scholarly journals Synthesis and Characterization of Vanadium (IV)-Flavonoid Complexes and its Antioxidant ability toward Superoxide and Radical Scavenging

2020 ◽  
Author(s):  
Himyan Akbar ◽  
Salma Habib ◽  
Mohammed Mahroof Tahir ◽  
Lakshmaiah Sreerama
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Synthesis And Characterization ◽  
Vanadium Complex ◽  
Antioxidant Ability ◽  
Ic50 Value ◽  
Anti Oxidant ◽  
Metal Charge Transfer

In this project Vanadium complex -Vanadium (IV) - flavone was synthesized using vanadium (IV) acetylacetonate (VO(acac)2) complex and 3-hydroxy-6-methyl flavone ligand. The complex stability was checked using FTIR and UV-vis spectroscopies. Peackes around 990 cm-1 conforms the formation of (V=O) in the complex, as well as (V-O) around 790 cm-1. In UV-Vis spectrum peak around 400-450 nm was noticed, which conforms the formation of the vanadium complex that correspond to the ligand to metal charge transfer (LMCT) transition. The radical scavenging abilities of vanadium complex were investigated using DPPH. The anti-oxidant activity using (BHA) as a standard reference, the complex synthesized displayed strong DPPH antioxidant radical scavenging activity compared to VO(acac)2 and BHA, with IC50 value of (105, 95 and 96) mM respectively. The absorbance in which the reducing power occurred were found to be (0.397, 0.825 and 0.228) for the complex, VO(acac)2 and BHA.

scholarly journals Biochemical characterization of pink husked coconut types

2021 ◽  
pp. 72-76
Author(s):  
Regi J. Thomas ◽  
M. Shareefa ◽  
H. Harsha ◽  
Anitha Karun
Keyword(s):  
Biochemical Characterization ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Total Phenol Content ◽  
Anthocyanin Content ◽  
Scavenging Activity ◽  
Traditional Medicines ◽  
Ic50 Value ◽  
Morphological Differences

Coconuts with various traits are available in different coconut growing countries. The pink husk is one such trait that has already been reported in coconut. There is a demand for tender nut water from pink husked types of coconut to treat hepatitis by traditional medicinal practitioners. Present studies were carried out to characterize pink husked types identified in Guam Tall variety of coconut. There were no morphological differences with respect to the nut characters between pink and non-pink husked types. Biochemical characterization of pink husked types revealed significantly higher total phenol content in the tender nut water of pink husked types than normal husked types. A significantly higher protein content of 86 mg 100 mL-1 was noted in pink husked type, compared to normal husked type with 58.7 mg 100 mL-1. Higher free radical scavenging activity based on DPPH assay with pink husked type was recorded with an IC50 value of 266.7 compared to normal type with an IC50 value of 358. Similarly, phosphomolybdate assay also revealed higher scavenging activity of pink husked type based on the IC50 value of 415.2 compared to 637.9 observed in normal husked type. Anthocyanin content of 25.98 mg 100g-1 fresh weight was noted in the exocarp of pink husked types, and it was negligible in normal husked type. These results justify the use of pink husked coconuts in various traditional medicines. There is tremendous potential for exploiting pink husked types of coconut in the pharmaceutical industry.

scholarly journals Green synthesis and Characterization of Silver Nanoparticles Synthesized Using Piper longum and its Antioxidant Activity

2021 ◽  
pp. 342-352
Author(s):  
Taanya Imtiaz ◽  
R. Priyadharshini ◽  
S. Rajeshkumar ◽  
Palati Sinduja
Keyword(s):  
Antioxidant Activity ◽  
Silver Nanoparticles ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Piper Longum ◽  
Pathological Conditions ◽  
Red Color ◽  
Anti Cancer ◽  
Anti Oxidant

