scholarly journals C-REACTIVE PROTEIN (CRP)

2015 ◽  
Vol 22 (01) ◽  
pp. 076-080
Author(s):  
Shuaib Ansari ◽  
Irfan Murtaza Shahwani ◽  
Zeeshan Ali ◽  
Syed Zulfiquar Ali Shah ◽  
Faisal Shahab
Keyword(s):  
Metabolic Syndrome ◽  
Diastolic Pressure ◽  
University Hospital ◽  
C Reactive Protein ◽  
Serum Triglycerides ◽  
Cross Sectional ◽  
Male And Female ◽  
Female Patients ◽  
Reactive Protein ◽  
The Mean

Objective: To determine the frequency of raised C-reactive protein (CRP) inpatients with metabolic syndrome. Patients and methods: This cross sectional descriptivestudy of six months study was conducted at Liaquat University Hospital Hyderabad. All thepatients of 20 to 60 years of age, of either gender presented with symptoms of metabolicsyndrome for more than 01 year duration were admitted and evaluated for C-reactive protein.The data was analyzed in SPSS 16 and the frequency and percentage was calculated. Results:Total one hundred patients (59 females and 41 males) with metabolic syndrome were evaluatedfor C-reactive protein. The mean waist circumference for males and female patients with raisedCRP was 48.93±2.33 and 48.42±3.41 while the mean ±SD of serum triglycerides level for maleand female with raised CRP was 192.41±3.21 and 196.31±3.43 respectively. The mean ±SD ofserum HDL-C level for male and female with raised CRP was 28.32±1.22 and 25.31±1.42. Themean ±SD of systolic and diastolic pressure for males and female patients with raised CRP was150±3.42 and 100.51±4.42. The mean ±SD of serum fasting blood sugar for male and femalepatients with raised CRP was 131.52±3.33 and 143.42±7.42 respectively. The mean ±SD ofCRP for male and female patients with raised CRP was 4.42±1.21 and 5.8±2.52. In relationto gender distribution, the majority of subjects from 40-49 years of age group with femalepredominance (p = 0.01) while the CRP was raised in 67% patients in relation to age (p=0.05)and gender (p=0.04) respectively. Out of 67 subjects with raised CRP 44 were females and 23were males.Conclusions: The CRP was raised in patients with metabolic syndrome.

scholarly journals C – REACTIVE PROTEIN

2015 ◽  
Vol 22 (02) ◽  
pp. 256-262
Author(s):  
Ahmed Hussain ◽  
Shahnawaz Abro ◽  
Ashfaque Ahmed Bhurgiri ◽  
Raheel Imtiaz Memon ◽  
Syed Zulfiquar Ali Shah
Keyword(s):  
Acute Appendicitis ◽  
University Hospital ◽  
Radiographic Imaging ◽  
C Reactive Protein ◽  
Diagnostic Laboratory ◽  
Cross Sectional ◽  
Male And Female ◽  
Reactive Protein ◽  
Laboratory Investigations ◽  
The Mean

Acute appendicitis is the most common abdominal surgical emergency despiteadvances in radiographic imaging and diagnostic laboratory investigations; the diagnosis ofacute appendicitis remains challenge. Objectives: To evaluate the C-reactive protein in patientswith acute appendicitis. Patients and methods: This cross sectional descriptive study of sixmonths study was conducted at Liaquat University Hospital Hyderabad. All the patients withacute appendicitis were admitted in the ward and were further evaluated for C-reactive protein.The data was analyzed in SPSS 16 and the frequency and percentage was calculated. Results:One hundred subjects with acute appendicitis were recruited and studies. The mean age ±SD ofthe patients was 27.83±07.52 in overall population while it was 29.73±06.64 and 25.84±04.92in male and female subjects with acute appendicitis. The CRP was raised in 60% patients. Thedistribution of age in relation to gender and CRP was statisitically significant (p= 0.01 and<0.01) whereas the CRP was also observed as statistically significant in context to genderand histopathology (p= 0.02 and 0.03) respectively. The mean ±SD of CRP was 7.53±1.52in overall population while it was 6.84±1.64 and 8.65±1.53 in male and female patients withraised CRP. Conclusions: The CRP was elevated in patients with acute appendicitis.

scholarly journals COMMUNITY ACQUIRED PNEUMONIA

2016 ◽  
Vol 23 (09) ◽  
pp. 1052-1056
Author(s):  
Samar Raza ◽  
Tariq Zaffar Shaikh ◽  
Ghulam Hussain Baloch ◽  
Zaheer Ahmed ◽  
Syed Zulfiquar Ali Shah
Keyword(s):  
Study Design ◽  
Community Acquired Pneumonia ◽  
University Hospital ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Male And Female ◽  
Reactive Protein ◽  
The Mean ◽  
Serum Crp

