scholarly journals Prospects for prevention of adhesion process during cardiac surgical interventions

2021 ◽  
Vol 6 (6-2) ◽  
pp. 125-132
Author(s):  
M. G. Shurygin ◽  
I. A. Shurygina
Keyword(s):  
Mechanical Properties ◽  
Cardiac Surgery ◽  
The Body ◽  
Postoperative Adhesions ◽  
Central Hemodynamics ◽  
Protective Function ◽  
Surgical Interventions ◽  
Barrier Materials ◽  
Ideal Agent ◽  
Adhesion Process

The article is devoted to the problem of prevention of adhesions in cardiac surgery. It was determined that the problem is urgent due to the increase in the number of heart surgeries. The formation of adhesions is a reaction of the body after surgery, which is a stage of healing and partly performs a protective function. Nevertheless, the presence of adhesions violates the mechanical properties of the heart, negatively affects central hemodynamics, complicates the surgeon’s task during repeated surgical interventions and increases the risk of repeated operations.It has been shown that at present, for the prevention of adhesions, researchers tend to use biodegradable barrier materials with biocompatibility and the ability to dissolve after performing the barrier function. The main anti-adhesion agents used in cardiac surgery are membranes and gels. The requirements for an “ideal” agent for the prevention of adhesion were determined: biocompatibility, no irritating effect, no effect on wound healing, suppression of the growth of connective tissue in the pericardium.Conclusions. Until now, none of the funds has all the necessary qualities to prevent adhesion in the pericardium. Therefore, the search for effective methods for the prevention of postoperative adhesions remains relevant for cardiac surgery.

scholarly journals BIOMATERIALS BASED ON CHITOSAN AND ITS DERIVATIVES TO PREVENT ADHESION FORMATION

2021 ◽  
Vol 26 ◽  
pp. 11-22
Author(s):  
Mariya Konovalova ◽  
◽  
Daria Tsaregorodtseva ◽  
Elena Svirshchevskaya ◽  
Keyword(s):  
Quality Of Life ◽  
Intestinal Obstruction ◽  
Abdominal Cavity ◽  
Adhesion Formation ◽  
Reproductive Function ◽  
Postoperative Adhesions ◽  
Surgical Interventions ◽  
Adhesion Process ◽  
Mechanisms Of Adhesion

An increase in the number and volume of surgical interventions leads to an increase in the frequency of postoperative adhesions. The development of the adhesion process in the abdominal cavity causes pain, a decrease in the quality of life of patients, a violation of the reproductive function of women as well as acute adhesion intestinal obstruction. Recently, polymer biomaterials, including those based on chitosan, have been widely used for the prevention of adhesions. Due to their biocompatibility and biodegradation ability, they do not require repeated operations to extract the material. It is believed that these materials act as barriers, physically separating the damaged surfaces. The molecular mechanism of their action is still poorly understood. In this review, the main mechanisms of adhesion formation, as well as ways to prevent them with the help of materials based on chitosan and its derivatives, are discussed.

scholarly journals Necrotizing fasciitis, poor hygiene and negligence in obese patients

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Dan Dumitrescu ◽  
Victor Dumitrescu ◽  
Costel Savlovschi
Keyword(s):  
Necrotizing Fasciitis ◽  
Abdominal Wall ◽  
Economic Status ◽  
Iliac Fossa ◽  
The Body ◽  
Large Area ◽  
Left Iliac Fossa ◽  
Protective Function ◽  
Surgical Interventions ◽  
Surgical History

The Tegument, the body's largest organ, also fulfills the protective function by preventing the pathogens from penetrating into the body. The barrier, once overcome, opens the gate to serious illnesses with varying degrees of severity. We present the case of an obese patient aged 63, BMI 40, admitted to emergency service for necrotizing fasciitis in the abdominal wall. Anamnesis and general clinical examination highlight the presence of a large area of necrosis in the lower abdominal wall, affecting the iliac fossa, the hypogastric region and the left iliac fossa, lack of substance at this level, limited supraaponvrotic, with multiple sepsis, isolated tissue areas granulation, anfractum edges, suggestive aspect for necrotizing fasciitis. Serious surgical interventions have been carried out, with the aim of broad, digital and instrumental debridement, the important lavage of the wound with hydrogen peroxide and betadine and antibiotic treatment according to the antibiogram. Subsequently, dressings were applied with negative pressure, with development of granulation tissue in the wound and in the end was chosen for secondary suture with favorable outcome and discharge from the hospital 33 days after admission. Precarius socio-economic status, poor hygiene in an obese, careless patient, without identifying other causes like diabetes or surgical history, have led to the development of a multilingual, life-threatening condition. Serious surgical attitude and postoperative care have led to a medical success, although burdened by significant costs, which could have been avoided with minimal effort especially from the patient.

