Parallel experiments were performed in rats as well as in vitro with human plasma. The rats were dialyzed with a PD fluid containing 100 μmol/L 3,4-DGE and 200 μmol/L 3-DG. Results The concentration of 3,4-DGE in the peritoneum decreased at a much higher rate than 3-DG during the dwell. 3,4-DGE was not, however, detected in the plasma of patients or rats during dialysis. The concentration of 3-DG in plasma peaked shortly after infusion of the fluid to the peritoneal cavity. The concentration of 3,4-DGE during experimental incubation in plasma decreased rapidly, while the concentration of 3-DG decreased only 10% as rapidly or less. Conclusion 3,4-DGE could not be detected in plasma from either PD patients or rats during dialysis. This is presumably due to its high reactivity. 3-DG may, on the other hand, pass through the membrane and be detected in the blood.

scholarly journals Performance, intestinal histomorphology and bone composition of broiler chickens fed diets supplemented with genistein

2020 ◽  
Vol 50 (2) ◽  
pp. 241-252
Author(s):  
M. Glisic ◽  
M. Boskovic ◽  
M. Z. Baltic ◽  
D. Sefer ◽  
A. Radovanovic ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Feed Conversion ◽  
Broiler Performance ◽  
Supplementation Period ◽  
Wet Weight ◽  
Small Intestinal ◽  
Positive Effect ◽  
Lactobacillus Spp

The effect of dietary genistein on performance, intestinal morphology, caecal Lactobacillus spp. count, and tibia composition in broiler chickens after 21 and 37 days of feeding was investigated. A total of 360 Cobb 500 broiler chickens (21 days old) were randomly allocated to five treatments with six replicates of 12 birds each. They were fed a basal diet (C) or a basal diet supplemented with 200 (T1), 400 (T2), 600 (T3) and 800 (T4) mg genistein/kg of feed. Genistein supplementation did not affect feed intake, but improved bodyweight, weight gain and feed conversion ratio (FCR) after 21 days, while 600 mg/kg led to a significant increase in FCR after 37 days of feeding. Plasma triglyceride level decreased with dietary genistein after 21 days, while increases were found in T3 and T4 groups after prolonged supplementation. Significantly improved duodenal and jejunal villus length and width, crypt depth and villus/crypt ratio were observed after the first and the second finishing periods, respectively, while adverse effects were found in the ileum for both periods. At 42 days old, greater spleen and heart weights were measured in broilers fed diets with 800 mg/kg than in other broiler groups. The shorter genistein supplementation period (21 days) of 200 and 400 mg/kg had a positive effect on tibia wet weight, ash and calcium (Ca) content, while 37 days of the higher genistein doses administered to the T2, T3 and T4 birds significantly increased caecal lactic acid bacteria (LAB) counts. Thus, recommended doses should not exceed 400 mg/kg. Keywords: broiler performance, blood triglyceride, Lactobacillus, prolonged fattening, small intestinal morphology

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