scholarly journals Trilostane Treatment of Canine Alopecia X in an American Pit Bull Terrier

2007 ◽  
Vol 76 (1) ◽  
pp. 113-120
Author(s):  
J. Kolevská ◽  
V. Brunclík ◽  
L. Bartošová ◽  
M. Svoboda
Keyword(s):  
Adverse Effects ◽  
Skin Biopsy ◽  
Treatment Option ◽  
Clinical Signs ◽  
Laboratory Findings ◽  
Hair Regrowth ◽  
Dermatological Examination ◽  
History Of ◽  
One Year ◽  
Hormone Imbalance

This paper describes the case of a one-year-old female American Pit Bull Terrier, presented with the history of progressive baldness. The initial clinical signs were demonstrated by symmetric, primarily non-pruritic alopecia that began in the perineal, genital, and ventral abdominal regions and propagated cranially to the thorax and to the neck. Based on physical and dermatological examination, laboratory findings, and results of skin biopsy, a hormone-responsive dermatosis was diagnosed. Once hypothyroidism and hyperadrenocorticism were ruled out, with the help of hormonal tests, the diagnosis was specified as alopecia X. The first treatment option recommended for the patient and subsequently completed was ovariohysterectomy. After three months, the owner reported improvement; the dog was almost covered with hair. The patient was presented again six months later, showing almost the same dermatological symptoms, which, however, were of a more striking character than before ovariohysterectomy. Again a series of hormonal tests was carried out. Considering the elevated basal and post-adrenocorticothropin stimulation progesterone concentrations, the final aetiology of the disease was determined as an adrenal sex hormone imbalance. Therefore trilostan therapy was initiated. The trilostan dosage of 8 mg/kg/day was divided and given 2 times daily. This treatment led to complete hair regrowth in the dog within four months. No adverse effects associated with trilostane were recognized.

scholarly journals Acute Pancreatitis Associated With Peritoneal Migration of Grass Awn in Two Dogs

2017 ◽  
Vol 67 (4) ◽  
pp. 587-592 ◽  
Author(s):  
Simonetta Citi ◽  
Tommaso Mannucci ◽  
Francesca Pedala’ ◽  
Iacopo Vannozzi ◽  
Massimo Vignoli
Keyword(s):  
Acute Pancreatitis ◽  
Foreign Body ◽  
Clinical Signs ◽  
Blood Analysis ◽  
Full Resolution ◽  
History Of ◽  
Right Lobe ◽  
One Year ◽  
Grass Awn

AbstractA 12 year old male Fox Terrier (case 1) and a one year old female Poodle (case 2) were presented with a history of dysorexia and vomiting, and case 2 also with distress associated with eating. Both dogs were diagnosed with acute pancreatitis based on clinical signs, blood analysis and ultrasonography which revealed the presence of a vegetable foreign body in the proximity of the pancreatic right lobe. Laparatomy enabled the gramineae awns to be removed which led to full resolution of clinical signs. We believe that these are the first reported cases of acute pancreatitis due to grass awns.

Possible drug-induced follicular mucinosis in a dog

2019 ◽  
Vol 7 (2) ◽  
pp. e000811
Author(s):  
Tatiana de Brito Lima ◽  
Laura Ordeix ◽  
Dolors Fondevila
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Complete Remission ◽  
Clinical Signs ◽  
Prostatic Hyperplasia ◽  
Daily Regimen ◽  
Drug Induced ◽  
History Of ◽  
Anti Inflammatory ◽  
One Year ◽  
Entire Male

A nine-year-old, entire male basset hound presented with one-year history of pruritus and patchy to diffuse alopecia accompanied by erythema, starting a few days after applying an implant of deslorelin for treatment of benign prostatic hyperplasia. Dermatopathological examination was diagnostic for follicular mucinosis, accompanied by a characteristic lymphocytic mural folliculitis at the level of the isthmus. Partial improvement with anti-inflammatory doses of prednisone was observed. Thereafter, oral ciclosporin was administered on a daily regimen until complete remission was achieved, after which it was gradually tapered until withdrawal. No other implants were applied thereafter, and two years later the patient remains free of clinical signs.

