scholarly journals Insights on Epidemiology, Pathogenesis, Diagnosis and Possible Treatment of COVID-19 infection

2020 ◽  
Author(s):  
SHASHANK KUMAR MAURYA ◽  
Amit Bhattacharya ◽  
Pooja Shukla ◽  
RAJNIKANT MISHRA

COVID-19, SARS-CoV-2 virus of the coronavirus family, created worldwide infectious outbreak affecting millions of people across the globe showing mild to severe symptoms of pneumonia and acute respiratory distress. Absence of precise information on primary transmission, diagnosis, prognosis, and therapeutics for patients with COVID-19 makes prevention and control tough. Treatment of millions of COVID19 patients without any specific drug is one of the biggest challenge, many existing antiviral drugs are in use as an alternative treatment and hunting is still on the way to develop COVID19 specific drug and vaccine. Being the world second largest populated country, fluctuating climatic condition at every 4 months, India is also at the high risk for spread of COVID19 infection. This review article has been intended to discuss biology of COVID-19, mechanism of COVID-19 infection in humans, epidemiology, possible effect of COVID19 infection on pregnancy, nervous system, individuals diabetes and cardiovascular disease, drug repurposing strategy as an alternative line of treatment and clinical practices recommended by World Health Organization (WHO) and other government agencies followed by situation and measures taken by Indian government to minimize the spread of COVID19 in India.

2021 ◽  
Vol 10 (1) ◽  
pp. 36-41
Author(s):  
Seyed Hesamaddin Banihashemi ◽  
Ahmadreza Karimi ◽  
Hasti Nikourazm ◽  
Behnaz Bahmanyar ◽  
Dariush Hooshyar

The severe acute respiratory syndrome coronavirus 2 virus and its associated disease, called coronavirus disease 2019 (COVID-19), first appeared in Wuhan, China in December 2019 and quickly spread around the world. Coronavirus was officially named COVID-19 by the World Health Organization and was recognized as a pandemic due to its rapid spread worldwide. Based on the published data, it is hoped to provide a source for later studies and to help prevent and control the contagious COVID-19 and its characteristics, and considerations that surgeons and medical staff must observe during the epidemic.


Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.


2021 ◽  
Vol 4 (4) ◽  
pp. 941-953
Author(s):  
Dyan Kunthi Nugrahaeni ◽  
Novie Elvinawaty Mauliku ◽  
Budiman Budiman ◽  
Gunawan Irianto ◽  
Arina Novilla

ABSTRAK The World Health Organization menetapkan outbreak SARS-CoV-2 sebagai Kedaruratan Kesehatan Masyarakat yang Meresahkan Dunia dan dinyatakan sebagai pandemik. Penyebaran dan penularan penyakit Coronavirus Disease-19 (COVID-19) sangat tinggi, dengan jumlah penderita lebih dari 117 juta di seluruh dunia. Diperlukan berbagai strategi dan tindakan yang dapat dilakukan untuk pencegahan, penanggulangan dalam rangka mengatasi COVID-19. Tujuan Pengabdian masyarakat yang dilakukan oleh Stikes Achmad Yani adalah ikut berperan serta dalam pencegahan dan penanggulangan COVID-19 di wilayah Kota Cimahi dan Kota Bandung. Metode yang digunakan adalah partisipatori dalam berbagai aktifias pencegahan dan penanggulangan COVID-19. Kegiatan Pengabdian Masyarakat yang dilakukan selama pandemic COVID-19 diantaranya adalah demontrasi pembuatan handsanitizer, penyemprotan disinfektan, mengirimkan tim relawan pemeriksaan Rapid Diagnostic Test (RDT) antibodi Cluster Lembang dan relawan Check Point pada kegiatan Pembatasan Sosial Berskala Besar di Kota Bandung. Pemberian donasi kepada masyarakat terdampak pandemik COVID-19 dan donasi Alat Pelindung Diri (APD) ke fasilitas pelayanan kesehatan seperti Rumah Sakit dan Puskesmas. Pelaksanaan Rapid Test Diagnostic (RTD) antibodi dan RTD antigen bagi mahasiswa, dosen dan Karyawan. Stikes Achmad Yani juga berperan serta dalam gebyar Vaksin COVID-19 bagi tenaga kesehatan dan mengirimkan relawan sebagai vaksinator yang diselenggarakan oleh Rumah Sakit Hasan Sadikin berkerjasama dengan PPNI. Partisipasi Stikes Achmad Yani Cimahi dalam berbagai kegiatan yang terkait dengan COVID-19 diharapkan dapat memberikan kontribusi dalam rangka pencegahan penularan, pengendalian dan penanggulangan COVID-19. Kata Kunci: COVID-19, disinfeksi, relawan, Rapid Diagnostic Test  ABSTRACT The World Health Organization recognize the SARS-CoV-2 outbreak as a public health emergency of Internasional Concerns and declared it as a pandemic. The spread and transmission of Coronavirus Disease-19 (COVID-19) are very high and reported that over 117 million people have been sufferers worldwide. Several strategies and actions can be carried out to prevention, controlling and overcoming COVID-19. The purpose of community service carried out by Stikes Achmad Yani is to participate in the prevention and control of COVID-19 in Cimahi and Bandung district. The methode used in community services are participatory methods in several activities for prevention and control of COVID-19. Community Service activities carried out during the COVID-19 pandemic included demonstrations of making hand sanitizers, spraying disinfectants, sending a team of volunteers to examine the Rapid Diagnostic Test (RDT) antibody for the Lembang Cluster, and volunteer Check Points at Large-Scale Social Restrictions activities in Bandung. Providing donations to people affected by the COVID-19 pandemic and donations of Personal Protective Equipment (PPE) to health service facilities such as hospitals and health centers. Implementation of Rapid Diagnostic Test (RTD) antibody and RDT antigen for students, lecturers, and staff. Stikes Achmad Yani also participated in the COVID-19 Vaccine for health workers and sent volunteers as vaccinators organized by Hasan Sadikin Hospital in collaboration with PPNI. The participation of Stikes Achmad Yani Cimahi in various activities to contribute prevention of disease transmission and controlling COVID-19. Kata Kunci: COVID-19, disinfection, volunteer, Rapid Diagnostic Test


