Investigating the relation between anti-oxidant activity and epileptic enzymes of formulation-40 capsules

2020 ◽  
Vol 4 (1) ◽  
pp. 6-9
Author(s):  
Bhavani J ◽  
Ravichandran S
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Chemical Constituents ◽  
Standard Drug ◽  
Protective Enzyme ◽  
Anti Oxidant ◽  
Dose Dependent ◽  
The Brain ◽  
Herbal Formulations ◽  
Human Nervous System

Seizures and Epilepsy are those major conditions that are common symptoms of many diseases that affect the human nervous system. It is one of the most chronic and commonest of the neurological disorders that is prevalent in almost 5crore people around the world. Even though the drugs are effective and potent, there are various side effects and adverse effects are associated with those drugs. General side effects include the nausea and vomitings, many other specific side effects include altered mental consciousness, confusion anorexia and excessive aggression are also noted in many cases of drugs. In this research, herbal formulations were designed to fight back the free radicals that are generated in the brain and those protective enzyme levels were analyzed to estimate the activity of the formulation in the brain tissue. In the research, the prepared formulation showed a dose dependent activity in restoring the brain protective enzymes and balancing them. The formulation contained herb powders that contain antioxidant chemical constituents which helped for the anti-epileptic formulation. The herbal capsules at dose 500mg/kg showed a better activity compared to the standard drug but without notable side effects and adverse effects.

Evaluation of Anticonvulsant and Anti-oxidant Potentials of Basella Alba by Influencing the Brain Enzyme Levels in Laboratory Animals

2020 ◽  
Vol 11 (3) ◽  
pp. 5031-5034
Author(s):  
Asokan B.R. ◽  
Jaikumar S ◽  
Somasundaram G
Keyword(s):  
Neurological Diseases ◽  
Chemical Constituents ◽  
The Body ◽  
Laboratory Animals ◽  
Basella Alba ◽  
Protective Enzyme ◽  
Anti Oxidant ◽  
Radical Generation ◽  
Brain Tissue Damage ◽  
The Brain

Epilepsy and convulsions constitute a significant class of symptoms that are commonly seen in many neurological diseases. It is understood that there is an apparent alteration in the levels of the enzymes which present brain during epilepsy. Anti-oxidant drugs are known to elevate the protective enzyme levels in the body and restore them to ensure the proper functioning is done. But when the enzyme levels are not managed properly, they can cause further damage and deterioration of the tissue. Basella alba is one of such drugs, which is rich in anti-oxidant chemical constituents. Many researchers concluded that many components like vitamin A, C and flavonoids, polyphenols are being reported. In the study, Basella alba was investigated for effect on an anti-oxidant enzyme in the brain. The extracts showed a better activity and prevented the brain tissue damage from any oxidative free radical generation. The enzyme levels were healthy at the dose of 400mg/kg of extract.

scholarly journals Gastroprotective effect of leaves of Breyniavitis-Idaea

2020 ◽  
Vol 11 (2) ◽  
pp. 2519-2524
Author(s):  
Poojitha M ◽  
Saravanakumar A S ◽  
Satyanarayana S V
Keyword(s):  
Side Effects ◽  
Chemical Constituents ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Standard Drug ◽  
Synthetic Drugs ◽  
Pylorus Ligation ◽  
Dose Dependent ◽  
Ligation Method

Due to the lure backs of synthetic drugs that are being used medical field has turned over to the traditional medicine which are devoid of side effects and major adverse effects. So that Herbal drugs were seen as probable replacements for the handling of PUD without showing side effects and equaling the treatment efficacy. The literature review on investigations of antiulcer activity of various plant drug, the present investigation was carried out to investigate the antiulcer potential, chemical constituents present in the methanol extract of traditional plant Breyniavitis-idaea. Gastric ulcers in experimental animals were brought by four different models like  Ethanol(Alcohol)  induced, NSIDS (Indomethacin) induced, Pylorus ligation method and Cold resistant stress induced method by comparing with the standard drug namely omeprazole (20mg/kg) which exhibited the dose dependent capacity of the extract (125mg/kg,250mg/kg, 500mg/kg) and also the biochemical parameters like ALP, GSH, pH and Gastric volume contents were estimated in all the selected groups (Design of Experiment). The results obtained from the study has helped to identify that 500mg/kg of plant extract has gastro protective effect in all the chosen models in comparison to the omeprazole (20mg/kg) standard drug. Owing to the prevalence of different phytoconstituents like poly phenols and flavonoids shown the dose dependent potent gastroprotective activity.

