Efficacy of ketosis therapy in dairy cows by intraperitoneal administration of glucose solution

Individual and combined effects of several isomers of retinoic acid (RA) and 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on interferon-gamma (IFN-gamma) secretion by blood mononuclear leukocytes (MNL) from nulliparous and postparturient Holstein cattle were evaluated in vitro. In the first experiment, effects on incubation period (24 to 72 hours) and time of supplementation (0 to 32 hours) with all-trans, 9-cis, 13-cis-, and 9,13-dicis-RAs (0 to 100 nM) on IFN-gamma secretion by pokeweed mitogen (PWM)-stimulated (0 and 10 mug/ml) MNL from nulliparous cattle were evaluated. In the second experiment, MNL from postparturient cows (bled at 0, 2, 4, and 16 days postpartum) were stimulated with PWM (0 and 10 mug/ml) in the presence of RA isomers (9-cis- or 9,13-dicis-RA; 0 to 100 nM), 1,25-(OH)2D3 (0 to 100 nM), or with combinations of these metabolites. The results show that individual isomers of RA had no effect on IFN-gamma secretion by PWM-stimulated MNL from nulliparous or postparturient cows. Furthermore 1,25-dihydroxyvitamin D3 inhibited IFN-gamma secretion by MNL from nulliparous and postparturient dairy cows; however, the degree of inhibition was greater when 9-cis- and 9,13-dicis-RA were also present in the cultures. Finally mononuclear leukocytes from postparturient dairy cows produced substantially less IFN-gamma than did MNL from nulliparous cattle. It is concluded that retinoic acids individually did not affect the capacity of leukocytes from dairy cattle to secrete IFN-gamma. This result is in marked contrast to studies in monogastric species indicating that RAs inhibit IFN-gamma secretion by peripheral blood T cells. Inhibition of IFN-gamma secretion by 1,25-(OH)2D3 was potentiated by 9-cis- and 9,13-di-cis-retinoics acids, suggesting that an excess of dietary vitamins A and D may compromise further the naturally immunosuppressed postparturient dairy cow. Additional research is necessary to determine if the combined effects of these metabolites on IFN-gamma secretion represent an increased susceptibility of the dairy cow to infectious diseases during the periparturient period. Lower secretion of IFN-gamma by MNL from postpartutient dairy cows, relative to nulliparous cattle, suggests that recently-calved cows are naturally immunosuppressed.

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Influence of the herbal component of a commercial feed additive on serum parameters, fertility and longevity of dairy cows

Planta Medica ◽

10.1055/s-0030-1264919 ◽

2010 ◽

Vol 76 (12) ◽

Author(s):

M Walkenhorst ◽

S Ivemeyer ◽

J Spranger ◽

G Arndt ◽

R Schaette

Keyword(s):

Dairy Cows ◽

Feed Additive ◽

Serum Parameters ◽

Commercial Feed

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Final results of the first phase I study of intraperitoneal administration of GL-ONC1, a marker gene modified vaccinia virus, in patients with peritoneal carcinomatosis

Zeitschrift für Gastroenterologie ◽

10.1055/s-0035-1559230 ◽

2015 ◽

Vol 53 (08) ◽

Author(s):

U Lauer ◽

M Zimmermann ◽

J Beil ◽

S Berchtold ◽

U Koppenhöfer ◽

...

Keyword(s):

Phase I ◽

Vaccinia Virus ◽

Peritoneal Carcinomatosis ◽

Phase I Study ◽

Marker Gene ◽

Intraperitoneal Administration

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Clinical and Scintigraphic Findings in Radiation Myositis Complicating the Intraperitoneal Administration of 198Au

Nuklearmedizin ◽

10.1055/s-0037-1621286 ◽

1965 ◽

Vol 05 (02) ◽

pp. 188-196

Author(s):

J. Němec ◽

J. Kubalt ◽

S. Vohnout ◽

J. Schubert ◽

J. Sudek ◽

...

Keyword(s):

Ovarian Cancer ◽

Ascitic Fluid ◽

Saline Solution ◽

Intraperitoneal Administration ◽

Clinical Findings ◽

Safety Measures ◽

Muscle Necrosis

SummaryPraeperitoneal administration of colloidal 198Au complicating the treatment of anascitic ovarian cancer is reported. Typical scintiscans and various clinical findings of muscle necrosis and radiation myositis are described. Administration of larger amount of saline solution preceding the radiogold instillation controlled by simultaneous scintiscanning are suggested as safety measures in patients when no ascitic fluid is present.

