scholarly journals Association of polycystic ovary syndrome with insulin resistance and glucose transporter GLUT 4.

2020 ◽  
Vol 27 (10) ◽  
pp. 2182-2186
Author(s):  
Roohi Jabbar ◽  
Rukhshan Khurshid ◽  
Uzma Jabbar ◽  
Mudassir Zia ◽  
Abeera Mazhar Siddiqui ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Transporter ◽  
Fasting Glucose ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Glut 4 ◽  
History Of ◽  
Age Range ◽  
Study Setting

Objectives: The study was designed to find out the association of PCOS with insulin resistance and GLUT4. Study Design: Cross Sectional study. Setting: Outdoor Department of Sir Ganga Ram Hospital Lahore. Period: March 2016 to December 2016. Material & Methods: 37 PCOS women visited Outdoor Department of Sir Ganga Ram Hospital Lahore. Their age range was 25- 36 years. 20 ages matched medical staff of the Sir Ganga Ram Hospital, Lahore with no history of any disease were selected as control. Rotterdam’s criteria were used to confirm PCOS. Levels of circulating insulin, GLUT 4 and fasting glucose were estimated. Results: Mean age of PCOS patients and of controls was 30.55 and 29.00 years respectively. Values of BMI were insignificantly raised in PCOS in comparison to controls. Levels of circulating GLUT-4, fasting glucose, insulin and resistance of insulin were increased significantly in women with PCOS in comparison to the controls. Decreased ratio of glucose to insulin was seen in PCOS women in comparison to their controls. Conclusion: A good association of PCOS was observed with insulin mediated release of glucose transporter GLUT 4 and insulin resistance.

scholarly journals PATIENTS WITH SUICIDE ATTEMPT

2015 ◽  
Vol 22 (10) ◽  
pp. 1321-1326
Author(s):  
Jamil Junejo ◽  
Badaruddin Junejo ◽  
Inayatullah Awan ◽  
Asma Perveen
Keyword(s):  
Tertiary Care ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Family Issues ◽  
Younger Age ◽  
History Of ◽  
Age Range ◽  
Study Setting ◽  
Status Level

Objective: To determine the demographic details (gender, age, marital status,level of education, and occupation) of suicide attempters attending the tertiary care hospitalservices at Hyderabad, Pakistan. Study Design: Cross sectional study. Setting: Liaquat universityhospital Hyderabad and Sir Cowasjee Jahangir Institute of psychiatry (CIJP) Hyderabad.Period: Twelve months from the 1st January 2011 to 31st December 2011. Methodology:The aim of the study was. Patients with a history of attempted suicide. Two hundred (200)consecutive cases were recruited and selected according to the inclusion criteria. An informedconsent was obtained from patients for being included in the study. A specially designed semistructuredProforma was used to record demographic details of the patients. Data were enteredinto and analyzed through statistical software SPSS version 20. Results: Total 200 hundredcases were included in the study. Males 78.5 % (N=157) outnumbered female patients 21.5% (N= 43). The age range of study subjects was between 15 -59 years. Mean age of the totalcases was 22.6 years. Majority of the patients presenting with suicide were single comprising61 % (N= 122) of study cases with a P value < 0.001. Total cases of married subjects were 27.5% (N= 55) with a P value < 0.001. While 5.5% subjects were separated and 6 % were divorced.Unskilled labors made the largest group comprising of 24.5 % (N=49) of all the cases. Otheroccupations included farmers (15.5 %), skilled labor (15%), jobless (11.5%), house wives (8.5%), students (7 %), and shopkeepers (6%). Out of the total 200 patients with attempted suicide32% were illiterate, 33.5 % were educated up to primary level, 19.5% were matriculate, 09 %were intermediate passed, and only 6 % were graduate. (Table-II). Conclusion: In Pakistan stillSuicide attacks are reported. Our results suggest that suicidal thoughts can be entirely predictby common reported in male and younger age due to very sensitive to family issues, lowereducation level and major depression due to unemployment or low level earning of unskilledlabor occupation in the Pakistan population.

