scholarly journals Role of remdisivir among COVID-19 patient’s recovery.

2021 ◽  
Vol 28 (12) ◽  
pp. 1862-1868
Author(s):  
Ather Mehmood ◽  
Javaria Malik ◽  
Attiya Hameed Khan ◽  
Wajid Hussain ◽  
Akhtar Ali Bandeshah ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Oxygen Saturation ◽  
Length Of Hospital Stay ◽  
Low Oxygen ◽  
Good Clinical Outcome ◽  
The Mean ◽  
Study Setting ◽  
Positive Effect

Objective: To assess the effect of Remedisvir, its safety Profile, and efficacy among COVID-19 patients. Study Design: Retrospective Observational study. Setting: South East Hospital and Research Center, Islamabad, Pakistan. Period: December 2020 to July 2021. Material & Methods: 100 patients were included in this study who received Remedisvir infusion, day 5, 7, and 10 after admitting the hospital with COVID-19 symptoms. We infuse 200mg I/V Remedisvir in 100cc N/S followed by 100mg I/V daily into 100cc N/S. After infusion, all patients were monitored strictly. Results: The mean age of the patients was (51. 89±15.441). The outcome of Remedisvir showed that 14% improved their condition, 42% discharged with oxygen, 27% discharged without oxygen, and only 17% expired). Remedisvir showed a positive effect at (p≤0.001) among laboratory values and oxygen support category. Conclusion: When patient suffering from COVID-19 symptoms and low oxygen saturation show good clinical outcome treated with Remedisvir. According to the results of our study, it is concluded that, at present Remedisvir remains a good drug, it shows a positive effect on oxygen saturation and length of hospital stay.

scholarly journals COVID-19 in Northeast Bosnia and Herzegovina and patients length of hospitalization

2020 ◽  
Author(s):  
Alma Trnacevic ◽  
Amer Mujkanovic ◽  
Noura Al-Salloum ◽  
Amra Sakusic ◽  
Emir Trnacevic ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Bosnia And Herzegovina ◽  
Clinical Factors ◽  
Low Oxygen ◽  
The World ◽  
The Mean ◽  
Elevated Creatinine ◽  
Underlying Diseases ◽  
Time Of Admission ◽  
Length Of Hospitalization

Abstract Background Since outbreak of COVID-19 pandemic clinical data from various parts of the world have been reported, until now there has been no provide data from Bosnia and Herzegovina (B&H) about COVID-19. Aim was to report on the first cohort of patients from B&H and to analyze clinical factors of COVID-19 patients that influence the length of hospitalization. Methods Retrospective cohort study conducted at UKC Tuzla. The study included 25 COVID-19 positive patients that were hospitalized between March 28th and April 27th 2020. The LOH was measured from the time of admission to discharge. Hospitalization greater than 10 days was considered as prolonged. Factors analyzed induced age, BMI, comorbidities, serum creatinine and oxygen saturation upon admission.Results The mean age was 52.92±19.15 years and BMI 28.80±4.22. LOH for patients with normal BMI was 9±SE2.646 days (CI 95% 3.814-14.816) vs 14.182 ±SE .937 (CI 95% 12.346-16.018; p<0.05) for ≥25 BMI. Patients without underlying diseases had a LOH of 11.70 ±SE1.075 (CI 95% 9.592-13.808), while those with comorbidities 14.8 ±SE1.303 (CI95% 12.247-17.353; p<0.05). Conclusion LOH varied among COVID-19 patients and was prolonged when clinical characteristics such as elevated BMI, comorbidities, elevated creatinine and low oxygen saturation levels were taken into consideration. Furthermore, risk factors for COVID-19 patients in B&H do not deviate from data reported in other countries.

