scholarly journals Elevated Cardiac Marker Enzymes with the Incidence of Complications in ACS Patients:

2021 ◽  
Author(s):  
Prihati Pujowaskito ◽  
Muhammad Aldiast Alhadiyanto ◽  
Wida Vianita Aziz ◽  
Muhammad Hanif Baswedan
Keyword(s):  
Marker Enzymes ◽  
Cardiac Marker

scholarly journals Serum enzymes markers in myocardial infarction: A study of rural area

2017 ◽  
Vol 8 (2) ◽  
pp. 34-37 ◽  
Author(s):  
Mamata Pochhi ◽  
MG Muddeshwar
Keyword(s):  
Myocardial Infarction ◽  
Coronary Flow ◽  
Oxygen Demand ◽  
Serum Enzymes ◽  
Marker Enzymes ◽  
Medical Sciences ◽  
Significant Elevation ◽  
Cardiac Enzymes ◽  
Cardiac Marker ◽  
Present Thesis

Background: Acute Myocardial Infarction is the reduction of coronary flow to such an extent that supply of oxygen to the myocardium do not need the oxygen demand of myocardial tissues. The diagnosis of AMI cannot be fulfilled unless the elevated levels of serum cardiac enzymes particularly CK-MB iso-enzyme activity. The rate of release of cardiac enzymes is highly diagnostic.Aims and Objectives: Therefore, the present thesis aim is-in evaluating, whether the elevated levels of cardiac marker enzymes can be compared to the extent of the Myocardial infarction.Material and Methods: Therefore the present study was undertaken on 50 patients of MI and 50 patients of control. They were group according to the age and sex. The activity of different cardiac enzymes were studied.Result: The AMI patients had significantly elevated levels of 90% patients of high LDH values and 86% patients have elevated levels of AST. The significant elevation of serum enzymes as compared to the control.Conclusion: The magnitude of the elevated levels of enzymes can be compared to the extent of the myocardial infarction. Serum GGT can also be useful marker of oxidative stress in myocardial infarction.Asian Journal of Medical Sciences Vol.8(2) 2017 34-37

scholarly journals Cardioprotective Potential of Polyphenolic Rich Green Combination in Catecholamine Induced Myocardial Necrosis in Rabbits

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Fatiqa Zafar ◽  
Nazish Jahan ◽  
Khalil-Ur-Rahman ◽  
Ahrar Khan ◽  
Waseem Akram
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Histopathological Examination ◽  
Cardiac Injury ◽  
Myocardial Necrosis ◽  
Myocardial Cell ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Synthetic Drugs ◽  
Plant Mixture

The present study was designed to develop safer, effective, and viable cardioprotective herbal combination to control oxidative stress related cardiac ailments as new alternatives to synthetic drugs. The synergetic cardioprotective potential of herbal combination of four plantsT. arjuna(T.A.),P. nigrum(P.N),C. grandiflorus(C), andC. oxyacantha(Cr) was assessed through curative and preventive mode of treatment. In preventive mode of treatment, the cardiac injury was induced with synthetic catecholamine (salbutamol) to pretreated rabbits with the proposed herbal combination for three weeks. In curative mode of treatment, cardiotoxicity/oxidative stress was induced in rabbits with salbutamol prior to treating them with plant mixture. Cardiac marker enzymes, lipids profile, and antioxidant enzymes as biomarker of cardiotoxicity were determined in experimental animals. Rabbits administrated with mere salbutamol showed a significant increase in cardiac marker enzymes and lipid profile and decrease in antioxidant enzymes as compared to normal control indicating cardiotoxicity and myocardial cell necrosis. However, pre- and postadministration of plant mixture appreciably restored the levels of all biomarkers. Histopathological examination confirmed that the said combination was safer cardioprotective product.

scholarly journals EVALUATION OF ANTI-HYPERTROPHIC POTENTIAL OF CAMELLIA SINENSIS IN ISOPROTERENOL INDUCED CARDIAC HYPERTROPHY

2018 ◽  
Vol 10 (10) ◽  
pp. 119
Author(s):  
Doss V. A. ◽  
Jeevitha Parthibhan ◽  
Dharaniyambigai Kuberapandian
Keyword(s):  
Lactate Dehydrogenase ◽  
Cardiac Hypertrophy ◽  
Aqueous Extract ◽  
Marker Enzymes ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Cardiac Marker ◽  
Serum Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Serum Glutamate

