scholarly journals Association Study between miR-181b rs322931 Polymorphism and Risk of Gastric Cancer

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Dingguo Pan ◽  
Yunfeng Li ◽  
Liang Ai ◽  
Qi Zhang
Keyword(s):  
Gastric Cancer ◽  
Venous Blood ◽  
Taqman Probe ◽  
Chinese Han ◽  
Age And Gender ◽  
Peripheral Venous Blood ◽  
Genotype C ◽  
Spss Software ◽  
And Gender ◽  
The Relationship

Objective: To explore the relationship between miR-181b rs322931 polymorphism and the risk of gastric cancer. Methods: The peripheral venous blood of 172 patients with gastric cancer and 224 healthy controls were collected. The miR-181b rs322931 was typed by TaqMan probe method, and correlation between miR-181b rs322931 and the risk of gastric cancer was evaluated using SPSS software.  Results: The frequencies of miR-181b rs322931 CC, CT, TT genotype, C, and T allele were 61.6, 33.7, 4.7, 78.5, and 21.5% in gastric cancer, and 74.1, 23.7, 2.2, 85.9, and 14.1% in controls, respectively. After the ?2 test and correction for age and gender, the risk of gastric cancer in carriers of CT and CT/TT genotypes increased by 1.71 and 1.79 times, respectively (CT vs. CC: 95% CI, 1.10-2.67, P=0.02; CT /TT compared with CC: 95%CI, 1.16-2.74, P=0.008). Moreover, compared with alleles, the risk of gastric cancer in T allele carriers increased by 1.69 times (95%CI, 1.16-2.44, P=0.006). Conclusion: miR-181b rs322931 polymorphism may be one of the susceptibility genes of gastric cancer in the Chinese Han nationality.

scholarly journals Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population

2021 ◽  
Vol 43 (1) ◽  
Author(s):  
Yonghui Yang ◽  
Dandan Li ◽  
Chunjuan He ◽  
Linna Peng ◽  
Shishi Xing ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chinese Han Population ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Rheumatoid Arthritis Risk ◽  
Age And Gender ◽  
Han Population ◽  
Genotype Frequencies ◽  
And Gender ◽  
The Relationship

Abstract Background Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases. It is suggested that genetic factors play a crucial role in the pathogenesis of this disease. In this study, we aimed to investigate the relationship between FCRL1 rs2050568, FCRL3 rs2317230 and FCRL6 rs58240276 polymorphisms and RA risk in the Chinese Han population. 506 with RA patients and 509 healthy controls were recruited in this study, and the single nucleotide polymorphisms (SNPs) was successfully genotyped using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjusting for age and gender were conducted to assess these SNPs polymorphisms and RA risk. The multifactor dimensionality reduction (MDR) method was conducted to analyze SNP-SNP interaction. Results Our results revealed that there no significant association was observed between the allele and genotype frequencies among these SNPs and RA risk (all p > 0.05). Straified analysis by age and gender, the results confirmed that FCRL1 rs2050568 T/T genotype enhanced the risk of RA in females (p = 0.014). The G/T - T/T genotype of FCRL3 rs2317230 was correlated with a decreased RA risk in males (p = 0.021). We also observed that the C/T-T/T genotype of FCRL6 rs58240276 was increased the risk of RA in the group at age >  54 years (p = 0.016). In addition, FCRL1 rs2050568-TT, FCRL6 rs58240276-TT and FCRL1 rs2050568-TT, FCRL3 rs2317230-TT, FCRL6 rs58240276-TT are the best models for multi-site MDR analysis (p < 0.05), and the two best models mentioned above and classes RA have the most significant correlation. Conclusions Our study demonstrated that FCRL1 rs2050568, FCRL3 rs2317230, and FCRL6 rs58240276 polymorphisms were correlated with RA susceptibility in the Chinese Han population.

scholarly journals No Self Without Salience: Affective and Self-relevance Ratings of 552 Emotionally Valenced and Neutral Dutch Words

2021 ◽  
Author(s):  
Lora I. Dimitrova ◽  
Eline M. Vissia ◽  
Hanneke Geugies ◽  
Hedwig Hofstetter ◽  
Sima Chalavi ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Emotional Valence ◽  
Age And Gender ◽  
Gender And Age ◽  
Main Effect ◽  
Emotional Salience ◽  
And Gender ◽  
The Relationship

