scholarly journals Control measures following a case of imported Lassa fever from Togo, North Rhine Westphalia, Germany, 2016

2017 ◽  
Vol 22 (39) ◽  
Author(s):  
Clara Lehmann ◽  
Matthias Kochanek ◽  
Diana Abdulla ◽  
Stephan Becker ◽  
Boris Böll ◽  
...  
Keyword(s):  
Virus Infection ◽  
Infection Control ◽  
Clinical Signs ◽  
Index Patient ◽  
The United States ◽  
Lassa Fever ◽  
Control Measures ◽  
University Hospital ◽  
Lassa Virus ◽  
Infection Control Measures

In a patient transferred from Togo to Cologne, Germany, Lassa fever was diagnosed 12 days post mortem. Sixty-two contacts in Cologne were categorised according to the level of exposure, and gradual infection control measures were applied. No clinical signs of Lassa virus infection or Lassa specific antibodies were observed in the 62 contacts. Thirty-three individuals had direct contact to blood, other body fluids or tissue of the patients. Notably, with standard precautions, no transmission occurred between the index patient and healthcare workers. However, one secondary infection occurred in an undertaker exposed to the corpse in Rhineland-Palatinate, who was treated on the isolation unit at the University Hospital of Frankfurt. After German authorities raised an alert regarding the imported Lassa fever case, an American healthcare worker who had cared for the index patient in Togo, and who presented with diarrhoea, vomiting and fever, was placed in isolation and medevacked to the United States. The event and the transmission of Lassa virus infection outside of Africa underlines the need for early diagnosis and use of adequate personal protection equipment (PPE), when highly contagious infections cannot be excluded. It also demonstrates that larger outbreaks can be prevented by infection control measures, including standard PPE.

scholarly journals 510. Exposure Investigation Following a Confirmed Case of Candida auris and Multiple Carbapenemase-Producing Carbapenem-Resistant Organisms

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S247-S247
Author(s):  
Frances Nicholson ◽  
Melanie Curless ◽  
Maggie Schiffhauer ◽  
Sean Zhang ◽  
Patricia Simner ◽  
...  
Keyword(s):  
Infection Control ◽  
Index Patient ◽  
The United States ◽  
Point Prevalence ◽  
Control Measures ◽  
Candida Auris ◽  
Infection Control Measures ◽  
Carbapenem Resistant ◽  
Surveillance Cultures ◽  
Routine Surveillance

Abstract Background Co-infections of Candida auris and carbapenemase-producing carbapenem-resistant Gram-negative organisms (CP-CRO) are an increasing global concern and rarely seen in the United States. We report the case of a 59-year-old male, with recent hospitalization in India, admitted to our facility with C. auris isolated from urine and axilla/groin specimens and CP-CRO from five body sites. Methods Travel screening in the emergency department identified a patient at high risk for colonization/infection with multidrug-resistant organisms (MDRO). Contact precautions were initiated. Eight CP-CRO isolates were subsequently identified from clinical and routine surveillance cultures from five separate sites. Of the isolates, seven contained one or more carbapenemase-producing genes detected by Xpert Carba-R assay (Cepheid, Sunnyvale, CA) (Table 1). The microbiology laboratory alerted the infection control department of a presumptive positive C. auris from a clinical urine culture from the same patient. Enhanced mitigation strategies were initiated in regards to cleaning and disinfection. An exposure investigation was also conducted using a point prevalence approach. Surveillance cultures were obtained from inpatients currently admitted to the same unit as the index patient. Axilla/groin specimens were collected for C. auris testing, and rectal specimens were collected for CP-CRO gene testing (CRE Real-Time PCR). Results Eighteen patients in addition to the index patient were hospitalized on the acute medicine unit. One patient refused testing for CP-CRO; therefore, 17 patients were tested for CP-CRO, and 18 patients were tested for C. auris. Neither CP-CRO nor C. auris were recovered from any patient. Conclusion A patient co-infected with C. auris and multiple CP-CRO was identified by clinical and routine surveillance cultures at Johns Hopkins Hospital. Travel screening allowed proactive isolation upon presentation. Enhanced infection control measures were implemented and a point prevalence surveillance study was conducted on the general acute care medicine inpatient unit. No transmission of either C. auris or CP-CRO was detected, likely due in part to rapid identification and strict infection control measures. Disclosures All authors: No reported disclosures.

