scholarly journals Delay in assessing vitamin D supplements and live vaccines for tuberculosis, polio, and measles to protect people from Covid-19

2021 ◽  
Author(s):  
David Gisselquist
Keyword(s):  
Vitamin D ◽  
The United States ◽  
World Health ◽  
Live Vaccines ◽  
The Us ◽  
Us Government ◽  
Vitamin D Supplements ◽  
Health Organization ◽  
Experimental Use ◽  
The Impact

Introduction: In March 2020, less than three months after China reported a cluster of pneumonia cases in Wuhan, the United States (US) government budgeted money to support development of Covid-19 vaccines. By mid-December 2020, two had been developed, tested, and received the US government’s experimental use authorization. Given evidence that vitamin D supplements and live vaccines for tuberculosis, polio, and measles reduce risks for acute respiratory infection, many experts hypothesized they might reduce risks for Covid-19 infection. Expedited randomized controlled trials, as done for Covid-19 vaccines, could have assessed their protection against C19 no later than end-July 2020. Methods: On 21 April 2021, I searched trial registries maintained by the US National Institutes of Medicine and the World Health Organization for trials with ≥400 participants to assess vitamin D or live vaccines to prevent Covid-19 infections (all or symptomatic). On 10-13 November 2021, I searched PubMed and medRxiv for results reported from these trials.Results: In April 2021, I found 32 trials (9 for vitamin D and 23 for live vaccines) proposing to assess the impact of these interventions on rates of new Covid-19 infections (all or symptomatic). Only 10 trials proposed to begin by June 2020, and only one to end in 2020. My search on 10-13 November 2021, almost 11 months after the US approved the first two Covid-19 vaccines, found results reported from only one of the 32 trials (live measles vaccine significantly reduced new symptomatic infections). Conclusions: If health experts had demonstrated similar urgency in assessing vitamin D supplements and live vaccines for tuberculosis, polio, and measles as in developing Covid-19 vaccines, trials could have reported by end-July 2020. Depending on what trials reported, these interventions could have prevented a large percentage of more than 600,000 Covid-19 deaths reported in the US from August 2020 through November 2021. Delay in assessing vitamin D has racial implications as well, since vitamin D deficiency and Covid-19 deaths in the US have been far more common among Blacks and Hispanics compared to Whites. Going forward, depending on what trials report, these interventions could help people live with Covid-19 as an endemic virus.

scholarly journals Impact of the Emerging COVID-19 Pandemic on the Consumption of Multivitamins (C, D and Zinc) by the Saudi Arabian Population

2021 ◽  
pp. 11-20
Author(s):  
Duaa Mohamed Bakhshwin ◽  
Abdulaziz Bakhshwin
Keyword(s):  
Vitamin D ◽  
Vitamin C ◽  
World Health ◽  
Saudi Population ◽  
Viral Spread ◽  
Significant Difference ◽  
Before And After ◽  
Zinc Supplements ◽  
Vitamin D Supplements ◽  
The Impact

