scholarly journals Effects of tramadol with tiletamine/zolazepam-xylazine as anaesthesia in cats

2013 ◽  
Vol 82 (2) ◽  
pp. 219-223
Author(s):  
Lin Li ◽  
Jing Dong ◽  
Dezhang Lu ◽  
Sheng Jiang ◽  
Dongqi Lin ◽  
...  
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Analgesic Effect ◽  
Muscle Relaxation ◽  
Anaesthetic Technique ◽  
Anaesthetic Induction ◽  
Physiological Indicators

This study was conducted to investigate the effect of the combination of tiletamine/zolazepam-xylazine-tramadol (TZXT) in cats and to compare its efficacy as an anaesthetic technique with tiletamine/zolazepam-xylazine (TZX). Fourteen healthy thirteen-month-old cats of both sexes were immobilized by TZXT or TZX on two different occasions. The cats’ scores for immobilization, analgesia and baseline physiological indicators, heart rate, respiratory rate and rectal temperature, were recorded before and 5, 10, 15, 20, 30, 40, 50, 60, 80, 100 and 120 min after administration of TZXT or TZX. Animals in both groups became laterally recumbent within 3 min and physiological indicators changed after administration. These changes were within biologically acceptable limits; these measurements did not differ between the treatments. Induction and recovery quality in animals was better with TZXT than with TZX. Sedation, analgesia, muscle relaxation and posture scores was higher in TZXT group. During recovery, cats in TZXT group were more conscious than cats in TZX group. This study showed that in cats, addition of tramadol (T) to TZX improved the quality of anaesthetic induction and increased the analgesic effect without adversely affecting the physiological indicators. Thus tiletamine/zolazepam-xylazine-tramadol shows to be more suitable for cat anaesthesia.

scholarly journals A comparative study between using of Midazolam-Ketamine and Diazepam-Ketamine combinations as anaesthetic program in sheep

2011 ◽  
Vol 10 (1) ◽  
pp. 66
Author(s):  
S. A. A. Al-Redah
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Recovery Time ◽  
Intramuscular Injection ◽  
Healthy Adult ◽  
Muscle Relaxation ◽  
Anaesthetic Drug ◽  
Group D ◽  
Apparently Healthy

The present study was designed to compare the efficacy for using of the two anesthetics combinations (Midazolam-Ketamine and Diazepam-Ketamine). The effect of combinations on the length of surgical anesthesia, degree of flank analgesia, degree of muscle relaxation, respiratory rate, heart rate and rectal temperature were assayed in sheep.The experiment was conducted on ten apparently healthy adult sheep of either sex weighting (24-33kg). Sheep were divided in two equal groups, Diazepam (1mg/kg BW) +Ketamine (10mg/kg BW) group (D+K), Midazolam (1mg/kg BW) +Ketamine 10mg/kg BW group (M+K), was used by intramuscular injection, benzodiazepine derivative (diazepam or midazolam) injected first and then followed by ketamine 10minutes later.The following parameter were recorded at 3minutes before injection of drug and 5, 10, 20, 30, 45, 60 and 75 minutes (min.) respectively after administration of anaesthetic drug (Rectal Temperature , Respiratory Rate , Heart Rate , Degree of Analgesia , Degree of Muscle relaxation), the induction time, surgical anaesthesia and recovery time also were recorded.The experiment showed that the anaesthesia with Midazolam + Ketamine combination in sheep was suitable compared with Diazepam + Ketamine as it produced reliable surgical anaesthesia, good analgesia and muscle relaxation.

scholarly journals Evaluation of Medetomidine-Ketamine for Immobilization of Feral Horses in Romania

2021 ◽  
Vol 8 ◽  
Author(s):  
Ovidiu Roşu ◽  
Iulia Melega ◽  
Alina L. Evans ◽  
Jon M. Arnemo ◽  
Susanne Küker
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Muscle Relaxation ◽  
Health Hazard ◽  
Blood Gases ◽  
Total Carbon ◽  
Feral Horses ◽  
Arterial Blood ◽  
Wide Range