Serosurvey on healthcare personnel caring for patients with Ebola virus disease and Lassa virus in the United States

2020 ◽  
Vol 41 (4) ◽  
pp. 385-390
Author(s):  
Colleen S. Kraft ◽  
Aneesh K. Mehta ◽  
Jay B. Varkey ◽  
G. Marshall Lyon ◽  
Sharon Vanairsdale ◽  
...  
Keyword(s):  
Infection Control ◽  
Ebola Virus ◽  
Virus Disease ◽  
Adenovirus Type ◽  
The United States ◽  
Ebola Virus Disease ◽  
University Hospital ◽  
Healthcare Personnel ◽  
Lassa Virus ◽  
Serum Samples

AbstractObjective:Healthcare personnel (HCP) were recruited to provide serum samples, which were tested for antibodies against Ebola or Lassa virus to evaluate for asymptomatic seroconversion.Setting:From 2014 to 2016, 4 patients with Ebola virus disease (EVD) and 1 patient with Lassa fever (LF) were treated in the Serious Communicable Diseases Unit (SCDU) at Emory University Hospital. Strict infection control and clinical biosafety practices were implemented to prevent nosocomial transmission of EVD or LF to HCP.Participants:All personnel who entered the SCDU who were required to measure their temperatures and complete a symptom questionnaire twice daily were eligible.Results:No employee developed symptomatic EVD or LF. EVD and LF antibody studies were performed on sera samples from 42 HCP. The 6 participants who had received investigational vaccination with a chimpanzee adenovirus type 3 vectored Ebola glycoprotein vaccine had high antibody titers to Ebola glycoprotein, but none had a response to Ebola nucleoprotein or VP40, or a response to LF antigens.Conclusions:Patients infected with filoviruses and arenaviruses can be managed successfully without causing occupation-related symptomatic or asymptomatic infections. Meticulous attention to infection control and clinical biosafety practices by highly motivated, trained staff is critical to the safe care of patients with an infection from a special pathogen.

scholarly journals Infant Case of Co-infection with SARS-CoV-2 and Citrobacter koseri Urinary Infection

2020 ◽  
Author(s):  
Hyppolite K Tchidjou ◽  
Bernard Romeo
Keyword(s):  
Mortality Rate ◽  
Infection Control ◽  
Disease Control ◽  
Urinary Infection ◽  
Severe Disease ◽  
Control Measures ◽  
University Hospital ◽  
Infection Control Measures ◽  
Control And Prevention ◽  
Infant Case

Abstract Since 2019 coronavirus disease (COVID-19) is highly contagious with a high mortality rate. France has taken strict infection control measures. According to the report by the Center for Disease Control and Prevention, children are less affected with COVID-19 and seem to have less severe disease than adults. We reported the first confirmed infant case of co-infection with SARS-CoV-2 and Citrobacter koseri urinary infection in 6-week-old child admitted on 25 March 2020 with mild symptoms in the Pediatric COVID Unit of Amiens University Hospital, France.

scholarly journals Nurses Practice Regarding Infection Control Measures during The Second Stage of Labor: A Multicenter Study

2021 ◽  
Vol 3 (1) ◽  
pp. 13
Author(s):  
Somia F. E. Fahmi ◽  
Zeinab A. A. Baraia ◽  
Inaam H. Abdelati
Keyword(s):  
Infection Control ◽  
General Hospital ◽  
Infection Control Practice ◽  
Control Measures ◽  
University Hospital ◽  
Second Stage Of Labor ◽  
Control Practice ◽  
Second Stage ◽  
Infection Control Measures ◽  
Significant Difference