In-vivo evaluation of lipid lowering ability of Chloris paraguaiensis extracts

2020 ◽  
Vol 7 (2) ◽  
pp. 21-24
Author(s):  
Pavani C H
Keyword(s):  
Medicinal Plants ◽  
Chemical Constituents ◽  
The Body ◽  
Lipid Lowering ◽  
Medical Systems ◽  
In Vivo Evaluation ◽  
Standard Drug ◽  
Anti Oxidant ◽  
And Control

Hyperlipidemia is the immediate results of the excessive fat intake in food. This results in the elevated levels of cholesterol and triglycerides in the blood. This leads to heart conditions like CAD, hypertension, congestive heart failure as risk factors which can be lethal. There are many drugs to treat and control the lipids levels in the body. These drugs are either designed to prevent LDL accumulation and VLDL synthesis. Some drugs also lower the elevated levels of saturated lipids in the body. But many drugs are known to cause side effects and adverse effects; therefore, alternatives to the drugs are the subjects for current investigations. Herbs and medicinal plants are used as treatment sources for many years. They have been used in the Indian medical systems like Ayurveda, Siddha etc. As the application of herbs in the treatment is growing, there is an urgent need for the establishment of Pharmacological reasoning and standardization of the activity of the medicinal plants. Chloris paraguaiensis Steud. is Poyaceae member that is called locally as Uppugaddi. Traditionally it is used to treat Rheumatism, Diabetes, fever and diarrhoea. The chemical constituents are known to have anti-oxidant properties and most of the anti-oxidants have anti-hyperlipidemic activity too. Since the plant has abundant flavonoid and phenol content, the current research focusses on the investigation of the anti-hyperlipidemic activity of the plant Chloris extracts. Extracts of Chloris at 200mg/kg showed a comparably similar anti hyperlipidemia activity to that of the standard drug. The extracts showed a dose based increase in the activity at 100 and 200mg/kg body weight.

scholarly journals MEDICINAL HERBS AND PHYTOCHEMICALS USED IN THE TREATMENT OF DEPRESSION: A REVIEW

2019 ◽  
pp. 8-14
Author(s):  
APOORVA HA ◽  
SEEMA MEHDI ◽  
KRISHNA KL ◽  
NABEEL K
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Clinical Evidence ◽  
Emotional State ◽  
Well Being ◽  
New Approach ◽  
Treatment Of Depression ◽  
Primary Hypothesis ◽  
The Brain ◽  
Additional Option

Depression is a condition of no mood and loss of interest in any activity that can diminish a person’s thinking, conduct, tendencies, emotional state, and a sense of well-being. Although there is a conventional class of medication which have been beneficial in the treatment of depression, current studies have reported having side effects which can be minimized by the intervention of herbs and phytochemicals. Most of the studies have proven the various mechanisms and have started to research a very ground-breaking method by glancing the ancient treatmen. Where this new approach of using the herbs and phytochemicals has shown better results alone and in combination with conventional drugs which has shown lesser adverse effects. The practice of phytomedicine is an additional option for the treatment of depression. In the various segments of treating the depression, the mainstream can be a breakthrough including phytoconstituents. In this aspect, there are many contributions for the treatment of the depression acting to the neuronal level signaling and the phytoconstituents also have shown some basic mechanisms in the treatment of depression as that of the conventional medications following some primary hypothesis and signaling pathways and life interactions that effects the brain in either way to treat the depression in all sort of way. Clinical evidence is required to provide backing to the safety and effectiveness of herbs and phytochemicals alone or in combination with currently available drugs to overcome the reported side effects during the treatment of depression.