Objective: Camellia sinensis (C. sinensis family-Theaceae) has potent antioxidant activity used in the treatment of cardiovascular disease. The present study evaluates the cardioprotective (anti-hypertrophic) effect of aqueous extract of C. sinensis in isoproterenol (ISO) induced cardiac hypertrophic rats.Methods: The beneficial effect of the green tea extract was examined by the administration of the aqueous extract of the leaves of C. sinensis (100 mg/kg b.w., oral., 7 d) in ISO (10 mg/kg b.w., subcutaneous.,7 d) induced cardiac hypertrophic rats with reference to the standard drug, losartan (50 mg/kg b.w., oral.,7 d) followed by biochemical estimations of glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) in serum and heart tissues thus collected at the end of 7 d.Results: The biochemical assays revealed significantly (P<0.05) increased glucose, protein, cholesterol, cardiac marker enzymes namely serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) lactate dehydrogenase (LDH) and significantly (P<0.05) decreased in ISO induced cardiac hypertrophic rats that were reciprocated by the effect of plant extract.Conclusion: Thus, this study showed that the aqueous leaf extract of C. sinensis possesses potent effect against cardiac hypertrophy. This potential is hypothesized to be due to the phytochemical, Catechin present in the plant that requires further isolation and characterization with respect to anti-hypertrophic therapeutics.

scholarly journals Cardioprotective Potential of Methanol Extract of Polygonum glabrum on Isoproterenol Induced Myocardial Necrosis in Rats

2017 ◽  
Vol 9 (3) ◽  
pp. 518
Author(s):  
Raja S ◽  
Ramya I
Keyword(s):  
Methanol Extract ◽  
Low Density Lipoprotein ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Myocardial Necrosis ◽  
Tissue Homogenate ◽  
Low Density ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Serum Glutamate

<p>Aim: The aim of present study was to evaluate the cardioprotective efficacy of <em>Polygonum glabrum</em> on isoproterenol induced myocardial necrosis in rats. Methods: Experimental rats were treated orally with methanol extract of <em>Polygonum glabrum</em> at two doses (200 mg and 400 mg/kg) for 30 days. Isoproterenol (85 mg/kg, s.c.) was administered on 29<sup>th</sup> and 30<sup>th</sup> day to induce myocardial necrosis.  At the end of the experiment, serum cardiac marker enzymes [creatine kinase muscle brain (CK-MB), lactate dehydrogenase (LDH), serum glutamate oxaloacetate transaminase (SGOT)], serum glutamate pyruvate transaminase (SGPT) and total protein (TP) were estimated. Plasma total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels were also recorded. Further, antioxidant parameters viz catalase (CAT), superoxide dismutase (SOD),  glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels were evaluated in heart tissue homogenate. Results: The results of the study indicated that, methanol extract of <em>Polygonum glabrum</em> showed greater cardioprotection by restoring the cardiac marker enzymes and attenuated the level of plasma lipid profiles along with an increase in HDL. Additionally, level of myocardial antioxidants significantly increased along with a reduction in the content of malondialdehyde. The cardioprotective effect was compared with propranolol     (10 mg/kg, oral) which was used as the standard. Histopathological findings revealed a decrease in the degree of necrosis and inflammation following pretreatment with <em>Polygonum glabrum</em>. Conclusion: The present investigation indicates that <em>Polygonum glabrum</em> could protect myocardium from isoproterenol induced necrosis.</p>

Studying the effect of g-irradiated celery leaves on antioxidant status and cardiac enzymes in hypercholesterolemic rats

2017 ◽  
Author(s):  
A.N. El Shahat ◽  
A. M. Abdul Azeem ◽  
H. M. S. Mekawey ◽  
Mohamed H.M. Abd El-megid
Keyword(s):  
Serum Lipid ◽  
Density Lipoprotein ◽  
Total Flavonoid ◽  
Biological Study ◽  
Total Phenolic ◽  
Tbars Level ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Lipid Contents ◽  
Anti Oxidant

This work aimed to study the effects of gamma (g) irradiation on the total phenols and total flavonoid contents of celery leaves and to investigate effect of g-irradiated celery leaves powder (g-Irr.CLP) against hypercholesterolemia in rats. Results obtained that g-irradiation increased the amount of total phenolic and total flavonoid contents of dried celery. The results of biological study showed marked increases in the concentrations of serum lipid contents, activities of liver and cardiac marker enzymes and level of TBARS with a significant decrease in serum high-density lipoprotein concentration and reduction in the activities of anti-oxidant enzymes and glutathione contents of serum and heart tissues of hypercholesterolemic rats compared to control rats. Treatment of hypercholesterolemic rats with raw CLP or g-Irr.CLP showed significantly less severe damage and remarkable improvement in all of the measured parameters when compared to hypercholesterolemic rats lowered the concentrations of serum lipid contents, liver and cardiac marker enzymes and TBARS level and ameliorate anti-oxidant enzymatic status in serum and cardiac tissue. These results suggest that, treatment with g-Irr.CLP has a powerful modulating effect on hypercholesterolemia induced oxidative stress and has the potential in reducing cardiovascular complications.

Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats

2012 ◽  
Vol 50 (11) ◽  
pp. 3971-3977 ◽  
Author(s):  
Thangaiyan Radhiga ◽  
Chellam Rajamanickam ◽  
Selvaraj Senthil ◽  
Kodukkur Viswanathan Pugalendi
Keyword(s):  
Lipid Profile ◽  
Ursolic Acid ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Enzyme Mapping

scholarly journals Cardioprotective Effect of Ethanolic Flower Extract of ClitoriaTernatea on Doxorubicin Induced Cardiotoxicity in Rats

2020 ◽  
Vol 11 (2) ◽  
pp. 1604-1611
Author(s):  
Tamizhselvi A ◽  
Durairaj S ◽  
Mohamed Sadiq A ◽  
Gopinath G ◽  
Rajeshkumar S
Keyword(s):  
Wistar Rats ◽  
Ethanolic Extract ◽  
Treated Group ◽  
Heart Tissue ◽  
Marker Enzyme ◽  
Aspartate Transaminase ◽  
Marker Enzymes ◽  
Serum Enzyme ◽  
Cardiac Marker ◽  
Flower Extract

There was a significant evidence that there are several of the medicinal plants encompass the prospective to treat cardiovascular disease. In this study, Doxorubicin is used as an effectual induction of cardiotoxicity and heart malfunction in the taken experimental rats which is an anthracycline chemotherapeutic mediator used to the treat of a wide variety of malignancies. To examine the shielding property of ethanolic flower extract of clitoraternatea  (EECT) scheduled doxorubicin(DOX) persuaded cardiotoxicity via albino wistar rats,through inspect the enzymatic,non-enzymatic antioxidant position,serum enzyme and Histopathology tissue.Experimental rats been provoked cardiotoxicity by means of a generous single dose of doxorubicin (15mg /body weight ) and treated orally through an ethanolic extract of clitoraternatea (EECT)  for 14 days (100 mg/kg bw, 200 mg/kg bw and 300mg/kg bw,n=5).On15 days, the rats are sacrificed by treated through Ketamine –Xylazine,Biochemical as well as histological remarks of the heart tissues had carry out. Cardiotoxicity had been calculated throughout to establish the cardio marker enzyme levels such as (LDH) Lactic acid dehydrogenase,(CK-MB) Creatinin kinase and (AST) Aspartate transaminase at the finish of the study. Managementthrough EECT of 200mg/kg and 300mg/kgconsiderablyreduced the levels of cardiac marker enzymes(p<0.05), and as wellminimize the decrease of weight of the heart of DOX treated group. In heart tissue superoxide dismutase, glutathione and catalase heightsbe significantly greater than before and lipid oxide peroxide (LPO) significantly decreased in the extract (200 &300 mg /kg bw) treated rats when compared to DOX treated with the significance of  P< 0.05. There was no significant recovery of the 100 mg/kg of EECT. These results will suggested that EECT having potential anti-cardiotoxic effects induced by Doxorubicin by preventing oxidative injure provoke by DOX in heart of taken experimental animals.

scholarly journals Cardioprotective activity of Piper betle juice in isoproterenol induced hypertrophic rat models

2020 ◽  
Vol 11 (4) ◽  
pp. 5214-5220
Author(s):  
Doss VA ◽  
Suruthi Arumugam ◽  
Dharaniyambigai Kuberapandian
Keyword(s):  
Cardiac Hypertrophy ◽  
Piper Betle ◽  
Histopathological Analysis ◽  
Enzymatic Antioxidants ◽  
Marker Enzymes ◽  
Cardiac Marker ◽  
Standard Drug ◽  
Electrolyte Homeostasis ◽  
Biochemical Estimation ◽  
Myocardial Architecture

Impaired electrolytes (preferably Na+, K+, Cl-, HCO3-) is one of the key fundamental complications associated with cardiac hypertrophy (enlarged heart) mediated heart failure. Piper betle (P. betle - family Piperaceae) due to its potent antioxidant activity is used in various pharmacological applications. The present study evaluates the cardioprotective (anti-hypertrophic) potential of aqueous (juice) extract of P. betle in restoring electrolyte homeostasis, thereby its ability to curb the fundamental progression of hypertrophy. Isoproterenol (ISO - 10 mg/kg b.w., i.p., 7 days) induced cardiac hypertrophic rats were developed that were simultaneously treated with the standard drug losartan (50mg/kg b.w., orally., 7days) and aqueous juice extract of P. betle (30mg/kg b.w., orally., 7 days). The biochemical estimation of glucose, protein, cholesterol, cardiac marker enzymes like SGOT, SGPT, LDH, enzymatic antioxidants namely SOD, catalase, GPx and electrolytes (Na+, K+, Cl- and bicarbonate) in serum were statistically performed along with the histopathological analysis of left ventricles (H&amp;E stain). The present study showed increased levels of glucose, protein, cholesterol, cardiac marker enzymes, reduced enzymatic antioxidants with reduced electrolytes during cardiac hypertrophy (ISO) that were reflected in a histopathological analysis by thickened abnormal myocardial architecture which was reversed similar to normal in plant juice administered rats. Hence, this study demonstrated the beneficial effect of P. betle (aqueous juice) on electrolytes (Na+, K+, Cl-, HCO3-), thereby imposing an interventional effect against cardiac hypertrophy.

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