Feral horses are immobilized for a variety of reasons including population control via contraceptives. Although opioid combinations have been successfully used for immobilization of feral horses, there is a need for combinations using drugs that are more readily available and present less of a human health hazard. We evaluated the chemical immobilization with physiological measurements and blood gas analyses of 91 free-ranging feral horses (Equus ferus caballus) remotely immobilized with a combination of 30 mg medetomidine and 775 mg ketamine in a single disposable 6 ml dart. During immobilization, heart rate, respiratory rate, rectal temperature, capillary refill time and peripheral oxygen hemoglobin saturation (SpO2) were evaluated. In eight horses, arterial blood samples were analyzed to evaluate the blood gases, acid-base status and hematologic variables. Targeted horses presented a wide range of age, size and body condition. Eighty-one horses had an uneventful mean induction of 7.2 min. Eighty-nine horses were immobilized in lateral recumbency with good muscle relaxation and a median recumbency time of 67 min. Ten horses required supplemental ketamine intravenously (x̄ = 434 mg) due to incomplete immobilization. In 58 horses the effects of medetomidine were antagonized with atipamezole intravenously. Increased respiratory rate (>20 breaths/min), increased heart rate (>45 beats/min) and decreased SpO2 < 90% were noted in more than half of the individuals, while increased rectal temperature (>39.0°C) was recorded in six animals. Blood parameters showed hypoxemia (<90 mmHg, n = 8), hypercapnia (>45 mmHg, n = 5), high glucose levels (>134 mmol/L, n = 3), increased blood lactate (>1.5 mmol/L), total carbon dioxide, bicarbonate and base excess which further increased in the second sample, whereas SpO2 and calcium values decreased. Recoveries were smooth, with one (n = 86) or more (n = 5) attempts of standing. Eighty-nine recoveries were uneventful, besides one male that showed signs of monoparesis of the left front leg and one mare with signs consistent with exertional myopathy. In conclusion, medetomidine-ketamine provided a reliable immobilization in feral horses over a wide range of body mass and age. However, based on the observed hypoxemia during immobilization, oxygen supplementation is strongly recommended for this protocol.

scholarly journals Anestesi Tetes Infus Gravimetrik Ketapol sebagai Alternatif Bius Umum Secara Inhalasi Guna Menjaga Status Teranestesi pada Babi

2018 ◽  
Vol 19 (1) ◽  
pp. 126
Author(s):  
I Gusti Agung Gde Putra Pemayun ◽  
I Gusti Ngurah Sudisma
Keyword(s):  
Heart Rate ◽  
Oxygen Saturation ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Average Length ◽  
Blood Oxygen Saturation ◽  
Saturation Pulse ◽  
Before And After ◽  
Anesthesia Time

This study aim was to evaluate quality and effectiveness of anaesthesia by using gravimetric infusion anaesthesia with ketamine and propofol (ketafol) on pigs. The quality of anesthesia time, the cardiovascular and respiratory response of anaesthesia were evaluated in twelve male pigs with average body weight 35±5 kg. The pigs were divided into four treatments and each treatment consisted of three pigs as repetition. All the experimental animals were premedicated with atropine 0.03 mg/kg mixed with xylazine 2 mg/kg in one syringe injected intramuscularly. Fifteen minutes after premedicated, the pigs was induced intravenously with ketamine 6 mg/kg and propofol 2 mg/kg. Furthermore, the anesthetized state maintaned with gravimetric, each through infusion with propofol (0.1 mg/kg/minute) (PI-P) , ketamine (0.3 mg/kg/ minute) (PIK), combination propofol-ketamin (0.1 and 0.3 mg/kg/minute) (PI-PK), and inhalation with isoflurane 1-2% (PI-I). The heart rate, pulse, respiratory rate, rectal temperature, blood oxygen saturation (SpO2 ), capillary refill time (CRT) were observed before and after treatment of the anesthetic. Premedication combination of atropin 0.03mg/kg mixed with xylazine 2 mg/kg in one syringe and then induced with ketamine 6 mg/kg and propofol 2 mg/kg showed the average length of anesthesia for 32,33 minutes, longer compared to five other treatments with average length of induction three minutes and average recovery time 20.33 minutes. Maintenance of anesthesia with propofol infusion drops (0.1 mg/kg/minute), or propofolketamine infusion drops (0.3 and 0.1 mg/kg/minute) showed safer anesthesia, because they did not make drastic change of heart rate, respiratory rate, rectal temperature, oxygen saturation, pulse, and CRT value in the experimental pigs. The conclusion of this study is the methode of gravimetric intravenous infusion by using ketamine and propofol (ketafol) can be used to maintain anesthesia as an alternative general inhalation anaesthesia in pigs.

