scholarly journals METABOLIC SYNDROME

2015 ◽  
Vol 22 (04) ◽  
pp. 414-419
Author(s):  
Tariq Zaffar Shaikh ◽  
Hamid Nawaz Ali Memon ◽  
Nisar Ahmed Shah ◽  
Syed Zulfiquar Ali Shah ◽  
Irfan Murtaza Shahwani
Keyword(s):  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Female Population ◽  
Gamma Glutamyltransferase ◽  
Gamma Glutamyl ◽  
The Mean ◽  
One Year ◽  
Glutamyl Transferase

Objective: To determine the role of gamma glutamyltransferase as a biochemicalmarker for the diagnosis of metabolic syndrome. Study Design: Cross sectional descriptivestudy. Period: One year. Setting: Department of Medicine, Liaquat University HospitalHyderabad / Jamshoro. Methods: All the patients with metabolic syndrome visited at OPD /admitted in the ward were further evaluated for serum gamma-glutamyltransferase level. Thedata was analyzed in SPSS 16 and the frequency and percentage was calculated. Results:During one year study period, total one hundred patients (23 males and 77 were females) withmetabolic syndrome were recruited and study for gamma glutamyl transferase level. The meanage ±SD for overall population was 56.84±6.52 whereas it was 48.92±5.82 and 58.61±7.73in male and female population respectively. The mean ± SD of systolic and diastolic bloodpressure (mmHg), triglycerides (mg/dl), high density lipoprotein pressure (mg/dl) and fastingblood sugar (mg/dl) in overall population was 161.20 ± 16.74 and 95.60 ± 8.34, 176.38 ±11.93, 29.44 ± 2.90 and 108.42± 6.25. The mean gamma glutamyl transferase level in overallpopulation was 86.75±7.74 while it was 84.83±5.32 and 89.52±6.84 in male and femalepopulation respectively. The gamma-glutamyltransferase was raised in 75 patients of which13 were males and 62 were females (p=0.02) and majority of patients were 50-59 year agegroup (p <0.01). Conclusions: It is concluded that GGT is a good diagnostic tool in metabolicsyndrome with statistical significant results.

scholarly journals GAMMA-GLUTAMYL TRANSFERASE AS AN INDICATOR OF OBESITY: A CROSS-SECTIONAL STUDY

2016 ◽  
Vol 9 (9) ◽  
pp. 240
Author(s):  
Vinodhini V M ◽  
Sudhan Kb
Keyword(s):  
Insulin Resistance ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Hepatic Insulin Resistance ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Elevated Liver Enzymes ◽  
The Mean ◽  
Glutamyl Transferase

ABSTRACTObjective: Obesity, characterized by an increase in excessive fat accumulation, represents a social problem worldwide and has been recognizedas a major underlying factor in the pathogenesis of several diseases. Gamma-glutamyl transferase (GGT) is a cell-surface protein contributing tothe extracellular catabolism of glutathione. Elevated GGT is strongly associated with obesity and excess deposition of fat in the liver, termed nonalcoholicfatty liver disease, which is thought to cause hepatic insulin resistance and contribute to the development of systemic insulin resistanceand hyperinsulinemia. Therefore, we have investigated the serum GGT levels in obese individuals and the correlation of serum GGT with bodymass index (BMI) and waist circumference.Methods: The study was carried out in 100 obese patients and 100 non-obese individuals.Results: Patients with obesity showed a significant increase in GGT levels when compared to the control group. The mean levels of BMI, WC, totalcholesterol, triglycerides, low-density lipoprotein-cholesterol (LDL-c), very LDL-cholesterol, total protein, and aspartate aminotransferase werefound to be significantly elevated in the obese individuals compared to controls. The mean levels of high-density lipoprotein-cholesterol showed asignificant decrease in the obese participants.Conclusion: Elevated liver enzymes, although in normal ranges, especially at upper quartiles as observed in our study, may play a central role inearly diagnosis of fat overflow to the liver. The findings of our study suggest that serum GGT levels may be a simple and reliable marker of visceral fataccumulation.Keywords: Diabetes mellitus, Gamma-glutamyl transferase, Insulin resistance, Metabolic syndrome, Obesity.

scholarly journals Serum gamma-glutamyl transferase level in acute stroke

2019 ◽  
Vol 7 (8) ◽  
pp. 2950
Author(s):  
Lagendra Kumar Singh ◽  
Sourabh Pradhan ◽  
Laxmikanta Dash ◽  
Jagannath Pradhan ◽  
Umakanta Raul ◽  
...  
Keyword(s):  
Standard Deviation ◽  
General Medicine ◽  
First Episode ◽  
P Value ◽  
Gamma Glutamyl Transferase ◽  
Stroke Patients ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
The Mean ◽  
Glutamyl Transferase

Background: Stroke is the second leading cause of death worldwide, causing 6.2 million deaths in 2011. Serum Gamma-Glutamyl Transferase (GGT) has been conventionally considered as a marker of excessive alcohol intake and/or liver dysfunction. There are accumulating evidences suggesting association of raised serum GGT level in stroke. So, this study was conducted to determine the association between the serum GGT level and stroke in population without history of alcohol consumption.Methods: This cross-sectional comparative study was carried out at Department of General medicine, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla from November 2016 to October 2018. 100 cases and 100 controls were included in this study. Cases were the patients admitted to Department of General Medicine, VIMSAR, Burla, presenting within 24 hours of first episode of stroke. Controls were the age (+/-5 years) and sex matched healthy attendants of the patients. Alcoholics or patients suffering from hepatitis, cirrhosis of liver, cholestasis or patients taking drugs like Phenytoin, Valproic acid, Carbamazepine etc or patients with past episode of stroke were excluded from this study. Serum GGT level of both cases and controls were measured and compared.Results: In stroke patients, the mean serum GGT level was 54.95 IU/L with standard deviation of 20.54. In controls, the mean serum GGT level was 32.14 IU/L with standard deviation of 5.07. The p-value was less than 0.0001 i.e. highly significant.Conclusions: Serum GGT level is significantly increased in stroke patients than healthy persons without stroke.

