scholarly journals POTENSI MADU SEBAGAI TERAPI TOPIKAL OTITIS EKSTERNA

2019 ◽  
Vol 8 (2) ◽  
pp. 7-22
Author(s):  
Yunis Sucipta Ibnu ◽  
Keyword(s):  
Inflammatory Cytokines ◽  
Broad Spectrum ◽  
Otitis Externa ◽  
Humid Tropics ◽  
Bacterial Activity ◽  
Predisposing Factors ◽  
Normal Flora ◽  
Pathogenic Microbes ◽  
Alternative Choice ◽  
Choice Of Therapy

Otitis externa (OE) is an external microbial Meatus acousticus (MAE) infection due to damage to the normal MAE serumen skin coat that protects and maintains MAE moisture and temperature. Living in the warm and humid tropics, a decrease in skin pH due to activity in the water including swimming, and excess cerumen cleaning are predisposing factors for OE. The use of antibiotics locally concentrated in OE can not only attack pathogenic microbes but also have an impact on normal flora so that it has the potential to cause resistant microbes. Honey has anti-bacterial properties without the risk of resistance and has even been shown to modulate immunity and inflammation. Various invivo and invitro studies prove that honey has broad spectrum anti-bacterial activity. Honey is proven invitro to modulate immunity by affecting the release of various inflammatory cytokines. This shows that honey has the potential for OE therapy. This article aims to discuss the potential of honey as a topical OE therapy in the hope that it can be an alternative choice of therapy in the management of OE in humans that is safe, effective, and efficient.

scholarly journals PERBANDINGAN UJI RESISTENSI BAKTERI STAPHYLOCOCCUS AUREUS TERHADAP OBAT ANTIBIOTIK AMPISILIN DAN TETRASIKLIN

2015 ◽  
Vol 3 (1) ◽  
pp. 25-33
Author(s):  
Finnie Luthfia Suheri ◽  
Zulkarnain Agus ◽  
Ivony Fitria
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Oral Cavity ◽  
Broad Spectrum ◽  
Inhibition Zone ◽  
Total Sample ◽  
Predisposing Factors ◽  
T Test ◽  
The Body ◽  
Normal Flora

Staphylococcus aureus is one of the normal flora in the oral cavity, but these bacteria can change to be pathogen if there are predisposing factors such as changes in quantities of bacteria and decreasing of the immune response of the body. One of the ways to prevent is to inhibit the activity of these bacteria using antibiotics. Ampicillin and tetracycline are the broad-spectrum antibiotics that can inhibit the growth of positive and negative gram bacteria. This research was a laboratory experimental with Kirby-Bauer method and using CLSI standard. Total sample are 16 discs of ampicillin and 16 discs of tetracycline then placed on MHA media contain Staphylococcus aureus to see the inhibition power. The result showed that the averages of inhibition zone of ampicillin is 36,64 mm while tetracycline is 25,58 mm. Independent sample t- test showed that p<0,01 which means there is a significantly difference between ampicillin and tetracycline. Ampicillin and tetracycline can inhibit the growth of Staphylococcus aureus with sensitive categories. Ampicillin is more sensitive and effective than tetracycline to inhibit the growth of Staphylococcus aureus

(+)-Altholactone exhibits broad spectrum immune modulating activity by inhibiting the activation of pro-inflammatory cytokines in RAW 264.7 cell lines

2013 ◽  
Vol 21 (14) ◽  
pp. 4358-4364 ◽  
Author(s):  
Tyler A. Johnson ◽  
Johann Sohn ◽  
Aidan E. Ward ◽  
Tanya L. Cohen ◽  
Nicholas D. Lorig-Roach ◽  
...  
Keyword(s):  
Cell Lines ◽  
Inflammatory Cytokines ◽  
Broad Spectrum ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Pro Inflammatory Cytokines

Yeasts and fungi

2011 ◽  
pp. 214-216
Author(s):  
Dr Mark Harrison
Keyword(s):  
Opportunistic Infection ◽  
Broad Spectrum ◽  
Bacterial Flora ◽  
Antibiotic Use ◽  
Normal Flora ◽  
Gi Tract ◽  
Broad Spectrum Antibiotics

17.1 Candida, 215 17.2 Cryptococcus, 216 17.3 Dermatophytes, 217 • Candida occurs as part of the normal flora of the mouth, skin, vagina, and GI tract. • Opportunistic infection, frequently presenting in association with immunocompromise and antibiotic use. • The use of broad spectrum antibiotics eliminates competing bacterial flora allowing the yeast to overgrow....