P–349 Does concomitant autoimmunity affect IVF/ICSI outcomes in women with endometriosis? A retrospective observational study

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
A Rebecchi ◽  
N Salmeri ◽  
C Patruno ◽  
R Villanacci ◽  
P Rover Querini ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Observational Study ◽  
Pregnancy Rates ◽  
Clinical Pregnancy ◽  
Retrospective Observational Study ◽  
Histopathological Diagnosis ◽  
Increased Risk ◽  
The Mean ◽  
Icsi Outcomes

Abstract Study question To investigate differences in In Vitro Fertilization (IVF)/Intracytoplasmic Sperm Injection (ICSI) outcomes between endometriosis women who do or don’t have a concomitant autoimmune disease. Summary answer Despite a higher oocyte yield, a trend for reduction in clinical pregnancy rates was observed in the autoimmunity group compared to women without concomitant autoimmunity. What is known already Endometriosis is an inflammatory chronic gynaecological disorder with a known detrimental impact on fertility. Endometriosis pathogenesis is still unclear. It has been postulated a role of both innate and adaptive immune system. The coexistence of endometriosis and autoimmunity is a well-documented occurrence Some recent findings have revealed an increased risk to have concomitant autoimmune disease in women with endometriosis, but no study has so far investigated whether this association could affect IVF/ICSI outcomes. Indeed, autoimmune phenomena, including proinflammatory cytokines and auto-antibody production, may result in diminished quality of oocytes/embryos with lower pregnancy rates among these patients. Study design, size, duration This was a retrospective observational study carried out at the Fertility Unit of IRCSS San Raffaele Hospital (Milan). We reviewed medical patients’ notes of women with a confirmed diagnosis of endometriosis who referred to our Fertility Unit from October 2018 to January 2021. Participants/materials, setting, methods Out of 1441 patients undergoing IVF/ICSI, 98 women had surgical/histopathological diagnosis of endometriosis. 25 of them had a clinical and/or serological diagnosis of autoimmunity. Autoimmunity was assessed by clinical data (blood tests for auto-antibodies or rheumatological records) obtained from the electronic patient files stored in the database of our Fertility Centre. Clinical pregnancy was defined as the presence of at least one intrauterine gestational sac with a viable embryo at week 6 after transfer. Main results and the role of chance 25/98 (25.5%) endometriosis women with a concomitant autoimmune disease (cases) were compared with 73/98 (74.5%) endometriosis patients without autoimmunity (controls). The mean age was 37.36±3.63 and 36.93±3.79 (p=.623) in cases and controls respectively. The mean number of oocytes retrieved was higher in cases (5.78±4.07) than in controls (3.82±2.69;p=.041); similarly, cases showed an higher number of embryos (2.13±1.93 vs. 1.19±1.37;p=.041) and blastocysts (1.89±2.02 vs. 0.85±1.61;p=.041) obtained. A total of 47 fresh embryo transfer (ET) were performed. Considering all the endometriosis patients, the clinical pregnancy rate (CPR) per cycle was 34.0% (16/47); when stratifying for the presence of autoimmunity the CPR was 23.1% (3/13) in cases, and 38.2% (13/34) in controls (p=.494). Limitations, reasons for caution This is a retrospective study based on data extraction from electronic records of our Fertility Centre. The sample size is limited and some information about past medical history could be missed. Results should be interpreted with caution until validated by future research providing more standardized data collection. Wider implications of the findings: Despite significantly higher numbers of oocytes retrieved and embryos/blastocysts formed, the presence of concomitant autoimmune disease in patients with endometriosis may impair pregnancy rates. Whether this finding is confirmed and whether it could be due to a defect in embryo/blastocysts quality or in endometrial receptivity deserves further studies. Trial registration number Not applicable

scholarly journals Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study

2016 ◽  
Vol 11 ◽  
Author(s):  
Gianfranco Maria Beghi ◽  
Antonio Maria Morselli-Labate
Keyword(s):  
Observational Study ◽  
Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Real Life ◽  
Treated Group ◽  
Clinical Settings ◽  
Homeopathic Medicine ◽  
Tract Infections ◽  
Positive Effect

