A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application

Electrospinning has been used in a wide variety of applications, such as tissue engineering, filtration and biomaterial scaffolds for vascular grafts or wound dressings. Recently, wound dressings have become more important in human life. They must have the superior biocompatibility, water absorption, water vapor permeation and antibacterial ability. Chitosan has been employed in clinical applications and exhibits excellent biocompatibility, biodegradation and bacteriostasis. In this investigation OR study, experiments were performed on a series of poly (vinyl alcohol) (PVA)/Chitosan (CS) fiber membranes at various blend ratios and electric fields to evaluate their spinnability. The morphology, diameter and structure of electrospun nanofibers were examined by scanning electron microscopy (SEM). When PVA/Chitosan=80:20 and electric field=0.67 kV/cm, the spinnability of electrospun membrane was good. IR spectra demonstrated strong intermolecular hydrogen bonds between the molecules of Chitosan and PVA. Furthermore, cell cultures demonstrate that both PAV and chitosan have good biocompatibility and are non-toxic.

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Computer simulation and comparative study on the pervaporation separation characteristics of sodium alginate and its blend membranes with poly(vinyl alcohol) to separate aqueous mixtures of 1,4-dioxane or tetrahydrofuran

Journal of Applied Polymer Science ◽

10.1002/app.21143 ◽

2004 ◽

Vol 94 (4) ◽

pp. 1827-1840 ◽

Cited By ~ 22

Author(s):

Tejraj M. Aminabhavi ◽

B. Vijaya Kumar Naidu ◽

S. Sridhar

Keyword(s):

Computer Simulation ◽

Comparative Study ◽

Sodium Alginate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Aqueous Mixtures ◽

Blend Membranes ◽

Pervaporation Separation

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Impact of the Type of Crosslinking Agents on the Properties of Modified Sodium Alginate/Poly(vinyl Alcohol) Hydrogels

Molecules ◽

10.3390/molecules26082381 ◽

2021 ◽

Vol 26 (8) ◽

pp. 2381

Author(s):

Katarzyna Bialik-Wąs ◽

Ewelina Królicka ◽

Dagmara Malina

Keyword(s):

Sodium Alginate ◽

Aqueous Extract ◽

Vinyl Alcohol ◽

Crosslinking Agent ◽

Echinacea Purpurea ◽

Poly Vinyl Alcohol ◽

Spectra Analysis ◽

Natural Origin ◽

Glycol Diacrylate ◽

Soxhlet Apparatus

Here, we report on studies on the influence of different crosslinking methods (ionic and chemical) on the physicochemical (swelling ability and degradation in simulated body fluids), structural (FT-IR spectra analysis) and morphological (SEM analysis) properties of SA/PVA hydrogels containing active substances of natural origin. First, an aqueous extract of Echinacea purpurea was prepared using a Soxhlet apparatus. Next, a series of modified SA/PVA-based hydrogels were obtained through the chemical crosslinking method using poly(ethylene glycol) diacrylate (PEGDA, Mn = 700 g/mol) as a crosslinking agent and, additionally, the ionic reaction in the presence of a 5% w/v calcium chloride solution. The compositions of SA/PVA/E. purpurea-based hydrogels contained a polymer of natural origin—sodium alginate (SA, 1.5% solution)—and a synthetic polymer—poly(vinyl alcohol) (PVA, Mn = 72,000 g/mol, 10% solution)—in the ratio 2:1, and different amounts of the aqueous extract of E. purpurea—5, 10, 15 or 20% (v/v). Additionally, the release behavior of echinacoside from the polymeric matrix was evaluated in phosphate-buffered saline (PBS) at 37 °C. The results indicate that the type of the crosslinking method has a direct impact on the release profile. Consequently, it is possible to design a system that delivers an active substance in a way that depends on the application.

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Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽

10.3390/polym13132104 ◽

2021 ◽

Vol 13 (13) ◽

pp. 2104

Author(s):

Sibusiso Alven ◽

Blessing Atim Aderibigbe

Keyword(s):

Mechanical Properties ◽

Wound Healing ◽

Vinyl Alcohol ◽

Wound Dressing ◽

Chronic Wounds ◽

Cellular Adhesion ◽

Wound Dressings ◽

Poly Vinyl Alcohol ◽

High Porosity ◽

Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

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Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

Molecules ◽

10.3390/molecules26010083 ◽

2020 ◽

Vol 26 (1) ◽

pp. 83

Author(s):

Cláudia Mouro ◽

Colum P. Dunne ◽

Isabel C. Gouveia

Keyword(s):

Composite Material ◽

Vinyl Alcohol ◽

Pathogenic Bacteria ◽

Antimicrobial Agents ◽

Coating Layer ◽

Wound Dressings ◽

Poly Vinyl Alcohol ◽

Microbial Invasion ◽

Layer Composite ◽

Medicinal Plant Extracts

Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination.

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Controlled mechanical and swelling properties of poly(vinyl alcohol)/sodium alginate blend hydrogels prepared by freeze-thaw followed by Ca2+ crosslinking

Journal of Applied Polymer Science ◽

10.1002/app.35083 ◽

2011 ◽

Vol 124 (1) ◽

pp. 823-831 ◽

Cited By ~ 40

Author(s):

Liang Xie ◽

Man Jiang ◽

Xiaogang Dong ◽

Xia Bai ◽

Jin Tong ◽

...

Keyword(s):

Sodium Alginate ◽

Vinyl Alcohol ◽

Poly Vinyl Alcohol ◽

Swelling Properties ◽

Freeze Thaw

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The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles

Nanomaterials ◽

10.3390/nano11010096 ◽

2021 ◽

Vol 11 (1) ◽

pp. 96

Author(s):

John Jackson ◽

Helen Burt ◽

Dirk Lange ◽

In Whang ◽

Robin Evans ◽

...

Keyword(s):

Silver Nanoparticles ◽

Antibacterial Activity ◽

Silver Nitrate ◽

Vinyl Alcohol ◽

Unmet Need ◽

Chemical Characterization ◽

Wound Dressings ◽

Poly Vinyl Alcohol ◽

Burn Wound

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

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