scholarly journals OVARIAN MALIGNANCY

2018 ◽  
Vol 25 (02) ◽  
pp. 237-241
Author(s):  
Shabana Rafiq ◽  
Razia Bibi ◽  
Samina Ashraf
Keyword(s):  
Cross Sectional Study ◽  
Reproductive Age ◽  
Ovarian Malignancy ◽  
Ovarian Mass ◽  
Sectional Study ◽  
Women Of Reproductive Age ◽  
Cross Sectional ◽  
Increased Risk ◽  
History Of ◽  
Study Setting

Objectives: To determine the frequency of ovarian malignancy in women ofreproductive age presenting with ovarian mass and to determine frequency of factors leadingto ovarian malignancy. Study Design: Cross sectional study. Setting: Department of Obstetrics& Gynaecology, Lady Wallington Hospital, Lahore. Period with Dates: From 05.11.11 to26.06.12. Results: The result of our study reveals majority of the patients between 21-30 yearsi.e. 45.88%(n=39), common age was 24.21+3.76 years, 43.53%(n=37) were nulliparous (inmajority), while frequency of ovarian malignancy in women of reproductive age presenting withovarian mass was recorded in 14.11%(n=12) while frequency of factors leading to ovarianmalignancy was 91.67%(n=11) patients were nulliparous while family history of ovarianmalignancy was in 8.33%(n=1) patients. Conclusions: The frequency of ovarian malignancy ishigher among reproductive age females with increased risk of nulliparity.

COVID-19: An Experience from a Tertiary Care Hospital of Nowshera

2020 ◽  
Vol 24 (2) ◽  
pp. 149-155
Author(s):  
Hamzullah Khan ◽  
Mohammad Zahid Khan ◽  
Mian Mohammad Naveed
Keyword(s):  
Tertiary Care ◽  
Relevant Information ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Cross Sectional ◽  
Number Of Patients ◽  
Epidemic Area ◽  
History Of ◽  
Severity Of The Disease ◽  
Age Range

Objective: To determine the frequency of COVID-19 and characteristics of patients presenting to the COVID-19 clinic at Qazi Hussain Ahmed Medical Complex (QHAMC) Nowshera. Methodology: This cross-sectional study was conducted from 21st Feb 2019 to April 8, 2020, in QHAMC Nowshera. Relevant information was collected on a pre-designed Performa prepared following the objectives of the study. Results: Out of 220 patients, 165(75%) were males, and 55(25%) females. 96(43.6%) of the patients were in the age range 18-30 years followed by 52(23.6%) in age range 31-45years and 17(7.7%) with age>60 years etc. Out of total the nasopharyngeal swabs of 26(11.6%) strong suspects were sent for PCR testing. 208(94.5%) were sent home while 12(5.5%) were advised quarantine. Forty-seven (21.4%) had a travel history to an epidemic area in the last 14 days. 51(23.2%) had a positive history of contact. Eighty-five (38.6%) had a fever and sore throat followed by 27(12.3%) with (fever & cough), 24(10.9%) with (cough and shortness of breath/dyspnea) and 14(6.4%) with a simple flue, etc. Out of 26 cases, 6(2.7%) were COVID-19 Positive, 12(5.5%) were negative and results of 8(3.6%) were still awaited. The PCR repeated the test for confirmed cases showed;  4(1.8%) negative, one died and one was refractory positive.  A positive correlation (p=0.03, r=0.4) of an increase in age with the severity of the disease/outcome was recorded. Conclusion: The frequency of infectivity with COVID-19 was 2.6%. A higher number of patients with mild symptoms attend the COVID clinic. The rate of infection and mortality was higher in age> 60 years.

scholarly journals Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Nasser M. Rizk ◽  
Elham Sharif
Keyword(s):  
Insulin Resistance ◽  
Leptin Receptor ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Compensatory Mechanism ◽  
Ovary Syndrome ◽  
Cross Sectional ◽  
Soluble Leptin Receptor ◽  
Median Level ◽  
Male Sex

