scholarly journals Amplified salience of somatic information in persistent depression

2021 ◽  
Author(s):  
Anna Bevan ◽  
Caitlin Hitchcock ◽  
Daniel Mitchell ◽  
Tim Dalgleish

Disrupted bodily awareness may reflect mechanisms which drive both symptomatology and disorder maintenance in clinical depression. We investigated attentional capture by somatic signals in clinically depressed individuals and healthy controls as one aspect of bodily awareness. Attentional performance in a cross-modal covert orienting task was globally disrupted when depressed participants attempted to ignore uninformative somatic cues, in a largely modality-specific manner. In a subsequent study employing a similar paradigm, attention was disproportionately captured in depressed participants by informative somatic cues, in a similarly modality-specific way. Taken together, the results suggest that the salience of somatic signals is amplified in clinical depression, and that attempts to ignore them may have a disruptive effect on attentional processing more generally in this population.


2014 ◽  
Vol 45 (7) ◽  
pp. 1425-1433 ◽  
Author(s):  
A. Sankar ◽  
J. Scott ◽  
A. Paszkiewicz ◽  
V. P. Giampietro ◽  
H. Steiner ◽  
...  

BackgroundDysfunctional attitudes are a feature of depression that has been correlated with receptor binding abnormalities in limbic and cortical regions. We sought to investigate the functional neuroanatomy of dysfunctional attitudes in major depressive disorder (MDD) and the effects of treatment with cognitive–behavioural therapy (CBT).MethodParticipants were 16 patients with unipolar depression in an acute depressive episode (mean age 40.0 years) and 16 matched healthy controls (mean age 39.9 years). Patients were medication free and received a course of treatment with CBT. All participants underwent functional magnetic resonance imaging (fMRI) scans at baseline and at week 16, prior to the initiation of therapy and following the course of CBT for patients. During each fMRI scan, participants indicated their attributions to statements from a modified Dysfunctional Attitudes Scale (mDAS-48).ResultsMDD patients in an acute depressive episode endorsed a greater number of extreme responses to DAS statements, which normalized following CBT treatment. Extreme attributions were associated with greater activation in the left hippocampal region, inferior parietal lobe and precuneus in MDD patients as compared with healthy controls as a main effect of group. An interaction effect was found in the left parahippocampal region, which showed less attenuation in MDD patients at the follow-up scan relative to healthy controls.ConclusionsAttenuation of activity in the parahippocampal region may be indicative of an improvement in dysfunctional thinking following CBT treatment in depression, while persistent engagement of regions involved in attentional processing and memory retrieval with extreme attributions reflects a trait feature of depression.



Psihologija ◽  
2006 ◽  
Vol 39 (4) ◽  
pp. 425-437 ◽  
Author(s):  
Zdenka Novovic ◽  
Petar Colovic ◽  
Maja Babic ◽  
Gordana Misic-Pavkov

Studies demonstrating the uniqueness of depression in old age are numerous, but conclusions on the fact if the problems of the elderly people cause depression or if they are a part of depression are not unique. The aim of this paper is to compare the structure of depression of old people without the history of mental illness and middle-aged people treated for depression. The sample consists of 82 healthy inmates of different Homes for the Aged and 78 patients diagnosed with some sort of affective disorder. A depression has been assessed with the shorten version of the MMPI D-scale. The structure of the geriatric and clinical depression has been compared with the method of maximum likelihood, over the matrix of co-variances of answers on the items on the depression scale. The results point out to the statistically significant difference in the structure of depression of the old and clinically depressed individuals. However, half of the items of the D-scale have significant loadings on the factor of depression in both groups. The essence of the depression in both samples is made of cognitive subject matters, depressive affect, decline of motivation and a negative estimate of one's basic abilities. Symptoms concerning low self-esteem, experiencing cognitive deficit, energy and impaired physical health have been significant in describing the clinical depression, while a feeling of reduced positive stimulation and the affective liability is typical for the depression of geriatric sample. The conclusion is that, despite the differences, there is a common core of symptoms that makes the essence of depression, apart from the samples.



2019 ◽  
pp. 108705471987949
Author(s):  
Bendik Rund Torgalsbøen ◽  
Pål Zeiner ◽  
Merete Glenne Øie

Objective: The aim of the study was to compare the development of working memory and preliminary stages of attentional processing in individuals with ADHD over a 23- to 25-year period. Method: Individuals with ADHD ( n = 19) and healthy controls ( n = 26) were followed up after 13 years (T2) and 23 to 25 years (T3) after initial assessment (T1). They were reassessed with diagnostic measures and the Backward masking task (pre-attention) and the Digit span distractibility test with and without distraction conditions (working memory). Results: The ADHD group performed below the healthy controls on all time points on the Digit span distractibility test. On the distractibility condition, we found a selective decline in performance from T2 to T3 for the ADHD group. Conclusion: The results highlight that ADHD individuals continue to display working memory deficits, also in adulthood, thus creating an imperative for cognitive rehabilitation techniques to help address attention difficulties.



2010 ◽  
Vol 3 ◽  
pp. NMI.S5044 ◽  
Author(s):  
A.J. Russo

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. Subjects and Methods Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and clinical depression.