Background: Homeopathic medicine is a branch of integrative medicine that has been gaining increasing popularity. However, its clinical application remains controversial. To improve the understanding of homeopathy, observational studies-which monitor the effects of homeopathy in real-life clinical settings-are a helpful adjunct to randomized controlled trials. The goal of this controlled observational study was to investigate the role of the homeopathic medicine in preventing respiratory tract infections (RTIs). Methods: This retrospective analysis of patients’ medical records focused on a single centre from 2002 to 2011, and examined 459 patients, out of whom 248 were treated with homeopathic medicine (specific extract of duck liver and heart) and 211 were not treated. All patients were followed-up for at least 1 year, and up to a maximum of 10 years. Results: A significant reduction in the frequency of onset of RTIs was found in both the homeopathic medicine and untreated groups. The reduction in the mean number of RTI episodes during the period of observation vs. the year before inclusion in the study was significantly greater in the homeopathic-treated group than in untreated patients (-4.76 ± 1.45 vs. -3.36 ± 1.30; p = 0.001). The beneficial effect of the homeopathic medicine was not significantly related to gender, age, smoking habits or concomitant respiratory diseases when compared to the effect observed in untreated patients. Conclusion: These results suggest that homeopathic medicine may have a positive effect in preventing RTIs. However, randomized studies are needed before any firm conclusion can be reached.

scholarly journals Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?

2021 ◽  
Author(s):  
Luisa Mari ◽  
Fabio Placidi ◽  
Andrea Romigi ◽  
Mario Tombini ◽  
Chiara Del Bianco ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Post Partum ◽  
First Trimester ◽  
Protective Role ◽  
Seizure Freedom ◽  
Good Clinical Outcome ◽  
Heart Malformation ◽  
First Trimester Of Pregnancy ◽  
Post Partum Period

Abstract Objective Epilepsy treatment during pregnancy is still challenging. The study is aimed at comparing the efficacy and safety of carbamazepine (CBZ), lamotrigine (LTG) and levetiracetam (LEV) monotherapies during pregnancy in women with focal (FE) or generalized (GE) epilepsy. Methods A multicentre retrospective study was conducted to evaluate seizures frequency and seizure freedom (SF) rate during 3 months before pregnancy, each trimester of gestation and post-partum period in women on monotherapy with CBZ, LTG and LEV. Results Fifty-seven pregnancies (45 FE, 12 GE) on monotherapy (29 CBZ, 11 LTG, 17 LEV) were included. A significant reduction of seizure frequency was found in the first trimester of pregnancy as compared with that one before pregnancy (p = 0.004), more evident in GE (p = 0.003) and in LEV group (p = 0.004). The SF rate significantly increased in the first trimester in comparison to that one before pregnancy and persisted in the post-partum period in the whole sample (p < 0.001) and in women on LEV (p = 0.004). Besides, 88.57% of SF women before pregnancy remained unchanged during gestation and the post-partum period. One major heart malformation in CBZ and no major malformations in LTG and LEV groups were found. Conclusions A better clinical outcome during pregnancy emerged since the first trimester in comparison to the before-pregnancy period, mostly evident in women with GE and LEV therapy, reinforcing the hypothesis of a protective role of pregnancy versus seizures. SF before pregnancy represents a significant predictive factor of good clinical outcome during gestation and the post-partum period. Compared to CBZ, LTG and LEV showed a better safety profile.

scholarly journals A New Rectus and Sartorius Sparing Approach for Periacetabular Osteotomy in Patients with Developmental Dysplasia of the Hip

2021 ◽  
Vol 10 (4) ◽  
pp. 601
Author(s):  
Jannis Löchel ◽  
Viktor Janz ◽  
Carsten Perka ◽  
Andre Hofer ◽  
Alexander Zimmerer ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Periacetabular Osteotomy ◽  
Length Of Hospital Stay ◽  
Developmental Dysplasia ◽  
Hemoglobin Level ◽  
Safe Procedure ◽  
Surgical Time ◽  
Outcome Parameters ◽  
Center Edge ◽  
The Mean