Background and Aim. Leptin has two forms in the circulation: free and bound forms. The soluble leptin receptor (sOB-R) circulates in the blood and can bind to leptin. The aim of this study is to assess the concentrations of the leptin and the sOB-R in PCOS and its relation to adiposity, insulin resistance, and androgens.Methods. A cross-sectional study included 78 female students aged 17–25 years. Fasting serum leptin and sOB-R concentrations were measured. The anthropometric variables and the hormonal profile such as insulin, female and male sex hormones, and prolactin were assessed.Results. In PCOS, leptin level (ng/ml) and free leptin index (FLI) increased significantly while sOB-R (ng/ml) significantly decreased compared to control subjects. In age-matched subjects, obese PCOS had increased leptin level in ng/ml (median level with interquartile levels) of 45.67 (41.98–48.04) and decreased sOB-R in ng/ml 11.47 (7.59–16.44) compared to lean PCOS 16.97 (10.60–45.55) for leptin and 16.62 (11.61–17.96) for sOB-R withpvalues 0.013 and 0.042, respectively. However, body mass index (BMI) is significantly correlated with leptin and s-OBR, while no significant correlations with parameters of insulin resistance were detected.Conclusion. PCOS is associated with hyperleptinemia and increased free leptin index. Decreased sOB-R could be a compensatory mechanism for the defective action of leptin.

scholarly journals Prevalence and reasons of use of different psychoactive substances among prisoners at Malir Prison, Karachi.

2020 ◽  
Vol 27 (07) ◽  
pp. 1488-1492
Author(s):  
Muhammad Ilyas Jat ◽  
Muhammad Tarique Arain ◽  
Saima Qureshi ◽  
Kheenpal Das ◽  
Anum Haider
Keyword(s):  
Substance Use ◽  
Peer Pressure ◽  
Cross Sectional Study ◽  
Psychoactive Substance ◽  
Psychoactive Substances ◽  
Ethical Considerations ◽  
Cross Sectional ◽  
History Of ◽  
Male Prisoners ◽  
Study Setting

The use psychoactive substances are on the rise in general population and even seen more among those who are involved in criminal activities. There are many reasons for such irrational use of psychoactive substances. Objectives: To determine the prevalence and reasons of use of different psychoactive substances among prisoners at Malir prison, Karachi. Study Design: Descriptive Cross-Sectional study. Setting: Malir prison, Karachi. Period: 22nd April 2019 to 26th May 2019. Material & Methods: This study was conducted at district Malir prison, Karachi. All the cases who were imprisoned due to any reason and had history of psychoactive substance use were enrolled. Thorough history and examination was carried out. Ethical considerations were taken as per international guidelines. Results: Among all 490 male prisoners who used to take different type of psychoactive substance, majority were of age ranges of 21 to 35 years and 55% were married while 44% were single and 1% were divorced or separated. Out of 490 cases 453 (92%) were using different substances thorough routes other than injections while 37 (8%) were injection users. Majority of prisoners 252 (52%) were using Heroin while 86 (17%) were using Crystals, 74 (15%) Cannabis, 37 (8%) Synthetic substances, 24 (5%) Ice, 6 (1%) Opioid and 11 (2%) were using some other type of substance. The most common reason of substance use was peer pressure followed by fun and frustration. Conclusion: Substance use prevalence is high in prison. Existing services for the management of drug dependence are not meeting the global standard of evidence based comprehensive drug treatment and rehabilitation.

scholarly journals Hubungan Resistensi Insulin dengan Gambaran Klinis Sindrom Ovarium Polikistik

2015 ◽  
Vol 4 (3) ◽  
Author(s):  
Meliza Wahyuni ◽  
Eva Decroli ◽  
Putri Sri Lasmini
Keyword(s):  
Insulin Resistance ◽  
Clinical Manifestation ◽  
Polycystic Ovary ◽  
Cross Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Common Causes ◽  
Chi Square Test ◽  
Reproductive Aged Women ◽  
The Relationship

