Interpretation and significance of the definition of anti-Mullerian hormone in the practice of juvenile gynaecologist

GYNECOLOGY ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 230-235
Author(s):  
Zaira K. Kumykova ◽  
Elena V. Uvarova ◽  
Zalina K. Batyrova
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Reserve ◽  
Physiological Role ◽  
Reproductive Period ◽  
Female Population ◽  
Diagnosis And Prognosis ◽  
Final Maturation ◽  
Important Diagnostic Tool ◽  
The Moment ◽  
Definition Of

The article presents an overview of the physiological role of anti-Mullerian hormone (AMH) during persons lifetime, the fluctuations of its values from birth to the reproductive period in women, the significance of its determination in the diagnosis and prognosis of treatment outcomes for many gynecological diseases. AMH is produced mainly by preantral and early antral follicles and decreases during the final maturation and luteinization. AMH plays a potential role in preserving the ovarian reserve by performing dual actions. AMH inhibits the initial recruitment of follicles, preventing the influence of stimulating growth factors for recruitment (KIT-ligand, the main fibroblast growth factor). From the moment of puberty, AMH reduces the sensitivity of primary follicles to the follicle-stimulating hormone, reducing the likelihood of their cyclic recruitment. The systematic review data presented the characteristics of the ovarian reserve in a healthy female population aged 0 to 19 years. At birth, very low AMH values were noted with an increase in its level in the first 3 months of life, followed by a monthly increase of 31%. A significant increase in AMH secretion was revealed by the beginning of puberty, then most authors noted a constant level of serum AMH in the adolescent period. The level of AMH in the blood serum decreases with an increase in chronological age by 68% annually and varies during the menstrual cycle. AMH is an important diagnostic tool in pediatric practice when differentiating various causes of puberty disorders, virilization and menstrual cycle disorders in girls.

Development of sensitivity to cAMP-inducing hormones in the rat stomach

1984 ◽  
Vol 247 (3) ◽  
pp. G231-G239
Author(s):  
C. Gespach ◽  
Y. Cherel ◽  
G. Rosselin
Keyword(s):  
Biological Activities ◽  
Physiological Role ◽  
H2 Receptor Antagonist ◽  
Adult Rats ◽  
Gastric Glands ◽  
Camp Generation ◽  
Final Maturation ◽  
Noncompetitive Inhibitor ◽  
Regulatory Properties

Development of cAMP responses to secretin, pancreatic glucagon, and histamine was measured in gastric glands of fetal (day 20), postnatal (days 1-30), and adult rats (day 65). cAMP stimulation by these hormones was already detected on day 20 of gestation. cAMP generation showed biphasic variations during the 1st days of life and at the onset of weaning (day 20). Anticipated weaning at day 14 triggered precocious maturation (efficacies) of the cAMP-generating systems sensitive to secretin, glucagon, and histamine without changing the potencies of the hormones. During development, the general characteristics (potency and pharmacological or regulatory properties) of the receptor-cAMP systems studied were comparable with those evidenced in adult rats. At days 5, 20, and 65, vasoactive intestinal peptide and the peptide having N-terminal histidine and C-terminal isoleucine amide (PHI) were about 100 times less potent than secretin (EC50 = 1.5 X 10(-9) M secretin). The histamine action could be blocked by the competitive H2-receptor antagonist cimetidine (70-100% inhibition) as well as by the noncompetitive inhibitor somatostatin (37-62% inhibition). The data indicate that these regulatory hormones (secretin, glucagon(s), histamine, and somatostatin) might have a direct effect on gastric glands and may modulate their biological activities (metabolism, differentiation, proliferation, and exocrine and endocrine secretions) from the neonatal period in rats. The important physiological role of weaning on the final maturation of the cAMP-generating systems in rat gastric glands is underlined.

