scholarly journals Endogenous uveitis as deuteropathy оf secondary acute infectious endocarditis

2020 ◽  
Vol 96 (7) ◽  
pp. 543-547
Author(s):  
N. E. Fomin ◽  
N. A. Baranova ◽  
A. V. Kuroyedov ◽  
V. V. Danilin ◽  
O. V. Gaponko ◽  
...  
Keyword(s):  
Immune System ◽  
Clinical Diagnosis ◽  
Inflammatory Process ◽  
Treatment Regimens ◽  
Total Prevalence ◽  
Immune Mediated ◽  
Somatic Diseases ◽  
Treatment And Diagnosis ◽  
Endogenous Uveitis

Uveitis is a heterogeneous polyetiological immune-mediated disease. Its common feature is inflammation of the choroid. The total prevalence of uveitis of various etiologies in the population varies from 15 to 38 people per 100 000. The cause of this pathology can be any infectious or somatic diseases (both endo- and exogenous in nature), when the body’s immune system is activated. The prevalence of the most common endogenous uveitis, caused by secondary foci of infection, is about 3% of the total number of diseases of this etiology. Uveitis, caused by Streptococcus bacteria, affects eyes due to dissemination from the foci of infection, being transmitted through the blood and lymph vessels. An important stage in the clinical diagnosis of uveitis is the determination of the etiological factor, which allows using of pathogenetic treatment regimens. The diagnosis is performed based on the totality of signs characterizing the specificity of the inflammatory process. Treatment and diagnosis of inflammation of the choroid are still one of the urgent tasks of modern ophthalmology.

AGGLUTINATION INHIBITION REACTIONS FOR THE DETERMINATION OF GONADOTROPHINS

1969 ◽  
Vol 62 (1_Suppl) ◽  
pp. S95-S112 ◽  
Author(s):  
A. H. W. M. Schuurs
Keyword(s):  
Immune System ◽  
Quantitative Determination ◽  
Haemagglutination Inhibition ◽  
Latex Agglutination ◽  
Literature Survey ◽  
New Method ◽  
Test Fluid ◽  
Main Application ◽  
Test Systems

ABSTRACT Various techniques for sensitising erythrocytes and latex particles with gonadotrophins, particularly with HCG, are described. The haemagglutination inhibition reactions are generally interpreted by means of »erythrocyte settling patterns«. By a new method of evaluating these patterns a relatively precise quantitative determination is possible. Latex agglutination inhibition reactions on slides are particularly suitable as rapid qualitative tests. In cases where the maximum attainable sensitivity of the agglutination inhibition tests is insufficient, e. g. for determining LH concentrations in urine, the hormone in the test fluid has to be concentrated or extracted. An alternative method is a modified haemagglutination inhibition test for large volumes which is applicable to unconcentrated urine. Due to non-specific inhibitions the above-mentioned tests cannot be applied to unprocessed serum. Agglutination inhibition tests with HCG are already well advanced, pregnancy diagnosis being their main application. Now that highly purified HCG is available, a satisfactory specificity for these tests can be attained. If the immune system for HCG is used for estimating LH, it has to meet additional specificity requirements. Furthermore, the measure of cross-reaction and the choice of standard merit special attention. Finally, a literature survey is given of test systems in which LH and FSH were used as antigens.

Determination of clinical efficiency of deproteinized dialysate from blood of milk-fed calves after endoprosthetics in patients with ventral hernias

2020 ◽  
Vol 28 (3) ◽  
pp. 323-333
Author(s):  
Sergej V. Ivanov ◽  
Ilya S. Ivanov ◽  
Evgenij G. Obyedkov ◽  
Liliya P. Popova
Keyword(s):  
Abdominal Wall ◽  
Inflammatory Reaction ◽  
Inflammatory Process ◽  
Anterior Abdominal Wall ◽  
Dynamic Change ◽  
Main Group ◽  
Control Group ◽  
Surgical Department ◽  
Regeneration Stage