AbstractIt is unknown how self-relevance is dependent on emotional salience. Emotional salience encompasses an individual's degree of attraction or aversion to emotionally-valenced information. The current study investigated the interconnection between self and salience through the evaluation of emotional valence and self-relevance. 56 native Dutch participants completed a questionnaire assessing valence, intensity, and self-relevance of 552 Dutch nouns and verbs. One-way repeated-measures ANCOVA investigated the relationship between valence and self, age and gender. Repeated-measures ANCOVA also tested the relationship between valence and self with intensity ratings and effects of gender and age. Results showed a significant main effect of valence for self-relevant words. Intensity analyses showed a main effect of valence but not of self-relevance. There were no significant effects of gender and age. The most important finding presents that self-relevance is dependent on valence. These findings concerning the relationship between self and salience opens avenues to study an individual's self-definition.

scholarly journals Reference intervals for serum lipids and prevalence of dyslipidaemia in 6–12-year-old children: The Health Oriented Pedagogical Project (HOPP)

2018 ◽  
Vol 46 (21_suppl) ◽  
pp. 21-27 ◽  
Author(s):  
Martin Frank Strand ◽  
Per Morten Fredriksen ◽  
Ole Petter Hjelle ◽  
Morten Lindberg
Keyword(s):  
Total Cholesterol ◽  
Serum Lipids ◽  
Venous Blood ◽  
Elevated Serum ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Reference Intervals ◽  
Age And Gender ◽  
Norwegian Population ◽  
And Gender

Aims: Elevated serum lipid concentrations in childhood are thought to be risk factors for the development of cardiovascular disease later in life. The present study aims to provide age- and gender-related reference intervals for total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol in healthy school children. We also investigated the prevalence of dyslipidaemia using the published criteria for these biomarkers. Methods: Venous blood and anthropometric data were collected from 1340 children in the HOPP study, aged between 6 and 12 years. Age- and gender-related reference intervals (2.5th and 97.5th percentiles) were established according to the IFCC recommendations, using the software RefVal 4.10. Results: Gender differences were observed for total cholesterol and non-HDL cholesterol, but not for HDL cholesterol. Age differences were observed for total cholesterol. The reference intervals were in the range of 3.1–5.9 mmol/L for total cholesterol, 1.0–2.4 mmol/L for HDL cholesterol and 1.4–4.2 mmol/L for non-HDL cholesterol. Dyslipidaemia prevalence was as follows: increased TC 9.6%, decreased HDL 1.6%, and increased non-HDL 5.6%. Conclusions: Age- and gender-related reference intervals in a Norwegian population are similar to those reported in other countries. The prevalence of dyslipidaemia among Norwegian children is significant, emphasising the importance of appropriate reference intervals in clinical practice.

Focus on Text Messages: A Review of Studies in French

2015 ◽  
pp. 1037-1050
Author(s):  
Olga Volckaert-Legrier ◽  
Antonine Goumi ◽  
Alain Bert-Erboul ◽  
Josie Bernicot
Keyword(s):  
Text Message ◽  
Text Messages ◽  
French Language ◽  
Age And Gender ◽  
Future Studies ◽  
Linguistic Markers ◽  
Production Processes ◽  
Language Research ◽  
And Gender ◽  
The Relationship

The study of text messages has given rise to a number of French language research topics. First, databases of natural text messages have been created in multiple Francophone countries in an effort to link the texters' characteristics with the linguistic markers of the text messages. Many studies have focused on textisms (changes in spelling as compared to the traditional written code), creating repertoires of spelling processes and classifying them into typologies. With regard to linguistic aspects, a few studies have analyzed vocabulary and syntax. Sociolinguistic aspects have also been studied, taking into account the relationship among textisms, age, and gender. To address the question of whether text message writing is a threat to spelling, several studies have analyzed the link between text message writing and traditional writing. Finally, a number of studies have focused on the production processes of text message writing. Future studies will need to take into account the dialogical and conversational aspects of text messages.

scholarly journals The relationship between human adenovirus 36 and obesity in Chinese Han population

2018 ◽  
Vol 38 (4) ◽  
Author(s):  
Yan Zhou ◽  
Qi Pan ◽  
Xiaoxia Wang ◽  
Lina Zhang ◽  
Fei Xiao ◽  
...  
Keyword(s):  
Protective Factor ◽  
Human Adenovirus ◽  
Chinese Han Population ◽  
Male Population ◽  
Chinese Han ◽  
Age And Gender ◽  
Female Population ◽  
Han Population ◽  
And Gender ◽  
Adenovirus 36

