EVALUATION RISK FACTORS OF NECROTIZING ENTEROCOLITIS
Introduction: Necrotizing enterocolitis (NEC) is a condition where the intestinesbecome infected and can begin to die. Necrotizing enterocolitis is a serious condition that mayrequire surgery, and has a high morbidity and mortality rate. Objectives: To evaluate the riskfactors of necrotizing enterocolitis among neonates at children hospital Multan. Study Design:Descriptive Cross-sectional study. Setting: Neonatal Unit of Children Hospital and Institute ofChild Health Multan. Period: October 2015 to September 2016. Material and Methods: A total of79 neonates presented with necrotizing enterocolitis were enrolled for the possible causes. Theparameters studied included gestational age at birth, birth weight, maternal risk factors, patientrisk factors, age when feeding was started, type of feed, age when signs of NEC appeared,per feed increment, presence of any antecedent associations, clinical features, radiologicalfeatures, blood investigations (complete blood counts, blood glucose, serum sodium, serumpotassium, serum creatinine, liver function tests), ABGs, stool for occult blood and culture,septic screening and blood culture, management(medical or surgical) and outcome. The datawas analyzed using SPSS-20. Results: Out of a total of 79 neonates, 48 (60.8%) were maleand 31(39.2%) female. There were 71% infants who were younger than 32 gestational weeksand 67.7% under 1500 grams. The majority of neonates 62 (78.5%) commenced enteral feedswithin the first 24 hours. First feeding was started at a mean 5.6 ± 3.85 (2-17) days. Prematuritywas the commonest factor and present in 63 (79.9%) neonates. Abdominal distention was thecommonest symptoms 55% followed by bilious vomiting in 15%. Blood culture was positive in22 (27.8%) with predominance of gram negative microorganisms. According to Bell’s staging,54 (68.35%) neonates had stage I, 17 (21.5%) stage II, and 8 (10.1%) neonates were in stageIII. Conclusion: In most of the cases, the causes of necrotizing enterocolitis were presentand prematurity was the main etiological factor. Cautiously introducing enteral feeds usingexpressed maternal breast milk and increasing feed volumes slowly is important in reducingthe incidence amongst high risk individuals.