The Home at the core of Modernity, an optimistic architecture

2021 ◽  
pp. 2-3
Author(s):  
Ana Tostões
Keyword(s):  
Daily Life ◽  
Single Family ◽  
The Core ◽  
The Moment ◽  
Definition Of ◽  
The Ideal ◽  
Modern Movement

Devoted to the theme of single-family houses, given the key role they played in the ideal definition of the Modern Movement architecture, as a symbolic and functional affirmation of the utopian turning of dreams into reality, the aim of this issue is to consider the transformation of daily life, and to address the architectural challenges that arose from the joy contained in what we might call the “architecture of happiness.” As we continue to endure a pandemic that has now lasted for more than a year, docomomo wishes to declare that “till the moment, the best vaccine to prevent contagion was invented by architects: the house”. Thus, in response to the question “How should we live?”, it is intended to debate the house and the home agenda as an important topic at the core of Modern Movement architecture. Nowadays, the growing emphasis on wellbeing goes beyond the seminal ideas that modern houses were “machines à habiter” and is closer to an idealistic vision of a stimulating shell for humans, which is shaped by imagination, experimentation, efficiency, and knowledge.

scholarly journals Age at Menarche and Menstrual Pattern of Elementary School Students in Medan

2017 ◽  
Vol 38 (3-4) ◽  
pp. 75
Author(s):  
Nurdiani Nurdiani ◽  
Evi Kamelia ◽  
Rusdi Andid ◽  
Ani Ariani ◽  
Hakimi Hakimi ◽  
...  
Keyword(s):  
Elementary School ◽  
Menstrual Cycle ◽  
Primary School ◽  
Elementary School Students ◽  
Primary Schools ◽  
Common Finding ◽  
Age At Menarche ◽  
School Students ◽  
Sexual Counseling ◽  
The Moment

This study aimed to determine the age at menarche and its influencing factors and the pattern of menstrual cycles in elementary school students in Medan. Subjects were 227 female students in six primary schools (private and government) in Medan municipal, during October until November 1995. Most students experienced menarche in government primary school (GPS: 35.8%) and private primary school (PPS: 24%), at the age of 10-12 years. The mean age at menarche of these students in government primary school was 11.41 (SD 0.95) years while in private primary school it was 10.65 (SD 0.78) years. Subjects who had had menarche had better nutritional status than who had not (p<0.001). Sports activities are also associated with age at menarche (p<0.001). On the other hand family's economical status and maternal age at menarche were not significantly associated with age at menarche (p>0.05). Most students who had had menarche had regular menstrual cycle; the duration of menarche was 4-6 days for GPS and 3 days for PPS. Dysmenorrhea was a common finding in the first three months of menstruation cycle but gradually diminishing with time. The duration of menstrual cycle was 25-34 days. These findings are useful as a guide for the parents, especially when mothers planning the best time/ the moment to discuss about reproduction and sexual counseling with her daughter.

scholarly journals Ultrafast epithelial contractions provide insights into contraction speed limits and tissue integrity

2018 ◽  
Vol 115 (44) ◽  
pp. E10333-E10341 ◽  
Author(s):  
Shahaf Armon ◽  
Matthew Storm Bull ◽  
Andres Aranda-Diaz ◽  
Manu Prakash
Keyword(s):  
Apical Cell ◽  
Physiological Role ◽  
Marine Animal ◽  
Trichoplax Adhaerens ◽  
Contraction Speed ◽  
Order Of Magnitude ◽  
Tissue Rupture ◽  
Epithelial Layers ◽  
Definition Of ◽  
External Forces