The study aimed to explore the prevalence of human adenovirus-36 (HAdV-36) infection and the association of HAdV-36 with obesity in Chinese Han population. A qualitative determination using ELISA was performed to determine by duplication of the antibodies to HAdV-36 in the serum samples. Logistic regression analysis was used to analyze the association between HAdV-36 seropositivity and obesity. The overall HAdV-36 seroprevalence was 49.8% amongst 824 participants. The prevalence of HAdV-36 seropositive was 42.9 and 51.4% in the obese and non-obese participants, respectively, which was not statistically significant (P=0.05). There were significant differences in the anthropometric and biochemical parameters observed between the two groups except for height (P=0.067) and total cholesterol (TC) (P<0.29). After the adjustment for age and gender, HAdV-36 seropositivity was a protective factor for obesity (odds ratio (OR) = 0.69, 95% confidence intervals (95% CI) = 0.48–0.97, P=0.03). In the male population, the adjusted OR for AD-36 antibody-positive status was statistically decreased for obese adults (OR = 0.59; 95% CI = 0.39–0.91; P=0.02). However, the similar result was not obtained in the female population (OR = 0.90; 95% CI = 0.48–1.67; P=0.73). We found a high prevalence of HAdV-36 infection in China and significant association between HAdV-36 infection and obesity or weight gain after the adjustment for age and gender. The HAdV-36 infection may be related to the weight loss in Chinese Han population, especially in the male group, which needs to be further confirmed.

Effects of Feature Variations on Attributions for Schematic Faces

1993 ◽  
Vol 73 (1) ◽  
pp. 275-288 ◽  
Author(s):  
Stuart J. McKelvie
Keyword(s):  
Age And Gender ◽  
Short Nose ◽  
Folk Wisdom ◽  
Perceived Age ◽  
Six Dimensions ◽  
Individual Features ◽  
And Gender ◽  
The Relationship

31 subjects classified 16 schematic faces on six dimensions. Attractiveness was generally associated with widely separated eyes, a short nose, and high feature placement. When features were considered in combination, faces with low placement were judged attractive, although the effect was mitigated by a narrow mouth. Previous findings concerning perceived age and gender were partially replicated, but folk wisdom linking intelligence to low placement (high forehead) was refuted. It is suggested that the relationship between individual features and attributions is nonlinear and interactive, and that researchers should investigate these hypotheses by exercising finer control over feature variations.

The Relationship of Human Saphenous Vein Smooth Muscle Contractile Responses to Donor Age and Gender

1995 ◽  
Vol 29 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Kelvin G. M. Brockbank ◽  
Mark G. Davies ◽  
Shirley M. Fields ◽  
Per-Otto Hagen
Keyword(s):  
Smooth Muscle ◽  
Saphenous Vein ◽  
Donor Age ◽  
Human Saphenous Vein ◽  
Age And Gender ◽  
Contractile Responses ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship ◽  
Muscle Contractile

scholarly journals Pneumonia: Does Age or Gender Relate to the Presence of an SLP Dysphagia Consultation?

Geriatrics ◽  
2020 ◽  
Vol 5 (3) ◽  
pp. 51
Author(s):  
Christopher Bolinger ◽  
James Dembowski ◽  
Kimberly Mory
Keyword(s):  
Geriatric Patients ◽  
Care Setting ◽  
Gender Disparities ◽  
Age And Gender ◽  
Speech Language Pathologist ◽  
Hospital Policies ◽  
And Gender ◽  
Relationship Of ◽  
The Relationship

A retrospective study of 1489 hospital records examined the relationship of speech-language pathologist (SLP) consults for dysphagia to age and gender in pneumonia patients from an acute care setting. Age and gender disparities exist in healthcare. The research sought to determine if disparities existed in the presence/absence of SLP dysphagia consults related to age and gender. Results suggested SLPs were consulted on a greater percentage of geriatric patients overall; however, there were differences in the number of consults for each pneumonia type. More males and geriatric patients were seen than females and non-geriatric adults, respectively. Results may be used to address local hospital policies and protocols and thus increase quality of care by improving morbidity and mortality outcomes of geriatric patients with pneumonia.

Sign in / Sign up

Export Citation Format

Share Document