scholarly journals Combination Therapy in Melasma with Lentigo Solaris

2020 ◽  
Vol 3 (1) ◽  
pp. 65-70
Author(s):  
Erty Witalaya Lumbantoruan ◽  
Khairina Nasution ◽  
Nelva Karmila Jusuf
Keyword(s):  
Glycolic Acid ◽  
Controlled Trial ◽  
Severity Index ◽  
Mitochondrial Enzymes ◽  
Street Vendor ◽  
Cytotoxic Effects ◽  
Dermatological Examination ◽  
History Of ◽  
One Year ◽  
Inhibition Of Dna Synthesis

Background: Melasma and lentigo solaris are common, recurrent, and refractory acquired hyperpigmentation disorder. In spite of variety of therapeutic options available for this cosmetically disfiguring condition, the treatment of this condition remains a challenge. Azelaic acid (AA) is a depigmenting agent which acts by inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on melanocytes. Glycolic acid (GA) peel is one of the most versatile agents in the treatment of melasma and lentigo solaris. GA peels alone or in combination with topical hypopigmenting agents has shown encouraging results. However, there is paucity of controlled trial demonstrating the efficacy of GA peels in conjunction with topical AA. Case: A 42-years-old female, works as a street vendor, came with dark brown spots on both cheeks, nose, chin and forehead that spreads to whole face since one year ago. She had a history of using contraceptives. From the dermatological examination, there were multiple well-circumscribed, irregular hyperpigmented macules that asymmetrical, with size ranging from lenticular to plaque on the maxillary, left buccalis, mentalis and frontalis region. We also found a numular dark brown hyperpigmented macules on right zygoma. She was diagnosed with melasma and lentigo solaris. The Melasma Area Severity Index (MASI) score was 25.6, which classified as moderate melasma. She was treated with 20% azaleic acid cream twice a day, broadspectrum sunscreen with SPF 50 and GA 20% peeling. Result: After 6 weeks of treatment, there were significant  improvement in both melasma and lentigo solaris.

scholarly journals First Autochthonous Infection of a Cat with Dirofilaria immitis in Austria

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1104 ◽  
Author(s):  
Lisa-Maria Kulmer ◽  
Maria Sophia Unterköfler ◽  
Hans-Peter Fuehrer ◽  
Varvara Janovska ◽  
Matus Pagac ◽  
...  
Keyword(s):  
Case Report ◽  
Dirofilaria Immitis ◽  
Complete Blood Count ◽  
Clinical Signs ◽  
Surgical Removal ◽  
Negative Results ◽  
Heartworm Disease ◽  
History Of ◽  
One Year ◽  
The Right

This case report is about a seven-year-old male neutered European Shorthair cat infected by Dirofilaria immitis as the first reported autochthonous Dirofilaria immitis infection in Austria. There was no history of periods abroad. Echocardiography showed suspected D. immitis in the right cardiac chamber with increased pulmonary pressure and ascites. Surgical removal of the heartworms was performed. Twenty adult heartworms were removed by transvenous jugular approach under general anesthesia and stored in 4% formalin. Five out of 20 specimens were examined via light and stereomicroscopy and feline heartworm infection was confirmed. Amplification of a 203 bp or 724 bp fragment of the cytochrome c oxidase subunit I gene was unsuccessful. After surgery the cat developed acute renal failure but recovered quickly. One year later, the cat underwent a control examination including echocardiography and blood work. There were no more D. immitis detectable at echocardiography. Lung pressure was mildly increased. Complete blood count and creatinine were unremarkable. The Knott’s test and Dirofilaria-Antigen-test produced negative results. The cat did not show any clinical signs during the follow-up period. The aim of this case report is to highlight the growing risk of acquiring infection with D. immitis not only for Austrian dogs, but also for cats. This case report represents the first report of autochthonous D. immitis infection in Austria. Moreover, even if the prognosis in cats with caval syndrome due to feline heartworm disease is guarded to poor, surgical removal of the filariae can be a successful treatment option.