Aim. To study the influence of deproteinized dialysate from blood of milk-fed calves on the type of exudative discharge and dynamics of inflammatory reaction after hernia repair with plastics of the anterior abdominal wall with hernioendoprosthesis of polypropylene. Materials and Methods. The study involved 59 patients being on stationary treatment in the surgical department of Kursk Regional Clinical Hospital. Patients were hospitalized for the herniation of small or medium dimension. The patients were divided to two groups: the main (n=30) and control (n=29) groups. After endoprosthetics, the patients of the control group were given complex conservative treatment. The patients of the main group, besides standard treatment, were administered deproteinized dialysate from blood of milk-fed calves intravenously in drips 10 ml + 200 ml of 0.9% sodium chloride solution within 7 days. For cytological examination and determination of the type of cytograms, the traumatic discharge was collected and analyzed using the method of M.F. Kamaev and M.A. Palthsev. Results. Cytomorphometric examination was conducted on the third, fifth and seventh day after endoprosthetics with the aim of studying dynamic changes. Determination of cell composition and also of its changes characteristic of each studied period, was necessary for obtaining further information characterizing inflammatory process in the region of placement of the endoprosthesis. After endoprosthetics in patients who were administered hemodialysate, the inflammatory reaction was less pronounced than in patients who did not receive the preparation. This was associated with a more dynamic change of stages of the inflammatory process. In patients of the main group who received deproteinized dialysate, regenerative type of inflammation first appeared on the fifth day and made 6.9%; by the seventh day the share of patients with the regenerative type rose to 17.5%, while in the patients of the control group no regeneration stage was observed in both periods. Conclusion. Analysis of the efficiency of influence of hemodialysate on the inflammatory reaction in plastics of the anterior abdominal wall with polypropylene endoprosthesis evidences faster course of all stages of inflammation and reduction of its intensity by 10%.

scholarly journals Vasculitis: From Target Molecules to Novel Therapeutic Approaches

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 757
Author(s):  
Sang-Wan Chung
Keyword(s):  
Systemic Vasculitis ◽  
Alkylating Agents ◽  
Large Vessel Vasculitis ◽  
Large Vessel ◽  
Biologic Therapies ◽  
Therapeutic Approaches ◽  
Novel Treatments ◽  
Treatment Regimens ◽  
Immune Mediated ◽  
Target Molecules

Systemic vasculitis is a group of diverse diseases characterized by immune-mediated inflammation of blood vessels. Current treatments for vasculitis, such as glucocorticoids and alkylating agents, are associated with significant side effects. In addition, the management of both small and large vessel vasculitis is challenging due to a lack of robust markers of disease activity. Recent research has advanced our understanding of the pathogenesis of both small and large vessel vasculitis, and this has led to the development of novel biologic therapies capable of targeting key cytokine and cellular effectors of the inflammatory cascade. It is anticipated that these novel treatments will lead to more effective and less toxic treatment regimens for patients with systemic vasculitis.

Determination of HE4-mediated roles in tumor immune system modulation in Epithelial Ovarian Cancer (EOC)

2015 ◽  
Vol 139 (3) ◽  
pp. 591
Author(s):  
Anze Urh ◽  
Nicole Romano ◽  
KyuKwang Kim ◽  
Jennifer Ribeiro ◽  
Christina Raker ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Immune System ◽  
Epithelial Ovarian Cancer ◽  
Immune System Modulation

scholarly journals Salivarian Trypanosomes Have Adopted Intricate Host-Pathogen Interaction Mechanisms that Ensure Survival in Plain Sight of the Adaptive Immune System

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 679
Author(s):  
Stefan Magez ◽  
Joar Esteban Pinto Torres ◽  
Seoyeon Oh ◽  
Magdalena Radwanska
Keyword(s):  
Immune System ◽  
Trypanosoma Brucei ◽  
Adaptive Immune System ◽  
Sub Saharan Africa ◽  
Survival Strategies ◽  
Mechanical Transmission ◽  
Sub Saharan ◽  
Animal Trypanosomiasis ◽  
Host Parasite ◽  
Treatment And Diagnosis

Salivarian trypanosomes are extracellular parasites affecting humans, livestock and game animals. Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense are human infective sub-species of T. brucei causing human African trypanosomiasis (HAT—sleeping sickness). The related T. b. brucei parasite lacks the resistance to survive in human serum, and only inflicts animal infections. Animal trypanosomiasis (AT) is not restricted to Africa, but is present on all continents. T. congolense and T. vivax are the most widespread pathogenic trypanosomes in sub-Saharan Africa. Through mechanical transmission, T. vivax has also been introduced into South America. T. evansi is a unique animal trypanosome that is found in vast territories around the world and can cause atypical human trypanosomiasis (aHT). All salivarian trypanosomes are well adapted to survival inside the host’s immune system. This is not a hostile environment for these parasites, but the place where they thrive. Here we provide an overview of the latest insights into the host-parasite interaction and the unique survival strategies that allow trypanosomes to outsmart the immune system. In addition, we review new developments in treatment and diagnosis as well as the issues that have hampered the development of field-applicable anti-trypanosome vaccines for the implementation of sustainable disease control.