Background: On March 11, 2020, the World Health Organization (WHO) announced the Coronavirus outbreak officially as a pandemic. This pandemic has led to new measurements to prevent viral spread. The measures included decreasing the person’s mobility outside homes with subsequent changes in the lifestyles, particularly in physical activity and eating habits. It has been noticed that consumption of some vitamins may help in preventing or reducing the symptoms of viral infection. Those vitamins include vitamin C, D and zinc. There is a common observation that the general public believes that the use of vitamins, especially vitamins C, D and zinc, reduces the chance of acquiring COVID-19. Objectives: The aim of this study was to determine the impact of COVID-19 pandemic on taking vitamins supplements by the Saudi general population in order to explore their believes regarding the protective value of these vitamins against COVID-19 infection. Subjects and Methods: This cross-sectional study was conducted using a self-administrated questionnaire that was designed, uploaded to the Google form and distributed online to the general Saudi population through the social media (Whatsapp, Twitter) as well as through email between August and December 2020. Statistical Packaged of Social Sciences program (SPSS) for Windows (version 17.0., Chicago: SPSS Inc) was used to analyze the data. A significant difference was considered when the p value is < 0.05. Student t-test and Chi-square (χ2) test were used to compare the studied variables as appropriate. Results: A total of 1043 participants were included in this study (64.9% females, 35.1% males). The mean age for them was 35.3±14.78 years. Only 9.3% (97 participants) were diagnosed to have COVID-19. About 28% of the participants were in contact with COVID-19 cases. Among participants diagnosed to have COVID-19 infection, (13% versus 29%) were taking vitamin C and (2% versus 15%) were taking zinc supplements daily during the 6 months before and after the pandemic, respectively, while (20% versus 25%) were taking vitamin D supplements weekly during the 6 months before and after the pandemic, respectively. Among participants who were in contact with COVID-19 cases, (8% versus 20%) and (3% versus 11%) were taking vitamin C and zinc supplements daily during the 6 months before and after the pandemic, respectively, while (14% versus 16%) were taking vitamin D supplements weekly during the 6 months before and after the pandemic Conclusion: The interest of taking multivitamin by Saudi population, such as vitamins C and D, zinc increased during and after the pandemic compared to that before it. There is no scientific evidence based on previous studies confirmed the role of dietary supplementation and multivitamins in preventing COVID-19 infection, therefore, effective education on the rationale use of vitamins during COVID-19 pandemic should be emphasized at local and/or national levels.

scholarly journals Quebec’s Economic and Commercial Linkages with the United States, 1994–2017

2017 ◽  
Author(s):  
Earl H. Fry
Keyword(s):  
United States ◽  
Trade Agreement ◽  
The United States ◽  
The North ◽  
Nation States ◽  
Wide Range ◽  
The Us ◽  
Us Government ◽  
Big Picture ◽  
The Impact

This article examines the ebb and flow of the Quebec government’s economic and commercial relations with the United States in the period 1994–2017. The topic demonstrates the impact of three major forces on Quebec’s economic and commercial ties with the US: (1) the North American Free Trade Agreement (NAFTA) which became operational in 1994 and was fully implemented over a 15-year period; (2) the onerous security policies put in place by the US government in the decade following the horrific events of 11 September 2001; and (3) changing economic circumstances in the United States ranging from robust growth to the worst recession since the Great Depression of the 1930s. The article also indicates that the Quebec government continues to sponsor a wide range of activities in the United States, often more elaborate and extensive than comparable activities pursued by many nation-states with representation in the US. 1 1 Stéphane Paquin, ‘Quebec-U.S. Relations: The Big Picture’, American Review of Canadian Studies 46, no. 2 (2016): 149–61.

scholarly journals A Quantitative Risk Assessment of Human Salmonellosis from Consumption of Walnuts in the United States

2018 ◽  
Vol 82 (1) ◽  
pp. 45-57 ◽  
Author(s):  
SOFIA M. SANTILLANA FARAKOS ◽  
RÉGIS POUILLOT ◽  
GORDON R. DAVIDSON ◽  
RHOMA JOHNSON ◽  
INSOOK SON ◽  
...  
Keyword(s):  
United States ◽  
Rare Event ◽  
The United States ◽  
Quantitative Risk Assessment ◽  
World Health ◽  
Baseline Model ◽  
Log Reduction ◽  
Human Salmonellosis ◽  
Health Organization ◽  
The Impact