Context: Infection prevention remains a significant public health challenge for healthcare systems, especially in maternity and delivery units. Good understanding and compliance of nurses with infection control measures during delivery are essential factors that improve maternal and neonatal outcomes and decrease morbidity and mortality. Aim: This study aimed to assess nurses' practice regarding infection control measures during the second stage of labor in multiple centers. Methods: Cross-sectional descriptive observational study was adopted in this study. The study population included all nurses working in labor rooms of four hospitals (100 nurses), namely Suez Canal University Hospital, Zagazig University Hospital, Ismailia General Hospital, And Zagazig General Hospital. Data collection tool encompassed a structured interviewing questionnaire to assess nurses' general characteristics, physical and organizational barriers that prevent nurses from complying with infection control measures, infection control practice checklist to assess nurses` compliance with infection control measures during the second stage of labor. Results: The highest percentage of the studied nurses' age was between 19-<29 (56.6%, 63.8%). Near half were technical nurses (43.4%, 44.7%). The majority of the studied nurses had not had periodic checks. Also, most of them were vaccinated against viral hepatitis B (86.8%, 91.5%). There was a statistically significant difference between Ismalia and Zagazig hospitals in physical barriers. The highest mean percent for infection control practice was for perineal care 100%, using the invasive device during labor 92%, preparing birthing room and its equipment 75.9%. A satisfactory infection control practice was revealed among 88% of the studied nurses. The satisfactory practice of nurses was 100%, 92.1%, 86.9%, 44.1% in Zagazig General Hospital, Ismalia University Hospital, Zagazig University Hospital, Ismalia General Hospital, respectively. Conclusion: The result of the study concluded that most nurses' practice regarding infection control in the delivery room was satisfactory. The study recommended upgrading and qualifying nurses in the labor room to improve their practical skills in Obstetric Nursing.

scholarly journals Coronavirus Disease-19 and Dentistry: A Review

2020 ◽  
Vol 8 (T1) ◽  
pp. 618-621
Author(s):  
Fareedi Mukram Ali ◽  
Kishor Patil ◽  
Elnur Ibrahim Albashir ◽  
Abdulhamid Aidarous Alamir
Keyword(s):  
Infection Control ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Control Measures ◽  
Clinical Settings ◽  
Related Information ◽  
Infection Control Measures ◽  
Dental Practitioners ◽  
Clinical Signs And Symptoms ◽  
Novel Coronavirus

Novel coronavirus (nCoV) is a novel form of virus with a new strain identified recently in humans. Common clinical signs and symptoms primarily consist of fever, cough, and breathing difficulties. In severe cases, it can results in pneumonia, severe acute respiratory syndrome, kidney failure, and even death. It is important to follow all infection control measures in prevention of the nCoV from spreading and controlling the epidemic situation. The risk of cross infection can be high between dental practitioners and patients due to the features of dental clinical settings. Here, we are summarizing the nCoV related information and infection control measures to be followed in dental practice.

scholarly journals Which policies most effectively reduce SARS-CoV-2 transmission in schools?

2020 ◽  
Author(s):  
Anna Bershteyn ◽  
Hae-Young Kim ◽  
Jessica McGillen ◽  
R. Scott Braithwaite
Keyword(s):  
New York ◽  
Infection Control ◽  
Primary Source ◽  
The United States ◽  
Control Measures ◽  
Infection Control Measures ◽  
Symptom Screening ◽  
Local Case ◽  
Transmission Reduction ◽  
The Impact

AbstractIntroductionNew York City (NYC) has the largest public school system in the United States (US). During the SARS-CoV-2 pandemic, NYC was the first major US city to open schools for in-person learning in the 2020-2021 academic year. Several policies were implemented to reduce the risk of in-school transmission, including infection control measures (facemasks, physical distancing, enhanced indoor ventilation, cohorting of small groups, and hand hygiene), option of all-remote instruction, alternative options for how class schedules would rotate in-person and remote instruction, daily symptom screening, and testing 10-20% of students and staff weekly or monthly depending on local case rates. We sought to determine which of these policies had the greatest impact on reducing the risk of in-school transmission.MethodsWe evaluated the impact of each policy by referring to global benchmarks for the secondary attack rate (SAR) of SARS-CoV-2 in school settings and by simulating the potential for transmission in NYC’s rotating cohort schedules, in which teachers could act as “bridges” across rotating cohorts. We estimated the impact of (1) infection control measures, (2) providing an option of all-remote instruction, (3) choice of class scheduling for in-person learners, (4) daily symptom screening, (5) testing to curtail transmission, and (6) testing to identify school outbreaks. Each policy was assessed independently of other policies, with the exception of symptom screening and random testing, which were assessed both independently and jointly.ResultsAmong the policies analyzed, the greatest transmission reduction was associated with the infection control measures, followed by small class cohorts with an option for all-remote instruction, symptom screening, and finally randomly testing 10-20% of school attendees. Assuming adult staff are the primary source of within-school SARS-CoV-2 transmission, weekly testing of staff could be at least as effective as symptom screening, and potentially more so if testing days occur in the beginning of the workweek with results available by the following day. A combination of daily symptom screening and testing on the first workday of each week could reduce transmission by 70%.ConclusionsAdherence to infection control is the highest priority for safe school re-opening. Further transmission reduction can be achieved through small rotating class cohorts with an option for remote learning, widespread testing at the beginning of the work week, and daily symptom screening and self-isolation. Randomly testing 10-20% of attendees weekly or monthly does not meaningfully curtail transmission and may not detect outbreaks before they have spread beyond a handful of individuals. School systems considering re-opening during the SARS-CoV-2 pandemic or similarly virulent respiratory disease outbreaks should consider these relative impacts when setting policy priorities.