STUDY ON EVALUATION OF SERUM GAMMA-GLUTAMYL TRANSFERASE (GGT) LEVELS IN ACUTE CORONARY SYNDROME

2021 ◽  
pp. 39-40
Author(s):  
Avtar Singh Dhanju ◽  
Deepshikha Singla ◽  
Pashaura Singh ◽  
Ajay Chhabra ◽  
Sukhraj Kaur
Keyword(s):  
Acute Coronary Syndrome ◽  
Cross Sectional Study ◽  
Gamma Glutamyl Transferase ◽  
Cross Sectional ◽  
Gamma Glutamyl ◽  
Coronary Syndrome ◽  
Healthy Control ◽  
Group A ◽  
Group B ◽  
Glutamyl Transferase

Aim: The present study was undertaken with the aim to evaluate serum Gamma Glutamyl Transferase (GGT) levels in patients of acute coronary syndrome. Methodology: This cross-sectional study was conducted on 50 cases with acute coronary syndrome (Group A) and 50 healthy control subjects (Group B) meeting inclusion and exclusion criteria. Results: There is signicant rise in serum GGT levels in patients presenting with ACS in Group A as compared to Group B. Conclusion: Higher levels of GGT in ACS patients with risk factors such as hypertension, dyslipidemia and smoking may serve as biomarker to predict the occurrence of ACS.

Development of Radioimmunoassay for Gamma-Glutamyl Transferase Using Pancreatic Enzyme

1983 ◽  
Vol 20 (4) ◽  
pp. 247-250 ◽  
Author(s):  
Masanobu Masuike ◽  
Michio Ogawa ◽  
Takeshi Kitahara ◽  
Atsuo Murata ◽  
Kazuhiko Matsuda ◽  
...  
Keyword(s):  
Enzyme Assay ◽  
Pancreatic Enzyme ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Standard Curve ◽  
Normal Individuals ◽  
The Mean ◽  
Glutamyl Transferase ◽  
Dilution Curves

A radioimmunoassay (RIA) for the determination of gamma-glutamyl transferase (GGT) was developed using human pancreatic enzyme as antigen. The assay allows the determination of GGT in concentrations as low as 80 ng/ml, and it is reproducible and specific. A good parallel relation was demonstrated between the standard curve and dilution curves for serum, urine, bile, and partially purified kidney GGT. In normal individuals, the mean serum concentration of GGT determined by RIA was found to be 3·43 μg/ml (SD ± 1·20). Enzyme activity calculated from the GGT concentration measured by the radioimmunoassay using a regression equation was approximately twice as great as that determined by conventional enzyme assay.

scholarly journals Role of gamma glutamyl transferase as a diagnostic marker of metabolic syndrome

2019 ◽  
Vol 5 (3) ◽  
pp. 122-126
Author(s):  
Sangamesh Asuti ◽  
◽  
Abhinay Tibdewal ◽  
Arun Narayan ◽  
◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Diagnostic Marker ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals ASSOCIATION OF GAMMA-GLUTAMYL TRANSFERASE WITH METABOLIC SYNDROME

2016 ◽  
Vol 3 (100) ◽  
pp. 5498-5502
Author(s):  
Vijayalakshmi Masilamani ◽  
Poonguzhali Gopinath ◽  
Sangeetha Kandasamy ◽  
Aravind Kumar
Keyword(s):  
Metabolic Syndrome ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Evaluation of pancreatic lipase and gamma-glutamyl transferase in acute pancreatitis

2020 ◽  
Vol 24 (3) ◽  
pp. 401-405
Author(s):  
Ahmed Baban
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Lipase ◽  
Digestive Enzymes ◽  
Reference Group ◽  
Gamma Glutamyl Transferase ◽  
Serum Lipase ◽  
Gamma Glutamyl ◽  
Healthy Control ◽  
The Mean ◽  
Glutamyl Transferase

Background and objective: Pancreas is a large organ behind the stomach that produces digestive enzymes and a number of hormones. Pancreatitis is a condition characterized by inflammation of the pancreas. When the digestive enzymes are activated before they are released into the small intestine, they begin attacking the pancreas, and pancreatic damage happens. This study aimed to evaluate the association between pancreatic lipase, gamma-glutamyl transferase, and acute pancreatitis in patients living in Erbil city. Methods: The present study was carried out at the College of Medicine, Hawler Medical University from December 2017 to July 2018. A total of 35 patients with acute pancreatitis and 25 healthy controls were investigated. Examinations of serum pancreatic lipase and gamma glutamyl transferase were carried out spectrophotometrically for both groups using commercial diagnostics kits. Results: The results showed that the mean level of serum pancreatic lipase in patients with pancreatitis was significantly higher (P <0.01)compared to normal healthy control. The mean serum gamma glutamyl transferase was higher in patients with acute pancreatitis when compared to the reference group but not statistically significant. Conclusion: In the frame of this work, we delineate that pancreatic diseases had a significant effect on pancreatic enzymes reflected by a significant increase in serum lipase, whereas the level of gamma glutamyl transferase increased marginally. Keywords: Pancreatitis; Pancreatic lipoprotein lipase; Gamma glutamyl transferase.

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