scholarly journals Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

2014 ◽  
Vol 26 ◽  
pp. 1-8 ◽  
Author(s):  
S. Parimala Vaijayanthi ◽  
N. Mathiyalagan
Keyword(s):  
Antimicrobial Activities ◽  
Experimental Results ◽  
Standard Drug ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Dose Dependent ◽  
Trichloroisocyanuric Acid ◽  
Hypertensive Activity

N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

scholarly journals Investigation and Preparation of Polyherbal Ointment for Arthritis

2018 ◽  
Vol 6 (2) ◽  
pp. 34-37
Author(s):  
Bhavani J ◽  
Ravichandran S ◽  
Satheesh Kumar D ◽  
Chandrasekaran A R ◽  
Saraladevi V ◽  
...  
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Elderly Patients ◽  
Plant Extract ◽  
Human Body ◽  
Opportunistic Infections ◽  
Chemical Constituents ◽  
The Body ◽  
Standard Drug

The process of inflammation and the arthritis was induced due to the immune system problems in elderly patients. They are encountering problems with the immune system which identifies the own body as a foreign system and acts against it. This causes inflammation in the joints and therefore causing pain and swelling in the joints. This immunity lowering drugs are the major classes of drugs that will affect the human body by lowering the immunity, and the side effects are caused by the opportunistic infections that occur when the body has low immunity. These effects are now dangerous, and the drugs that treat arthritis are now considered deadly, and their use is minimized too. In this respect, the herbs are found to be the best sources of the treatment of arthritis that produce the chemical constituents that target and cure inflammation that causes arthritis. The plant extract was used to incorporate into the ointment, and this was investigated for the anti-arthritic activity. This was compared to the activity of the extract and standard drug. The ointment that was prepared showed a significantly better activity compared with the standard drug.

scholarly journals In Vivo Antitumor Activity of Ethanolic Extract of Lepidagathis Pungens Nees Whole Plant

2020 ◽  
Vol 11 (4) ◽  
pp. 6763-6770
Author(s):  
Manoharan Dhanalakshmi ◽  
Subramaniam AnandaThangadurai ◽  
Swaminathan Gomathi
Keyword(s):  
Side Effects ◽  
Chemical Constituents ◽  
Ethanolic Extract ◽  
Synthetic Drugs ◽  
In Vivo Antitumor Activity ◽  
Whole Plant ◽  
Chemotherapy Patients ◽  
Dose Dependent ◽  
Plant Sources

Cancer is the most dreadful of all the diseases and is the major contributors to the mortality in the world. Out of all the population, almost 1.2 million patients die due to cancer and related problems. The rate and spread of cancer are wide and even in both women and men. It is presently as high as 3.5 million people who have cancer in India alone. There are many ways of treatment of cancer like the surgery, radiation therapy, cryosurgery and chemotherapy. A part of chemotherapy is the usage of a lot of chemicals and synthetic drugs. Due to the side effects of chemotherapy, patients often get symptoms due to the usage of drugs, and so the cancer treatment often is toxic. Because of this, herbal drugs are seemed to have no side effects, and non-toxic effects, and so this project deals with identifying the plant sources of the drugs that treat cancers effectively. The present study focusses on the extraction of the chemical constituents from Lepidagathis pungens whole  plant and using the same to estimate the anti-tumour potential in EAC induced tumour induction method. The activity was tested in two doses 200 and 400 mg/kg of the extract. They showed a dose-dependent activity when estimated for the tumour parameters and other haematological measures like RBC, WBC counts. They showed similar activity when estimated for the antioxidant enzymes like SGOT, SGPT, Catalases, LPO and ALP levels.