By definition of multicellularity, all animals need to keep their cells attached and intact, despite internal and external forces. Cohesion between epithelial cells provides this key feature. To better understand fundamental limits of this cohesion, we study the epithelium mechanics of an ultrathin (∼25 μm) primitive marine animal Trichoplax adhaerens, composed essentially of two flat epithelial layers. With no known extracellular matrix and no nerves or muscles, T. adhaerens has been claimed to be the “simplest known living animal,” yet is still capable of coordinated locomotion and behavior. Here we report the discovery of the fastest epithelial cellular contractions known in any metazoan, to be found in T. adhaerens dorsal epithelium (50% shrinkage of apical cell area within one second, at least an order of magnitude faster than other known examples). Live imaging reveals emergent contractile patterns that are mostly sporadic single-cell events, but also include propagating contraction waves across the tissue. We show that cell contraction speed can be explained by current models of nonmuscle actin–myosin bundles without load, while the tissue architecture and unique mechanical properties are softening the tissue, minimizing the load on a contracting cell. We propose a hypothesis, in which the physiological role of the contraction dynamics is to resist external stresses while avoiding tissue rupture (“active cohesion”), a concept that can be further applied to engineering of active materials.

scholarly journals Economic assessment of energy efficiency investments in dwellings = Evaluación económica de inversiones de eficiencia energética en viviendas

2017 ◽  
Vol 1 (2) ◽  
pp. 36 ◽  
Author(s):  
Hector Hernández
Keyword(s):  
Energy Efficiency ◽  
Energy Savings ◽  
Economic Assessment ◽  
Energy Performance ◽  
Point Of View ◽  
Economic Modelling ◽  
Evaluación Económica ◽  
Energy Performance Of Buildings ◽  
The Moment ◽  
Definition Of

In order to improve the energy performance of buildings, the need to value economically investments of energy efficiency associated with the rehabilitation of dwellings arises. This point of view provides an useful tool for analysts who start in the economic appraisal of energy efficiency investments. The present research gives a conceptual framework for the economic assessment of these types of investments in dwellings. As a result, it is possible to identify two techniques in the appraisals of this nature: dynamic and static approaches. Both methods contrast the benefits (energy savings) with the costs of investments over time. However, they differentiate the opportunity and the moment when investment must be carried out given an uncertainty scenario. This conceptual precision allows the study of several publications where different alternatives in retrofitting houses where evaluated, confirming the considerations that must be taken into account when economic modelling is made: the type of approach to be used (dynamic or static) and; at the definition of the investment alternatives and scenarios, the aspects of time, irrevocability and uncertainty.ResumenEn pro de la mejora del desempeño energético de los edificios, surge la necesidad de evaluar económicamente las inversiones de eficiencia energética asociadas a la rehabilitación de viviendas. Este punto de vista trata de ser una herramienta útil para analistas que se inicien en la evaluación económica de inversiones en eficiencia energética. La presente investigación muestra un marco conceptual de la evaluación económica de este tipo de inversiones en viviendas. Como resultado, es posible identificar dos enfoques presentes en los análisis económicos de esta naturaleza: el dinámico y el estático. Ambos métodos contrastan los beneficios (ahorros energéticos) con los costes de las inversiones en el tiempo. Sin embargo, diferencian la oportunidad y el momento en que la inversión debe realizarse dado un escenario de incertidumbre. Esta precisión conceptual permite estudiar varias publicaciones donde se evaluaron diferentes alternativas de reacondicionamiento en viviendas, confirmándose las consideraciones que deben tenerse presentes en momento de realizar la modelación económica: el tipo de enfoque a usar (dinámico o estático) y, en la definición de las alternativas de inversión y escenarios, los aspectos de tiempo, irrevocabilidad e incertidumbre.

scholarly journals Cytokine signature and COVID-19 prediction models in the two waves of pandemics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Serena Cabaro ◽  
Vittoria D’Esposito ◽  
Tiziana Di Matola ◽  
Silvia Sale ◽  
Michele Cennamo ◽  
...  
Keyword(s):  
Prediction Models ◽  
Regression Tree ◽  
Classification And Regression Tree ◽  
Diagnostic Tools ◽  
Linear Discriminant ◽  
Diagnosis And Prognosis ◽  
Machine Learning Approach ◽  
Set Up ◽  
Definition Of ◽  
Second Wave