scholarly journals Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 691
Author(s):  
O. Sánchez-Aguinagalde ◽  
Ainhoa Lejardi ◽  
Emilio Meaurio ◽  
Rebeca Hernández ◽  
Carmen Mijangos ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Bioactive Glass ◽  
Vinyl Alcohol ◽  
Release Kinetics ◽  
The Body ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Inorganic Particles ◽  
Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

Influence of the mechanical stretch property of fabrics on the wear comfort of men’s suit pants

2021 ◽  
pp. 004051752110191
Author(s):  
Hiroyuki Kanai ◽  
Kentaro Ogawa ◽  
Tetsu Sasagawa ◽  
Kiyohiro Shibata
Keyword(s):  
Mechanical Properties ◽  
Pressure Measurement ◽  
Mechanical Stretch ◽  
The Body ◽  
Weft Yarn ◽  
Elongation Ratio ◽  
Weft Direction ◽  
Wear Comfort ◽  
Finishing Process ◽  
Elastic Thread

The stretch property of fabrics is one of the most important factors that provide comfort to wearers. It is expected that tension building up in the fabric can be relaxed and the garment pressure on the body can be reduced by appropriately exploiting its stretch property. Currently, the stretch property is predominantly realized using spandex. However, weaving or knitting elastic threads cannot be employed for the worsted fabric used to design men’s suits because of their effects on the mechanical properties of the fabric (e.g., embrittlement), which deteriorate with time. In this study, worsted fabric with a graded mechanical stretch property was produced, and the effect of the mechanical stretch property on comfort was verified. The mechanical stretch property is developed from the tension relaxation and fabric shrinkage along the weft yarn during the crabbing, scouring, and drying stages of the finishing process. Then, the form of the fabric is set by heating. In this study, the worsted fabric had an elongation ratio varying from 5.9% to 16.1% along the weft direction that was produced without using elastic thread. Furthermore, men’s suit pants were made from the fabrics. The effect of the stretch property on the garment comfort was verified through sensory evaluation and garment pressure measurement. The contribution of the mechanical stretch property in improving the garment comfort of men’s suit pants is discussed.

scholarly journals Injectable non-leaching tissue-mimetic bottlebrush elastomers as an advanced platform for reconstructive surgery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Erfan Dashtimoghadam ◽  
Farahnaz Fahimipour ◽  
Andrew N. Keith ◽  
Foad Vashahi ◽  
Pavel Popryadukhin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Reconstructive Surgery ◽  
Biomedical Applications ◽  
The Body ◽  
Surrounding Tissue ◽  
Curing Time ◽  
Materials Used ◽  
Significant Health

AbstractCurrent materials used in biomedical devices do not match tissue’s mechanical properties and leach various chemicals into the body. These deficiencies pose significant health risks that are further exacerbated by invasive implantation procedures. Herein, we leverage the brush-like polymer architecture to design and administer minimally invasive injectable elastomers that cure in vivo into leachable-free implants with mechanical properties matching the surrounding tissue. This strategy allows tuning curing time from minutes to hours, which empowers a broad range of biomedical applications from rapid wound sealing to time-intensive reconstructive surgery. These injectable elastomers support in vitro cell proliferation, while also demonstrating in vivo implant integrity with a mild inflammatory response and minimal fibrotic encapsulation.