Lupus mastitis

2021 ◽  
Author(s):  
N. WILLERS ◽  
P. BERTELOOT ◽  
I. WITTEVRONGHEL ◽  
G. JACOMEN ◽  
V. SCHELFHOUT ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Inflammatory Process ◽  
Breast Lesion ◽  
Cell Lymphoma ◽  
Subcutaneous Fat ◽  
Fat Tissue ◽  
Lupus Panniculitis ◽  
Immune Mediated ◽  
History Of ◽  
Subcutaneous Fat Tissue

Lupus mastitis Systemic lupus erythematosus (SLE) infrequently presents itself as lupus panniculitis. In lupus panniculitis the subcutaneous fat tissue is involved in the inflammatory process. Lupus mastitis is again a rare variant of lupus panniculitis, probably caused by an immune-mediated inflammatory process. In literature on the topic we can find 30 cases of lupus mastitis in men and women. Lupus mastitis may present like a breast lesion suspected to be malignant, clinically and radiologically. In the differential diagnosis we consider inflammatory breast cancer, subcutaneous panniculitis-like T-cell lymphoma (SPTL) and diabetes mastopathy. With a medical history of SLE and signs of inflammation of the skin above the lesion however, a diagnosis of lupus mastopathy is more presumable. Medical treatment seems more indicated in lupus mastitis, because delayed healing after surgical procedures is often reported. Even though methylprednisolone and chloroquine give clinical improvement, they need to be repeated often because of a high risk of relapse.

HEART INJURY IN PATIENTS WITH MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH SARS-CоV-2: A DESCRIPTION OF A SERIES OF CLINICAL CASES

2021 ◽  
Vol 100 (5) ◽  
pp. 35-45
Author(s):  
K.E. Belozerov ◽  
◽  
A.D. Kupreeva ◽  
I.S. Avrusin ◽  
V.V. Masalova ◽  
...  
Keyword(s):  
Laboratory Tests ◽  
Inflammatory Process ◽  
Scientific Data ◽  
Patient Treatment ◽  
Review Of Literature ◽  
Treatment Regimens ◽  
The World ◽  
Heart Injury ◽  
Inflammatory Syndrome ◽  
Clinical Cases

Multisystem inflammatory syndrome in children and adolescents associated with SARS-CoV-2 (MBS-D) is a new challenge for pediatricians around the world. Scientific data is updated daily and patient treatment regimens are developed. The involvement of the heart in the inflammatory process complicates the course of the disease and further rehabilitation of patients. The article describes 12 patients with heart disease in the structure of MVS-D, who underwent laboratory tests and instrumental studies, including MRI of the heart, and also provides detailed descriptions of three clinical cases and a review of literature data.

Introduction

2004 ◽  
Vol 8 (2_suppl) ◽  
pp. 1-2
Author(s):  
Daniel N. Sauder
Keyword(s):  
T Cells ◽  
Immune System ◽  
Ultraviolet A ◽  
Activated T Cells ◽  
Keratinocyte Proliferation ◽  
Memory T Cell ◽  
Immune Mediated ◽  
Selective Targeting ◽  
Traditional Therapies ◽  
Pathogenic Process

Psoriasis is an immune-mediated skin disease in which T cells initiate and maintain the pathogenic process.1 T cells become activated, migrate into the skin, and induce the keratinocyte proliferation associated with the psoriatic phenotype. The activated T cells that infiltrate the skin express the memory phenotype (CD45RO+).2,3 Both CD4+ and CD8+ memory T-cell subtypes are believed to play a role in the pathogenesis of psoriasis. The effectiveness of many traditional therapies for psoriasis (e.g., cyclosporine, methotrexate, psoralen/ultraviolet A light) can be attributed, at least in part, to the potent immunosuppressive effects of these treatments.4,5 Unfortunately, a lack of selective targeting of the immune system by these therapies may result in treatment-limiting side effects.

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