Background: Piper longum, a traditional plant used for regenerative medicine commonly known as the long pepper, is used to treat many pathological conditions. Piper longum is used as a source for obtaining the production of various nanoparticles and testing their efficacy. Piper longum has many beneficial activities, such as antifungal, anti-amoebic, anti-asthmatic, anti-cancer, anti-oxidant, anti-inflammatory, antidepressants activities. Silver nanoparticles are widely and commonly used for its antimicrobial activity against various microorganisms. Our study aimed to synthesize Piper longum based silver nanoparticles and to investigate its anti-oxidant property. Materials and Methods: Piper longum plant extract was prepared and silver nanoparticles extract was synthesized. DPPH assay was then performed to assess the free radical scavenging activity of the Piper longum silver nanoparticle extract. The further analysis was that the formation of brownish-red color observed was evident, resulting in thesynthesization of silver nanoparticles. Results: Brown discolouration represents formation of silver nanoparticles and the antioxidant activity was noted to be from 60% to 70% from 10 to 50μL. But when compared to standard vitamin C values the Piper longum silver nanoparticles showed less antioxidant activity. Conclusion: The Piper longum mediated silver nanoparticles showed remarkable and considerable antioxidant activity but when compared with the standard sample values the antioxidant activity was low.

COMPARATIVE STUDY OF TOTAL PHENOLIC CONTENT, ANTI-OXIDANT ACTIVITY AND FREE RADICALSCAVENGING POTENTIAL OF TWO DIFFERENT SOLVENT EXTRACTS OF MOMORDICA DIOICA ROXB.EX WILD. & MOMORDICA CHARANTIA L. (CUCURBITACEAE)

INDIAN DRUGS ◽  
2012 ◽  
Vol 49 (10) ◽  
pp. 33-41
Author(s):  
M. S Kale ◽  
◽  
S. D. Katekhaye
Keyword(s):  
Total Phenolic Content ◽  
Phenolic Content ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Momordica Charantia ◽  
In Vitro Assays ◽  
Total Phenolic ◽  
Anti Oxidant ◽  
Acetone Extracts

The fruits of Momordica dioica Roxb. ex Wild. & Momordica charantia L. (Cucurbitaceae) are used as vegetable in India. The fruits are used in the management of diabetes and other diseases. Since these effects may be correlated with the presence of anti-oxidant compounds, methanol and 70% acetone extracts of these plants were evaluated and compared for their total phenolic content, anti-oxidant activity and radical scavenging activity. Total phenolic content of methanol extract of both fruits was found to be relatively higher than acetone extract. The anti-oxidant potential of the extracts were assessed by employing different in vitro assays such as reducing power assay, DPPH, hydrogen peroxide scavenging assay, OH radical scavenging capacities, peroxidation inhibiting activity through linoleic acid emulsion system and anti-hemolytic assay. Though all the extracts exhibited dose dependent reducing power activity, acetone extracts of the samples were found to have more hydrogen donating ability.

Hepatoprotective and Anti-oxidant Activities ofGlossogyne tenuifoliaAgainst Acetaminophen-Induced Hepatotoxicity in Mice

2014 ◽  
Vol 42 (06) ◽  
pp. 1385-1398 ◽  
Author(s):  
Yu-Hsiu Tien ◽  
Bing-Huei Chen ◽  
Guoo-Shyng Wang Hsu ◽  
Wan-Teng Lin ◽  
Jui-Hua Huang ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Serum Levels ◽  
Oxidative Capacity ◽  
Positive Control ◽  
Hot Water ◽  
Total Phenolic ◽  
Control Group ◽  
Anti Oxidant

The present study investigated the anti-oxidative and hepatoprotective effects of Glossogyne tenuifolia (GT) Cassini, against acetaminophen-induced acute liver injury in BALB/c mice. The extracts of GT by various solvents (hot water, 50% ethanol and 95% ethanol) were compared for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power, total phenolic content, and total anti-oxidant capacity. The results showed that hot water (HW) extracts of GT contained high levels of phenolics and exerted an excellent anti-oxidative capacity; thus, these were used in the animal experiment. The male BALB/c mice were randomly divided into control group, acetaminophen (APAP) group, positive control group and two GT groups at low (GT-L) and high (GT-H) dosages. The results showed that mice treated with GT had significantly decreased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). GT-H increased glutathione levels and the ratios of reduced glutathione and oxidized glutathione (GSH/GSSG) in the liver, and inhibited serum and lipid peroxidation. This experiment was the first to determine phenolic compounds, chlorogenic acid and luteolin-7-glucoside in HW extract of GT. In conclusion, HW extract of GT may have potential anti-oxidant capacity and show hepatoprotective capacities in APAP-induced liver damaged mice.

scholarly journals ANTIOXIDANT ACTIVITIES OF HYPERICUM FURSEI L.