Background: periacetabular osteotomy (PAO) is known as the gold standard surgical treatment in young adults with symptomatic hip dysplasia. With the aim of reducing soft tissue trauma, we developed a new rectus and sartorius sparing (RASS) approach. We hypothesized that this new PAO technique was equal regarding acetabular reorientation, complication rate, and short-term clinical outcome parameters, compared to our conventional, rectus sparing (RS) approach. Patients and Methods: we retrospectively assessed all PAO procedures performed by a single surgeon between 2016 and 2019 (n = 239 hips in 217 patients). The cases in which the new RASS technique were used (n = 48) were compared to the RS cases for acetabular orientation parameters, surgical time, perioperative reduction of hemoglobin level, and length of hospital stay (LOHS). Inclusion criteria were a lateral center-edge angle (LCEA) <25° and osteoarthritis Tönnis grade ≤1. Patients with acetabular retroversion or additional femoral osteotomy were excluded. Results: the mean patient age at the time of surgery was 29 years (14 to 50, SD ± 8.5). Females accounted for 79.5% in this series. The mean preoperative LCEA were 16° (7 to 24°, SD ± 4.4) and 15° (0 to 23°, SD ± 6) in the RASS and the RS group, respectively (p = 0.96). The mean preoperative acetabular index (AI) angles were 14° (2 to 25°, SD ± 4) and 14° (7 to 29°, SD ± 4.3), respectively (p = 0.67). The mean postoperative LCEA were significantly improved to 31° (25 to 37°, SD ± 3.5, p < 0.001) and 30.2° (20 to 38°, SD ± 4, p < 0.001), respectively. The mean postoperative AI angles improved to 2.8° (−3 to 13°, SD ± 3.3, p < 0.001) and 3° (−2 to 15°, SD ± 3.3, p < 0.001), respectively. There were no significant differences between the RASS and the RS group for surgical time, perioperative reduction in hemoglobin level, and LOHS. No blood transfusions were necessary perioperatively in either group. No major perioperative complication occurred in either group. We observed one surgical site infection (SSI) requiring superficial debridement in the RS group. Conclusion: the RASS approach for PAO showed to be a safe procedure with equivalent acetabular reorientation and equivalent clinical outcome parameters compared to the RS approach. Additionally, patients have fewer postoperative restrictions in mobilization with the RASS approach.

scholarly journals Clipping of previously coiled cerebral aneurysms: efficacy, safety, and predictors in a cohort of 111 patients

2016 ◽  
Vol 125 (6) ◽  
pp. 1337-1343 ◽  
Author(s):  
Badih Daou ◽  
Nohra Chalouhi ◽  
Robert M. Starke ◽  
Guilherme Barros ◽  
Lina Ya'qoub ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Cerebral Aneurysms ◽  
Endovascular Coiling ◽  
Good Clinical Outcome ◽  
Surgical Clipping ◽  
Anterior Circulation ◽  
Intraoperative Angiography ◽  
Aneurysm Size ◽  
Aneurysm Occlusion ◽  
The Mean

OBJECTIVE With the increasing number of aneurysms treated with endovascular coiling, more recurrences are being encountered. The aim of this study was to evaluate the efficacy and safety of microsurgical clipping in the treatment of recurrent, previously coiled cerebral aneurysms and to identify risk factors that can affect the outcomes of this procedure. METHODS One hundred eleven patients with recurrent aneurysms whose lesions were managed by surgical clipping between January 2002 and October 2014 were identified. The rates of aneurysm occlusion, retreatment, complications, and good clinical outcome were retrospectively determined. Univariate and multivariate logistic regressions were performed to identify factors associated with these outcomes. RESULTS The mean patient age was 50.5 years, the mean aneurysm size was 7 mm, and 97.3% of aneurysms were located in the anterior circulation. The mean follow-up was 22 months. Complete aneurysm occlusion, as assessed by intraoperative angiography, was achieved in 97.3% of aneurysms (108 of 111 patients). Among patients, 1.8% (2 of 111 patients) had a recurrence after clipping. Retreatment was required in 4.5% of patients (5 of 111) after clipping. Major complications were observed in 8% of patients and mortality in 2.7%. Ninety percent of patients had a good clinical outcome. Aneurysm size (OR 1.4, 95% CI 1.08–1.7; p = 0.009) and location in the posterior circulation were significantly associated with higher complications. All 3 patients who had coil extraction experienced a postoperative stroke. Aneurysm size (OR 1.2, 95% CI 1.02–1.45; p = 0.025) and higher number of interventions prior to clipping (OR 5.3, 95% CI 1.3–21.4; p = 0.019) were significant predictors of poor outcome. An aneurysm size > 7 mm was a significant predictor of incomplete obliteration and retreatment (p = 0.018). CONCLUSIONS Surgical clipping is safe and effective in treating recurrent, previously coiled cerebral aneurysms. Aneurysm size, location, and number of previous coiling procedures are important factors to consider in the management of these aneurysms.