Objectives: To determine the frequency of raised serum CRP level in patientswith community acquired pneumonia. Study Design: Cross sectional descriptive study.Period: Six months. Setting: Liaquat University Hospital Hyderabad. Patients and Methods:All the patients with 20 -75 years of age, either gender diagnosed as community acquiredpneumonia were further evaluated for C-reactive protein while the data was analyzed in SPSSversion 16. Results: During six month study period, total 135 patients with community acquiredpneumonia were evaluated for C-reactive protein. The mean ±SD for age of patients with CAPwas 48.93±8.41 whereas it was 53.53±6.73 and 50.54±5.81 in male and female subjectsrespectively. The mean age ±SD of patient with raised CRP was 46.94±8.43. The mean ±SDof CRP in overall population was 08.8±1.52 while it was 07.94±1.32 and 10.83±1.64 in maleand female individuals respectively. Of 135 subjects 84(62.2%) were males and 51(37.8%) werefemales while the CRP was elevated in 91(67.4%) patients. The age in relation to gender andCRP was statistically significant (p= 0.02 and 0.05) while the gender in relation to CRP was alsostatistically significant (p=0.03). Conclusion: The present study found that the CRP was raisedin 91(67.4%) predominantly male individuals with community acquired pneumonia

scholarly journals Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Mónica Acevedo ◽  
Paola Varleta ◽  
Verónica Kramer ◽  
Giovanna Valentino ◽  
Teresa Quiroga ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Phospholipase A2 ◽  
High Sensitivity ◽  
Roc Curves ◽  
Activity Levels ◽  
Pla2 Activity ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Cv Disease

High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS.Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS.Results. Mean age was 46 ± 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 ± 48 nmol/mL/min, and mean hsCRP was 2.1 ± 2.2 mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P=0.03) and hsCRP (P<0.0001) than those without MS. ROC curves showed that both markers predicted MS.Conclusion. Lp-PLA2 and hsCRP are elevated in subjects with MS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.

scholarly journals Comparison of Clinical Features Between Patients with Positive and Negative Appendectomy

2020 ◽  
Author(s):  
Guner Cakmak ◽  
Baris Mantoglu ◽  
Emre Gonullu ◽  
Kayhan Ozdemir ◽  
Burak Kamburoglu
Keyword(s):  
Acute Appendicitis ◽  
Clinical Features ◽  
Total Bilirubin ◽  
Negative Appendectomy ◽  
C Reactive Protein ◽  
Future Studies ◽  
Female Patients ◽  
Reactive Protein ◽  
Male Patients ◽  
The Mean

Abstract Background: The objective of this study was to retrospectively compare clinical features and prognostic values between the patients who were referred to the general surgery clinic of our hospital with the presumed diagnosis of acute appendicitis and underwent positive or negative appendectomy.Methods: Patients were divided into two groups as positive (PA) (n:362) and negative appendectomy (NA) (n:284) and the data obtained were compared between these two groups.Laboratory investigations were performed in all patients, and white blood cell (WBC), mean platelet volume (MPV), neutrophils count (NEU), neutrophils (%) (NEU%), C-reactive protein (CRP) and total bilirubin (TBIL) values were studied.Results: The mean MPV value was found as 7.88 fl in PA groups and 8.09 fl in NA group, and the mean MPV value was not statistically significantly difference in PA group, compared to NA groups (p=0.012). Laboratory parameters were also compared between genders. Accordingly, the mean MPV value was statistically significantly higher in female patients compared to male patients in PA group (p = 0.04). The mean TBIL value was 0.97 mg/dl in PA group and 0.69 mg/dl in NA group, and the mean TBIL value was statistically significantly higher in PA group (p< 0.001). Finally, TBIL value was statistically significantly lower in female patients compared to male patients in NA and PA group (p < 0.05).Conclusions: According to the results of our study, MPV and T. BIL values differ in PA and NA groups depending on gender. Therefore, these values may not be used as specific biomarkers in predicting positive acute appendicitis. We believe that these results will contribute to the literature and will be guiding for future studies.