2014 ◽  
Vol 44 (1) ◽  
pp. 19-23
Author(s):  
B. S. ALIPOUR ◽  
M. A. EBRAHIMZADEH ◽  
B. ESLAMI ◽  
Z. RAHMANI
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Scavenging Activity ◽  
Ic50 Value ◽  
Ic50 Values ◽  
Chelating Ability ◽  
Dpph Radical Scavenging ◽  
Gallic Acid Equivalent

In this study, antioxidant activities of H. fursei were investigated. Different model were used for assay. IC50 for DPPH radical-scavenging activity was 7.5±1.2 μg ml-1. The IC50 value for BHA was 92.9±4.5 µg ml-1. The extract showed very good reducing power that was comparable with vitamin C (p> 0.05) but showed weak nitric oxide scavenging activity and Fe2+ chelating ability. Extract showed good activity in scavenging of H2O2. Inhibition was 99.1% at 800 μg ml-1. The IC50 values for extract and BHA were 333.1±14.7 and 52.0±4.5 μg ml-1, respectively. Total phenol compounds, by the Folin Ciocalteu method, was 274±9.6 mg gallic acid equivalent/g of extract and the total flavonoid content, by AlCl3 method was 23.9 ± 1.4 mg quercetin equivalent/g of extract. Antioxidant activity may be attributed to the presence of phenols and flavonoids in the extract.

Amelioration Effect of Carica papaya Fruit Extracts on Doxorubicin – induced Cardiotoxicity in Rats

2020 ◽  
Keyword(s):  
Carica Papaya ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Free Radical Scavenging ◽  
Nutritional Values ◽  
Ic50 Value ◽  
The Family ◽  
The World ◽  
Medicinal Properties

Papaya (Carica papaya Linn) belongs to the family Caricaceae. Papaya is commonly known for its food and nutritional values throughout the world. Papaya possess excellent medicinal properties for treatment of different ailments. This article focuses on the antioxidant, free radical scavenging activity and antitoxin activity of papaya. The antioxidant activity of Carica papaya Fruits, have the highest of reducing power which were 184.15, 151.19 and139.52 %, at the concentrations of 40mg/ml, of methanolic, ethanolic and aqueous extract, respectively. Also, when using (DPPH), of the same extract, the IC50 value were 0.809, 0.832 and 0.896 at the concentrations of 40mg/ml, respectively. Furthermore, the study showed the active effect of plant extracts as antitoxin when tested on rats.

scholarly journals Synthesis and Characterization of N1-Phenylhydrazine-1,2-bis(carbothioamide) and Its Evaluation for Antimicrobial, Antioxidant, and Brine Shrimp Lethality Bioassay

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
G. M. Golzar Hossain ◽  
Md. Mainul Abedin ◽  
Sitesh C. Bachar
Keyword(s):  
Brine Shrimp ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Butylated Hydroxytoluene ◽  
Synthesis And Characterization ◽  
Reference Standard ◽  
Brine Shrimp Lethality ◽  
Elemental Analyses

The compound N1-phenylhydrazine-1,2-bis(carbothioamide) was synthesised from phenylisothiocyanate reacting with thiosemicarbazide refluxing the mixture in ethanol. The new compound obtained was characterised by various spectral and elemental analyses. It was subjected to antibacterial, antioxidant and brine shrimp lethality bioassay. The compound showed brine shrimp lethality with LC50 value of 12.79 μg which was comparable to vincristine with LC50 value of 0.33 μg. The compound did not exhibit any antimicrobial activity against Gram +ve and Gram −ve organisms, as well as against the tested fungal strains. But very good free radical scavenging activity was observed at concentration range of 0.185–100 μg with IC50 values of 1.43 μg in comparison to reference standard butylated hydroxytoluene (BHT) with IC50 value 16.46 μg.

scholarly journals Antioxidant and Antidiabetic activities of Alangium salvifolium and Bombax ceiba

2014 ◽  
Vol 12 (2) ◽  
pp. 159-163
Author(s):  
Ronok Zahan ◽  
Laizuman Nahar ◽  
Mahmuda Haque ◽  
Mst Luthfun Nesa ◽  
Zahangir Alam
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Diabetic Rats ◽  
Dependent Manner ◽  
Phenol Content ◽  
Continuous Administration ◽  
Plant Materials ◽  
Methanol Extracts ◽  
Ic50 Value