scholarly journals Persuading Students Of Their Responsibilities In The Learning Process

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Leon Hoshower ◽  
Yining Chen
Keyword(s):  
Test Score ◽  
Control Group ◽  
Student Effort ◽  
Course Work ◽  
The Mean ◽  
And Performance ◽  
Individual Effort ◽  
Positive Effect ◽  
Experimental Group

Education is a two-sided coin, with teaching technique and curriculum on one side and student effort and motivation on the other side.  Much educational research is directed predominately at the teaching side, while slighting the student's side.  This study reports an experiment that emphasizes the role of the student’s effort in learning.  The students in the experimental group were asked to compare their individual effort and test score to the mean reported effort and test score of the class.  They were then asked to consider making adjustments in their efforts with the hope of improving their performance.  As a result, the students in the experimental group increased their study hours and significantly increased their exam scores as compared to the control group students.  The results of this study indicate that actively reminding students of their effort and performance in course work has a positive effect on students' effort of study which can ultimately translate into improvement of academic performance.

ROLE OF VESTIBULAR EVOKED MYOGENIC POTENTIALS (VEMP) IN PREDICTING THE OUTCOME OF STAPEDOTOMY- A PROSPECTIVE OBSERVATIONAL STUDY

2021 ◽  
pp. 60-62
Author(s):  
Thirunavukarasu Palanisamy ◽  
Sathishkumar Jayagandhi ◽  
Somu Lakshmanan ◽  
Ajaykumar Prabakar ◽  
Arthi Arun ◽  
...  
Keyword(s):  
Observational Study ◽  
Pure Tone ◽  
Tertiary Care ◽  
Linear Acceleration ◽  
Vestibular Evoked Myogenic Potentials ◽  
Care Hospital ◽  
Non Invasive ◽  
Pure Tone Audiogram ◽  
The Mean

Vestibular evoked myogenic potentials (VEMP) is an objective and non-invasive measure of saccule function that primarily respond to linear acceleration in any direction. Stapedotomy is a procedure done for otosclerosis to improve hearing. The aim of this study was to correlate the VEMPresults with pure tone audiogram pre- and post- stapedotomy in otosclerotic patients. Aprospective observational study was conducted from 2017-2020 in a tertiary care hospital of south India. Patients who underwent stapedotomy for otosclerosis and satised the study criteria were included. Atotal of 22 patients were included in the study. All patients underwent pure tone audiogram (PTA) and VEMP preoperatively and postoperatively. The results were compared and analysed. The mean pre-operative and post-operative ABG were 26.32±9.36 dB and 18.10 ±8.06 dB respectively. (P=0.001). There was no signicant change in VEMP positivity rates, latency and amplitude. The results showed that there was no correlation between the PTAvalues and VEMPpositivity rate in otosclerotic patients. The VEMPpositivity rate was also not affected signicantly by stapedotomy. Based on above ndings we conclude that stapedotomy is a safe and effective procedure with no signicant inner ear trauma.

