scholarly journals Effects of Surgical Skills of Veterinary Medicine Students on Postoperative Stress, Oxidative Stress and Pain in Bitches Undergoing Ovariohysterectomy

2021 ◽  
Author(s):  
Merve CAN ◽  
Oktay YILMAZ
Keyword(s):  
Oxidative Stress ◽  
Veterinary Medicine ◽  
Surgical Skills ◽  
Postoperative Stress ◽  
Stress Oxidative

Abstract #402: Beta Blockers Suppress Dextrose-Induced Endoplasmic Reticulum Stress, Oxidative Stress and Apoptosis in Human Coronary Artery Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85
Author(s):  
Harshit Shah ◽  
William Kurban ◽  
Luisa Onstead-Haas ◽  
Michael Haas ◽  
Arshag Mooradian
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Coronary Artery ◽  
Endoplasmic Reticulum Stress ◽  
Beta Blockers ◽  
Human Coronary Artery ◽  
Stress Oxidative

scholarly journals Isoprostanes in Veterinary Medicine: Beyond a Biomarker

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 145
Author(s):  
Ashley K. Putman ◽  
G. Andres Contreras ◽  
Lorraine M. Sordillo
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Veterinary Medicine ◽  
Biological Fluids ◽  
Biological Action ◽  
Clinical Applications ◽  
Animal Medicine ◽  
Inflammatory Processes ◽  
Oxidized Products ◽  
Biomarkers Of Oxidative Stress

Oxidative stress has been associated with many pathologies, in both human and animal medicine. Damage to tissue components such as lipids is a defining feature of oxidative stress and can lead to the generation of many oxidized products, including isoprostanes (IsoP). First recognized in the early 1990s, IsoP are formed in numerous biological fluids and tissues, chemically stable, and easily measured by noninvasive means. Additionally, IsoP are highly specific indicators of lipid peroxidation and thereby are regarded as excellent biomarkers of oxidative stress. Although there have been many advancements in the detection and use of IsoP as a biomarker, there is still a paucity of knowledge regarding the biological activity of these molecules and their potential roles in pathology of oxidative stress. Furthermore, the use of IsoP has been limited in veterinary species thus far and represents an avenue of opportunity for clinical applications in veterinary practice. Examples of clinical applications of IsoP in veterinary medicine include use as a novel biomarker to guide treatment recommendations or as a target to mitigate inflammatory processes. This review will discuss the history, biosynthesis, measurement, use as a biomarker, and biological action of IsoP, particularly in the context of veterinary medicine.

Oxidative stress in primary culture hepatocytes isolated from partially hepatectomized rats

2007 ◽  
Vol 85 (10) ◽  
pp. 1047-1051 ◽  
Author(s):  
Daniel Francés ◽  
M. Teresa Ronco ◽  
Elena Ochoa ◽  
M. Luján Alvarez ◽  
Ariel Quiroga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Primary Culture ◽  
Cell Injury ◽  
Cultured Cells ◽  
Male Wistar Rats ◽  
Metabolic Activities ◽  
Stress Oxidative ◽  
Species Production

The aim of this study was to evaluate the influence of partial hepatectomy prior to cell isolation on hepatocytes in vitro. We characterized the possible changes of various stress oxidative parameters within the first 24 h after seeding. Male Wistar rats served as donors. Hepatocytes were isolated by collagenase digestion from either liver of simulated surgery (SH) or from liver 1 h after 70% hepatectomy (PH), and the changes in stress parameters were analyzed after 1, 3, 18, and 24 h in culture. At 24 h, only hepatocytes from PH maintained significantly increased reactive oxygen species production, oxidized glutathione percentage, and Cu/Zn superoxide dismutase and catalase activities. Our results show that hepatocytes suffer significant cell injury as a result of the isolation procedure, but primary cultured cells from SH metabolically recover from this stress after 18 h. After this time, primary culture hepatocytes primed by PH maintain their in vivo-like metabolic activities (increase in both oxidative stress and antioxidant status).

scholarly journals The Link between Chronic Stress and Accelerated Aging

Biomedicines ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 198 ◽  
Author(s):  
Yegor E. Yegorov ◽  
Anastasia V. Poznyak ◽  
Nikita G. Nikiforov ◽  
Igor A. Sobenin ◽  
Alexander N. Orekhov
Keyword(s):  
Oxidative Stress ◽  
Chronic Stress ◽  
Traumatic Stress ◽  
Accelerated Aging ◽  
Post Traumatic Stress ◽  
Mitochondrial Uncoupling ◽  
Post Traumatic ◽  
Stress Oxidative ◽  
Inflammatory Changes ◽  
Component Gene

People exposed to chronic stress age rapidly. The telomeres in their cells of all types shorten faster. Inflammation is another important feature of stress that, along with aging, accounts for the phenomenon of inflammaging. In addition to aging itself, inflammaging can contribute to the development of several pathologies, including atherosclerosis, diabetes, hypertension, and others. Oxidative stress is one of the main mechanisms related to stress. Oxidative stress is caused by the over-production of reactive oxygen species (ROS) that can damage various tissues. The main source of ROS is mitochondria. Being suppressed by mitochondrial mutations, mitophagy can aggravate the situation. In this case, the aging-specific pro-inflammatory changes are amplified. It happens because of the inability of cells to maintain the normal state of mitochondria. Macrophages are the crucial element of the innate immunity associated with the chronic inflammation and, subsequently, with the inflammaging. In this review, we focus on the therapy approaches potentially reducing the deleterious effects of oxidative stress. These include stimulation of mitophagy, activation of mitochondrial uncoupling, induction of the expression of the telomerase catalytic component gene, and use of antioxidants. Any method reducing oxidative stress should improve post-traumatic stress disorder.