Abstrak Sindrom Ovarium Polikistik (SOPK) merupakan kelainan endokrin dan metabolik pada wanita usia reproduksi. SOPK merupakan kumpulan gejala dari amenore, oligomenore, infertilitas, obesitas, hirsutisme, acne, alopesia, dan akantosis nigrikan. Resistensi insulin diyakini sebagai salah satu penyebab tersering dari SOPK melalui berbagai mekanisme. Tujuan penelitian ini adalah untuk mengetahui hubungan resistensi insulindengan gambaran klinis SOPK. Penelitian ini dilakukan pada pasien SOPK dengan menggunakan studi cross sectional dengan pendekatan retrospektif, yaitu mengumpulkan kejadian masa lalu dari tahun 2009 - 2011, jumlah sampel 105 orang. Analisis statistik yang digunakan adalah uji chi-square. Hasil penelitian didapatkan 33,3% penderita SOPK mengalami resistensi insulin. Berdasarkan gambaran klinis 35,23% amenore, 64,77% oligomenore, 72,04% infertilitas, 50,5% obesitas, 0,95% hirsutisme, acne 20%, alopesia dan akantosis nigrikan0%. Dari 33,3% SOPK dengan resistensi insulin 40% amenore, 60% oligomenore, 71,9% infertilitas, 77,14% obesitas, dan 0% hirsutisme. Berdasarkan hasil uji statistik ditemukan hubungan bermakna antara resistensi insulin dengan obesitas (p<0,05) dan tidak ditemukan hubungan bermakna antara resistensi insulin dengan infertilitas, hirsutisme, dan acne (p>0,05).Kata Kunci: SOPK, resistensi insulin, gambaran klinisAbstract Polycystic Ovary Syndrome (PCOS) is an endocrine and metabolic disorders that is common in reproductive-aged women. PCOS is a group of symptoms, such as amenorrhea, oligomenorrhea, infertility, obesity, hirsutism, acne, alopecia, and achanthosis nigricans. Insulin resistance is believed to be one of the most common causes of PCOS through a various mechanisms. The objective of this study was to find out the relationship between insulin resistance and clinical manifestation of PCOS. This research was done in patients with PCOS using cross sectional study with retrospective approach. Data was collected from 2009-2011, with the sample of 105 patients. This research used statistical analysis, that was chi square test. This research found that  33.3% patients of PCOS have insulin resistance. Based on clinical manifestation found that 35.23% amenorrhea, 64.77% oligomenorrhea, 72.04% infertility, 50.5% obesity, 0.95% hirsutism, 20% acne, 0% alopecia and achanthosis nigricans. From 33.3% PCOS with insulin resistance, 40% amenorrhea, 60%  oligomenorrhea, 71.9% infertility, 77.14% obesity, and 0% hirsutism. The results showed that there is a significant relationship between insulin resistance and obesity (p<0.05) and no significant reslationship between insulin resistance and infertility, hirsutism, and acne (p>0.05).Keyword: PCOS, insulin resistance, clinical manifestation 

scholarly journals FREQUENCY OF STROKE IN HYPERTENSIVE PATIENTS

2014 ◽  
Vol 21 (03) ◽  
pp. 484-488
Author(s):  
Ashok Kumar Lohano ◽  
Adnan Samie ◽  
Noor Nabi Siayal
Keyword(s):  
Risk Factors ◽  
Intracerebral Hemorrhage ◽  
Cross Sectional Study ◽  
Medical Department ◽  
Cross Sectional ◽  
Medical College ◽  
Long Duration ◽  
History Of ◽  
Study Setting ◽  
Improve Patient

Objective: To determine the frequency of intracerebral hemorrhage inhypertensive patients. Study design: Cross sectional study. Setting: This study was conductedat Medical department of Peoples Medical College & Hospital Nawabshah, from 01-01-2012 to31-12-2012. Material and methods: Admitted patient through emergency department withhistory of hypertension more than two years, meeting the inclusion criteria taken consent fromattendant. Patient was referred for C.T scan brain presence of hyperdense area was consideredas intracerebral hemorrhage. Inclusive criteria were age >20 years, either sex and patients withhistory of hypertension more than two year with any two or more sign and symptoms like suddenunconsciousness or with hemiplegia, hemiparesis, dysarthria. Aphasia, cranial nerve palsies.Exclusion criteria were age less than 20 years, normotensive patients with cerebral hemorrhageand patients with traumatic hemorrhage. Results: Among 281 patients that had stroke, therewere 147 males and 134 females with a sex ratio males: female 1:1. Mean age of patientsadmitted with intracerebral hemorrhage was 37.89 ± 7.33 years with an average age amongmales and females was same. Duration of hypertension was greater than 20-25 years in most ofthe patients nearly 63.7%. Patients with long duration of diabetes and hypertension presentedwith intracerebral hemorrhage. Nearly all the patients with intracerebral hemorrhage weresmokers 145, only 2 patients were non smokers and nearly all had long history of smoking. The127 patients who presented with intracerebral hemorrhage were obese. All risk factors werestatistically significant and were responsible for intracerebral hemorrhage. Conclusions:Hypertension is a risk factor for intra cerebral hemorrhage. An effort should be made to controlblood pressure and other modifiable risk factors to reduce incidence of intra cerebralhemorrhage and improve patient outcomes.