scholarly journals Energy Supplementation during the Last Third of Gestation Improves Mother–Young Bonding in Goats

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 287
Author(s):  
Juan M. Vázquez-García ◽  
Gregorio Álvarez-Fuentes ◽  
Héctor O. Orozco-Gregorio ◽  
Juan C. García-López ◽  
Milagros González-Hernández ◽  
...  
Keyword(s):  
Heart Rate ◽  
Birth Weight ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
First Feeding ◽  
Labor Duration ◽  
Daily Energy ◽  
Energy Supplementation ◽  
Birth Body Weight ◽  
Birth Type

We tested whether maternal energy supplementation during the last third of gestation improves birth weight, neonatal wellbeing, and mother–young bonding. Thirty-six pregnant French Alpine goats were randomly allocated among three nutritional treatments for the last third of pregnancy: (i) Control, fed alfalfa (T-0; n = 12); (ii) alfalfa + 150 g/head daily energy concentrate (T-150; n = 12); (iii) alfalfa + 300 g/head daily energy concentrate (T-300; n = 12). At birth, we collected progeny data on birth weight, birth type, sex, rectal temperature, heart rate, respiratory rate, time to standing, time to udder connection, and time to first feeding. For the dams, we collected data on the duration of labor, time to clean the progeny, and time to allow first suckling. At birth, body weight, rectal temperature, heart rate, and the respiratory rate did not differ among treatments (p > 0.05). In the dams, labor duration was not affected by the treatments (p > 0.05). The T-150 dams were faster to clean the newborn and allow first suckling (p < 0.05). The T-150 progeny were faster to stand and the T-300 progeny were faster to connect to the udder (p < 0.05). We conclude that energy supplementation of the dam during the last third of gestation does not affect the birth weight of the progeny, but enhances the mother–young bonding.

scholarly journals Monitoring of physiological and blood parameters during perinatal and neonatal period in calves

2010 ◽  
Vol 62 (1) ◽  
pp. 1-12 ◽  
Author(s):  
G. Piccione ◽  
S. Casella ◽  
P. Pennisi ◽  
C. Giannetto ◽  
A. Costa ◽  
...  
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Total Cholesterol ◽  
Rectal Temperature ◽  
Neonatal Period ◽  
Blood Parameters ◽  
External Jugular Vein ◽  
Individual Values ◽  
Functional Development ◽  
Adaptation Processes

Rectal temperature, heart and respiratory rates, and the course of some blood parameters were monitored in calves during perinatal and neonatal periods. The study was carried out on eight Limousine calves. From all subjects, rectal temperature, heart rate, and respiratory rate were measured. Blood samples were taken at the same hour (9am) from the external jugular vein, and then centrifuged and stored until analyses. By means of an UV spectrophotometer, the following blood parameters were assessed for each subject: total protein, total cholesterol, triglycerides, glucose, non-esterified fatty acids (NEFA), urea, creatinine, cholinesterase, lactate dehydrogenase (LDH), hydroxybutirate, glutamate pyruvate transaminases (GPT), glutamate oxalacetate transaminases (GOT), direct and total bilirubin, magnesium, iron, potassium, phosphorus, chloride and sodium. The results showed a significant effect of days of life (P<0.05) only on total cholesterol, creatinine and GOT during the first week of life and a significant effect of days of life on rectal temperature, heart rate, respiratory rate, total cholesterol, NEFA, creatinina, and GOT during the first month of life. A correlation among individual values for postnatal age (days of life) and heart rate in calves during the first month of life was observed. In conclusion, modifications of studied parameters could be attributed to functional development of calves in neonatal period and contribute to the knowledge of adaptation processes in calf during the first week and the first month of life resulting useful for the diagnosis and treatment of any neonatal diseases.