ABSTRACT We assessed the risk of human salmonellosis from consumption of shelled walnuts in the United States and the impact of 0- to 5-log reduction treatments for Salmonella during processing. We established a baseline model with Salmonella contamination data from 2010 to 2013 surveys of walnuts from California operations to estimate baseline prevalence and levels of Salmonella during preshelling storage and typical walnut processing stages, considered U.S. consumption data, and applied an adapted dose-response model from the Food and Agriculture Organization and the World Health Organization to evaluate risk of illness per serving and per year. Our baseline model predicted 1 case of salmonellosis per 100 million servings (95% confidence interval [CI], 1 case per 3 million to 1 case per 2 billion servings) of walnuts untreated during processing and uncooked by consumers, resulting in an estimated 6 cases of salmonellosis per year (95% CI, &lt;1 to 278 cases) in the United States. A minimum 3-log reduction treatment for Salmonella during processing of walnuts eaten alone or as an uncooked ingredient resulted in a mean risk of &lt;1 case per year. We modeled the impact on risk per serving of three atypical situations in which the Salmonella levels were increased by 0.5 to 1.5 log CFU per unit pretreatment during processing at the float tank or during preshelling storage or posttreatment during partitioning into consumer packages. No change in risk was associated with the small increase in levels of Salmonella at the float tank, whereas an increase in risk was estimated for each of the other two atypical events. In a fourth scenario, we estimated the risk per serving associated with consumption of walnuts with Salmonella prevalence and levels from a 2014 to 2015 U.S. retail survey. Risk per serving estimates were two orders of magnitude larger than those of the baseline model without treatment. Further research is needed to determine whether this finding reflects variability in Salmonella contamination across the supply or a rare event affecting a portion of the supply.

scholarly journals Is COVID-19 the end of US hegemony? Public bads, leadership failures and monetary hegemony

2020 ◽  
Vol 96 (5) ◽  
pp. 1281-1303 ◽  
Author(s):  
Carla Norrlöf
Keyword(s):  
United States ◽  
Public Goods ◽  
The United States ◽  
World Health ◽  
The Public ◽  
The Us ◽  
Us Hegemony ◽  
Health Organization ◽  
Public Bads ◽  
The Relationship

Abstract COVID-19 is the most invasive global crisis in the postwar era, jeopardizing all dimensions of human activity. By theorizing COVID-19 as a public bad, I shed light on one of the great debates of the twentieth and twenty-first centuries regarding the relationship between the United States and liberal international order (LIO). Conceptualizing the pandemic as a public bad, I analyze its consequences for US hegemony. Unlike other international public bads and many of the most important public goods that make up the LIO, the COVID-19 public bad not only has some degree of rivalry but can be made partially excludable, transforming it into more of a club good. Domestically, I demonstrate how the failure to effectively manage the COVID-19 public bad has compromised America's ability to secure the health of its citizens and the domestic economy, the very foundations for its international leadership. These failures jeopardize US provision of other global public goods. Internationally, I show how the US has already used the crisis strategically to reinforce its opposition to free international movement while abandoning the primary international institution tasked with fighting the public bad, the World Health Organization (WHO). While the only area where the United States has exercised leadership is in the monetary sphere, I argue this feat is more consequential for maintaining hegemony. However, even monetary hegemony could be at risk if the pandemic continues to be mismanaged.

scholarly journals Probiotic Products in Canada with Clinical Evidence: What Can Gastroenterologists Recommend?

2008 ◽  
Vol 22 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Gregor Reid ◽  
Kingsley Anukam ◽  
Tara Koyama
Keyword(s):  
United States Of America ◽  
Clinical Evidence ◽  
Health Benefit ◽  
The United States ◽  
World Health ◽  
Therapeutic Effects ◽  
The Us ◽  
Health Organization ◽  
Health Canada

Probiotics, defined as ‘live microorganisms, which when administered in adequate amounts, confer a health benefit on the host’, are finally becoming an option for gastroenterologists in Canada, after being available for many years in Japan, Europe and the United States of America. Unfortunately, Health Canada and the US Food and Drug Administration have not controlled the use of the term ‘probiotic’ or put into place United Nations and World Health Organization guidelines. The net result is that a host of products called ‘probiotics’ are available but are not truly probiotic. The aim of the present review was to discuss the rationale for probiotics in gastroenterology, and specifically examine which products are options for physicians in Canada, and which ones patients might be using. It is hoped that by clarifying what probiotics are, and the strengths and limitations of their use, specialists will be better placed to make recommendations on the role of these products in patient care. In due course, more clinically documented probiotics will emerge, some with therapeutic effects based on a better understanding of disease processes.