Supracollicular fluid accumulation type 3 with concurrent hydrocephalus in a five-month-old crossbreed dog

2019 ◽  
Vol 7 (2) ◽  
pp. e000800
Author(s):  
Sophie Martin ◽  
Sara Shivapour ◽  
Elsa Beltran
Keyword(s):  
Revision Surgery ◽  
Clinical Signs ◽  
Fluid Accumulation ◽  
Shunt System ◽  
History Of ◽  
Neurologically Normal ◽  
One Year ◽  
Type 3 ◽  
Shunt Tubing ◽  
Ct And Mri

A five-month-old crossbreed dog was referred with a 36-hour history of cervical hyperaesthesia. CT and MRI of the head and neck identified supracollicular fluid accumulation type 3 with concurrent hydrocephalus, syringohydromyelia and cerebellar herniation. Medical treatment consisting of analgesia and mannitol was instigated, and once the patient was stabilised a supracollicular-peritoneal shunt system was placed. The patient initially responded very well to this treatment. Six days postoperatively, the patient sustained disconnection of the shunt system at the level of the pressure valve and distal shunt tubing. Revision surgery to repair the shunt was performed without further complication. The dog returned to being neurologically normal within four weeks. One year postoperatively, the patient remains neurologically normal with no further clinical signs nor shunt system complications.

scholarly journals Peritumoral (pseudo)cystic meningioma in a cat

2020 ◽  
Vol 89 (4) ◽  
pp. 215-220
Author(s):  
V. Volckaert ◽  
E. Royaux
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Clinical Signs ◽  
Abnormal Behavior ◽  
Histopathologic Examination ◽  
Resonance Imaging ◽  
Axial Mass ◽  
History Of ◽  
One Year ◽  
The Brain

A nine-year-old, male, neutered domestic shorthair cat was referred with a three-month history of abnormal behavior. On neurological examination, the cat showed circling towards the left. Magnetic resonance imaging of the brain revealed an extra-axial mass at the level of the left forebrain surrounded by a large peritumoral (pseudo)cyst. A left-sided rostrotentorial craniectomy to drain the fluid and to remove the tumor was performed. On histopathologic examination, the presence of a meningioma was confirmed. The owners did not report any clinical signs one year postoperatively.

scholarly journals Renal toxic disease in a cat

2021 ◽  
Vol 14 (2) ◽  
pp. 142-144
Author(s):  
Alex dos Santos ◽  
◽  
Mariana Martins ◽  
Keyword(s):  
Epithelial Cells ◽  
Abdominal Cavity ◽  
Clinical Signs ◽  
Clinical History ◽  
Abdominal Ultrasound ◽  
Tubular Epithelial Cells ◽  
Moderate Amount ◽  
Laboratory Findings ◽  
Hospitalization Period ◽  
History Of

Clinical History: This 8-month-old, male, mixed breed domestic shorthaired cat had a recent history of acute apathy and anorexia. It remained under hospital care for two days, during which it did not produce any urine. On the second day of hospitalization, another cat from the same household was brought in with similar clinical signs. These cats did not have any history of recent ingestion of antibiotics or other medication. Furthermore, they did not have any street or yard access since they were kept in an apartment. Both cats died spontaneously after a brief hospitalization period. Laboratory Findings: Marked increase of urea and creatinine in both cats was reported (values not informed). On abdominal ultrasound, both cats had perirenal edema, and small amount of free abdominal effusion was observed in this cat. Necropsy Findings: There was moderate amount of translucent, slightly yellowish fluid within the abdominal cavity, thoracic cavity and pericardial sac. There was moderate diffuse pulmonary edema. Moderate perirenal edema was observed bilaterally. The kidneys were diffusely swollen and pale (Fig. 1). On histopathologic exam, the cortical tubular epithelial cells were swollen, with hypereosinophilic cytoplasm and nuclear changes (karyolysis, pyknosis and karyorrhexis). These cells were frequently detached from the basement membrane. Some other tubular epithelial cells were swollen and markedly vacuolated. Accompanying these changes, multiple granular casts filled the tubular lumens in the cortical and medullar regions (Fig. 2).

scholarly journals  Erythema multiforme minor in a dog following inappropriate intranasal Bordetella bronchiseptica vaccination: a case report

2011 ◽  
Vol 56 (No. 11) ◽  
pp. 568-572 ◽  
Author(s):  
MH Kang ◽  
HM Park
Keyword(s):  
Case Report ◽  
Erythema Multiforme ◽  
Clinical Signs ◽  
Skin Lesions ◽  
Bordetella Bronchiseptica ◽  
Hydropic Degeneration ◽  
First Case ◽  
History Of ◽  
One Year