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Relation between intravascular electrolyte level and course of parturition in dairy cows

Tierärztliche Praxis Ausgabe G Großtiere / Nutztiere ◽

10.1055/s-0038-1623185 ◽

2013 ◽

Vol 41 (05) ◽

pp. 289-296 ◽

Cited By ~ 2

Author(s):

K. Seyrek-Intas ◽

K. Failing ◽

G. Yilmazbas Mecitoglu ◽

H. Bostedt ◽

D. Seyrek-Intas

Keyword(s):

Dairy Cows ◽

Inorganic Phosphate ◽

Post Partum ◽

Total Calcium ◽

Normal Delivery ◽

P Values ◽

Normal Birth ◽

Factors Influencing ◽

Electrolyte Homeostasis ◽

Convalescence Phase

Summary Objective: To determine the intravascular electrolyte status in dairy cows with respect to age and different courses of parturition to clarify etiological factors influencing peri- or intrapartal imbalances of electrolyte homeostasis. Material and methods: A total of 64 cows at birth were evaluated (primiparous n = 34, pluriparous n = 30). Thirty-three cows showed normal delivery, while 31 cows had a complicated birth. Blood samples were collected intra partum (i. p.) and 2, 4, 6, 8, 12, 16, 24 h post partum (p. p.) as well as [2, 3, 4, 5, 7, 10 days p. p. and levels of total calcium (Catotal), ionized calcium (Caion), inorganic phosphate (Pa), Mg, Na, K, Cl were determined. Results: The results revealed that electrolytes show great fluctuation during and immediately p. p. in relation to age. Already during parturition pluriparous cows had a lower Catotal and Pa concentration compared to primiparous animals. Cows with dystocia exhibited a more intensive and longer lasting decrease of Ca compared to cows with normal birth. In relation to age and severity of birth Pa concentration showed a differing but basically typical course for this electrolyte. Mg, Na, K and Cl concentrations were higher during and immediately after birth compared to p. p. values. Until day 10 p. p. these electrolyte concentrations declined more in older cows with dystocia compared to younger animals. However, the influence of dystocia on concentration of these electrolytes was milder in contrast to Ca and Pa. Conclusions: In summary, primarily older cows are predisposed to imbalances of electrolyte homeostasis intra partum and at the beginning of the lactation. These changes are potentiated in case of complications during parturition. Intravascular Catotal, Caion as well as Pa are most severely affected. Clinical relevance: These results may constitute the basis for a comprehensive metaphylaxis during the peripartal period, especially in cows after dystocia, to positively influence the early convalescence phase.

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A case study on year round fodder production scheme for smallholder dairy producers in Bangladesh

Bangladesh Journal of Livestock Research ◽

10.3329/bjlr.v26i1-2.49940 ◽

2020 ◽

Vol 26 (1-2) ◽

pp. 79-102

Author(s):

NR Sarker ◽

F Tabassum D Yeasmin ◽

MA Habib ◽

MR Amin

Keyword(s):

Dairy Cows ◽

Family Income ◽

Live Weight ◽

Production Model ◽

Variable Cost ◽

Small Scale ◽

Common Salt ◽

Cost Ratio ◽

Her Family ◽

Fodder Production

This study was undertaken to develop a year round fodder production model for small scale dairy farmers. Five pregnant dairy cows of Red Chittagong Cattle (RCC) genotype were selected. For rearing five cows, 66 decimal of land was selected from existing fodder plots under Pachutia Research Farm at Bangladesh Livestock Research Institute (BLRI), Savar, Dhaka. The selected land was divided into two parts (33 decimal in each). One part was brought under perennial (Napier-4 and Splendida) and the 2nd part of land for seasonal (Maize & Matikalai) fodder production. Data on live weight and live weight gain of cows, birth weight of calves, feed intake, milk production, actual biomass yield for both perennial and seasonal fodder, yearly manure production were recorded and calculated. Napier-4 grass, splendida, maize, straw, silage were supplied to the experimental cows according to the seasonal availability in different months. Concentrate mixture were also supplied consisting of wheat bran, kheshari (red gram), soybean meal, maize crushed, til oil cake, DCP and common salt. Economics of the model revealed that considering the sale of milk, calves and manure and cost included only feed and land leased, a farm/family rearing 5 indigenous dairy cows with his/her family labours, he/she could earn around BDT 98 thousand in a year (1$ = 85 BDT) and the benefit cost ratio of the model on total variable cost and total cost were 1.86 and 1.66, respectively. Therefore, it may be recommended that a farmer having 5 adult dairy cows with 66 decimal land under fodder cultivation may earn substantial share of his/her family income as small-scale rural dairying. Bang. J. Livs. Res. Vol. 26 (1&2), 2019: P. 89-102

