scholarly journals Effects of oxytocin administration and conditioned oxytocin on brain activity: an fMRI study.

2019 ◽  
Author(s):  
Aleksandrina Skvortsova ◽  
Dieuwke S. Veldhuijzen ◽  
Mischa de Rover ◽  
Gustavo Pacheco-Lopez ◽  
Marian Bakermans-Kranenburg ◽  
...  
Keyword(s):  
Placebo Group ◽  
Brain Activity ◽  
Region Of Interest ◽  
Superior Temporal Gyrus ◽  
The Other ◽  
Future Research ◽  
Optimal Timing ◽  
Fearful Faces ◽  
Brain Responses ◽  
Classically Conditioned

It has been demonstrated that secretion of several hormones can be classically conditioned, however, the underlying brain responses of such conditioning have never been investigated before. In this study we aimed to investigate how oxytocin administration and classically conditioned oxytocin influence brain responses. In total, 88 females were allocated to one of three groups: oxytocin administration, conditioned oxytocin, or placebo, and underwent an experiment consisting of three acquisition and three evocation days. Participants in the conditioned group received 24 IU of oxytocin together with a conditioned stimulus (CS) during three acquisition days and placebo with the CS on three evocation days. The oxytocin administration group received 24 IU of oxytocin and the placebo group received placebo during all days. On the last evocation day, fMRI scanning was performed for all participants during three tasks previously shown to be affected by oxytocin: presentation of emotional faces, crying baby sounds and heat pain. Region of interest analysis revealed that there was significantly lower activation in the right amygdala and in two clusters in the left superior temporal gyrus in the oxytocin administration group compared to the placebo group in response to observing fearful faces. The activation in the conditioned oxytocin group was in between the other two groups for these significant clusters but did not significantly differ from either group. No group differences were found in the other tasks. The findings carefully suggest that a conditioned response in brain activity was observed, however the conditioned group did not significantly differ from the other groups. Future research should therefore investigate the optimal timing of conditioned endocrine responses and study whether the findings generalize to other hormones as well.

scholarly journals Sex-Specific Brain Responses to Imaginary Dance but Not Physical Dance: An Electroencephalography Study of Functional Connectivity and Electrical Brain Activity

2021 ◽  
Vol 15 ◽  
Author(s):  
Johanna Wind ◽  
Fabian Horst ◽  
Nikolas Rizzi ◽  
Alexander John ◽  
Tamara Kurti ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Brain Activity ◽  
Future Research ◽  
Electrical Brain Activity ◽  
Test Conditions ◽  
Brain Responses ◽  
Modern Jazz ◽  
Before And After ◽  
Specific Contact ◽  
Independent Effects

To date, most neurophysiological dance research has been conducted exclusively with female participants in observational studies (i.e., participants observe or imagine a dance choreography). In this regard, the sex-specific acute neurophysiological effect of physically executed dance can be considered a widely unexplored field of research. This study examines the acute impact of a modern jazz dance choreography on brain activity and functional connectivity using electroencephalography (EEG). In a within-subject design, 11 female and 11 male participants were examined under four test conditions: physically dancing the choreography with and without music and imagining the choreography with and without music. Prior to the EEG measurements, the participants acquired the choreography over 3 weeks with one session per week. Subsequently, the participants conducted all four test conditions in a randomized order on a single day, with the EEG measurements taken before and after each condition. Differences between the male and female participants were established in brain activity and functional connectivity analyses under the condition of imagined dance without music. No statistical differences between sexes were found in the other three conditions (physically executed dance with and without music as well as imagined dance with music). Physically dancing and music seem to have sex-independent effects on the human brain. However, thinking of dance without music seems to be rather sex-specific. The results point to a promising approach to decipher sex-specific differences in the use of dance or music. This approach could further be used to achieve a more group-specific or even more individualized and situationally adapted use of dance interventions, e.g., in the context of sports, physical education, or therapy. The extent to which the identified differences are due to culturally specific attitudes in the sex-specific contact with dance and music needs to be clarified in future research.

scholarly journals Individual Differences in Brain Responses: New Opportunities for Tailoring Health Communication Campaigns

2020 ◽  
Vol 14 ◽  
Author(s):  
Richard Huskey ◽  
Benjamin O. Turner ◽  
René Weber
Keyword(s):  
Individual Differences ◽  
Brain Activity ◽  
Brain Regions ◽  
Future Research ◽  
Message Processing ◽  
Response Patterns ◽  
Message Tailoring ◽  
Brain Responses ◽  
And Behavior ◽  
The Brain

