scholarly journals TYPE 2 DIABETES;

2017 ◽  
Vol 24 (06) ◽  
pp. 899-903
Author(s):  
Muhammad Zafar Majeed Babar ◽  
Mazhar Hussain ◽  
Asma Manzur
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Glycemic Control ◽  
Post Treatment ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Treatment Changes ◽  
Group B

Background: The data among vitamin D supplementation on glycemic control isvariable and contradictory in various clinical studies. Objectives: To determine the efficacy of vitD supplementation on glycemic control in type 2 diabetic patients. Study Design: Case controlstudy. Setting: Private Clinical Set up of District, Rahim Yar Khan. Period: August to October2016. Patients and methods: 100 cases of type 2 diabetes were randomly divided into groupA and group B each contained 50 patients .The cases in group A were treated with vitamin D3at the dose of 50,000 units per week orally while cases in group B were treated with placeboalong with the standard doses of anti-diabetic drugs. The value of HbA1c and Vit D wereassayed pre and post treatment by high performance liquid chromatography. Results: Therewas significant post treatment changes observed in vitamin D level in group A vs group B inmales 20.46±2.45 vs 15.16±1.47 (p= 0.001) and females 18.32±1.44 vs 13.95±2.48 (p= 0.09)There was significant post treatment changes in HbA1c in males 6.65±0.12 vs 8.34±0.71 (p=0.01) and in females 6.81±0.43 vs 8.04±0.71 (p= 0.03) in group A and group B respectively.Similarly better improvement in vitamin D and HbA1c level was seen with respect to aged group30-50 years and duration of diabetes less than 5 years. Conclusion: Vitamin D is deficient in ourpopulation and its supplementation not only improves its own level but also glycemic control intype 2 diabetic patients.

scholarly journals C-Reactive Protein and Cholesterol level In Male Type 2 Diabetic Patients.

2012 ◽  
Vol 9 (1) ◽  
pp. 113-119
Author(s):  
Baghdad Science Journal
Keyword(s):  
Type 2 Diabetes ◽  
Control Group ◽  
Diabetic Patients ◽  
C Reactive Protein ◽  
Type 2 Diabetic Patients ◽  
Reactive Protein ◽  
Male Type ◽  
Group A ◽  
Group B

Elevated C-Reactive Protein (CRP) level in serum is a risk factor for type 2 diabetes ,this relationship is likely to be the cause it means elevated CRP leads to T2D in future . Our objective was to examine CRP in male Type 2 Diabetes(T2D) patients in different age ,we studied 120 male subjects divided to two groups according to their age. First group A age (31 - 40) year old ,60 person )30 control & 30 T2D patients(,3 person for each same age: second group B age (41 – 50) years old ,60 person )30 control & 30 T2D patients(,3 person for each same age. We examined blood sugar ,cholesterol and CRP in each group. and we toke the mean of samples in the same age in each data in all the 4 groups. Our data shows that CRP raised significantly P?0.05 in group A(T2D) and in group B(T2D) comparing with control group of each .And cholesterol levels, and sugar levels raised significantly P?0.05 in group A(T2D) and in group B(T2D) comparing with control group of each. CRP ,Cholesterol and sugar are higher in group B(T2D) than in group A(T2D),and in group B (control) than in group A (control). CRP level can predict diabetes but not causal, diabetes may cause a kind of inflammation (showed by high CRP) by its effect on body and this effect (inflammation) may cause rising CRP level.

scholarly journals Tumor Necrosis Factor Microsatellite Polymorphism Influences the Development of Insulin Dependency in Adult-Onset Diabetes Patients with the DRB1∗1502-DQB1∗0601 Allele and Anti-Glutamic Acid Decarboxylase Antibodies

2000 ◽  
Vol 85 (9) ◽  
pp. 3348-3351
Author(s):  
Hiroshi Obayashi ◽  
Goji Hasegawa ◽  
Michiaki Fukui ◽  
Kenji Kamiuchi ◽  
Akane Kitamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Tumor Necrosis ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Adult Onset ◽  
Group A ◽  
Group B ◽  
Necrosis Factor