Abstract TP424: Re-bleed in Nontraumatic Convexity Subarachnoid Hemorrhage

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Jennifer Harris ◽  
Rachel Forman ◽  
James Conners ◽  
Rajeev Garg ◽  
Sayona John ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Clinical Outcome ◽  
Clinical Presentation ◽  
Clinical Symptoms ◽  
Severe Headache ◽  
Neurological Deficits ◽  
Amyloid Angiopathy ◽  
Good Clinical Outcome ◽  
Cerebral Vasoconstriction ◽  
The Mean

Introduction: Re-bleeding can have significant adverse consequences, but has not been well described in isolated nontraumatic convexity subarachnoid hemorrhage (cSAH), and therefore we sought to report the clinical spectrum of re-bleed in this population. Methods: With IRB approval, we retrospectively reviewed consecutive nontraumatic cSAH admitted to our institution from August 1, 2006 to June 1, 2016. cSAH was defined as radiographic hemorrhage isolated to the convexities, without cisternal component. Trauma was excluded. Data was abstracted on demographics, medical history, neuroimaging, etiology, and clinical presentation. Good clinical outcome was defined as modified rankin score of 0-2 at 3 months. Results: Among 93 cSAH patients, re-bleed occurred in 9 (10%) patients. The mean age of patients with re-bleed was 55.6 years (range, 24-68) and 8 (89%) were women. The majority 6 (67%) were Hispanic. Most patients 8 (89%) presented with severe headache. The etiology of cSAH was reversible cerebral vasoconstriction syndrome (RCVS) in 6 (67%), amyloid angiopathy in 1 (11%), cerebral venous thrombosis (CVT) in 1 (11%), and post-procedural related in 1 (11%). Initial re-bleeding was new remote subarachnoid hemorrhage in 1 (11%) and new intracerebral hemorrhage in 8 (89%). Clinical symptoms of initial re-bleeding included isolated worsening headache in 2 (22%), focal neurological deficits in 4 (44%), and no clinical change in 3 (33%). Time from initial neuroimaging documenting cSAH to CT documenting re-bleed was 40 hours (range, 5 - 74), and re-bleed occurred within 60 hrs in most patients (89%). Two patients had subsequent re-bleeding (due to CVT and RCVS) documented at 1.9 and 11.8 hours after the initial re-bleed CT. Good clinical outcome was seen in 7 (78%) . Conclusion: Re-bleeding was seen in 10% of cSAH patients and in the majority of patients occurred early, within 2.5 days. Clinicians should be aware of this potential complication of cSAH.

Effects of Non-negotiated Pre-modified Input, Negotiation of Input without Output, and Negotiation of Input plus Pushed Output on EFL Learners’ Vocabulary Learning

2016 ◽  
Vol 7 (4) ◽  
pp. 773 ◽  
Author(s):  
Arash Azizi
Keyword(s):  
Adult Students ◽  
Vocabulary Learning ◽  
Production Test ◽  
Female Adult ◽  
Male And Female ◽  
Efl Learners ◽  
The Mean ◽  
L2 Vocabulary ◽  
Positive Effect

This experimental study investigated the comparative effects of non-negotiated pre-modified input, negotiation of input without output, and negotiation of input plus pushed output on EFL learners’ comprehension and production.  Before starting the study, forty-three male and female adult students at intermediate level took the Preliminary English Test (PET) and 30 of the students who scored one standard deviation above and below the mean score in the PET were randomly assigned to three experimental groups. The whole treatment took 10 sessions and, after the treatment, two sets of tests were administered; i.e., one written and the other oral. Analysis of Variance on comprehension test and analysis of nonparametric alternative, i.e., Kruskal-Wallis test, on production test, indicated that (a) negotiation had a positive effect on the comprehension and production of targeted L2 vocabulary items and (b) negotiation of input plus pushed output did not promote production of L2 vocabulary more than negotiation of input without output. The findings of this study provide empirical evidence on the important role of negotiation in facilitating comprehension and production of targeted L2 vocabulary items.

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