Nanotechnology based herbal formulations: A survey of recent patents, advancements and transformative headways

2021 ◽  
Vol 15 ◽  
Author(s):  
Anureet Kaur ◽  
Lakhvir Kaur ◽  
Gurjeet Singh ◽  
RK Dhawan ◽  
Ayushi Mahajan
Keyword(s):  
Side Effects ◽  
Herbal Medicine ◽  
Adverse Effects ◽  
Traditional Medicine ◽  
Synergistic Effects ◽  
Complete Information ◽  
Review Article ◽  
Innovative Technology ◽  
Herbal Drugs ◽  
Herbal Formulations

: Nanotechnology in association with the herbal medicine can lead to enhanced therapeutic and diminished adverse effects of medication. In turn, it can lead to synergistic effects of administered compound overcoming its demerits. Now-a-days, the trend of herbal compounds to treat even a small illness is gaining momentum. Gone are the days when the ineffectiveness of a compound was impossible to be dealt with. Nevertheless, in this competitive era of science and innovative technology, it has become possible to maximize the usefulness of ineffective yet potent herbal compounds. The demand of herbal compounds is getting amplified because of their ability to treat myriad of diseases including COVID-19, showing less side effects. The merger of nanotechnology with traditional medicine augments the potential of herbal drugs for devastating dangerous and chronic diseases like cancer. In this review article, we have tried to assimilate the complete information regarding the use of different nanocarriers to overcome the drawbacks of herbal compounds. In addition, all the recent advancements in the herbal field as well as the future exploration to be emphasized have been discussed.

Investigation of Arthritis Suppressing Potency of Chloris Paraguaiensis on Freund’s Adjuvant Induced Arthritis in Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 5047-5050
Author(s):  
Somasundaram G ◽  
Jaikumar S ◽  
Balaji subramaniyan R
Keyword(s):  
Immune System ◽  
Side Effects ◽  
Chemical Constituents ◽  
Inflammatory Disorder ◽  
Standard Drug ◽  
Experimental Animals ◽  
Adjuvant Induced Arthritis ◽  
Grass Family ◽  
The World ◽  
Comparable Activity

Arthritis is a widespread disorder that occurs in elderly patients currently in the world. It is one of those disorders that affect the joints and is classified as an inflammatory disorder that is a result of immune system malfunctioning. Taking into consideration the side effects of immune suppressants that are used to treat arthritis; generally, plants are being investigated for the chemical constituents to treat the diseases. It is proved that moieties obtained from herbal sources are relatively safer and potent too. The economical methods of treating illness are using plants, and so the herbs are investigated for the treatment of arthritis. ., is one of the members of grass family which is grown wildly in tropical countries all around the world. It usually grows like a weed and can be employed for many pharmacological problems. Traditional claims are there to treat DM, Rheumatism and . Chemical constituents like , and have been isolated from the plant earlier. was selected as a subject to investigate its anti-arthritis potential in using experimental animals following the folklore claims that the plant can be used to treat arthritis. It may be due to the presence of and chemical constituents in the plant. The exact mechanism of action is to be established and the extracts in this current study showed a significantly comparable activity with that of the standard drug .

Evaluation of antipyretic activity of Capsicum annuum by Brewer’s yeast method

2020 ◽  
Vol 9 (1) ◽  
pp. 11-13
Author(s):  
Dinesh Babu J
Keyword(s):  
Weight Loss ◽  
Capsicum Annuum ◽  
Chemical Constituents ◽  
Gastrointestinal Function ◽  
Standard Drug ◽  
Antipyretic Activity ◽  
Similar Chemical ◽  
Anti Cancer ◽  
Science Investigations ◽  
Crucial Ingredient

Plants are being used in medicine and treatment of diseases from years in the evolution. During the development of science, investigations to establish eh scientific proof and validation for the activities and mechanism of herbs to treat diseases. Capsicum annuum has anti-cancer properties, analgesic properties, anti lithogenic and thermogenic properties. It is used to alter the gastrointestinal function and boost metabolism. Many formulations are enriched with capsaicin which is a crucial ingredient in Capsicum to exhibit its weight loss properties. Based on the anti-inflammatory and analgesic properties of the plant and taking into consideration, the current research will focus on the investigation and comparison of the antipyretic activity of Capsicum in fruits and leaves. Results show that the leaves have similar chemical constituents that had antipyretic potential compared to the fruits. Overall, the Capsicum showed a comparatively same activity with the standard drug, paracetamol.

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