A Novel Bioresorbable Film Reduces Postoperative Adhesions After Infant Cardiac Surgery

2008 ◽  
Vol 86 (2) ◽  
pp. 614-621 ◽  
Author(s):  
Andrew J. Lodge ◽  
Winfield J. Wells ◽  
Carl L. Backer ◽  
James E. O'Brien ◽  
Erle H. Austin ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Adhesions

Relationship between Microstructure and Mechanical Properties in Q&P-Steels

2016 ◽  
Vol 879 ◽  
pp. 1933-1938 ◽  
Author(s):  
Richard G. Thiessen ◽  
Georg Paul ◽  
Roland Sebald
Keyword(s):  
Mechanical Properties ◽  
Dual Phase Steel ◽  
High Strength Steels ◽  
High Strength ◽  
The Body ◽  
Advanced High Strength Steels ◽  
Passenger Safety ◽  
Back Scattering ◽  
Body In White ◽  
Expected Increase

Third-Generation advanced high strength steels are being developed with the goal of reducing the body-in-white weight while simultaneously increasing passenger safety. This requires not only the expected increase in strength and elongation, but also improved local formability. Optimizing elongation and formability were often contradictory goals in dual-phase steel developments. Recent results have shown that so-called "quench and partitioning" (Q&P) concepts can satisfy both requirements [1]. Many Q&P-concepts have been studied at thyssenkrupp Steel Europe. Thorough investigation of the microstructure has revealed relationships between features such as the amount, morphology and chemical stability of the retained austenite and the obtained mechanical properties. An evaluation of the lattice strain by means of electron-back-scattering-diffraction has also yielded a correlation to the obtained formability. The aim of this work is to present the interconnection between these microstructural features and propose hypotheses for the explanation of how these features influence the macroscopically observed properties.

scholarly journals Analysis of Stress and Strain to Determine the Pressure Changes in Tight-Fitting Garment

2020 ◽  
Vol 20 (1) ◽  
pp. 49-55
Author(s):  
Nareerut Jariyapunya ◽  
Blažena Musilová
Keyword(s):  
Mechanical Properties ◽  
Mathematical Models ◽  
Initial Phase ◽  
Circumferential Stress ◽  
The Body ◽  
Stress And Strain ◽  
Laplace’S Law ◽  
Pressure Changes ◽  
The Relationship ◽  
Laplace's Law

AbstractBased on the mechanical properties of stretch fabrics and Laplace’s law, the mathematical models have been developed enabling one to determine the values of the relationship between the fabric strain and the circumferential stress depending on pressure and diameter of the body. The results obtained refer to the values of the parameters assessed for the initial phase of their exploitation, which allow us to preliminarily predict the values of these parameters.

scholarly journals PENGARUH SPUTTERING TiN TERHADAP KEKASARAN, KEKERASAN PERMUKAAN MATERIAL AISI316L

2019 ◽  
Vol 18 (3) ◽  
pp. 331-338
Author(s):  
Jemssy Ronald Rohi ◽  
Priyo Tri Iswanto ◽  
Tjipto Sujitno ◽  
Erich Umbu Kondi
Keyword(s):  
Mechanical Properties ◽  
Surface Roughness ◽  
Corrosion Resistance ◽  
Deposition Time ◽  
Low Cost ◽  
Surface Hardness ◽  
The Body ◽  
Aisi 316L ◽  
Good Corrosion Resistance ◽  
Long Time

AISI 316L is widely used for implantation in orthopedic surgery due to its good corrosion resistance, mechanical properties and low cost. However, AISI 316L is not well suited for biocompatibility with the body, so implant material with AISI 316L can’t be used for a long time. One way to improve the corrosion resistance and mechanical properties of AISI 316L is to perform a surface treatment such as sputtering. This study discusses the effect of deposition sputtering TiN of 60, 90, 120 and 150 minutes on roughness and surface hardness at a ratio of argon gas and nitrogen to 80% Ar:20% N2. The results of the surface roughness value of the TiN sputtering layer deposited to AISI 316L for 60, 90, 120, and 150 minutes were 0.02 μm, 0.04 μm, 0.06 μm, and 0.04 μm respectively. This shows that the coating time of TiN in AISI 316L has no significant influence on value of surface roughness. Surface hardness results at 60, 90, 120, and 150 minutes were obtained with 268 HVN, 275 HVN, 278 HVN and 282 HVN. Increased hardness value, as the TiN thin layer has a higher hardness value compared to AISI 316L. The longer the deposition time, the more layers are formed and the layer becomes thicker. With the thickness of the layer, the density at the grain boundary increases. Because the higher density leads to grain growth, in which form micropores.

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