Abstract Recently, several studies have demonstrated that tumor necrosis factor microsatellite polymorphism (TNFa) contributes to the susceptibility of type 1 diabetes. This study investigates the influence of TNFa on the predisposition to insulin dependency in adult-onset diabetic patients with type 1 diabetes-protective human leukocyte antigen haplotypes. The TNFa of three groups of DRB1∗1502-DQB1∗0601-positive diabetic patients who had initially been nonketotic and noninsulin dependent for more than 1 yr was analyzed. Group A included 11 antibodies to glutamic acid decarboxylase (GADab)-positive patients who developed insulin dependency within 4 yr of diabetes onset. Group B included 11 GADab-positive patients who remained noninsulin dependent for more than 12 yr. Group C included 12 GADab-negative type 2 diabetes, and a control group included 18 nondiabetic subjects. In the group C and control subjects, DRB1∗1502-DQB1∗0601 was strongly associated with the TNFa13 allele. DRB1∗1502-DQB1∗0601 was strongly associated with the TNFa12 allele among the group A patients, but not among the group B patients. Interestingly, sera from all patients with non-TNFa12 and non-TNFa13 in group B reacted with GAD65 protein by Western blot. These results suggest that TNFa is associated with a predisposition to progression to insulin dependency in GADab/DRB1∗1502-DQB1∗0601-positive diabetic patients initially diagnosed with type 2 diabetes and that determination of these patients’ TNFa genotype may allow for better prediction of their clinical course.

scholarly journals A study in prevalence of diabetic nephropathy in recently detected cases of type 2 diabetes mellitus as evidenced by altered creatinine clearance, urinary albumin and serum creatinine, with special emphasis on hypertension, hypercholesterolemia and obesity

2018 ◽  
Vol 5 (2) ◽  
pp. 351 ◽  
Author(s):  
Vitan Patel ◽  
Minal Shastri ◽  
Nisha Gaur ◽  
Prutha Jinwala ◽  
Abhishek Y. Kadam
Keyword(s):  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Creatinine Clearance ◽  
Urinary Albumin ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Group A ◽  
Group B ◽  
Associated Risk Factors

Background: Diabetic nephropathy is one of the commonest and most dreaded complications of Diabetes. The Aim was to evaluate the significance of microalbuminuria and creatinine clearance for detecting incipient diabetic nephropathy, and to find out the prevalence of nephropathy among freshly detected Type 2 diabetic patients with vs. those without hypertension, hypercholesterolemia and/or obesity.Methods: In this prospective study, 100 recently diagnosed diabetics were studied. Group A had 50 patients with at least one risk factor are hypertension, hypercholesterolemia and obesity. Group B had 50 patients without any of the aforementioned factors. Patients were investigated for presence of Diabetic nephropathy with abnormal serum Creatinine, creatinine clearance and urinary albumin levels.Results: As many as 43 out of 100 patients were found to have Diabetic nephropathy. The number was significantly higher in group A compared to group B (34/50 vs. 9/50). Incidence of nephropathy was higher with higher number of associated risk factors. Urinary microalbuminuria was the commonest abnormality, Serum creatinine was found in only 30.23% of total positive cases.Conclusions: Incidence of diabetic nephropathy is much larger than imagined in freshly diagnosed/new onset cases of DM type 2. Author also conclude that hypertension, obesity and hypercholesterolemia can contribute to development of nephropathy (68% vs. 18% in those who had the factors vs. those who didn’t). Also, urinary microalbuminuria appears to be much more sensitive than serum creatinine as screening tool.

Glibenclamide Therapy in Type 2 Diabetes

2009 ◽  
Vol 2 (1) ◽  
pp. 465-470
Author(s):  
Sai Laxmi M. ◽  
Venkatesham A. ◽  
A. Rama Narsimha Reddy ◽  
Shankaraiah P. ◽  
Krishna D. R. ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Glycosylated Hemoglobin ◽  
Early Morning ◽  
Peak Serum ◽  
Diabetic Patients ◽  
Serum Drug Concentration ◽  
Type 2 Diabetic Patients ◽  
Drug Concentrations