scholarly journals Decreasing Prevalence of Multidrug-Resistant Acinetobacter Baumannii in Rīga East University Hospital / Multirezistentās Acinetobacter Baumannii Izplatības Mazināšanās Rīgas Austrumu Klīniskajā Universitātes Slimnīcā

2016 ◽  
Vol 70 (4) ◽  
pp. 232-236
Author(s):  
Māris Liepiņš ◽  
Raimonds Sīmanis ◽  
Aivars Lejnieks
Keyword(s):  
Infection Control ◽  
Acinetobacter Baumannii ◽  
Venous Catheter ◽  
Multidrug Resistant ◽  
Control Measures ◽  
University Hospital ◽  
Hospital Environment ◽  
Central Venous ◽  
Infection Control Measures ◽  
Time Period

Abstract There has been an increasing tendency of infections caused by multidrug-resistant organisms (MDRO), including multidrug-resistant Acinetobacter baumannii (MDRAB), in the Rīga East University Hospital (REUH) during the last decade. Over the last two years (2014-2015), this tendency has reversed and the prevalence of MDRAB has decreased considerably. In this study we assessed the prevalence of MDRAB in intensive care units (ICUs), internal medicine, surgery units and analysed antibiotic sensitivity profiles. In addition, we determined if current infection control measures are preventing further increase of infections caused by MDRAB in REUH. Retrospective Acinetobacter baumannii prevalence data were collected for the period from 2009 until 2012. For the time period from the beginning of 2013 until 2015, after implementing such infection control measures as control of compliance to hand hygiene guidelines, a review of central venous catheter insertion protocols and regular search for sources of MDRAB in hospital environment, prospective follow-up of new cases was conducted. Antimicrobial sensitivity profiles were assessed for the period from 2013 until 2015. Data were processed with the statistical software WHONET 5.5. Bacteria identification and antibiotic susceptibility testing were performed by VITEK 2 compact, BioMerieux, France. The prevalence of MDRAB in the period 2009 to 2013 increased from 71 to 217 cases per year, but from between 2013 (time of implementing infection control measures) and 2015 it decreased to 113 cases in 2015. In the three year period (2013-2015), the proportion of MDRAB causing bloodstream infections (BSI) and central nervous system infections (CNSI) was 15.85% from all identified MDRAB cases. Of the 113 MDRAB infections diagnosed in 2015, BSI was found in 16.81% cases (n = 19). Antibiotic resistance testing showed that colistin is the most effective drug against MDRAB. The majority of Acinetobacter baumannii isolates were resistant to Ampicillin/Sulbactam, Piperacillin/Tazobactam, Ceftazidime, Cefepime, Imipenem, Meropenem, Amikacin, Gentamicin, Tobramycin, and Ciprofloxacin. Over the last two years (2014-2015), prevalence of MDRAB infections decreased considerably. In the time period from 2013 to 2014, resistance of Acinetobacter baumannii increased to imipenem, ciprofloxacin and colistin, while decreased slightly to amikacin. Rigorous infection control measures, such as identification and elimination of new MDRAB sources in environment, review of the central venous catheter insertion protocol and improvements in hand hygiene, are crucial for decreasing distribution of and invasive infections caused by MDRAB in the hospital environment.

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