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

2009 ◽  
Vol 28 (12) ◽  
pp. 739-745 ◽  
Author(s):  
Davood Attaran ◽  
Shahrzad M Lari ◽  
Mohammad Khajehdaluee ◽  
Hossein Ayatollahi ◽  
Mohammad Towhidi ◽  
...  
Keyword(s):  
Lung Function ◽  
Sulfur Mustard ◽  
Chronic Obstructive ◽  
Case Group ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
The Mean ◽  
Hs Crp

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 ± 9.18 years were enrolled in this cross sectional study. Thirty healthy men were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 ± 0.76 L (58.98% ± 17.51% predicted). The mean serum hs-CRP was 9.4 ± 6.78 SD and 3.9 ± 1.92 SD mg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p = .01). The serum hs-CRP levels were also correlated with Global Initiative for Chronic Obstructive Lung disease (GOLD) stages (r = .45, p < .001). Conclusions: Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

scholarly journals Adiponectin and highly sensitive C-reactive protein levels in obese children aged 9 to 15 years

2011 ◽  
Vol 51 (1) ◽  
pp. 7
Author(s):  
Frecilia Regina ◽  
Kristellina Tirtamulia ◽  
Sarah Maria Warouw
Keyword(s):  
Metabolic Syndrome ◽  
Obese Group ◽  
Controlled Study ◽  
Low Grade ◽  
Obese Children ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Inflammatory State ◽  
The Mean

Background Childhood obesity is a widespread and growing problem associated with health problems such as metabolic syndrome, diabetes mellitus and cardiovascular disease. A low􀁗grade chronic inflammatory state, reflected by decreased adiponectin and increased highly sensitive C􀁗reactive  protein (hsCRP) levels, may play a role in metabolic syndrome associated with obesity.Objective To assess and compare adiponectin and hsCRP levels in obese and nonnal weight children.Methods We conducted a cross-sectional, case􀁗controlled study in Manado from May to July 2010. Subjects were selected from obese, but otherwise healthy children aged 9-15 years. Control subjects were schoolmates 'With normal body mass index (BMI). We perfonned physical examinations, measured blood pressure, weight and height, and calculated BMI for all subjects. After an overnight fast, all subjects were tested for fasting blood glucose, adiponectin and hsCRP levels.Results The mean adiponectin level in the obese group was 3.6 μg/mL (SD 1.43), lower than that of the normoweight group, 4.8 μg/mL (SD 1.67) (P<0.0001). The mean hsCRP level in the obese group was 3.3 mg/L (SD 3.62) while that of the normoweight group was 0.8 mg/L (SD 1.39) (P<0.0001). There was no inverse correlation between adiponectin and hsCRP levels in obese group (r= 0.048; P= 0.362).Conclusions Lower adiponectin and higher hsCRP levels in the obese group is consistent 'With a low-grade chronic inflammatory state. Other factors that influence adiponecrin and hsCRP production or inflammatory pathways of other adipokines need further evaluation. Early intervention is needed to reduce body weight in obese children.

scholarly journals Association between Dietary Inflammatory Index, C-Reactive Protein and Metabolic Syndrome: A Cross-Sectional Study

Nutrients ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 831 ◽  
Author(s):  
Zhongxia Ren ◽  
Ai Zhao ◽  
Yan Wang ◽  
Liping Meng ◽  
Ignatius Szeto ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Cross Sectional Study ◽  
Dietary Inflammatory Index ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Inflammatory Index ◽  
Reactive Protein

scholarly journals The effect of hepcidin on components of metabolic syndrome in chronic kidney disease: a cross-sectional study

2020 ◽  
Vol 66 (8) ◽  
pp. 1100-1107
Author(s):  
Sibel Gökçay Bek ◽  
Berna Üstüner ◽  
Necmi Eren ◽  
Zeynep Sentürk ◽  
Betül Kalender Gönüllü
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Cross Sectional Study ◽  
Renal Diseases ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

SUMMARY BACKGROUND Hepcidin is an important regulator of iron homeostasis. OBJECTIVES This cross-sectional study was conducted to evaluate the association between hepcidin and components of metabolic syndrome in patients with chronic kidney disease (CKD). DESIGN AND SETTING 103 CKD patients and 59 healthy volunteers were included in the study from the University Hospital. METHODS Serum hepcidin levels were measured by enyzme-linked immunosorbent assay (ELISA) test. As for the study parameters, age, sex, body mass index, renal diseases, serum biochemistry, complete blood count, iron and total iron-binding capacity, ferritin, high-sensitive C-reactive protein (hsCRP), C- reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated. RESULTS The mean age of the patients was 58.63 ± 11.8 years. Hepcidin level was significantly associated with hypertension and higher uric acid levels (P < 0.05). There was a positive correlation between hepcidin and urea, uric acid, creatinine, ferritin, CRP, ESR, phosphorus, triglyceride, low-density lipoprotein (LDL), proteinuria and albuminuria in 24-hour urine collection. A negative correlation was found between hepcidin and estimated glomerular filtration rate (eGFR), hemoglobin, hematocrit, calcium, 25 OH vitamin D, pH, and bicarbonate levels. CONCLUSION Hepcidin, a well-known hormone regulator of iron metabolism, may play an important role in the pathogenesis of metabolic syndrome in patients with CKD, and further studies might delineate in-depth its potential as a promising early marker in these patients.