Glibenclamide is a second generation sulfonylurea used in the treatment of type 2 diabetes. The study included 57 type 2 diabetic patients of either sex, aged above 21 years, an who were under treatment with glibenclamide. Blood samples were collected after 2 hours of drug intake and the next day, early morning before taking the drug. Serum glucose levels and glycosylated hemoglobin levels were estimated. The effect of glibenclamide treatment on long-term glycemic control was studied. There was no correlation between peak serum drug concentrations and post prandial glucose level as well as between trough serum drug and fasting glucose concentrations as could be observed from the coefficient of correlation (R2) values of 0.0319 and 0.0013, respectively. There is no correlation between peak serum drug concentration and HbA1c% as can be observed from the R2 value of 0.0101.The insignificant correlation between the parameters indicates that upon chronic therapy with glibenclamide desensitization and receptor down regulation occurs leading to loss of glycemic control. It was observed that the increased dose of glybenclamide also did not improve glycemic control.

Effect of 8 Weeks of Vitamin D Supplementation and Water-Based Exercise on Cardiometabolic Profile in Women With Type 2 Diabetes

2021 ◽  
Author(s):  
Mona Salarinia ◽  
Mohammad Azizi ◽  
Worya Tahmasebi ◽  
Hadi Khalvandi
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Protein Profile ◽  
Vitamin D Supplementation ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Water Exercise ◽  
Vitamin D 3 ◽  
Cardiometabolic Profile

Abstract BackgroundSince type 2 diabetes is the most common metabolic disease, it is necessary to know the factors affecting on the complications of this disease. The aim of this study was to investigate the Effect of 8 weeks of vitamin D supplementation and water exercise on cardiometabolic profile in women with type 2 diabetes.Methods40 women with type 2 diabetes participated in this study voluntarily and randomly divided to four groups: 1) vitamin D+ water exercise, 2) vitamin D, 3) water exercise, and 4) control groups. Water exercise groups (groups 1 and 3) performed 3 sessions of water training per week during 8 weeks (15 minutes of warm-up, 45 to 60 minutes of main activity with a Borg scale of 14 and 10 minutes of cooling). Vitamin D groups (groups 1 and 2) received 50,000 (IU) vitamin D supplements once a week. Levels of fasting blood sugar (FBS), insulin, hemoglobin A1c (HbA1c), C- reactive protein (CRP) levels, as well as lipid protein profile (triglyceride, total cholesterol, high and low density lipoproteins (LDL and HDL)) were measured before and after intervention. Insulin resistance was also obtained by calculating HOMA-IR.ResultsWeight, waist circumference, and body fat mass were significantly decrease after intervention in Vitamin D+ water exercise group (P= 0.001, 0.001, 0.032, and 0.013 respectively), as well as CRP, glycemic and lipid profile were significantly improved after intervention in water exercise group.ConclusionThe results of the present study showed that water exercise plus vitamin D supplementation had synergism beneficial effects on anthropometric indices and cardiometabolic status of type 2 diabetic patients and can be used as a non-pharmacological and non-invasive method to reduce complications of type 2 diabetes. Iranian Clinical Trials Registry number: IRCT20201223049811N1, data of registration: 12.01.2021; https://en.irct.ir/trial/53230

scholarly journals Evaluation of the relationship between different factors of self-management and control of diabetes in diabetic patients group

2021 ◽  
Vol 6 (1) ◽  
pp. e18-e18
Author(s):  
Sara Afshari ◽  
Narges Kalhor ◽  
Mostafa Vahedian ◽  
Rasoul Shajari ◽  
Soroush Sharifimoghadam ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Health Care Use ◽  
Self Management ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Control Of Diabetes ◽  
The Mean ◽  
And Control