AbstractIn Europe, multiple waves of infections with SARS-CoV-2 (COVID-19) have been observed. Here, we have investigated whether common patterns of cytokines could be detected in individuals with mild and severe forms of COVID-19 in two pandemic waves, and whether machine learning approach could be useful to identify the best predictors. An increasing trend of multiple cytokines was observed in patients with mild or severe/critical symptoms of COVID-19, compared with healthy volunteers. Linear Discriminant Analysis (LDA) clearly recognized the three groups based on cytokine patterns. Classification and Regression Tree (CART) further indicated that IL-6 discriminated controls and COVID-19 patients, whilst IL-8 defined disease severity. During the second wave of pandemics, a less intense cytokine storm was observed, as compared with the first. IL-6 was the most robust predictor of infection and discriminated moderate COVID-19 patients from healthy controls, regardless of epidemic peak curve. Thus, serum cytokine patterns provide biomarkers useful for COVID-19 diagnosis and prognosis. Further definition of individual cytokines may allow to envision novel therapeutic options and pave the way to set up innovative diagnostic tools.

scholarly journals O SKUTKOWOŚCI PRZESTĘPSTW FORMALNYCH

2016 ◽  
Vol 14 (1) ◽  
pp. 159
Author(s):  
Paweł Nowak
Keyword(s):  
Criminal Law ◽  
Polish Law ◽  
The Moment ◽  
Definition Of

CRIMINAL CONSEQUENCES OF FORMAL OFFENCESSummaryThe author discusses the concept of criminal consequence in Polish law. Debate is still going on in the theory and jurisdiction of Polish criminal law on whether a particular crime or offence should be classified as formal (przestępstwa formalne) or as consequential (przestępstwa skutkowe – viz. crimes/offences incurring criminal consequences; cf. inchoate crimes or offences). A point which turns out to be particularly problematic in this respect is the definition of criminal consequence, to enable a distinction to be drawn between formal and consequential (inchoate) offences/crimes. The author concludes that in practice all offences and crimes have a consequence. If a state in which a specific danger has emerged may be treated as a criminal consequence, it should also be admissible to treat a state in which an abstract danger has been created as a criminal consequence. Viewed from this aspect, all crimes are formal; for instance incitement is committed the moment when its perpetrator addresses words encouraging the commission of a crime to another person.

scholarly journals ISSUES AND PROSPECTS FOR IMPROVEMENT IN SIMPLIFYING THE PRE-TRIAL INVESTIGATION

2021 ◽  
Vol 75 (2) ◽  
pp. 132-139
Author(s):  
Andriy Vorobey ◽  
Keyword(s):  
Legal Status ◽  
Full Range ◽  
Practical Importance ◽  
Criminal Procedure ◽  
Negative Consequences ◽  
Procedure Code ◽  
Criminal Offenses ◽  
The Moment ◽  
Definition Of ◽  
National Police

The article deals with the problematic issues of pre-trial investigation of criminal offenses, under investigation by the units of the National Police of Ukraine, have not been studied in the scientific literature. The author of the article points out the problems of the legal status of a head of an inquest body, the author's definition of this term is given and proposed changes to the current criminal procedural legislation, which should eliminate legal gaps. Considered the inconsistencies of the current criminal procedural legislation in terms of regulating the order of attachment for seizure of the property during the pre-trial investigation of criminal offenses. Analyzed judicial practice on this issue and proposed changes to legislation according to the needs of practice. The drawbacks are noted in establishing the terms of pre-trial investigation of criminal offenses, which are caused by the need to conduct psychiatric and other forensic examinations, it is proposed to provide in the Criminal Procedure Code of Ukraine for an inquiry period of 2 months from the moment a person is informed of suspicion. The author's specified legal inconsistencies in the issue of regulating the conduct of a search during an inquiry, it is indicated that there is a need to standardize Articles 234–236 of the Criminal Procedure Code. Due to fact that the activities of the inquest bodies of the National Police of Ukraine are noticeably inefficient, it is proposed to introduce a shortened inquiry procedure in order to implement the principle of economy in the criminal process and saving resources used during the pre-trial investigation.The current procedural form of criminal investigation in Ukraine provides for the need to conduct a full range of investigative and procedural actions in a short time, even for obvious criminal offenses, when the suspect unequivocally pleads guilty and compensates for the damage, which has negative consequences. The introduction of an abbreviated procedure for inquiry is possible only for a clearly defined range of criminal offenses, the legislation must approve guarantees to ensure the rights of suspects from law enforcement abuses and the criteria under which an abbreviated form of inquiry is impossible. The study of the possibility of implementing an abbreviated order of inquiry is of practical importance and is an important area for further study.

