A review on the synthesis, surface modification and drug delivery of nanoparticles

Over the past few years, the evolution of nanotechnology has extended into a wide range of applications. Nanotechnology has now become a multidisciplinary science that applies to electronics, materials science, biomedical engineering, microbiology, etc. Recently, nanotechnology is being used in biomedical and pharmaceutical science. Among them drug delivery is set to spread rapidly. Application of nanotechnology in health sector also created a potential impact such as in the fields of immunology, cardiology, endocrinology, ophthalmology, and oncology. Nanoparticles are unique because of their large surface area and it has the potential to change the properties of a bulk number of materials. The surface of nanoparticles can be modified with the help of various polymers, organic and inorganic substances according to the specific application and their use. Nanoparticles are also utilized as nano shells in drug delivery systems and cancer therapy. Nano shells can recognize the cancer cells when they are injected into the cancer area. The heat generated by the light absorbing nano shells due to the application of the near infrared light successfully kills tumour cells leaving the noncarcinogenic cells intact. In this review article, nanoparticles, the health implication of nanoparticles and their synthesis are discussed.

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“Smart” materials-based near-infrared light-responsive drug delivery systems for cancer treatment: A review

Journal of Materials Research and Technology ◽

10.1016/j.jmrt.2018.03.007 ◽

2019 ◽

Vol 8 (1) ◽

pp. 1497-1509 ◽

Cited By ~ 44

Author(s):

Ali Raza ◽

Uzma Hayat ◽

Tahir Rasheed ◽

Muhammad Bilal ◽

Hafiz M.N. Iqbal

Keyword(s):

Drug Delivery ◽

Cancer Treatment ◽

Smart Materials ◽

Drug Delivery Systems ◽

Near Infrared ◽

Delivery Systems ◽

Infrared Light ◽

Near Infrared Light

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l-cysteine assisted synthesis of Bi2S3 hollow sphere with enhanced near-infrared light harvesting for photothermal conversion and drug delivery

Materials Letters ◽

10.1016/j.matlet.2019.02.104 ◽

2019 ◽

Vol 245 ◽

pp. 158-161 ◽

Cited By ~ 3

Author(s):

Yunhui Yan ◽

Kaiwen Chang ◽

Tianjun Ni ◽

Kun Li

Keyword(s):

Drug Delivery ◽

Hollow Sphere ◽

Near Infrared ◽

Light Harvesting ◽

Infrared Light ◽

Near Infrared Light ◽

Photothermal Conversion

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Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer

Nanomaterials ◽

10.3390/nano9010091 ◽

2019 ◽

Vol 9 (1) ◽

pp. 91 ◽

Cited By ~ 8

Author(s):

Chuan Zhang ◽

Yuzhuo Wang ◽

Yue Zhao ◽

Hou Liu ◽

Yueqi Zhao ◽

...

Keyword(s):

Drug Delivery ◽

Near Infrared ◽

Mixed Micelles ◽

Infrared Light ◽

Stimuli Responsive ◽

High Concentration ◽

Chemotherapy Drugs ◽

In Vivo Experiments ◽

Low Efficiency

The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.

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Triggered drug release from hybrid thermoresponsive nanoparticles using near infrared light

Nanomedicine ◽

10.2217/nnm-2019-0270 ◽

2020 ◽

Vol 15 (3) ◽

pp. 219-234 ◽

Cited By ~ 1

Author(s):

Isabel Ortiz de Solorzano ◽

Martin Prieto ◽

Gracia Mendoza ◽

Victor Sebastian ◽

Manuel Arruebo

Keyword(s):

Drug Delivery ◽

Gold Nanoparticles ◽

Colloidal Stability ◽

Near Infrared ◽

Chemical Characterization ◽

Infrared Light ◽

Galvanic Replacement ◽

Heating Efficiency ◽

Hollow Gold Nanoparticles

Aim: Developing hybrid poly(N-isopropylacrylamide)-based nanogels decorated with plasmonic hollow gold nanoparticles for on-demand drug delivery and their physico-chemical characterization, bupivacaine loading and release ability upon light irradiation, and in vitro cell viability. Materials & methods: Hollow gold nanoparticles were prepared by galvanic replacement reaction; poly(N-isopropylacrylamide)-based nanogels were synthesized via precipitation polymerization and their electrostatic coupling was accomplished using poly(allylamine hydrochloride) as cationic polyelectrolyte linker. Results & conclusion: Colloidal stability of the resulted hybrid nanovectors was demonstrated under physiological conditions together with their fast response and excellent heating efficiency after light stimulation, indicating their potential use as triggered drug-delivery vectors. Moreover, their influence on cell metabolism and cell cycle under subcytotoxic doses were studied showing excellent cytocompatibility.

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