Biology of colorectal cancer: An overview of genetic factors Marc J Abramowicz

2001 ◽  
pp. 21-28
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors

scholarly journals Tailored Treatment of Colorectal Cancer: Surgical, Molecular, and Genetic Considerations

2017 ◽  
Vol 11 ◽  
pp. 117955491769076 ◽  
Author(s):  
Knut Magne Augestad ◽  
Marianne A Merok ◽  
Dejan Ignatovic
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors ◽  
Treatment Approach ◽  
Cancer Recurrence ◽  
Postoperative Phase ◽  
Cancer Disease ◽  
Tailored Treatment ◽  
Surgical Complexity ◽  
The Individual ◽  
Rectal Anatomy

Colorectal cancer (CRC) is a complex cancer disease, and approximately 40% of the surgically cured patients will experience cancer recurrence within 5 years. During recent years, research has shown that CRC treatment should be tailored to the individual patient due to the wide variety of risk factors, genetic factors, and surgical complexity. In this review, we provide an overview of the considerations that are needed to provide an individualized, patient-tailored treatment. We emphasize the need to assess the predictors of CRC, and we summarize the latest research on CRC genetics and immunotherapy. Finally, we provide a summary of the significant variations in the colon and rectal anatomy that is important to consider in an individualized surgical approach. For the individual patient with CRC, a tailored treatment approach is needed in the preoperative, operative, and postoperative phase.

Genetic factors associated with the aetiology and treatment of colorectal cancer

Toxicology ◽  
2006 ◽  
Vol 226 (1) ◽  
pp. 14
Author(s):  
C. Roland Wolf ◽  
Robert J.C. Steele ◽  
Francis A. Carey ◽  
Norman D. Pratt ◽  
D. Timothy Bishop ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors ◽  
Factors Associated

scholarly journals Association of Polygenic Risk Score and Bacterial Toxins at Screening Colonoscopy with Colorectal Cancer Progression: A Multicenter Case-Control Study

Toxins ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 569
Author(s):  
Alfonso Piciocchi ◽  
Elena Angela Pia Germinario ◽  
Koldo Garcia Etxebarria ◽  
Silvia Rossi ◽  
Lupe Sanchez-Mete ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Progression ◽  
Genetic Factors ◽  
Bacterial Toxins ◽  
Screening Colonoscopy ◽  
Polygenic Risk Score ◽  
Chronic Infections ◽  
Predisposing Factor ◽  
Microbial Dysbiosis

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and its incidence is correlated with infections, chronic inflammation, diet, and genetic factors. An emerging aspect is that microbial dysbiosis and chronic infections triggered by certain bacteria can be risk factors for tumor progression. Recent data suggest that certain bacterial toxins implicated in DNA attack or in proliferation, replication, and death can be risk factors for insurgence and progression of CRC. In this study, we recruited more than 300 biopsy specimens from people undergoing colonoscopy, and we analyzed to determine whether a correlation exists between the presence of bacterial genes coding for toxins possibly involved in CRC onset and progression and the different stages of CRC. We also analyzed to determine whether CRC-predisposing genetic factors could contribute to bacterial toxins response. Our results showed that CIF toxin is associated with polyps or adenomas, whereas pks+ seems to be a predisposing factor for CRC. Toxins from Escherichia coli as a whole have a higher incidence rate in adenocarcinoma patients compared to controls, whereas Bacteroides fragilis toxin does not seem to be associated with pre-cancerous nor with cancerous lesions. These results have been obtained irrespectively of the presence of CRC-risk loci.

scholarly journals Colorectal cancer: a review

2017 ◽  
Vol 5 (11) ◽  
pp. 4667 ◽  
Author(s):  
Juan José Granados-Romero ◽  
Alan Isaac Valderrama-Treviño ◽  
Ericka Hazzel Contreras-Flores ◽  
Baltazar Barrera-Mera ◽  
Miguel Herrera Enríquez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Protective Factors ◽  
Cause Of Death ◽  
Genetic Factors ◽  
Colonic Polyps ◽  
Diagnostic Methods ◽  
Degree Relative ◽  
Basis Risk ◽  
Intestinal Inflammatory Disease