scholarly journals MON-099 The Association Between C-Reactive Protein, Metabolic Syndrome, and Pre-Diabetes in Korean Children and Adolescents

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Jihyun Kim ◽  
Jong Bin Lee ◽  
Jung Sub Lim
Keyword(s):  
Metabolic Syndrome ◽  
Children And Adolescents ◽  
Geometric Mean ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Hscrp Level ◽  
Cross Sectional ◽  
Korean Children ◽  
Reactive Protein

Abstract Objective: Cardiovascular disease (CVD) is a leading cause of death worldwide, including in Korea. In adults, the risk for CVD is increased approximately three-fold in subjects with metabolic syndrome (MetS), and the hazard ratio for subjects with MetS has been reported as 1.37 for mortality from CVD after adjustment for other confounders. Furthermore, MetS in childhood predicts adult MetS and T2DM 25 to 30 years later. Because MetS is a state of chronic low-grade inflammation, measurements of the circulating levels of the inflammatory molecules might provide diagnostic and therapeutic approaches to modulate or alter disease progression. High sensitivity C-reactive protein (hsCRP), a biomarker of inflammation, has emerged as an independent predictor of CVD and T2DM development. The aim of this paper is to evaluate the association between hsCRP and MetS and its components in Korean children and adolescents. Methods: We performed a cross-sectional analysis using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016–2017. We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the KNHANES 2016–2017. MetS were defined by the modified NCEP-ATP III criteria. Results: Among the 1,247 subjects (mean age: 14.2 ± 2.7 years), the prevalence of MetS was 5.8% (7.0% in male subjects and 4.6% in female subjects; p = 0.070). The mean hsCRP level was 0.861 ± 1.567 mg/l (median and interquartile range: 0.370 and 0.430mg/l). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/l, p &lt; 0.001). The prevalence of MetS in the lowest, second, third, and highest hsCRP quartiles were 1.8%, 2.4%, 3.5%, and 15.2%, respectively. Compared to the lowest quartile, the odds ratio (OR) for having MetS in the highest quartile was 8.414 (3.272–21.638), adjusting for age and sex. The OR for having abdominal obesity and low HDL-C in the highest quartile were 9.657 (4.818–19.355) and 2.408 (1.286–4.510), adjusting for age, sex, and other components of the MetS. Additionally, the OR for having pre-diabetes (HbA1c ≥ 5.7%) in the highest quartile was 2.061 (1.097–3.870). Conclusion: Serum hsCRP level is positively associated with MetS and pre-diabetes in Korean children and adolescents.

scholarly journals Study of renal functions in metabolic syndrome and its correlation with various parameters

2020 ◽  
Vol 8 (3) ◽  
pp. 960
Author(s):  
Anand N. ◽  
Vidya T. A.
Keyword(s):  
Metabolic Syndrome ◽  
Renal Function ◽  
Diastolic Pressure ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
University Hospital ◽  
Cross Sectional ◽  
Renal Functions ◽  
Cholesterol Levels

Background: Metabolic syndrome includes a constellation of various metabolic abnormalities that have been associated with cardiovascular disease, stroke and all-cause mortality in the general population. It has now been established that it is also associated with renal dysfunction. This study was done to assess renal function in metabolic syndrome in Indian population as well as its correlation with different parameters of the metabolic syndrome.Methods: A cross-sectional study was conducted in a university hospital from 2014 - 2015. Renal functions were studied in 100 obese individuals, 50 with and 50 without metabolic syndrome after informed consent and the results were analysed.Results: 100 obese individuals, 50 with and 50 without metabolic syndrome were compared. All underwent a physical examination and relevant investigations. All parameters of renal function showed significant derangement in cases as compared to controls. 38 patients (76%) among the cases (N=50) of metabolic syndrome had altered renal functions versus 9 patients (18%) among controls (n=50). Individually, there was a significant correlation of altered renal function (reduced estimated glomerular filtration rate eGFR and presence of microalbuminuria) with fasting blood glucose and systolic blood pressure (p=0.001), diastolic pressure (p=0.003) and triglyceride levels (p=0.036). High density lipoprotein-cholesterol levels did not show a significant correlation.Conclusions: Obese individuals with metabolic syndrome have significant derangement of renal functions as compared to those without metabolic syndrome. Most parameters of the syndrome are also independently associated with alteration of renal functions.

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