Emerging and Reemerging Infectious Diseases - Past, Present and Future

2007 ◽  
Vol 2 (2) ◽  
pp. 66-70 ◽  
Author(s):  
Yoshifumi Takeda ◽  
Keyword(s):  
Infectious Diseases ◽  
Emerging Infectious Diseases ◽  
World Health ◽  
Control Law ◽  
Global Response ◽  
The Us ◽  
The World ◽  
Us Government ◽  
Health Organization ◽  
Global Threat

The global threat of new infectious diseases first became widely recognized in the 1990s. The US government published a report on emerging and reemerging infectious diseases followed by the World Health Organization (WHO), which adopted the slogan "Emerging Infectious Diseases: Global Alert, Global Response" in 1997. Typical examples of the more than 30 infectious diseases emerging since 1970s are HIV/AIDS, Vibrio cholerae O139 infection, enterohemorrhagic Escherichia coli infection, severe acute respiratory syndrome (SARS), and avian influenza. The New Infectious Diseases Control Law enacted in Japan in 1999 was to control these emerging infectious diseases and the already existing ones.

scholarly journals The COVID States Project #75: Attitudes toward COVID-19 boosters before and after Omicron

2021 ◽  
Author(s):  
Roy H. Perlis ◽  
Matthew Baum ◽  
Kristin Lunz Trujillo ◽  
David Lazer ◽  
Alauna Safarpour ◽  
...  
Keyword(s):  
District Of Columbia ◽  
The United States ◽  
World Health ◽  
Vaccine Hesitancy ◽  
Dominant Form ◽  
The Us ◽  
Before And After ◽  
Control And Prevention ◽  
Health Organization ◽  
To Receive

Recognizing that the protection conferred by COVID-19 vaccines may wane over time, the US Centers for Disease Control and Prevention (CDC) has encouraged adults in the United States to receive booster shots that can augment their immunity to the virus. While the Biden administration sought to encourage all adults to receive boosters, the CDC initially authorized the shots only for higher-risk individuals. Subsequently, authorization was broadened to all adults, although only higher-risk individuals were encouraged to pursue boosters. Most recently, after substantial criticism, the CDC changed its language to encourage all adults to receive boosters.But regardless of the language, are US adults sufficiently convinced to seek booster shots? Will the same factors that contributed to COVID-19 vaccine hesitancy and vaccine resistance impact booster shots? The answers may have profound public health implications as the US enters the season during which respiratory viruses typically have the greatest impact, and the highly-transmissible Omicron variant rapidly becomes the dominant form of COVID-19, after being labeled a variant of concern by the World Health Organization on November 26th.Between November 3rd and December 3rd, 2021, the COVID States Project asked 22,277 adults in all 50 US states and the District of Columbia about their attitudes and behaviors regarding COVID-19. In particular, we asked about whether people are vaccinated or intend to be vaccinated, and whether they had sought booster shots or intend to seek a booster shot. In this brief report, we examine attitudes toward COVID-19 booster shots, and whether they differ across particular groups of people. Since the survey was ongoing when news about Omicron emerged in the US, we also take an initial look at whether these attitudes have begun to shift along with perceptions of the threat posed by COVID-19 subsequent to the November 26th announcement.

The United Nations system under stress: financial pressures and their consequences

1991 ◽  
Vol 17 (4) ◽  
pp. 365-382 ◽  
Author(s):  
Paul Taylor
Keyword(s):  
United States ◽  
United Nations ◽  
The United States ◽  
World Health ◽  
The United Nations ◽  
United Nations System ◽  
Health Organization ◽  
The Impact ◽  
Nations System ◽  
Financial Pressures

This essay is about the response by the United Nations system to financial pressures in the 1980s and early 1990s. These pressures resulted from two developments: the decision of the main contributing states to adopt a policy of zero growth in real terms in the budgets of the organizations; and the additional withholdings by the United States which resulted from the Kassebaum Amendment to the Senate Foreign Relations Act of August 1985. This required a 20 per cent underpayment by the United States of its assessed financial contributions until a range of reforms in budgetary procedures, judged acceptable by the US Administration, had been introduced. The impact of the resulting financial squeeze is considered with particular reference to three Specialized Agencies: the World Health Organization (WHO), the International Labour Organization (ILO), and the Food and Agriculture Organization (FAO).

Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia

Blood ◽  
2004 ◽  
Vol 104 (8) ◽  
pp. 2263-2268 ◽  
Author(s):  
Jack M. Guralnik ◽  
Richard S. Eisenstaedt ◽  
Luigi Ferrucci ◽  
Harvey G. Klein ◽  
Richard C. Woodman
Keyword(s):  
United States ◽  
Older Persons ◽  
Chronic Renal Disease ◽  
Nutrient Deficiency ◽  
The United States ◽  
High Rate ◽  
World Health ◽  
Anemia Of Chronic Disease ◽  
Health Organization ◽  
The Impact

Abstract Clinicians frequently identify anemia in their older patients, but national data on the prevalence and causes of anemia in this population in the United States have been unavailable. Data presented here are from the noninstitutionalized US population assessed in the third National Health and Nutrition Examination Survey (1988-1994). Anemia was defined by World Health Organization criteria; causes of anemia included iron, folate, and B12 deficiencies, renal insufficiency, anemia of chronic inflammation (ACI), formerly termed anemia of chronic disease, and unexplained anemia (UA). ACI by definition required normal iron stores with low circulating iron (less than 60 μg/dL). After age 50 years, anemia prevalence rates rose rapidly, to a rate greater than 20% at age 85 and older. Overall, 11.0% of men and 10.2% of women 65 years and older were anemic. Of older persons with anemia, evidence of nutrient deficiency was present in one third, ACI or chronic renal disease or both was present in one third, and UA was present in one third. Most occurrences of anemia were mild; 2.8% of women and 1.6% of men had hemoglobin levels lower than 110 g/L (11 g/dL). Therefore, anemia is common, albeit not severe, in the older population, and a substantial proportion of anemia is of indeterminate cause. The impact of anemia on quality of life, recovery from illness, and functional abilities must be further investigated in older persons.

scholarly journals COVID-19 and its possible impact on the UN system

2020 ◽  
pp. 444-447
Author(s):  
Yaryna Zhukorska
Keyword(s):  
Decision Making ◽  
Security Council ◽  
Large Scale ◽  
The United States ◽  
World Health ◽  
Collective Security ◽  
National Interests ◽  
Health Organization ◽  
The Right ◽  
The Impact

In the article, the author analyzes the impact of the coronavirus pandemic on the activities of the UN system. Draws attention tothe ineffectiveness of the UN itself, WHO, as well as the activities of the Security Council and the General Assembly during this period.Draws a parallel with the Spanish flu of the early twentieth century and explores its impact on the development of international orga -nizations.The coronavirus pandemic has shown that the priority for any state is primarily national interests, not common ones. The existenceof international law and international mechanisms has simply been forgotten in the context of protecting national interests. Internationalorganizations such as the United Nations and the World Health Organization have proved ineffective and inflexible and tooslow to deal effectively with today’s threats.In fact, during the pandemic, the UN failed to reach a consensus on joint action in a critical international situation. The Secretary-General has openly stated that he expects the problem to be resolved and concrete measures to be taken by the G-20.As for WHO, its actions have been somewhat slow, but it has responded to information from Member States.According to the WHO, the main reason for such a rapid spread of the virus was the reluctance of states to heed the recommendationsof the WHO.There is currently no alternative to health cooperation other than WHO. Despite the shortcomings in its operation, which haveemerged in the face of such a large-scale and rapid threat, it is appropriate to improve decision-making in such situations, as well as toprovide additional leverage over Member States. Collective security must come first here, not the sovereign interests of an individualstate, be it China, the United States or Germany.The main problem for both the UN and WHO has been the imperfect decision-making mechanism. On the issue with the UN –the right of veto in the Security Council, WHO – the recommendatory nature of the decisions. Considers the possibility of grantingsupranational powers to the UN in key areas where the issue of collective security must clearly prevail over national interests. Jointaction must be the only right solution for the international community in combating today’s threats. And the national interest in suchcases must come after collective security.

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