Colorectal cancer (CCR) is the third most common cancer worldwide in men and women, the second largest cause of death related to cancer, and the main cause of death in gastrointestinal cancer. The risk of developing this cancer is related to bad alimentary habits, smoking, intestinal inflammatory disease, polyps, genetic factors, and aging. Of the patients that are diagnosed with colorectal cancer 90% are older than 50, with a median age of 64 years; however, the disease is more aggressive in patients that are diagnosed at younger ages. According to the American Cancer Association, it was accounted for more than 49,700 deaths in 2015. The goal is to reduce the mortality rate with early diagnosis and treatment. Currently, the survival rate is used to predict a patient’s prognosis. The patient is considered to have a positive familial history if a first-degree relative has been diagnosed with colorectal cancer or colonic polyps before the age of 60, or also if two or more first-degree relatives have been diagnosed with cancer or polyps at any age. There are several methods for detecting colorectal cancer, such as the guaiac test, immunochemical test of stool, DNA stool test, sigmoidoscopy, colonoscopy, and barium enema. The stage in which the cancer is detected determines the prognosis, survival, and treatment of the patient. Provide a review about generalities, genetic basis, risk factors, protective factors, clinical course, diagnostic methods, therapy and survival in colorectal cancer. Conducted research from different databases such as PubMed, Medline, MedScape, on the definition, genetic factors, classification, risk factors, protective factors, diagnostic methods, epidemiology, survival and treatment of colorectal cancer. Articles from 2000 to 2017 were included using the following keywords.

scholarly journals Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1162 ◽  
Author(s):  
Purushottam Lamichhane ◽  
Morgan Maiolini ◽  
Omar Alnafoosi ◽  
Sedra Hussein ◽  
Hasan Alnafoosi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Family History ◽  
Gut Microbiome ◽  
Genetic Factors ◽  
Bacterial Species ◽  
Cancer Epidemiology ◽  
Bacterial Strains ◽  
Prevention And Treatment ◽  
Therapeutic Responses

Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment.

scholarly journals Determining Risk of Colorectal Cancer and Starting Age of Screening Based on Lifestyle, Environmental, and Genetic Factors

2018 ◽  
Vol 154 (8) ◽  
pp. 2152-2164.e19 ◽  
Author(s):  
Jihyoun Jeon ◽  
Mengmeng Du ◽  
Robert E. Schoen ◽  
Michael Hoffmeister ◽  
Polly A. Newcomb ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors

scholarly journals Colorectal Cancer and Nutrition

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 164 ◽  
Author(s):  
Kannan Thanikachalam ◽  
Gazala Khan
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Mortality Rate ◽  
Genetic Factors ◽  
Young Patients ◽  
Protective Role ◽  
Review Article ◽  
The Third ◽  
Common Cancer ◽  
The Us

Colorectal Cancer is the third most common cancer diagnosed in the US. While the incidence and the mortality rate of colorectal cancer has decreased due to effective cancer screening measures, there has been an increase in number of young patients diagnosed in colon cancer due to unclear reasons at this point of time. While environmental and genetic factors play a major role in the pathogenesis of colon cancer, extensive research has suggested that nutrition may play both a causal and protective role in the development of colon cancer. In this review article, we aim to provide a review of factors that play a major role in development of colorectal cancer.

scholarly journals Erratum: Corrigendum: Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Gemma Ibáñez-Sanz ◽  
Anna Díez-Villanueva ◽  
M. Henar Alonso ◽  
Francisco Rodríguez-Moranta ◽  
Beatriz Pérez-Gómez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Genetic Factors ◽  
Risk Model ◽  
Spanish Population
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