A one-year-old, intact female, Yorkshire terrier dog was presented with a six-month history of multifocal, polycyclic erythematous lesions with epidermal collarette formation at the axillae, the trunk and ventral abdomen. The dog had a history of an inappropriate vaccine administration one day prior to the onset of clinical signs. The histopathology of the lesions revealed apoptosis of keratinocytes in the overlying epidermis, hydropic degeneration and lymphocytic exocytosis. The clinical signs and histopathology of the lesions were compatible with erythema multiforme. The skin lesions resolved after treatment with prednisolone combined with azathioprine for one month. No recurrence of clinical signs occurred during the follow-up period (four months). This is the first case report of erythema multiforme associated with an accidental subcutaneous injection of a Bordetella bronchiseptica vaccine.  

scholarly journals The first case of feline cytauxzoonosis in Germany: clinical description and molecular confirmation

2020 ◽  
Author(s):  
Luciana Catalina Panait ◽  
Graham Stock ◽  
Majda Globokar ◽  
Jörg Balzer ◽  
Bernhard Groth ◽  
...  
Keyword(s):  
Blood Smear ◽  
Clinical Chemistry ◽  
Clinical Importance ◽  
Domestic Cat ◽  
Laboratory Findings ◽  
First Case ◽  
Signet Ring ◽  
History Of ◽  
Clinical Description ◽  
One Year

Abstract Background Cytauxzoonosis is gaining clinical importance in recent years, being described as an emerging tick-borne disease of domestic and wild felids caused by protozoans of the genus Cytauxzoon . While in the Americas the condition is described as a fatal disease, in Europe, reports on the clinical expression of the infection are scarce. This study describes the first case of Cytauxzoon sp. infection in a domestic cat in Germany. Methods Clinical and laboratory findings, and molecular and DNA sequencing results were collected from a domestic cat suspected for cytauxzoonosis after the microscopic examination of a blood smear. Results A 6-year-old male domestic cat living in Saarlouis (Germany) was presented with a history of recent anorexia and weight loss. The cat had an outdoor lifestyle and had not travelled abroad. Serum clinical chemistry analysis revealed azotaemia with markedly increased symmetric dimethylarginine, hypercreatinemia, hyperphosphatemia and hypoalbuminemia. Moreover, a mild non-regenerative anaemia was present. Approximately one year prior these findings, the patient was diagnosed with a FIV infection. These results point toward a decreased glomerular filtration rate, presumably as a result of a kidney dysfunction. Therefore, a glomerulonephropathy was suspected. Round to oval signet-ring shaped intraerythrocytic organisms, morphologically suggestive for a piroplasm, were revealed during blood smear evaluation with a degree of parasitaemia of 32.95%. PCR analyses and sequencing of the partial 18S gene confirmed the presence of a Cytauxzoon sp. infection, with 99-100% nucleotide sequence identity with previously published Cytauxzoon sp. isolates. Conclusion This study provides the first case of molecularly confirmed Cytauxzoon sp. infection in a domestic cat in Germany and describes the clinical picture of the disease in association with FIV infection. These findings suggest that cytauxzoonosis should be considered as a differential diagnosis in cases of anaemia in domestic outdoor cats, particularly in areas where wild felid populations are present.

Disparate histopathology of sebaceous adenitis in a rabbit

2020 ◽  
Vol 8 (3) ◽  
pp. e001128
Author(s):  
Nicole A Heinrich ◽  
Douglas Chamroeun ◽  
Erin Locke
Keyword(s):  
Physical Examination ◽  
Skin Biopsy ◽  
Clinical Signs ◽  
Response To Therapy ◽  
Cutaneous Lesions ◽  
One Year ◽  
Rex Rabbit ◽  
Sebaceous Adenitis ◽  
Over Time

A 13-month-old, spayed, female rex rabbit presented with mildly pruritic, progressive patches of alopecia, erythema and scaling of the head, trunk and legs of five months’ duration. Initial skin biopsy was consistent with cutaneous epitheliotropic lymphoma, but a follow-up skin biopsy and response to therapy revealed that the rabbit actually had sebaceous adenitis. Nearly one year after presentation, the rabbit’s clinical signs remained well controlled. This case demonstrates the importance of interpreting histopathology in light of history, physical examination, supportive tests and response to therapy. It also demonstrates how cutaneous lesions may evolve over time and that serial biopsies may be required to achieve a diagnosis. Finally, this case suggests that there may be histopathological overlap between cutaneous epitheliotropic lymphoma and sebaceous adenitis in rabbits.

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