Introduction: Diabetes is one of the most common chronic diseases that severely affects the quality of life. Self-Management and glycemic control minimize the development and progression of diabetes’s complications. Objectives: We aimed to evaluate self-care behaviors and their relationship with hemoglobin A1c (HbA1c) level in patients with type 2 diabetes, using the Diabetes Self-Management Questionnaire (DSMQ). Patients and Methods: This is a cross-sectional study conducted on type 2 diabetic patients referred to the Shahid Beheshti hospital of Qom. A total of 325 patients with type-2 diabetes participate in the study. Diabetes self-management parameters were assessed using the translated (Persian) version of the DSMQ. Results: The mean score of self-management (±SD) in patients was 26.82 (±9.43). In addition, the mean HbA1c and fasting blood sugar (FBS) levels of the participants respectively were 8.35 (±1.97) and 187.25 (±77.51). There was a significant inverse correlation between self-management score metabolic control indices. (P<0.001). Health care use subscales have been best associated with better glycemic control (P<0.001) and physical activity had the least effect on it (P<0.001). Conclusion: The findings of this study revealed that there is a significant relationship between self-management indicators and control of diabetes.

scholarly journals Non-Diabetic Renal Disease in Type 2 Diabetic Patients with Nephropathy

2021 ◽  
Vol 10 (2) ◽  
pp. 73-78
Author(s):  
Jubaida Khanam Chowdhury ◽  
AKM Rashed Ul Hasan ◽  
Rajee Mahmud Talukder ◽  
Md Nizamuddin Chowdhury ◽  
Md Nazrul Islam
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Diabetic Renal Disease ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Background: In diabetic patients a good proportion of nephropathy is due to nephropathy other than diabetic renal disease. The detection of superimposed primary nondiabetic renal disease in diabetic patients has an obvious prognostic and therapeutic importance. Objectives: To find out the proportion of diabetic subjects suffering from nondiabetic renal disease (NDRD) and to describe histological varieties in appropriate group. Materials and Methods: This crosssectional study was done in Department of Nephrology, Dhaka Medical College & Hospital, Dhaka from August 2015 to October 2016. Total 37 type 2 diabetic patients were selected. Renal biopsy was done and four cases were excluded due to inadequate sample. Tissue was sent for histopathology and direct immunofluorescence (DIF) examination. On the basis of histological diagnosis of biopsy reports patients were divided into three groups. Group I: Isolated NDRD, Group II: NDRD superimposed on diabetic nephropathy (mixed lesion) and Group III: Isolated diabetic nephropathy (DN). Each patient was evaluated for retinopathy from Ophthalmology department. Based on the presence or absence of retinopathy 33 patients were again divided into two groups. Group A includes patients with diabetic retinopathy (DR) and Group B includes patients without diabetic retinopathy. Results: NDRD was found in 57.6% cases, NDRD plus diabetic nephropathy (DN) in 21.2% and isolated DN in 21.2% cases. In Group A (patients with DR) NDRD, DN and mixed lesion were present in 7 (41.2%), 5 (29.4%) and 5 (29.4%) cases. In Group B (patients without DR) NDRD, DN and mixed lesion were present in 12 (75%), 2 (12.5%) and 2 (12.5%) cases respectively. p value (0.189) was not significant. Conclusion: Kidney disease other than diabetic nephropathy can occur in type 2 diabetic patients. In this study NDRD was found in high frequency. Lack of retinopathy is a poor predictor of nondiabetic kidney disease. Therefore, renal biopsy should be recommended in type 2 diabetic patients with risk factors of NDRD for accurate diagnosis, prompt initiation of disease-specific treatment and ultimately better renal outcome. J Enam Med Col 2020; 10(2): 73-78

scholarly journals Geriatric Type 2 diabetes; the risk factors and associations for medication non-adherence.

2020 ◽  
Vol 27 (02) ◽  
pp. 260-267
Author(s):  
Nadia Shams ◽  
Sadia Amjad ◽  
Naresh Kumar Seetlani ◽  
Furquana Niaz ◽  
Shazia Farhat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Medication Adherence ◽  
Glycemic Control ◽  
Functional Status ◽  
Functional Dependence ◽  
Diabetes Duration ◽  
Group A ◽  
Group B