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LIME AND DAIRY PRODUCTION

Proceedings of the New Zealand Grassland Association ◽

10.33584/jnzg.1982.43.1608 ◽

1982 ◽

pp. 93-103

Author(s):

N.A. Thomson

Keyword(s):

Soil Moisture ◽

Dairy Cows ◽

Milk Production ◽

Soil Ph ◽

Dairy Production ◽

Pasture Production ◽

The Third ◽

One Year ◽

Plasma Magnesium

In a four year grazing trial with dairy cows the application of 5000 kg lime/ ha (applied in two applications of 2500 kg/ha in winter of the first two years) significantly increased annual pasture production in two of the four years and dairy production in one year. In three of the four years lime significantly increased pasture growth over summer/autumn with concurrent increases in milk production. In the last year of the trial lime had little effect on pasture growth but a relatively large increase in milkfat production resulted. A higher incidence of grass staggers was recorded on the limed farmlets in spring for each of the four years. In the second spring immediately following the second application of lime significant depressions in both pasture and plasma magnesium levels were recorded. By the third spring differences in plasma magnesium levels were negligible but small depressions in herbage magnesium resulting from lime continued to the end of the trial. Lime significantly raised soil pH, Ca and Mg levels but had no effect on either soil K or P. As pH levels of the unlimed paddocks were low (5.2-5.4) in each autumn and soil moisture levels were increased by liming, these factors may suggest possible causes for the seasonality of the pasture response to lime

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USE OF ENERGOPROTEIN CONCENTRATES BASED ON LUPINE IN FEEDING DAIRY COWS IN THE CONDITIONS OF THE KALININGRAD REGION

Multifunctional adaptive fodder production ◽

10.33814/mak-2020-24-72-126-130 ◽

2020 ◽

Author(s):

Zinaida Fedorova ◽

Yuri Tkachenko ◽

Vasily Bliadze

Keyword(s):

Heat Treatment ◽

Dairy Cows ◽

Milk Production ◽

Lower Cost ◽

Protein Concentrate ◽

Biological Value ◽

Kaliningrad Region

The data on feeding dairy cows of an energy protein concentrate (EPC) are presented. EPC consists of grain of narrow-leaved lupine, flax, triticale, subjected to heat treatment on a press extruder. The effect of EPC on the change in milk production of cows was determined. The inclusion of extruded concentrate based on lupine grains in the diets of cows made it possible to obtain an increase in milk. Concentrate based on lupine, flax, triticale is equal in biological value to full-fat soy, and at a much lower cost.

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Method of high frequency therapy at cows' mastitis during machine milking

Veterinaria Kubani ◽

10.33861/2071-8020-2020-2-9-12 ◽

2020 ◽

pp. 9-12

Author(s):

Viktor E. Lyubimov ◽

Keyword(s):

Dairy Cows ◽

Electromagnetic Fields ◽

High Frequency ◽

High Efficiency ◽

Environmentally Friendly ◽

Ultrahigh Frequency ◽

Machine Milking ◽

High Frequency Electromagnetic Field ◽

Milking Machine ◽

Methods Of Treatment

Health of dairy cows ensures human health, so it is important that dairy products do not contain antibiotics that are used to treat any inflammation, including mastitis. In Russia at present, the problem of mastitis in cows exists with both attached and loose housing of cows. Mastitis of dairy cows are the great problem in milking husbandry. Losses from mastitis in milk yield can reach 15-20%. The main reasons for the occurrence of nonspecific mastitis of cows are the shortcomings of the working components of the milking machine: the degree of deterioration of the nipple rubber and the violation of machine milking technology (the reduction in pre-milking time and vacuum fluctuations account for 70% of all causes). Treatment of mastitis with antibiotics is effective, but not environmentally friendly and unacceptable. For the treatment of inflammation of the udder, it is necessary to use more environmentally friendly methods of treatment, one of which is the exposure to ultra-high frequency electromagnetic field tested by medicine. Use of three types of medical-mobile milking machines with the same method of exposure to ultrahigh-frequency electromagnetic fields on cow's nipples through electrodes in milking cups: LPDA-1-UHF, LPDA-2-UHF and LPDA-UHF-30 M, is described in the article. Author proved that cows with subclinical forms of mastitis recovered faster during milking with exposure to the ultrahigh frequency than when treated by antibiotics, and milking with the ultrahigh frequency device helps to recover 82% of the affected quarters with clinical forms and 100% of cows with subclinical forms of mastitis or with udder irritation. The high efficiency of the method of exposure to electromagnetic fields of the ultrahigh frequency during machine milking by means of medical-mobile milking machines LPDA-UHF for the prevention and treatment of mastitis of cows was shown.

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