Randomized phase II study of axitinib versus physicians best alternative choice of therapy in patients with recurrent glioblastoma

2016 ◽  
Vol 128 (1) ◽  
pp. 147-155 ◽  
Author(s):  
J. Duerinck ◽  
S. Du Four ◽  
F. Vandervorst ◽  
N. D’Haene ◽  
M. Le Mercier ◽  
...  
Keyword(s):  
Phase Ii ◽  
Phase Ii Study ◽  
Recurrent Glioblastoma ◽  
Randomized Phase Ii ◽  
Alternative Choice ◽  
Choice Of Therapy

scholarly journals A crustin isoform from black tiger shrimp, Penaeus monodon exhibits broad spectrum anti-bacterial activity

2015 ◽  
Vol 2 ◽  
pp. 106-111 ◽  
Author(s):  
Debashis Banerjee ◽  
Biswajit Maiti ◽  
Shivani Kallappa Girisha ◽  
Moleyur Nagarajappa Venugopal ◽  
Indrani Karunasagar
Keyword(s):  
Broad Spectrum ◽  
Penaeus Monodon ◽  
Bacterial Activity ◽  
Black Tiger Shrimp ◽  
Tiger Shrimp

scholarly journals Microbial Contamination, an Increasing Threat to the Consumption of Fresh Fruits and Vegetables in Today’s World

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Gadafi Iddrisu Balali ◽  
Denis Dekugmen Yar ◽  
Vera Gobe Afua Dela ◽  
Priscilla Adjei-Kusi
Keyword(s):  
Clostridium Botulinum ◽  
Microbial Contamination ◽  
Fruits And Vegetables ◽  
Surveillance Systems ◽  
Normal Flora ◽  
Vibrio Cholera ◽  
Production Chain ◽  
E Coli ◽  
Pathogenic Microbes ◽  
Etiological Agents

Microbes are found all over the globe with some few exceptions, including sterilized surfaces. They include normal flora that is nonpathogenic, which contribute to the larger percentage, and pathogenic species which are few. Hence, the activities of humans cannot be completely separated from microbes. Thus, many pathogenic microbes have found their way into fresh fruits and vegetables which are a great source of a healthy diet for humans. The growing demand for fresh fruits and vegetables has necessitated larger production. The larger production of vegetables within the shortest possible time to meet the growing demand has placed them at a higher risk of contamination with the pathogenic microbes, making the safety of consumers uncertain. Study of sources of contamination and type of pathogenic etiological agents isolated from fresh fruits and vegetables includes Bacillus cereus, Campylobacter jejuni, Clostridium botulinum, E. coli O157: H7, Listeria monocytogenes, Salmonella spp., Shigella, Staphylococcus, and Vibrio cholera. Several measures have proven to be effective in controlling contamination of microbes and they include the establishment of surveillance systems to monitor the production chain and thoroughly washing vegetables with vinegar water. Saltwater and other washing techniques are effective but caution should be taken to make sure one does not use one cycle of water for washing all vegetables. The consumption of fresh fruits and vegetables is still encouraged by this review but significant measures must be taken to check the safety of these products before consumption.

scholarly journals Frequency and predisposing factors for canine otitis externa in the UK – a primary veterinary care epidemiological view

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Dan G. O’Neill ◽  
Andrea V. Volk ◽  
Teresa Soares ◽  
David B. Church ◽  
Dave C. Brodbelt ◽  
...  
Keyword(s):  
Otitis Externa ◽  
Predisposing Factors ◽  
Welfare Impact ◽  
Cohort Design ◽  
One Year ◽  
The One ◽  
The Uk ◽  
High Welfare ◽  
Yorkshire Terrier

Abstract Background Otitis externa is a commonly diagnosed disorder in dogs and can carry a high welfare impact on affected animals. This study aimed to report the prevalence and explore the role of breed and aural conformation as predisposing factors for canine otitis externa in the UK. The study used a cohort design of dogs under UK primary veterinary care at clinics participating in the VetCompass Programme during 2016. Risk factor analysis used multivariable logistic regression modelling. Results The study included a random sample of 22,333 dogs from an overall population of 905,554 dogs under veterinary care in 2016. The one-year period prevalence of otitis externa was 7.30% (95% confidence interval [CI]: 6.97 to 7.65). Breed and ear carriage were the highest ranked risk factors. Compared with crossbred dogs, sixteen breed types showed increased odds, including: Basset Hound (odds ratio [OR] 5.87), Chinese Shar Pei (OR 3.44), Labradoodle (OR 2.95), Beagle (OR 2.54) and Golden Retriever (OR 2.23). Four breeds showed protection (i.e. reduced odds) of otitis externa: Chihuahua (OR 0.20), Border Collie (OR 0.34), Yorkshire Terrier (OR 0.49) and Jack Russell Terrier (OR 0.52). Designer breed types overall had 1.63 times the odds (95% CI 1.31 to 2.03) compared with crossbred dogs. Compared with breeds with erect ear carriage, breeds with pendulous ear carriage had 1.76 times the odds (95% CI 1.48 to 2.10) and breeds with V-shaped drop ear carriage had 1.84 times the odds (95% CI 1.53 to 2.21) of otitis externa. Conclusions Breed itself and breed-associated ear carriage conformation are important predisposing factors for canine otitis externa. Greater awareness of these associations for both predisposed and protected breeds could support veterinary practitioners to promote cautious and low-harm approaches in their clinical advice on preventive care for otitis externa, especially in predisposed breeds.

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