Objectives: To determine medication adherence in geriatric type 2 diabetes cases, risk factors for non-adherence and association with functional dependence. Study Design: Descriptive cross sectional. Setting: Department of Medicine, RIHS Islamabad. Period: Sept. 2016 - Feb. 2017. Material & Methods: 100 type 2 diabetes cases (>65 years) included in group-A (geriatric group) and 100 gender matched type 2 diabetes cases (<65 years) in group-B (non-geriatric group). Type 1 diabetes cases, critically ill and with incomplete medication record were excluded. Morisky Diabetes Questionnaire (MMAS-8) applied for medication adherence. Glycemic control, diabetes duration, co-morbids, treatment regime, poly-pharmacy, alternative medicine, functional status (Katz index) and visual morbidity assessed in both groups. Data analyzed by SPSS V-20 and Chi-square test applied with significant p < 0.05. Results: Mean age was 71.43+5.58 years (group-A) vs. 49.28+6.57 years (group-B). Mean diabetes duration was 9.61+8 years (group-A) vs. 7.4+4.9 years (group B). Functional status was independent in 53%(group-A) vs. 86%(group-B), significantly dependent 40%(group-A) vs. 11%(group-B) and dependent 7% (group-A) vs. 3% (group-B). High adherence in 3% (group-A) vs. 10%(group B); medium 24%(group-A) vs. 32%(group-B) and low 73%(group-A) vs. 58% (group B). Non-adherence in 73%(group-A) vs. 58%(group-B). Poly-pharmacy, co-morbids, combination anti-diabetes regimes, visual morbidity, physical dependence and poor glycemic control was frequent in geriatric diabetes cases (p<0.05). Conclusions: Medication adherence has pivotal role to attain target glycemic control. Higher medication non-adherence in geriatric diabetes cases needs to be addressed. Counseling sessions supported by literature in local language and addressing the identified risk factors may improve medication adherence in geriatric diabetes cases, hence improved glycemic control and morbidity.

scholarly journals HUBUNGAN KADAR FIBRINOGEN PLASMA DAN MIKROALBUMINURIA PADA PENDERITA DIABETES MELLITUS TIPE 2

2018 ◽  
Vol 14 (1) ◽  
pp. 11
Author(s):  
Rikarni . ◽  
Lillah . ◽  
Yoesri .
Keyword(s):  
Endothelial Dysfunction ◽  
Diabetic Patients ◽  
Fibrinogen Concentration ◽  
Creatinine Ratio ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Group A ◽  
Group B ◽  
Type 2 Diabetic

Increase of fibrinogen concentration in type 2 diabetic patients is an indicator for vascular inflammation, endothelial dysfunction. Hyperfibrinogenemia is a strong marker and independently for atherosclerosis. Beside that, hyperfibrino -genemia can precede macroand microvascular complication. In type 2 diabetic, microalbuminuria is early marker for diabetic nephropathy and show that there isendothelial dysfunction. Microalbuminuria not only useful to predict renal damage, but also useful to predict cardiovascular damage.Microalbuminuria is a marker for endothelial dysfunction. To know the correlation between increase of fibrinogen concentration andmicroalbuminuria in type 2 diabetic patients. The study was performed in Dr. M. Djamil central Hospital by using cross sectionalmethod and consecutive random sampling. Sample were type 2 diabetic patients included criteria were measured albumin/ creatinineratio and the patients was divided in 2 group, that is group A (normoalbuminuria) and group B (microalbuminuria) with totalsample were 90 patients. Each group were performed measurement of albumin/ creatinine ratio, random glucose concentration, andfibrinogen concentration in plasma. In group A, we found the average of albumin/ creatinine ratio is 6.6 μg/mg and in group B is107.5 μg/mg. The average of random glucose concentration in group A is 181.3 mg/dl, and in group B is 204 mg/dl and the difference of concentration is not significantly (p > 0.05). The average of fibrinogen concentration in group A is 383.5 ± 104.6 mg/dl, and in group B is 467 ± 79 mg/dl. Increasing fibrinogen concentration in group B is higher than group A and the increasing is significantlystatistical difference (p <0.05). In this study we also founded the positive correlation between concentration of fibrinogen plasma andalbuminuria ( r = 0.036, p =0.0004). In type 2 diabetic patients with normoalbuminuria has been increased fibrinogen concentration,and the increasing of fibrinogen concentration in type 2 diabetic patients with microalbuminuria is higher than type 2 diabetic patientswith normoalbuminuria. There are positive correlation between fibrinogen plasma concentration and albumin/creatinine ratio

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