Prevention neuroscience investigates the brain basis of attitude and behavior change. Over the years, an increasingly structurally and functionally resolved “persuasion network” has emerged. However, current studies have only identified a small handful of neural structures that are commonly recruited during persuasive message processing, and the extent to which these (and other) structures are sensitive to numerous individual difference factors remains largely unknown. In this project we apply a multi-dimensional similarity-based individual differences analysis to explore which individual factors—including characteristics of messages and target audiences—drive patterns of brain activity to be more or less similar across individuals encountering the same anti-drug public service announcements (PSAs). We demonstrate that several ensembles of brain regions show response patterns that are driven by a variety of unique factors. These results are discussed in terms of their implications for neural models of persuasion, prevention neuroscience and message tailoring, and methodological implications for future research.

scholarly journals Sentence processing is modulated by the current linguistic environment and a priori information: An fMRI study

2018 ◽  
Author(s):  
K. Weber ◽  
C. Micheli ◽  
E. Ruigendijk ◽  
J.W. Rieger
Keyword(s):  
Sentence Processing ◽  
Language Comprehension ◽  
Brain Activity ◽  
Superior Temporal Gyrus ◽  
The Other ◽  
Anterior Cingulate ◽  
Double Object ◽  
Syntactic Structures ◽  
Linguistic Experience ◽  
Language Network

AbstractWords are not processed in isolation but in rich contexts that are used to modulate and facilitate language comprehension. Here, we investigate distinct neural networks underlying two types of contexts. Firstly, the current linguistic environment, presented as the relative frequencies of two syntactic structures (prepositional object (PO) and double-object (DO)), which would either follow everyday linguistic experience or not. Secondly, preference towards one or the other structure depending on the verb; learned in everyday language use and stored in memory. German participants were reading PO and DO sentences in German while brain activity was measured with functional magnetic resonance imaging. Firstly, the anterior cingulate cortex (ACC) showed a pattern of activation that integrated the current linguistic environment with everyday linguistic experience. When the input did not match everyday experience, the unexpectedly frequent structure showed higher activation in the ACC than the other conditions and more connectivity from the ACC to posterior parts of the language network. Secondly, verb-based surprisal of seeing a structure given a verb (PO verb preference but DO structure presentation) resulted, within the language network (left inferior frontal and left middle/superior temporal gyrus) and the precuneus, in increased activation compared to a predictable situation. In conclusion, 1) beyond the canonical language network, brain areas engaged in cognitive control, such as the ACC, might use the statistics of syntactic structures to facilitate language comprehension, 2) the language network is directly engaged in processing verb preferences. These two networks show distinct influences on sentence processing.

Behavior in the Brain

2010 ◽  
Vol 24 (2) ◽  
pp. 76-82 ◽  
Author(s):  
Martin M. Monti ◽  
Adrian M. Owen
Keyword(s):  
Motor Behavior ◽  
Functional Neuroimaging ◽  
Brain Activity ◽  
Motor Output ◽  
The Unconscious ◽  
Ethical Implications ◽  
Brain Responses ◽  
Minimally Conscious ◽  
Brain Insults ◽  
Brain Behavior

Recent evidence has suggested that functional neuroimaging may play a crucial role in assessing residual cognition and awareness in brain injury survivors. In particular, brain insults that compromise the patient’s ability to produce motor output may render standard clinical testing ineffective. Indeed, if patients were aware but unable to signal so via motor behavior, they would be impossible to distinguish, at the bedside, from vegetative patients. Considering the alarming rate with which minimally conscious patients are misdiagnosed as vegetative, and the severe medical, legal, and ethical implications of such decisions, novel tools are urgently required to complement current clinical-assessment protocols. Functional neuroimaging may be particularly suited to this aim by providing a window on brain function without requiring patients to produce any motor output. Specifically, the possibility of detecting signs of willful behavior by directly observing brain activity (i.e., “brain behavior”), rather than motoric output, allows this approach to reach beyond what is observable at the bedside with standard clinical assessments. In addition, several neuroimaging studies have already highlighted neuroimaging protocols that can distinguish automatic brain responses from willful brain activity, making it possible to employ willful brain activations as an index of awareness. Certainly, neuroimaging in patient populations faces some theoretical and experimental difficulties, but willful, task-dependent, brain activation may be the only way to discriminate the conscious, but immobile, patient from the unconscious one.