PLoS ONE ◽  
2021 ◽  
Vol 16 (10) ◽  
pp. e0256553
Author(s):  
Martin Vollmann ◽  
Christiane Schwieren ◽  
Margarete Mattern ◽  
Knut Schnell

Depression in the workplace is a significant factor for reduced personal well-being and productivity. Consequently, this has negative effects on the economic success of the companies in which depressed people are employed. In addition, the economy has to deal with the significant burden of this illness on the health system. In this paper, we investigated how different working contexts—working in a group or individually—influenced depressed individuals towards higher or lower well-being and productivity. We examined this using a laboratory experiment. In this setting, we were also able to analyze how, in turn, a depressive individual impacted the productivity and affective situation of their workgroup, reflecting the company perspective. The experimental design mimicked the very basic processes of a workplace in a stylized way. We used two distinct samples: subclinically and clinically depressed, both working in a group with healthy controls. As expected, we found generally lower performance in the clinically depressed sample, but in the subclinically depressed sample, we only found this in the individual work context. In contrast to our expectations, the performance of subclinically depressed individuals working in groups with healthy controls was even higher than that of healthy controls in homogenously healthy groups. The performance of the entire group with a depressed member was lower for the sample with clinically manifested depression, while the performance of groups with a subclinically depressed participant was significantly higher than the performance of homogeneously non-depressed control groups. We discuss our results with a focus on the design of workplaces to both re-integrate clinically depressed employees and prevent subclinically depressed employees from developing major depression.



1993 ◽  
Vol 23 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Shelley Channon ◽  
Jane E. Baker ◽  
Mary M. Robertson

SynopsisThis study compared clinically depressed subjects with normal controls on a range of working memory tasks. The findings suggested the articulatory loop and visuospatial sketch pad components of working memory to be unimpaired in depression. On a range of clinical tasks likely to involve central executive function, depressed subjects showed impairment only on some tasks.



2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Thomas Suslow ◽  
Charlott Maria Bodenschatz ◽  
Anette Kersting ◽  
Markus Quirin ◽  
Vivien Günther

Abstract Background Clinical depression is characterized by high levels of negative affect (NA) and attenuated positive affect (PA). Psychological and pharmacological treatments have been shown to reduce NA and to enhance PA in depressed patients. Following dual-process models, two types of affect can be distinguished: explicit (or self-reported) affect, which is formed by conscious reflections, and implicit affect, which relates to automatic affective reactions. The present study was conducted to examine, for the first time, both implicit and explicit affectivity in patients suffering from acute depression. Moreover, changes in patients’ implicit and explicit affectivity were investigated over the course of inpatient treatment. Methods Thirty-nine patients suffering from major depression and 39 healthy individuals participated in the study. Implicit affectivity was assessed using the Implicit Positive and Negative Affect Test. The explicit state and trait affectivity were measured by the Positive and Negative Affect Schedule. The level of depressive symptoms was assessed with the Beck Depression Inventory. Tests were administered to patients after admission and after 7 weeks of therapy, whereas healthy controls were investigated only once. We examined whether either comorbidity or antidepressant medication has an effect on affectivity. Results Patients with acute depression had lower implicit and explicit PA scores and higher implicit and explicit NA scores than the healthy controls. After treatment, patients’ level of depression decreased significantly. At posttreatment, patients exhibited heightened implicit and explicit PA and diminished explicit trait NA. Independent of antidepressant medication and comorbidity, no significant change in implicit NA was observed over the course of treatment. Implicit NA was correlated with explicit NA in acute depression but not during recovery. Conclusions Acute depression appears to be characterized by decreased implicit and explicit PA and increased implicit and explicit NA. After 7 weeks of treatment, depressed patients’ implicit and explicit PA increased, and explicit trait NA decreased. No decrease in implicit NA and explicit state NA occurred over the course of treatment. Finally, it seems that in the state of acute depression, the interplay between the automatic and reflective systems could be increased for negative affectivity.





2004 ◽  
Vol 26 (4) ◽  
pp. 623-633 ◽  
Author(s):  
Torunn Bodin ◽  
Egil W. Martinsen

Physical activity is associated with an antidepressant effect in clinical depression. Self-efficacy is one mechanism proposed to explain this effect. In this study we compared the changes in mood following exercise sessions with high and stable self-efficacy (stationary bike exercise) to exercise sessions with initially low but increasing self-efficacy (martial arts). The experimental design incorporated repeated measures and counter-balancing. Twelve clinically depressed participants completed 45-min exercise sessions consisting of stationary bike use and martial arts. A waiting control condition of 30 minutes was conducted before each exercise session. During martial arts, statistically significant increases in positive affect, reductions in negative affect and state anxiety, and increased self-efficacy were observed. During the stationary bike exercise no statistically significant changes were found. The results indicate that an increase in self-efficacy may be important for mood benefits to occur.



2011 ◽  
Vol 26 (S2) ◽  
pp. 1455-1455
Author(s):  
L. Moreno ◽  
J. Valero ◽  
A.M. Gaviria ◽  
A. Labad

IntroductionImpaired sustained and selective attention have been seen as vulnerability factors to psychotic disorders. Relatives of psychotic patients are a risk population for psychosis, and previous studies have shown that they displayed more attentional deficits compared with healthy controls. Additionally, relatives have more pathological personality and schizotypy, the least considered also to be the expression of the genetic vulnerability to schizophrenia. There are few studies that relate attention to personality factors in relatives of psychotic patients.AimsTo compare attentional performance of siblings of psychotic patients with those of healthy controls, taking into account their pathological and schizotypal personality.MethodsThe Spanish version of the SPQ and the DAPP-BQ were administered to a sample of 51 subjects that were divided into four groups by a hierarchical cluster analysis: siblings with high pathological personality (SHPP), siblings with low pathological personality (SLPP), controls with high pathological personality (CHPP), and controls with low pathological personality (CLPP). In all the subjects we assessed a sustained attention index (SUA) and a selective attention index (SEA). We compared the performance of the four groups on these attentional indexes.ResultsWe found that SHPP had worse performance on sustained attention compared with CLPP. Specifically this difference was in the reaction time item of the SUA.ConclusionsThe high schizotypy and pathological personality had an influence on sustained attentional performance in the siblings of patients with psychosis, but not in the healthy controls.



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