scholarly journals Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses

2014 ◽  
Vol 44 (3) ◽  
pp. 517-523 ◽  
Author(s):  
Leandro Guimarães Franco ◽  
Juan Carlos Duque Moreno ◽  
Antônio Raphael Teixeira Neto ◽  
Moisés Caetano e Souza ◽  
Luiz Antônio Franco da Silva
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Respiratory Rate ◽  
Analgesic Effect ◽  
Randomized Study ◽  
Behavioral Changes ◽  
Behavior Changes ◽  
Clinical Effects ◽  
Nociceptive Threshold ◽  
Mechanical Nociceptive Threshold

This study assessed the clinical effects and the mechanical antinociceptive potential of intravenous (IV) tramadol in horses.A blinded and randomized study was designed with 7 horses treated with 1 (Tr1), 2 (Tr2) or 3 (Tr3) mg kg-1 of tramadol IV. The heart rate, respiratory rate (fR), arterial pressure, degree of sedation, gastrointestinal motility (GI), behavior changes and the mechanical nociceptive threshold (MNT) were evaluated. The MNT was determined with von Frey device method.Tr3 had a significant increase in their fR and more pronounced behavioral changes than other treatments.The Tr1 showed a significant increase in arterial pressure. The GI reduced significantly, mainly in Tr2. The tramadol did not change the MNT of the horses.The clinical alterations observed with the different treatments were considered mild and transitory, being most evident in Tr2. However the tramadol did not have any analgesic effect with any of the doses evaluated.

Acclimatization of calves to a hot dry environment

1959 ◽  
Vol 52 (3) ◽  
pp. 296-304 ◽  
Author(s):  
W. Bianca
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Heat Production ◽  
Metabolic Heat Production ◽  
Metabolic Heat ◽  
Physiological Reactions

1. Three calves were individually exposed in a climatic room to an environment of 45° C. dry-bulb and 28° C. wet-bulb temperature for 21 successive days up to 5 hr. each day.2. In the 21-day period, mostly during the first half of it, the following changes in the physiological reactions of the animals were observed: progressive reductions in rectal temperature, in heart rate and in respiratory rate with a change of breathing from a laboured to a less laboured type.3. It was suggested that a decrease in metabolic heat production might play a part in the observed acclimatization.

Study on Comparison Between Lignocaine and Lignocaine-Xylazine on Caudal Epidural Injection on Fogera Breed Cow in Gondar University Dairy Farm

2021 ◽  
Author(s):  
Endalkachew hailu ◽  
Gashaw Kasse
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Epidural Anesthesia ◽  
Physiological Parameters ◽  
Additive Effect ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
Caudal Epidural

Abstract Background: Caudal epidural anesthesia commonly utilized in veterinary practice to allow diagnostic, obstetrical, and surgical interventions in the perineal region of cows. An experimental study conducted on epidural anesthesia from October 2018 to March 2019 on 6 cows with repeated treatments after one week by two groups of anesthetic drugs. Methods and materias First Lignocaine is given for Group-I of cows in the first intercoccygeal space and then the same animals after one week injected Lignocaine-Xylazine together in the intercoccygeal space. The Clinical-physiological parameters such as the onset of analgesia, duration of analgesia, ataxia, sedation, heart rate, respiratory rate, and rectal temperature between the two groups studied by compression. Finally, the significance of the change in the study unit between Lignocaine and Lignocaine-Xylazine analyzed according to SPSS version 19 for t-test and P-value <0.05 taken as statistically significant. Results: There was no significant change that appeared between the onset of analgesia of Lignocaine (4.3±0.6min) alone and Lignocaine-Xylazine (4.9±1.1min) injection together (t=1.17; P>0.05). This indicates that the addition of Xylazine to Lignocaine does not significantly delay the onset of anesthesia. However, there was a significant difference observed in the duration of analgesia between two groups (t=13.2; P<0.05) with Lignocaine-Xylazine (259.5±12.38min) longer duration than Lignocaine alone (84±4.05min). This indicates that Lignocaine and Xylazine have an additive effect on the duration of analgesia. In the case of physiological parameters, there were significant variations in heart rate (t=7.5; P<0.05) with Group II cows lower in heart rate than Group I cows. Statistically, a significant difference was also observed on respiratory rate (t=2.13; P<0.05) in which the addition of Xylazine on Lignocaine significantly lower breathing rate than Lignocaine injection alone. Finally, on rectal temperature, there was no statistically significant difference appeared (t=1.7; P>0.005) with rectal temperature in Group I cows (0.15± 0.28 OC) and in Group II cows (0.9±0.31 OC) which indicate that addition of Xylazine to Lignocaine lower rectal temperature similar to Lignocaine injection alone. Mild ataxia was observed in three groups I, cows, and there was no sedation and salivation noted at all. In Group II, cows mild to severe ataxia, deep sedation, salivation, and falling observed. In both groups, there was no anesthetic complication during epidural analgesia and after recovery noted.Conclusion: generally this study showed that, combination of Lignocaine and Xylazine have an additive effect on the duration and quality of analgesia.