scholarly journals The grounds for initiation of service-related objects of patent law in the system of the MIA of Russia

2021 ◽  
Vol 2021 (3) ◽  
pp. 44-51
Author(s):  
Aleksandr Molchanov ◽  
Elizaveta Zaytseva
Keyword(s):  
Industrial Design ◽  
Patent Law ◽  
Controversial Issues ◽  
Utility Model ◽  
Legal Regime ◽  
Legal Norms ◽  
Correct Definition ◽  
Internal Affairs ◽  
The Moment ◽  
Definition Of

The article is devoted to the study of the grounds for initiation of service-related objects of patent law in the system of the Ministry of the Internal Affairs of Russia. The authors define the conditions necessary for the recognition of the service-related character of an invention, utility model, or industrial design. This is especially important for the correct definition of the legal regime of the created results and the application of legal consequences to the relations arising between the subjects. The purpose of the work is to analyse the grounds for initiation of service-related objects in the system of the Ministry of the Internal Affairs of Russia. As a result of the study, the legal relationships between the subjects of patent law in the system of the Ministry of the Internal Affairs of Russia, the grounds for their occurrence and the specifics are analysed, the question of the relationships between the moment of creation of the service-related product and the period of validity of the working contract between the author and the employer are determined, the procedure of distributing intellectual rights to service-related products, including those created as a result of the joint creative activity of several persons are clarified, other conditions and criteria for vesting an invention, utility model, industrial design with a service-related character are determined. As a separate basis, a civil law contract is highlighted, which has essential importance in the implementation of service-related objects of patent law in the system of the Ministry of the Internal Affairs of Russia. The analysis of legal norms revealed the lack of the legally fixed list of the grounds for the initiation of service-related objects of patent law, and therefore a number of controversial issues arising in practice require additional clarification.

Age structure, growth, and demographic parameters in breeding-age female subantarctic fur seals, Arctocephalus tropicalis

2004 ◽  
Vol 82 (7) ◽  
pp. 1043-1050 ◽  
Author(s):  
Willy Dabin ◽  
Gwénaël Beauplet ◽  
Enrique A Crespo ◽  
Christophe Guinet
Keyword(s):  
Age Distribution ◽  
Reproductive Rate ◽  
Reproductive Period ◽  
Demographic Parameters ◽  
Island Population ◽  
Female Population ◽  
Regulatory Processes ◽  
Fur Seals ◽  
Subantarctic Fur Seals ◽  
Arctocephalus Tropicalis

Age distribution was estimated for 108 breeding-age female subantarctic fur seals, Arctocephalus tropicalis (Gray, 1872), sampled during the 1999–2000 breeding season on Amsterdam Island, southern Indian Ocean. The growth features were described and demographic parameters assessed from transversal life tables constructed for this female population. The breeding females had a longer mean body length than was observed for other breeding populations of the same species. These females also showed a later start to reproduction (6 years old), a lower overall age-specific reproductive rate (R6–16 = 48.0%), and a lower survival in older age classes (>13 years). Females reproduced up to a maximum age of 16 years, with none older than 19 years observed in the colony, suggesting an apparent senescence in the population. This consequently reduced the theoretical reproductive period of the females, which has led to a lower number of reproductive outputs per individual (i.e., 3.65 weaned pups per female throughout its reproductive life). Although such differences between islands may be related to genotypic traits, these results are consistent with low food availability and suggest that density-dependent regulatory processes operate on the Amsterdam Island population.

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