The Attenuation of Very Low Frequency Brain Oscillations in Transitions from a Rest State to Active Attention

2009 ◽  
Vol 23 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Suzannah K. Helps ◽  
Samantha J. Broyd ◽  
Christopher J. James ◽  
Anke Karl ◽  
Edmund J. S. Sonuga-Barke
Keyword(s):  
Brain Activity ◽  
Sampling Rate ◽  
Low Frequency ◽  
Future Research ◽  
Adhd Symptoms ◽  
Default Mode ◽  
Very Low Frequency ◽  
Wide Range ◽  
Interference Hypothesis ◽  
Mode Interference

Background: The default mode interference hypothesis ( Sonuga-Barke & Castellanos, 2007 ) predicts (1) the attenuation of very low frequency oscillations (VLFO; e.g., .05 Hz) in brain activity within the default mode network during the transition from rest to task, and (2) that failures to attenuate in this way will lead to an increased likelihood of periodic attention lapses that are synchronized to the VLFO pattern. Here, we tested these predictions using DC-EEG recordings within and outside of a previously identified network of electrode locations hypothesized to reflect DMN activity (i.e., S3 network; Helps et al., 2008 ). Method: 24 young adults (mean age 22.3 years; 8 male), sampled to include a wide range of ADHD symptoms, took part in a study of rest to task transitions. Two conditions were compared: 5 min of rest (eyes open) and a 10-min simple 2-choice RT task with a relatively high sampling rate (ISI 1 s). DC-EEG was recorded during both conditions, and the low-frequency spectrum was decomposed and measures of the power within specific bands extracted. Results: Shift from rest to task led to an attenuation of VLFO activity within the S3 network which was inversely associated with ADHD symptoms. RT during task also showed a VLFO signature. During task there was a small but significant degree of synchronization between EEG and RT in the VLFO band. Attenuators showed a lower degree of synchrony than nonattenuators. Discussion: The results provide some initial EEG-based support for the default mode interference hypothesis and suggest that failure to attenuate VLFO in the S3 network is associated with higher synchrony between low-frequency brain activity and RT fluctuations during a simple RT task. Although significant, the effects were small and future research should employ tasks with a higher sampling rate to increase the possibility of extracting robust and stable signals.

Computed Tomography (CT) Attenuation Value in Relation with Body Dimension, Gender and Age in Malay population: A Literature Review

2020 ◽  
Vol 5 (1) ◽  
pp. 12
Author(s):  
Siti Aisyah Munirah Bohang ◽  
Zainul Ibrahim Zainuddin ◽  
Norhanna Suhoimi
Keyword(s):  
English Language ◽  
Region Of Interest ◽  
Time Frame ◽  
Future Research ◽  
Body Dimension ◽  
Attenuation Value ◽  
Gender And Age ◽  
Ct Attenuation ◽  
Malay Population ◽  
Ct Attenuation Value

Interaction of CT’s x-ray beams with patient resulted in attenuation process and there are various factors affecting CT attenuation values. The aim of this review is to examine the existed literatures regarding the concept of attenuation in CT and its relationship with body dimension, gender and age in Malay population. Guided by primary question, literature searches were conducted using the established online database; SCOPUS and PubMed. The time frame for literatures was from 2000 to 2019 and only literatures in English language were selected. The size of body dimension has affected the CT attenuation value but it also depending on the type of tissue presence within the region of interest (ROI) such as muscle and fat tissues. Due to larger body framework and higher amount of skeletal muscle mass theoretically males would have higher CT attenuation value than female. CT attenuation value reduces with aging process. Asians including Malay population have smaller body dimension than Caucasians and the mean attenuation value of abdominal region in Asians could differ from 20 HU. Thus, there is a need for future research to investigate the interrelatedness of attenuation in CT (HU) and body dimension within Malay population and close this gap of knowledge. 

Imaging the “social brain” in schizophrenia: A systematic review of neuroimaging studies of social reward and punishment

2020 ◽  
Author(s):  
Jessica Mow ◽  
Arti Gandhi ◽  
Daniel Fulford
Keyword(s):  
Brain Activity ◽  
Interaction Network ◽  
Social Motivation ◽  
Social Impairment ◽  
Future Research ◽  
Social Reward ◽  
Schizophrenia Spectrum Disorders ◽  
Social Stimuli ◽  
Schizophrenia Spectrum ◽  
Reward And Punishment

Decreased social functioning and high levels of loneliness and social isolation are common in schizophrenia spectrum disorders (SSD), contributing to reduced quality of life. One key contributor to social impairment is low social motivation, which may stem from aberrant neural processing of socially rewarding or punishing stimuli. To summarize research on the neurobiology of social motivation in SSD, we performed a systematic literature review of neuroimaging studies involving the presentation of social stimuli intended to elicit feelings of reward and/or punishment. Across 11 studies meeting criteria, people with SSD demonstrated weaker modulation of brain activity in regions within a proposed social interaction network, including prefrontal, cingulate, and striatal regions, as well as the amygdala and insula. Firm conclusions regarding neural differences in SSD in these regions, as well as connections within networks, are limited due to conceptual and methodological inconsistencies across the available studies. We conclude by making recommendations for the study of social reward and punishment processing in SSD in future research.

scholarly journals Sensory over-responsivity is related to GABAergic inhibition in thalamocortical circuits