scholarly journals CPR Compression Rotation Every One Minute Versus Two Minutes: A Randomized Cross-Over Manikin Study

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Nutthapong Pechaksorn ◽  
Veerapong Vattanavanit
Keyword(s):  
Heart Rate ◽  
Respiratory Rate ◽  
Chest Compression ◽  
Life Support ◽  
Chest Compressions ◽  
Compression Depth ◽  
End Points ◽  
The One ◽  
Support Guidelines

Background. The current basic life support guidelines recommend two-minute shifts for providing chest compressions when two rescuers are performing cardiopulmonary resuscitation. However, various studies have found that rescuer fatigue can occur within one minute, coupled with a decay in the quality of chest compressions. Our aim was to compare chest compression quality metrics and rescuer fatigue between alternating rescuers in performing one- and two-minute chest compressions. Methods. This prospective randomized cross-over study was conducted at Songklanagarind Hospital, Hat Yai, Songkhla, Thailand. We enrolled sixth-year medical students and residents and randomly grouped them into pairs to perform 8 minutes of chest compression, utilizing both the one-minute and two-minute scenarios on a manikin. The primary end points were chest compression depth and rate. The secondary end points included rescuers’ fatigue, respiratory rate, and heart rate. Results. One hundred four participants were recruited. Compared with participants in the two-minute group, participants in the one-minute group had significantly higher mean (standard deviation, SD) compression depth (mm) (45.8 (7.2) vs. 44.5 (7.1), P=0.01) but there was no difference in the mean (SD) rate (compressions per min) (116.1 (12.5) vs. 117.8 (12.4), P=0.08), respectively. The rescuers in the one-minute group had significantly less fatigue (P<0.001) and change in respiratory rate (P<0.001), but there was no difference in the change of heart rate (P=0.59) between the two groups. Conclusion. There were a significantly higher compression depth and lower rescuer fatigue in the 1-minute chest compression group compared with the 2-minute group. This trial is registered with TCTR20170823001.

A STANDARDIZED METHOD FOR THE PRODUCTION OF HEMORRHAGIC SHOCK IN THE RAT

1955 ◽  
Vol 33 (3) ◽  
pp. 436-447 ◽  
Author(s):  
H. G. Downie ◽  
J. A. F. Stevenson
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Mortality Rate ◽  
Hemorrhagic Shock ◽  
Respiratory Rate ◽  
Rectal Temperature ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Standardized Method

Although the blood pressure is one of the important criteria in the standardization of hemorrhagic shock in the dog, it has rarely been used for this purpose in the rat. A method resembling the reservoir technique developed by Wiggers and Werle (1942) for the dog using blood pressure as the criterion has been modified for use with the rat. Male Sprague-Dawley rats weighing approximately 400 gm. were used. In the standardization of this technique the blood pressure was reduced to 30 mm. Hg in a 10-min. period of hemorrhage and then maintained at this level by subsequent small hemorrhages into the reservoir until reinfusion indicated the beginning of vascular collapse, at which time all the blood in the reservoir was returned. Considering that those animals which lived longer than 48 hr. were survivors, in a series of 27 animals, 21 died and 6 survived—a mortality rate of 78%.During the hypotensive period there was a consistent and steady drop in the respiratory rate and rectal temperature. The heart rate declined initially and tended to recover as the hypotensive period progressed. After reinfusion the blood pressure rose but. did not reach prehemorrhage levels. Hemorrhage into the bowel and convulsions were significant postreinfusion findings.

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