2020 ◽  
Vol 7 (1) ◽  
pp. 85-88 ◽  
Author(s):  
Kiran Sapkota ◽  
Ganesh Dangal ◽  
Madhu Koirala ◽  
Kalyan Sapkota ◽  
Asmita Poudel ◽  
...  

Coronavirus disease (COVID-19) outbreak, caused by the most recently discovered coronavirus, is currently affecting a large population across the globe. World health organization (WHO) has already declared COVID-19, a pandemic, and the world is fighting to contain the COVID-19 outbreak. Nepal has taken several preventive measures to control the coronavirus outbreak. However, some additional steps are needed to prevent community transmission of the disease. This brief communication discusses the government of Nepal actions and provides recommendations for the prevention and control of COVID-19 infection in Nepal.


2020 ◽  
Vol 21 (8) ◽  
pp. 2839 ◽  
Author(s):  
Ayumu Asai ◽  
Masamitsu Konno ◽  
Miyuki Ozaki ◽  
Chihiro Otsuka ◽  
Andrea Vecchione ◽  
...  

Since the infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in China during December 2019, the coronavirus disease 2019 (COVID-19) has spread on a global scale, causing the World Health Organization (WHO) to issue a warning. While novel vaccines and drugs that target SARS-CoV-2 are under development, this review provides information on therapeutics which are under clinical trials or are proposed to antagonize SARS-CoV-2. Based on the information gained from the responses to other RNA coronaviruses, including the strains that cause severe acute respiratory syndrome (SARS)-coronaviruses and Middle East respiratory syndrome (MERS), drug repurposing might be a viable strategy. Since several antiviral therapies can inhibit viral replication cycles or relieve symptoms, mechanisms unique to RNA viruses will be important for the clinical development of antivirals against SARS-CoV-2. Given that several currently marketed drugs may be efficient therapeutic agents for severe COVID-19 cases, they may be beneficial for future viral pandemics and other infections caused by RNA viruses when standard treatments are unavailable.


2020 ◽  
Vol 8 ◽  
Author(s):  
Xuanzhen Cen ◽  
Dong Sun ◽  
Ming Rong ◽  
Gusztáv Fekete ◽  
Julien S. Baker ◽  
...  

Recently, an unprecedented coronavirus pandemic has emerged and has spread around the world. The novel coronavirus termed COVID-19 by the World Health Organization has posed a huge threat to human safety and social development. This mini review aimed to summarize the online education mode and plans for schools to resume full-time campus study in China during COVID-19. Chinese schools have made significant contributions to the prevention and control of the transmission of COVID-19 by adopting online learning from home. However, normal opening and classroom teaching have been affected. For education systems at all levels, online education may be an effective way to make up for the lack of classroom teaching during the epidemic. To protect staff and students from COVID-19, the timing of students returning to full-time campus study needs to be considered carefully. Reviewing and summarizing of the Chinese education system's response to the virus would be of great value not only in developing educational policy but also in guiding other countries to formulate educational countermeasures.


2021 ◽  
Vol 9 (T4) ◽  
pp. 212-217
Author(s):  
Mundakir Mundakir ◽  
Asri Asri ◽  
SG Winata

BACKGROUND: Tuberculosis (TB) is major community health problem in Indonesia. The World Health Organization report in 2017 shows that 6.4 million new TB cases were officially notified to national authorities, worldwide. Indonesia has 842,0000 cases and places it as the country with the third highest number in the world. The national program Directly Observed treatment, short-course started since 2014 has not able to handle TB cases comprehensively. Communities have important role in TB management. AIM: The aim of this study was to explore the existed condition of TB management and control. METHODS: A descriptive qualitative study was conducted in Tandes Sub-district, which is an endemic area for TB and has the highest incident in Surabaya. Semi-structured interview was conducted to 13 participants who consist of sub-urban TB task force, community health volunteer, Community Health Nurses, and sub-district officer. RESULTS: Result reveal six themes: Altruism as intentional caring factor, in adequate number of staff, the need to improve training skill, insufficient of resources, limited of financial support, and social support. CONCLUSION: To be effective program, community-based TB management need to be improve in the availability of budget, staff, training, and resources while maintaining the ongoing work of TB task force team. Community-based TB program is one of the activities whose efficiency was reliable for handling TB.


2021 ◽  
Vol 15 (5) ◽  
pp. e0009373
Author(s):  
Adriano Casulli

The second World Neglected Tropical Diseases (NTDs) Day was celebrated on 30 January 2021. To mark the occasion, the World Health Organization (WHO) launched its roadmap for NTDs for the period 2021 to 2030, which is aimed at increasing prevention and control of these too-long neglected diseases. Described here is a global overview on past achievements, current challenges, and future prospects for the WHO NTDs roadmap 2021–2030.


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