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Emily T. Wood ◽  
Kaitlin K. Cummings ◽  
Jiwon Jung ◽  
Genevieve Patterson ◽  
Nana Okada ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Sensory Information ◽  
Network Connectivity ◽  
Sensory Stimulation ◽  
Autism Spectrum ◽  
Future Research ◽  
Resonance Spectroscopy ◽  
Gamma Aminobutyric Acid ◽  
Sensory Stimuli ◽  
Brain Responses

AbstractSensory over-responsivity (SOR), extreme sensitivity to or avoidance of sensory stimuli (e.g., scratchy fabrics, loud sounds), is a highly prevalent and impairing feature of neurodevelopmental disorders such as autism spectrum disorders (ASD), anxiety, and ADHD. Previous studies have found overactive brain responses and reduced modulation of thalamocortical connectivity in response to mildly aversive sensory stimulation in ASD. These findings suggest altered thalamic sensory gating which could be associated with an excitatory/inhibitory neurochemical imbalance, but such thalamic neurochemistry has never been examined in relation to SOR. Here we utilized magnetic resonance spectroscopy and resting-state functional magnetic resonance imaging to examine the relationship between thalamic and somatosensory cortex inhibitory (gamma-aminobutyric acid, GABA) and excitatory (glutamate) neurochemicals with the intrinsic functional connectivity of those regions in 35 ASD and 35 typically developing pediatric subjects. Although there were no diagnostic group differences in neurochemical concentrations in either region, within the ASD group, SOR severity correlated negatively with thalamic GABA (r = −0.48, p < 0.05) and positively with somatosensory glutamate (r = 0.68, p < 0.01). Further, in the ASD group, thalamic GABA concentration predicted altered connectivity with regions previously implicated in SOR. These variations in GABA and associated network connectivity in the ASD group highlight the potential role of GABA as a mechanism underlying individual differences in SOR, a major source of phenotypic heterogeneity in ASD. In ASD, abnormalities of the thalamic neurochemical balance could interfere with the thalamic role in integrating, relaying, and inhibiting attention to sensory information. These results have implications for future research and GABA-modulating pharmacologic interventions.

Children With Intellectual Disability and Victimization: A Logistic Regression Analysis

2021 ◽  
pp. 107755952199417
Author(s):  
Katherine R. Brendli ◽  
Michael D. Broda ◽  
Ruth Brown
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Intellectual Disability ◽  
Logistic Regression Analysis ◽  
District Of Columbia ◽  
The Other ◽  
Future Research ◽  
Common Assumption ◽  
Research And Practice ◽  
Demographic Correlates

It is a common assumption that children with disabilities are more likely to experience victimization than their peers without disabilities. However, there is a paucity of robust research supporting this assumption in the current literature. In response to this need, we conducted a logistic regression analysis using a national dataset of responses from 26,572 parents/caregivers to children with and without disabilities across all 50 states, plus the District of Columbia. The purpose of our study was to acquire a greater understanding of the odds of victimization among children with and without intellectual disability (ID), while controlling for several child and parent/adult demographic correlates. Most notably, our study revealed that children with ID have 2.84 times greater odds of experiencing victimization than children without disabilities, after adjusting for the other predictors in the model. Implications for future research and practice are discussed.

scholarly journals A taxonomy of antonymy in Arabic: Egyptian and Saudi proverbs in comparison

2021 ◽  
Vol 7 (1) ◽  
pp. 200-222
Author(s):  
Hamada Hassanein ◽  
Mohammad Mahzari
Keyword(s):  
Main Clause ◽  
The Other ◽  
Subordinate Clause ◽  
Future Research ◽  
Case Marking ◽  
News Discourse ◽  
Discourse Functions ◽  
Syntactic Frames

Abstract This study has set out to identify, quantify, typify, and exemplify the discourse functions of canonical antonymy in Arabic paremiography by comparing two manually collected datasets from Egyptian and Saudi (Najdi) dialects. Building upon Jones’s (2002) most extensive and often-cited classification of the discourse functions of antonyms as they co-occur within syntactic frames in news discourse, the study has substantially revised this classification and developed a provisional and dynamic typology thereof. Two major textual functions are found to be quantitatively significant and qualitatively preponderant: ancillarity (wherein an A-pair of canonical antonyms project their antonymicity onto a more important B-pair) and coordination (wherein one antonym holds an inclusive or exhaustive relation to another antonym). Three new functions have been developed and added to the retrieved classification: subordination (wherein one antonym occurs in a subordinate clause while the other occurs in a main clause), case-marking (wherein two opposite cases are served by two antonyms), and replacement (wherein one antonym is substituted with another). Semicanonical and noncanonical guises of antonymy are left and recommended for future research.

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