In the present study, a methanol extract of flower of Alangium salvifolium (AS) and bark of Bombax ceiba (BC) were evaluated for its antioxidant and antidiabetic activities. Both methanol extracts exhibited DPPH free radical scavenging activity and reducing power activity in dose dependent manner. Continuous administration for of methanol extracts of AS for seven days significantly decreased blood glucose level than BC in alloxan induced diabetic rats at a dose of 200 mg/kg body weight. The IC50 value of AS and BC were 17.3 ?g/ml and 32.1 ?g/ml, respectively. Both extract showed significant decrease of blood sugar after glucose loading points (30, 60 and 120 min). In addition, flower of AS possesses high phenol content than the bark of BC (152.73±13.60 vs 74.38±7.42 mg/g of gallic acid). This is the first report of antioxidant and reducing power evaluation and quantitative analysis of phenol content for this two plant materials. This finding suggest that the potential antioxidant activity and antidiabetic effect of flowers of AS could be due to the presence of phenolic compounds. Dhaka Univ. J. Pharm. Sci. 12(2): 159-163, 2013 (December) DOI: http://dx.doi.org/10.3329/dujps.v12i2.17617

Design, Synthesis and Characterization of Some Novel 3-Coumarinyl- 5-aryliden-1,3-thiazolidine-2,4-diones and Their Antioxidant Activity

2011 ◽  
Vol 66 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Milan Čačić ◽  
Maja Molnar
Keyword(s):  
Antioxidant Activity ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Free Radical Scavenging ◽  
Biologically Active ◽  
Synthesis And Characterization ◽  
Knoevenagel Reaction ◽  
Design Synthesis

In our effort to obtain biologically active compounds, new 3,5-disubstituted 1,3-thiazolidine-2,4- diones (5a - r) were synthesized. A series of 5-arylmethylidene-1,3-thiazolidine-2,4-diones (3a - r) were prepared by Knoevenagel reaction from 1,3-thiazolidine-2,4-dione (2) and appropriate aromatic aldehydes. Condensation of 3a - r with 7-hydroxy-4-bromomethyl-2-oxo-2H-chromene (1) afforded novel 3-(7-hydroxy-2-oxo-2H-chromen-4-ylmethyl)-5-arylidene-1,3-thiazolidine-2,4-diones 5a - r. Compounds 3a - r and 5a - r were evaluated for their antioxidant activity (DPPH free radical scavenging activity).

scholarly journals Anti-oxidant and anti-acetylcholinesterase activities of Zygophyllum album

2015 ◽  
Vol 11 (1) ◽  
pp. 54 ◽  
Author(s):  
Mouna Kchaou ◽  
Hichem Ben Salah ◽  
Rania Mhiri ◽  
Noureddine Allouche
Keyword(s):  
Radical Scavenging Activity ◽  
Video Clip ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Acetylcholinesterase Activity ◽  
Phenolic Contents ◽  
Power Effect ◽  
Anti Oxidant ◽  
Ethanol Extracts

<p class="Abstract">The present study was carried out to explore the anti-acetylcholinesterase activity and anti-oxidant effect as well as content of phenolic compounds of various extracts from Zygophyllum album. It was observed that dichloromethane and ethanol extracts were endowed with a powerful anti-acetylcholinesterase activity with IC<sub>50</sub> values of 40 and 58 µg/mL, respectively. These two extracts exhibited the highest DPPH radical scavenging activity (IC<sub>50</sub>=0.2 mg/mL), the highest total anti-oxidant capacity (185.2 and 222.4 mg vitamin E/mg extract, respectively), the highest reducing power effect, and the highest β-carotene bleaching capacity. The findings showed that the extents of anti-acetylcholinesterase activity of Z. album extracts as well as their anti-oxidant capacity are in accordance with their phenolic contents. Hence, Z. album leaves would be useful against Alzheimer's disease.</p><p> </p><p><strong>VIDEO CLIP</strong></p><p><a href="https://www.youtube.com/v/M03zi4Mzh6k">Determination of flavonoids content:</a>  2 min 50 sec</p><p> </p>

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