scholarly journals DNA Damage in Lymphocytes in Hypertensive Subjects in Bangladesh

2013 ◽  
Vol 5 (3) ◽  
pp. 535-543
Author(s):  
M. Saiedullah ◽  
S. Hayat ◽  
M. R. Zamir ◽  
M. Arif ◽  
Z. H. Howlader ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Dna Damage ◽  
Superoxide Dismutase ◽  
Oxidative Dna Damage ◽  
Protein Carbonyl ◽  
Protein Carbonyl Content ◽  
Ribonucleic Acids ◽  
Stress Oxidative ◽  
Bangladeshi Population

Oxidative stress due to imbalance between the production of reactive oxygen species and their dismutation is claimed to be higher in hypertensive subjects than normotensive subjects. In hypertensive subjects oxidative stress may damage deoxy-ribonucleic acids (DNA). In this study plasma superoxide dismutase (SOD) activities, protein carbonyl contents (PCCs) and extent of DNA damage in lymphocytes were measured in specimens obtained from 86 subjects to compare oxidative stress and oxidative DNA damage between normotensive and hypertensive subjects and to assess their relationship with the degree of blood pressure. Results were expressed as mean±SD. Two-tailed unpaired t test and Pearson’s correlation test were done to compare or to determine the relationship between groups or variables. SOD activities were 2.85±0.12 unit/mg protein and 3.84±0.45 unit/mg protein (p<0.05) in hypertensive and normotensive groups respectively. PCCs were 4.77±0.36 nmol/mg protein and 3.75±0.23 nmol/mg protein in hypertensive and normotensive groups respectively. Olive tail moments (OTM) were 124.7±11.69 units and 108.9±9.27 units in hypertensive and normotensive groups respectively. The correlation coefficient of OTM was 0.3924 (p<0.05) for diastolic blood pressure and 0.3618 (p<0.05) for systolic blood pressure. Oxidative stress and DNA damage was higher in hypertensives than normotensives and DNA damage correlated positively with blood pressure. Keywords: Superoxide dismutase, Protein carbonyl content, Oxidative stress, Oxidative DNA damage, Hypertension, Bangladeshi population. © 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v5i3.15022 J. Sci. Res. 5 (3), 535-543 (2013)  

Oxidative Stress Induced by Cadmium and Copper inBrassica rapaLeaves: Indicators of Stress, Oxidative Damage, and Antioxidant Mechanisms

2015 ◽  
Vol 46 (19) ◽  
pp. 2475-2489 ◽  
Author(s):  
Inês Neto Moreira ◽  
Miguel Pedro Mourato ◽  
Rafaela Reis ◽  
Luisa Louro Martins
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Stress Oxidative ◽  
Antioxidant Mechanisms

scholarly journals Nitrative stress, oxidative stress and plasma endothelin levels after inhalation of particulate matter and ozone

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Prem Kumarathasan ◽  
Erica Blais ◽  
Anushuyadevi Saravanamuthu ◽  
Agnieszka Bielecki ◽  
Ballari Mukherjee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Nitrative Stress ◽  
Stress Oxidative

scholarly journals Diverse and Specific Gene Expression Responses to Stresses in Cultured Human Cells

2004 ◽  
Vol 15 (5) ◽  
pp. 2361-2374 ◽  
Author(s):  
John Isaac Murray ◽  
Michael L. Whitfield ◽  
Nathan D. Trinklein ◽  
Richard M. Myers ◽  
Patrick O. Brown ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Heat Shock ◽  
Hela Cells ◽  
Stress Responses ◽  
Cell Communication ◽  
Lung Fibroblasts ◽  
Specific Gene ◽  
Primary Fibroblasts ◽  
Stress Oxidative

We used cDNA microarrays in a systematic study of the gene expression responses of HeLa cells and primary human lung fibroblasts to heat shock, endoplasmic reticulum stress, oxidative stress, and crowding. Hierarchical clustering of the data revealed groups of genes with coherent biological themes, including genes that responded to specific stresses and others that responded to multiple types of stress. Fewer genes increased in expression after multiple stresses than in free-living yeasts, which have a large general stress response program. Most of the genes induced by multiple diverse stresses are involved in cell-cell communication and other processes specific to higher organisms. We found substantial differences between the stress responses of HeLa cells and primary fibroblasts. For example, many genes were induced by oxidative stress and dithiothreitol in fibroblasts but not HeLa cells; conversely, a group of transcription factors, including c-fos and c-jun, were induced by heat shock in HeLa cells but not in fibroblasts. The dataset is freely available for search and download at http://microarray-pubs.stanford.edu/human_stress/Home.shtml .

scholarly journals Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

2014 ◽  
Vol 53 (1) ◽  
pp. 532-544 ◽  
Author(s):  
Venkata Prasuja Nakka ◽  
Phanithi Prakash-babu ◽  
Raghu Vemuganti
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Therapeutic Targets ◽  
Stress Oxidative
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