scholarly journals DENTAL PROSTHESIS;

2018 ◽  
Vol 25 (08) ◽  
pp. 1261-1264
Author(s):  
Wasiq Riaz ◽  
Ayesha Aslam ◽  
Sara Aziz
Keyword(s):  
Survival Rates ◽  
Cross Sectional Study ◽  
Class I ◽  
High Survival ◽  
Cross Sectional ◽  
Dental Prostheses ◽  
History Of ◽  
Fixed Dental Prostheses ◽  
History Of Use ◽  
Study Setting

Introduction: Fixed dental prostheses (FDPs) are still preferred owing to theirdurability, esthetics, cost-effectiveness, adequate retention and lack of a surgical procedure.These restorations generally demonstrate longer life and durability in clinical service. Despitethe high survival rates, FDP complications are frequently encountered. Although severalstudies have reported on complications associated with FDPs, there is a lack of a standardand universal reporting system for FDP failures. Objectives: To evaluate FDP failures using aneasy classification scheme relevant to all conventional FDP failures. To assess the prevalenceof FDP failures based on this system. Study Design: Cross-sectional study. Setting: MargallaInstitute of Health Sciences (MIHS), Rawalpindi. Period: From 20th July 2014 to 20th January2015. Materials and Methods: Subjects reporting to the outpatient department with complaintsof failed crowns or bridges were included in the study. FDP failures were classified accordingto Manappallil’s classification. Data was analyzed using SPSS version 24. Descriptive statisticswere calculated. Results: Majority (31.6%) of the FDP failures were classified as Class I failureswhile the second most common FDP failures belonged to Class IV with a prevalence of 30.1%.Majority of the study subjects had been wearing FDPs for a period of 2 – 5 years while a few(2%) reported a history of use of FDP for more than 15 years. Conclusion: Class I failures arethe most prevalent failures in FPDs.

scholarly journals Evaluation of elderly patients with hearing impairment.

2020 ◽  
Vol 27 (10) ◽  
pp. 2154-2158
Author(s):  
Syed Ali Naqi ◽  
Syed Maisam Ali ◽  
Arslan Akhtar ◽  
Tabassum Aziz ◽  
Tahira Sajid ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
Past History ◽  
Clinical History ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Variable Degree ◽  
Cross Sectional ◽  
Detailed Clinical History ◽  
History Of ◽  
Study Setting

Hearing is decreased in later age is due to aging and is normally seen in most of the elderly people all over the world. Objectives: To ascertain the degree of hearing in elders in relation to age, pattern and extent of hearing weakness in old age so that interventional strategies can be planned to improve their wellbeing. Study Design: Cross Sectional Study. Setting: ENT Outdoor Clinic of Akbar Niazi Teaching Hospital of Islamabad Medical and Dental College, Bhara Kahu, Islamabad. Period: December 2017 to October 2018. Material & Methods: 200 patients were part of the study with age > 50 years and no past history of drug therapy. Data was gathered by detailed clinical history, clinical examination and audiometric findings. Result: 57% patients were found with normal hearing and 43% had variable degree of hearing deterioration. Highest number of hearing weakness was found in 9th decade. Most of hearing deterioration was found in both the ears and that of sensorineural in type. Conclusion: Sensorineural type of hearing impairment is very frequently occurring problem seen in the latter part of life in our community. The frequency and severity of decreased hearing is directly proportional to age.

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